1. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) activates p38 to affect pulmonary fibrosis
- Author
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Yan An, Su-Yan Yan, Wei Xu, Mei-Qi Li, Rong-Rong Dong, Qing-Rui Yang, and Zhen-Zhen Ma
- Subjects
Heparin ,Epidermal growth factor ,p38 ,MAPK ,Medicine (General) ,R5-920 ,Cytology ,QH573-671 - Abstract
Objective: We aimed to examine whether heparin-binding epidermal growth factor-like growth factor (HB-EGF) affects the lung fibrosis process through the activation of p38 protein in mitogen-activated protein kinases (MAPK) signaling pathway, as well as the expression of downstream inflammatory factors. Methods: The expression levels of HB-EGF, collagen type I (COL-I), and hexokinase 2 (HK2) in peripheral blood mononuclear cells (PBMCs) of patients with connective tissue disease-related interstitial lung disease (CTD-ILD) were examined by qPCR, Western blotting and ELISA. Results: In vitro experiments showed that HB-EGF was increased in almost all subtypes [rheumatoid arthritis (RA), systemic sclerosis (SSc) and idiopathic inflammatory myopathies (IIMs)] as well as in all groups (P
- Published
- 2024
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