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From studying the bibliography and from experience we found that education issues regarding coordination abilities are addressed very vaguely and made by practical means scientifically unproven as effective. In today's sports branches, the importance of coordinative capacities is the starting point in the correct performance of motor skills but also in the ability to quickly adapt to different situations or working conditions. With the increase in the level of development of these motor capacities, in schools, through dedicated lessons, we could speak of a much better selection for certain sports branches but also for performance sports. Research presented at various scientific conferences and the published papers had a good impact on the specialists of Sport Science and Physical Education. We believe today that these studies are just the beginning to modernize the entire contents aimed at optimizing the motor capacities of the child. We know that today's young people, with problems of a motor nature, also have problems of an affective-social nature. This psychosocial imbalance is closely related to psychomotor development. In this sense, psychomotricity must be promoted as the main part of personality development.

This paper analyzes, from a spatial point of view, the places in Bihor County where we have sports associations, private clubs, small teams of children and juniors, where children and young people who have not yet reached the age of majority work. Among the research methods used and applied in carrying out this paper we mention: observation method, analytical method, the statistical-mathematical method and the method of graphic and cartographic representation and the basic tool is represented in the cartographic modeling by the ArcGis program. The Bihor football map includes 55 clubs, of which 12 have only activity with junior teams. The total number of clubs with junior teams is 31 and which totals 84 junior teams. A number of 24 clubs with senior teams 55.8% (out of 43) have no activity with junior teams. Most clubs that have junior activity are in Oradea 16, followed by Salonta 3, the rest of the localities having only one club. These clubs are distributed in 23 localities. Only 19 clubs with activity in the senior teams also have groups of children registered in official competitions. Through this study we aimed to improve the cartographic aspect the representation of the sports phenomenon in general and the football one in particular in order to show the importance of the cartographic product in the qualitative and quantitative spatial analysis, in the analytical and synthetic one.

The present paper offers a theoretical insight regarding the quality of life and health state of people with mental deficiency. Research results regarding the link between physical activity and quality of life of people with mental disorders are discussed. Literature review outlined that physical activity generates major benefits for people with mental deficiency. Conclusions point out the need to implement physical activities that can be performed by people with mental deficiency to increase their quality of life. Public and private stakeholders should cooperate in order to develop specific strategies and policies, as well as adapted programs for people with mental deficiency to maintain their health status and quality of life at a decent level.

Throughout the all known history of humanity, physical activities - regardless of type or organization - have occupied an important place in people's lives. Given these aspects, to which we can add its pedagogical, psychological, sociological valences, the body education is transformed into a higher category, which motivates the wide range of concerns related to the evolution of all the instruments designed to optimize it. On the other hand, given the special character and the particular place that the physical education and sports students occupies in relation to the mentioned category, we believe that the concern for monitoring the evolution of some components of human motility, highlighting the tendency that they register, is motivated.

Developing creativity has been a topical theme in all areas. In the field of physical activity, the term creativity is familiar, whether it is physical education or sports. However, we can see a lack of involvement, creativity in the physical education lesson, both on the part of the teachers and the students from the faculties. In view of these considerations, we believe that our intervention is opportune because in the preparatory part of the physical education lesson, it is possible to associate and realize multiple variants of walking, running, jumping, use of objects, balls, ladders, movement games, etc. and, in this way, the teacher can express his creativity in a particular way. In this regard, we propose a creative development variant, a "creative clock", to support those interested in optimizing the ways to achieve the third link in the physical education lesson.

This study examines the implications of the FDI on economy of the Republic of Moldova. Using a data approach, the results show that global financial and economic crisis of 2008-2009 has strongly influenced the dynamics of FDI. Our results also demonstrate that Moldova needs to take cardinal measures to overcome the crisis phenomenon and to direct its economy on ascending development trajectory.

Related rather to spider and scorpion, these blue-blooded, forgotten by time, Horseshoe crab own some of the most interesting secrets. This shellfish has survived on Earth for millions of years 562/450, without suffering major changes. Today, unfortunately, the problem faced extinction horseshoe crab. Measures should be taken for conservation of this species and for maintaining ecological balance, but also because of the importance of this species: the blood of this arthropod finds applications in medicine.

