Search

Your search keyword '"Su, Wei Juin"' showing total 273 results
Start Over Author "Su, Wei Juin"
273 results on '"Su, Wei Juin"'

2. Circulating mitochondrial cell-free DNA dynamics in patients with mycobacterial pulmonary infections: Potential for a novel biomarker of disease

Author

Pan, Sheng-Wei, Syed, Rehan R, Catanzaro, Donald G, Ho, Mei-Lin, Shu, Chin-Chung, Tsai, Tsung-Yeh, Tseng, Yen-Han, Feng, Jia-Yih, Chen, Yuh-Min, Su, Wei-Juin, Catanzaro, Antonino, and Rodwell, Timothy C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Tuberculosis, Lung, Rare Diseases, Infection, Good Health and Well Being, Humans, Cell-Free Nucleic Acids, Pneumonia, Mitochondrial Dynamics, Tuberculosis, Pulmonary, Mycobacterium Infections, Nontuberculous, Biomarkers, Latent Tuberculosis, cell-free DNA, mitochondria, pulmonary tuberculosis, treatment response monitoring, biomarker, Immunology, Medical Microbiology, Biochemistry and cell biology, Genetics
Abstract

ObjectivesHuman mitochondrial cell-free DNA (Mt-cfDNA) may serve as a useful biomarker for infectious processes. We investigated Mt-cfDNA dynamics in patients with pulmonary mycobacterial infections to determine if this novel biomarker could be used to differentiate disease states and severity.MethodsPatients with pulmonary tuberculosis (PTB), latent tuberculosis infection (LTBI), and nontuberculous mycobacterial-lung disease (NTM-LD) were enrolled at a tertiary care hospital in Taiwan between June 2018 and August 2021. Human Mt-cfDNA and nuclear-cfDNA (Nu-cfDNA) copy numbers were estimated by quantitative polymerase chain reaction. Variables associated with PTB and 2-month sputum culture-positivity, indicating poor treatment response, were assessed using logistic regression.ResultsAmong 97 patients with PTB, 64 with LTBI, and 51 with NTM-LD, Mt-cfDNA levels were higher in patients with PTB than in LTBI (p=0.001) or NTM-LD (p=0.006). In the Mycobacterium tuberculosis-infected population, Mt-cfDNA levels were highest in smear-positive PTB patients, followed by smear-negative PTB (p

Published
2022

6. Safety and efficacy of oral nemonoxacin versus levofloxacin in treatment of community-acquired pneumonia: A phase 3, multicenter, randomized, double-blind, double-dummy, active-controlled, non-inferiority trial

Author

Zhao, Li, Wang, Xiongbiao, Wang, Xuefen, Wang, Dexi, Li, Xiangyang, Peng, Yiqiang, Liang, Yongjie, Liu, Hua, Xiao, Zuke, Lv, Xiaoju, Wu, Shiman, Dai, Yuanrong, Huang, Yijiang, Hu, Zhenghong, Qiu, Chen, Li, Xi, Zhang, Suiyang, Li, Wenpu, Liu, Shuang, Shi, Yi, Xiong, Chang, Kuang, Jiulong, Xiu, Qingyu, Cui, Shehuai, Li, Jianguo, Lin, Qichang, Huang, Wenxiang, Wan, Yixin, Qimanguli, Shen, Ce, Xiao, Yi, Wu, Xiaoju, Chuang, Yin Ching, Perng, Wann Cherng, Tsao, Shih-Ming, Hsu, Jeng-Yuan, Wang, Chin-Chou, Wang, Jen-Hsien, Yeh, Pen-Fang, Lin, His-Hsun, Kuo, P.H., Lin, Ming-Shian, Su, Wei-Juin, Yuan, Jinyi, Mo, Biwen, Ma, Zhuang, Lv, Yuan, Cheng, Shih-Lung, Yang, Yanping, Tong, Zhaohui, Wu, Renguang, Sun, Shenghua, Cao, Zhaolong, Wu, Jufang, Zhu, Demei, Chang, Liwen, and Zhang, Yingyuan

Published
2019
Full Text
View/download PDF

12. Influenza Vaccination and Incident Tuberculosis among Elderly Persons, Taiwan

Author

Yen, Yung-Feng, Pan, Sheng-Wei, Su, Vincent Yi-Fong, Chuang, Pei-Hung, Feng, Jia-Yih, and Su, Wei-Juin

Subjects
Influenza vaccines -- Analysis, Online databases -- Analysis, National health insurance -- Analysis, Elderly -- Analysis, Influenza -- Analysis, Vaccination -- Analysis, Tuberculosis -- Analysis, Health insurance industry -- Analysis, Online database, Health
Abstract

Tuberculosis (TB) remains a common and deadly disease throughout the world (1). In 2014, there were 9.6 million cases of TB worldwide, and 1.5 million persons died of this disease [...]

