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70 results on '"Sturniolo, Giovanni"'

3. Immunoreactions for P53 isoforms are associated with ultrastructural proliferative profiles in benign thyroid nodules

Author

Concetta Trovato, Maria, Ruggeri, Rosaria Maddalena, Scardigno, Marco, Sturniolo, Giacomo, Vita, Roberto, Vitarelli, Enrica, Arena, Grazia, Gambadoro, Orazio, Sturniolo, Giovanni, Trimarchi, Francesco, Benvenga, Salvatore, Bourdon, Jean-Christophe, and Cavallari, Vittorio

Subjects
Adult, Male, endocrine system, P53, Apoptotic subcellular phenotypes, Immunohistochemistry, P53 isoforms, Proliferating subcellular profiles, Transmission electron microscopy, Ultrastructure, 2734, Histology, 6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU], Middle Aged, Microscopy, Electron, Transmission, Biomarkers, Tumor, Humans, Protein Isoforms, Female, Thyroid Nodule, Tumor Suppressor Protein p53, Aged
Abstract

Background: P53 isoforms originate from the alternative initiation of P53 gene translation through usage of an internal promoter located in intron 4. All P53 isoforms are spliced in intron 9 and may modulate cell proliferation and cell fate outcome in response to DNA damage. Aim: To examine immunoexpression of P53 isoforms in benign proliferative lesions occurring in multinodular thyroids and to assess the ultrastructural phenotype of P53 distribution in the thyrocytes of those lesions by electron microscopy. Materials and Methods: By immunohistochemistry and transmission electron microscopy (TEM), we evaluated 38 multinodular thyroids containing a total of 102 benign lesions: 38 nodular goiters (NG; colloid=20, parenchymatous=18), 52 follicular adenomas (FA) and 12 Hashimoto’s thyroditis (HT). FA were classified into 10 normo-follicular, 9 macro-follicular, 28 microfollicular and 5 solid variants. Results: Immunoreaction for P53 isoforms was observed in approximately 50% of all lesions, except macrofollicular variant FA (33%). At TEM analysis, immunoreactive NG, FA and TH lesions showed signs of proliferation by simultaneous appearance of dispersed chromatin, increased amounts of cytoplasmic organelles and dilation of the rough endoplasmic reticulum. TEM signs of apoptosis and proliferation were also detected in FA, but with different rates compared to NG. Conclusion: The immunohistochemical expression of P53 isoforms in NG, FA and HT suggests their role in the development of these lesions. Ultrastructural findings support the hypothesis that P53 immunoexpression correlates with reactive proliferative changes in thyrocytes.

Published
2016

5. Liver trauma. Diagnosis and treatment

Author

Barbuscia, Maria Adelfina, Querci, A, Tonante, A, Taranto, F, Sano', MJRIAM CRISTINA ELVIRA, Cingari, E, Ilacqua, Alessandro, and Sturniolo, Giovanni

Subjects
Adult, Male, Trauma Severity Indices, Adolescent, Abdominal Injuries, Middle Aged, Wounds, Nonpenetrating, Treatment Outcome, Liver, Liver trauma - Liver resection - Hepatectomy - Hemoperitoneum, Hemoperitoneum, Hepatectomy, Humans, Female, Child, Aged, Retrospective Studies
Abstract

The authors summarize the essential steps in liver surgery. Modern imaging techniques are of great help in establishing a circumstantiated diagnosis of post-traumatic lesions of the intra-abdominal parenchymatous organs, and especially the liver. Such diagnosis must always be based on the AAST (American Association for the Surgery of Trauma) classification, essential for a correct approach. Each therapeutic choice must be based on a careful clinical evaluation to establish whether emergency exploration of the abdomen or simple patient monitoring is indicated. Organ injuries and consequent hemoperitoneum must be found and quantified. In any case, diagnosis and treatment must only begin once all measures have been taken to ensure the maintenance of vital functions and the normalization of the main blood chemistry parameters.