Veterinary pharmaceutical products intended for use in fish should comply with all usual requirements regarding approval for marketing, according to the Order of the President of the National Sanitary Veterinary Agency and for Food Safety No.187/2007, with subsequent amendments and additions. According to the legislation the technical file should containe documentation of quality, safety of animals, consumer, user and environment and demonstration of efficacy and tolerance in the target species. This paper provides the important information on requirements for demonstration on efficacy of pharmaceutical products indended for use in fish. The principal aim of the efficacy data is to prove the therapeutic value of pharmaceutical products and to establish an optimal dose and period of dose administration. In efficacity clinical trial is needed, also, to take into account, the various conditions such as climatic aspects, disease situation, water temperature and salinity, because these may influence the outcome and veracity of the studies.

Antibiotics are one of the most important therapeutic discoveries in medical history. They have revolutionized the way we treat patients with bacterial infections and have contributed to reducing the mortality and morbidity from bacterial diseases. Unfortunately, antibiotics have been liable to misuse which leads to the emergence and selection of resistant bacteria. Doctors in Europe and worldwide now are sometimes facing situations where infected patients cannot be treated adequately because the responsible bacterium is totally resistant to available antibiotics. The correct use of antimicrobials is one of the most important tools which could limit the spread of this phenomenon - resistance to antimicrobials. Specialists from Institute for Control of Biological Products and Veterinary Medicines understood to involve in this fight against antibioresistance, by tacking appropriate measures according to the european approches concerning reducing of the antibiotic consumption, correct usage and responsible of them.

Biocidal products are necessary in our lives in order to protect us against pathogenic microorganisms. But their use must be subject to a strict regulation because their harmful potential on human and animal health and environment is huge. Biocidal products must be authorized by a competent authority before placing them on the market and all active substances from their composition must be tested and certified to ensure they are in compliance with regulatory requirements in the field. Also biocides, with antimicrobials, may be involved in causing the phenomenon of antibiotic resistance. Their misuse can lead to the emergence of resistant organisms, through mechanisms similar to those that appear in incorrect treatment with antibiotics. We should, therefore, be aware of this aspect particularly important to prevent unwanted effects of cross resistance to antibiotics and biocides. The more so as, lately, there are pulled many alarm signals about the fact that, in a very short time, mankind is in danger of remaining without the main arsenal for fighting harmful microorganisms.

The present case report describes a mother and son with arrhythmogenic cardiomyopathy (ACM) with early and greater left ventricle (LV) involvement. The presence of curly hair in both, together with the resuscitated sudden cardiac death of the mother, allowed timely genetic testing, which found a pathogenic nonsense mutation of the desmoplakin gene. While asymptomatic from an arrhythmic point of view, the son’s evolution was characterized by a well-documented exercise-induced myocarditis-like stage.

The microbiological contamination of pharmaceutical products could have major consequences on the physical – chemical characteristics, safety and efficiency of the medicinal products and also on the out of specification products recall-associated costs. Quality control of the pharmaceutical products should be a major objective for both the pharmaceutical industry as well as for the official quality control laboratories and the final results of these tests should provide most accurate data regarding the safety and the efficiency of the controlled pharmaceutical products. This report is presenting the results which were obtained in 2013 in the Microbiological Control Laboratory following the quality control of the products according to their pharmaceutical form and therapeutical class.

The credit crises are the consequences of demonetization process failure of MONEY-LIABILITY. To initiate a treatment of this process more "overshadowed" by the financial-banking system, it is required a comprehensive analysis of GLOBAL DEBT; GLOBAL GDP and the ratio between them called "FINANCIAL LEVERS" [3]. The "malfunctions" of DEBT monitoring process are random, but in principle can be formalized by setting them based on statistical probability of credit crisis in the last 100 years [7, 8].