Published
2018
Full Text
View/download PDF

16. Circulating mitochondrial cell-free DNA dynamics in patients with mycobacterial pulmonary infections: Potential for a novel biomarker of disease

Author

Pan, Sheng-Wei, primary, Syed, Rehan R., additional, Catanzaro, Donald G., additional, Ho, Mei-Lin, additional, Shu, Chin-Chung, additional, Tsai, Tsung-Yeh, additional, Tseng, Yen-Han, additional, Feng, Jia-Yih, additional, Chen, Yuh-Min, additional, Su, Wei-Juin, additional, Catanzaro, Antonino, additional, and Rodwell, Timothy C., additional

Published
2022
Full Text
View/download PDF

18. Sex-Specific Associations Between Susceptibility to Mycobacterium avium Complex Lung Disease and Programmed Cell Death 1 Gene Polymorphisms.

Author

Pan, Sheng-Wei, Feng, Jia-Yih, Wu, Lawrence Shih-Hsin, Shu, Chin-Chung, Wang, Ping-Huai, Wang, Jann-Yuan, Wang, Hao-Chien, Su, Wei-Juin, Chen, Yuh-Min, and Yu, Chong-Jen

Subjects
APOPTOSIS, MYCOBACTERIUM avium, GENETIC polymorphisms, PROGRAMMED cell death 1 receptors, LUNG diseases
Abstract

Background Mycobacterium avium complex lung disease (MAC-LD) preferentially occurs in postmenopausal women and may have immune exhaustion involving the programmed cell death 1 (PD-1) pathway. It is still unknown whether sex-specific associations between susceptibility to MAC-LD and programmed cell death 1 gene (PDCD1) polymorphisms exist. Methods Adult patients with MAC-LD (n = 152) and controls (n = 167) were included at 2 medical centers in Taiwan. Five single-nucleotide polymorphisms in PDCD1 genes were genotyped, and their associations with MAC-LD and soluble PD-1 protein were analyzed, especially in sex subgroups. Results PDCD1 rs2227982 polymorphism was associated with increased risk of MAC-LD in women (adjusted odds ratio for AA vs AG vs GG, 2.205 [95% confidence interval, 1.108–4.389]; P =.02), and the rs10204525 TT genotype was associated with low risk in men (TT vs TC and CC, 0.396 [.176–.890]; P =.02). Compared with men with rs10204525 TT, women with rs2227982 AG and with AA had 2.7- and 5.0-fold increased risks, respectively. Soluble PD-1 levels were lower in the female subgroup with rs2227982 AG and AA than in the remainder (median level [interquartile range], 46.7 [33.7-71.5] pg/mL vs 66.2 [48.6–101.5] pg/mL; P <.001). Conclusions PDCD1 genetic polymorphisms were associated with the risk of MAC-LD in a sex-specific pattern, possibly through regulation of PD-1 expression. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

23. Plasma Concentrations of sTREM-1 as Markers for Systemic Adverse Reactions in Subjects Treated With Weekly Rifapentine and Isoniazid for Latent Tuberculosis Infection

Author

Wang, Tsai-Yu, primary, Feng, Jia-Yih, additional, Shu, Chin-Chung, additional, Lee, Susan Shin-jung, additional, Chen, Chung-Yu, additional, Wei, Yu-Feng, additional, Lin, Chih-Bin, additional, Huang, Wei-Chang, additional, Su, Wei-Juin, additional, and Lin, Shu-Min, additional

Published
2022
Full Text
View/download PDF

26. Disease Progression in Patients With Nontuberculous Mycobacterial Lung Disease of Nodular Bronchiectatic (NB) Pattern: The Roles of Cavitary NB and Soluble Programmed Death Protein-1

Author

Pan, Sheng Wei, primary, Su, Wei Juin, additional, Chan, Yu Jiun, additional, Ho, Mei Lin, additional, Feng, Jia Yih, additional, Shu, Chin Chung, additional, Wang, Jann Yuan, additional, Wang, Hao Chien, additional, Yu, Chong Jen, additional, and Chen, Yuh Min, additional

Published
2021
Full Text
View/download PDF

29. Sleep apnea and risk of pneumonia: a nationwide population-based study

Author

Su, Vincent Yi-Fong, Liu, Chia-Jen, Wang, Hsin-Kai, Wu, Li-An, Chang, Shi-Chuan, Perng, Diahn-Warng, Su, Wei-Juin, Chen, Yuh-Min, Lin, Elizabeth Ya-Hsuan, Chen, Tzeng-Ji, and Chou, Kun-Ta

