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Background and Aims: In order to evaluate the impacts of lifestyles on the newly developed Type 2 Diabetes and ensuing development of primary preventive interventions in high risk people, a nationally standardized, multi-professionally integrated, evidence-based and patient-center healthcare program-DCMP 2001 was implementing in a medical center, Mid-Taiwan. Materials and methods: From Jan. 2003 to Jan. 2004, 5404 diabetes beneficiaries were randomly and cumulatively recruited in DCMP 2001 via monthly outpatient visits. Accordingly, the lifestyle measurements (lifestyle I: no smoking, no alcoholic and regular exercise; lifestyle II: smoking and/or alcoholic and/or no exercise), total daily caloric intakes, macronutrient consumptions and dietary recommendations were tri-monthly recorded following adequate dietary history taking in each diabetes patient after seeing physician. From this cohort, all the newly developed diabetes (n=837) were randomly sorted out and further divided up into 6 groups with different age of onset of disease, ≤ 40 years, < 40 to ≤ 50 years, < 50 to ≤ 60 years, < 60 to ≤ 70 years, < 70 to ≤ 80 years and over 80 years for study. Comparisons between groups were performed by using Chi-Square test. The significant level was set at p<0.05. Results: The case and percentage distributions of lifestyle I and II at different age ranges in this newly developed T2DM cohort were shown on Table 1. It were statistically significant to demonstrate that the younger onset of diabetes, more than 70% of patients living on lifestyle If, whereas the older onset of diabetes, greater than 60% of patients sticking on lifestyle I ( p<0.0001). Comparison between exercisers and non-exercisers also shown that non-exercisers developed diabetes were significantly earlier than the exercisers (p<0.001). Conclusions: The aforementioned results clearly indicated that lifestyles and regular physical activity had significant impact on the development of diabetes. Therefore, for the primary prevention of the development of diabetes in high risk population, early lifestyle intervention would be strongly recommended. [ABSTRACT FROM AUTHOR]