Published
2012

22. SURGICAL THERAPY OF MEDULLARY THYROID CARCINOMA

Author

Sturniolo, Giovanni, Bonanno, Loretta, Gagliano, Ettore, Tonante, Agata, Taranto, Filippo, Mamo, Marcello, DE SALVO, Giovanni, and Sturniolo, Giacomo

Subjects
Adult, Male, Time Factors, Adolescent, Laryngoscopy, Multiple Endocrine Neoplasia Type 2a, Multiple Endocrine Neoplasia Type 2b, Middle Aged, total thyroidectomy, Postoperative Complications, Carcinoma, Medullary, medullary thyroid carcinoma, Thyroidectomy, Humans, Lymph Node Excision, Neck Dissection, Female, Thyroid Neoplasms, Child, Tomography, X-Ray Computed, Aged, Follow-Up Studies, Retrospective Studies
Abstract

This study describes the findings of a retrospective study of 57 medullary thyroid cancer patients observed at the main Sicilian centres for endocrine surgery. Six of these patients were observed locally in order to add a further dimension to the discussion of surgical therapies for medullary thyroid carcinoma. A review of the literature on sporadic forms of medullary thyroid carcinoma and hereditary neoplastic syndromes is followed by presentation of the authors' series. Diagnostic protocols, surgical therapies and pathological observations are discussed. Particular attention is paid to patterns of metastases of medullary thyroid carcinoma and to the differing opinions regarding the extent of lymph-node dissection required and the treatment of recurrent disease. Total extracapsular thyroidectomy with lymph-node dissection is identified as the gold standard of surgical therapies for this form of cancer.

Published
2007

28. LE LESIONI IATROGENE DEL COLON

Author

D'Alia, C., Bonanno, L., LO SCHIAVO, M. G., Tonante, A., Gagliano, Ettore, Taranto, F., and Sturniolo, Giovanni

Published
2004

49. Morphological Changes of Follicular Cell Basal Borders and Basement Membranes in Benign and Malignant Nodular Lesions of the Thyroid Gland: An Ultrastructural Study.

Author

Cavallari, Vittorio, Albiero, Francesca, Cicciarello, Rocco, Gagliardi, Maria Ester, Costa, Gregorio, D'Alia, Claudio, Sturniolo, Giovanni, Tonante, Ada, Labate, Agata, Torre, Valerio, Vermiglio, Francesco, and Caillou, Bernard

Subjects
THYROID gland, ENDOCRINE glands, DIFFERENTIAL diagnosis, HYPERPLASIA, CELLULAR pathology, CANCER
Abstract

Microfollicular nodular lesions of the thyroid gland may represent a differential diagnosis problem. Firstly, nodular areas of follicular hyperplasia have to be distinguished from follicular adenomas. On the other hand, nodular microfollicular areas exhibiting large pale nuclei, occasionally found in hyperplastic nodules and follicular adenomas, must be discriminated from latent papillary carcinomas with predominant follicular architecture. The diagnosis of follicular carcinoma still requires the detection of vascular and/or capsular microinvasion. A more refined study was planned to search for additional descriptors useful for diagnosis The authors report the results of an ultrastructural investigation carried out on 220 thyroid nodular lesions and 50 specimens of macroscopically nonnodular glands. An infolding arrangements of the thyreocyte basal border(TBB)and follicular basement membrane(FBM)was demonstrated in 50/50 nonnodular thyroid tissue specimens and 53/67(79.1%)hyperplastic nodular lesions(p < .005). A linear arrangement of the TBB and FBM was found in 85/121(70.2%)follicular adenomas and in 32/32 differentiated carcinomas(p < .001). In the last group, 12/32(37.5%)cases showed focal discontinuities of FBM. In conclusion, the benign thyroid nodules show a prevalently infolding arrangements of TBBs, whereas the majority of proliferative lesions display a linear morphology. In absence of an infiltrating pattern there is no morphological evidence of discriminating potentially malignant vs. benign lesions. The linear distribution of TBBs and FBMs places the case in a group of borderline lesions that involve a more careful postsurgery investigation. [ABSTRACT FROM AUTHOR]

Published
2004
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50. THE UMBILICUS: A RARE SITE FOR MELANOMA. CLINICAL CONSIDERATIONS IN TWO CASES: Case reports.

Author

Colonna, Michele R., Giovannini, Uberto M., Sturniolo, Giovanni, and Colonna, Ugo

Subjects
NAVEL, MELANOMA
Abstract

The umbilicus is a rare site for malignant melanoma. We report two cases of umbilical melanoma and analyse the mechanisms of diffusion of the neoplasm in relationship to the arterial, venous, and lymphatic anatomy of the region. Because of the peculiarity of these connections, we propose a revision of the concept of melanoma stage for the umbilical region. [ABSTRACT FROM AUTHOR]

Published
1999
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