Subjects
Bacterial pneumonia -- Risk factors, Pneumonia -- Risk factors, Sleep apnea syndromes -- Complications and side effects, Health
Abstract

Background: Evidence evaluating the risk of pneumonia in patients with obstructive sleep apnea is limited and mostly focuses on patients who receive continuous positive airway pressure (CPAP) therapy or on pediatric patients. We aimed to explore the risk of incident pneumonia among adults with sleep apnea, either with or without the need of CPAP therapy. Methods: From Jan. 1, 2000, we identified adult patients with sleep apnea from the Taiwan National Health Insurance Research Database. A control cohort without sleep apnea, matched for age, sex and comorbidities, was selected for comparison. The 2 cohorts were followed until Dec. 31, 2010, and observed for occurrence of pneumonia. Results: Of the 34 100 patients (6816 study patients and 27 284 matched controls), 2757 (8.09%) had pneumonia during a mean follow-up period of 4.50 years, including 638 (9.36%) study patients and 2119 (7.77%) controls. Kaplan-Meier analysis showed a higher incidence of pneumonia among patients with sleep apnea (log rank test, p < 0.001). After multivariate adjustment, patients with sleep apnea experienced a 1.20-fold (95% confidence interval 1.10-1.31) increase in incident pneumonia. The risk was even higher among patients who received CPAP therapy. Interpretation: Sleep apnea appeared to confer a higher risk for future pneumonia, possibly in a severity-dependent manner., Obstructive sleep apnea is a prevalent disorder that affects about 20% of Americans and probably a higher percentage of Asian people. (1,2) This disease is characterized by intermittent collapse of [...]

Published
2014
Full Text
View/download PDF

30. Disease Progression in Patients With Nontuberculous Mycobacterial Lung Disease of Nodular Bronchiectatic (NB) Pattern: The Roles of Cavitary NB and Soluble Programmed Death Protein-1.

Author

Pan, Sheng Wei, Su, Wei Juin, Chan, Yu Jiun, Ho, Mei Lin, Feng, Jia Yih, Shu, Chin Chung, Wang, Jann Yuan, Wang, Hao Chien, Yu, Chong Jen, and Chen, Yuh Min

Subjects
*DISEASE progression, *BIOMARKERS, *CONFIDENCE intervals, *LUNG diseases, *MYCOBACTERIUM avium, *SPUTUM, *DESCRIPTIVE statistics, *BRONCHIECTASIS, *MYCOBACTERIAL diseases, *BODY mass index
Abstract

Background In patients with nodular bronchiectatic (NB) nontuberculous mycobacterial lung disease (NTM-LD), risk factors for disease progression have not been clearly investigated. The roles of cavitary NB and soluble programmed death protein-1 (sPD-1), an immune-related biomarker, in the disease course of NB NTM-LD remain unknown. Methods Patients with NB NTM-LD were enrolled from 2 medical centers in 2014–2020. We identified cavitary NB, measured sPD-1 levels, and analyzed factors associated with cavitary NB and predictors for disease progression of NB NTM-LD. Results Of 120 cases of NB NTM-LD, 87 (72.5%) were caused by Mycobacterium avium complex. sPD-1 levels were lower in 13 (10.8%) patients with cavitary NB than in noncavitary patients (P  = .020). Over 1.41 ± 1.43 years of follow-up, 12 (92.3%) patients in the cavitary and 66 (61.7%) in the noncavitary group developed disease progression (P  = .032). In multivariable analysis, body mass index (BMI [kg/m2]; adjusted hazard ratio [aHR],.895 [95% confidence interval,.811–.988]), sputum smear grade (aHR, 1.247 [1.014–1.534]), cavitary NB (aHR, 2.008 [1.052–3.834]), and sPD-1 (per 10-pg/mL increase; aHR,.889 [.816–.967]) were predictive for disease progression. Notably, sPD-1 showed a dose-dependent association with disease progression (sPD-1 ≤23.5 pg/mL; aHR, 3.306 [1.664–6.567]; sPD-1: 23.6–53.7 pg/mL; aHR, 2.496 [1.390–4.483]) compared with the reference (sPD-1 >53.7 pg/mL). Conclusions Patients with NB NTM-LD and low sPD-1, low BMI, high smear grade, and cavitary NB were at high risk for disease progression. sPD-1 was low in patients with cavitary NB phenotype and dose-responsively associated with disease progression. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results