Government debt (also known as public debt and national debt) is the debt owed by a central government. (In the U.S. and other federal states, "government debt" may also refer to the debt of a state or provincial government, municipal or local government). By contrast, the annual "government deficit" refers to the difference between government receipts and spending in a single year, that is, the increase of debt over a particular year. Government debt is one method of financing government operations, but it is not the only method. Governments can also create money to monetize their debts, thereby removing the need to pay interest. But this practice simply reduces government interest costs rather than truly canceling government debt, and can result in hyperinflation if used unsparingly. Governments usually borrow by issuing securities, government bonds and bills. Less creditworthy countries sometimes borrow directly from a supranational organization (e.g. the World Bank) or international financial institutions). As the government draws its income from much of the population, government debt is an indirect debt of the taxpayers. Government debt can be categorized as internal debt (owed to lenders within the country) and external debt (owed to foreign lenders). Sovereign debt usually refers to government debt that has been issued in a foreign currency. Another common division of government debt is by duration until repayment is due. Short term debt is generally considered to be for one year or less, long term is for more than ten years. Medium term debt falls between these two boundaries. A broader definition of government debt may consider all government liabilities, including future pension payments and payments for goods and services the government has contracted but not yet paid.

The Microbiology Laboratory from the Institute for the Control of Veterinary Biological Products and Medicines participated in a collaborative study in order to determine the potency of rifamycin CRS, batch 4, according to the protocol sent by the EDQM (European Directorate for the Quality of Medicines) - coordinating of the study. The purpose of the study was to establish the potency of the batch 4 rifamycin in the characterization of the substance as reference standard. Potency was determined by microbiological method, based on comparison of the inhibition zones of growth of micro-organisms sensitive to those of a reference standard, as specified in European Pharmacopoeia, Chapter 2.7.2. - Microbiological testing of antibiotics. After analysis of received data from participants and their statistical processing by the EDQM, the potency of the batch 4, rifamycin - reference materials, was established in 870 UI/mg.

The Microbiology Laboratory from the Institute for the Control of Veterinary Biological Products and Medicines participated to a collaborative study in order to determine the potency of teicoplanin CRS, batch 2, according to the protocol sent by the EDQM (European Directorate for the Quality of Medicines) - coordinator of the study. The purpose of the study was to determine the potency of the batch 2 teicoplanin in the characterization of the substance as reference standard. Potency was determined by microbiological method, based on comparing the inhibition zones of growth of micro-organisms sensitive to those of a reference standard, as specified in European Pharmacopoeia, Chapter 2.7.2. - Microbiological testing of antibiotics. After analysis of received data from participants and their statistical processing by the EDQM, the potency of the batch 2, teicoplanin - reference materials, was established in 50150UI/fiola.

The microbiological contamination of pharmaceutical products could have major consequences on the physical – chemical characteristics, safety and efficiency of the medicinal products, on the out of specification products recall-associated costs and, very important, on the safety of the humans and animals. Quality control of the pharmaceutical products should be a major objective for both the pharmaceutical industry as well as for the official quality control laboratories and the final results of these tests should provide most accurate data regarding the safety and the efficiency of the controlled pharmaceutical products. This report is presenting the results which were obtained in 2014 in the Microbiological Control Laboratory following the quality control of the products according to their pharmaceutical form and therapeutical class.

The Microbiology Laboratory from the Institute for the Control of Veterinary Biological Products and Medicines participated to a collaborative study in order to determine the potency of kanamycin CRS, batch 3, according to the protocol sent by the EDQM (European Directorate for the Quality of Medicines) - coordinating of the study. The purpose of the study was to establish the potency of the batch 3 for in the characterization of the substance as reference standard. Potency was determined by microbiological method, based on comparison of the inhibition zones of growth of micro-organisms sensitive to those of a reference standard, as specified in European Pharmacopoeia, Chapter 2.7.2. - Microbiological testing of antibiotics. After analysis of received data from participants and their statistical processing by the EDQM, the potency of the batch 3, kanamycin - reference materials, was established in 790 UI/mg.

The microbiological contamination of pharmaceutical products could have major consequences on the physical – chemical characteristics, safety and efficiency of the medicinal products and also on the out of specification products recall-associated costs. Quality control of the pharmaceutical products should be a major objective for both the pharmaceutical industry as well as for the official quality control laboratories and the final results of these tests should provide most accurate data regarding the safety and the efficiency of the controlled pharmaceutical products. This report is presenting the results which were obtained in 2012 in the Microbiological Control Laboratory following the quality control of the products according to their pharmaceutical form and therapeutic class.