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2. Abstracts of papers and posters

Author

Veninga, C. C. M., Denig, P., Haaijer-Ruskamp, F. M., Dijkers, F. W., Meyboom-de Jong, B., de Vries, Corinne S., Timmer, Jos W., de Jong-van den Berg, Lolkje, van Eijk, M. E. C., de Boer, A., van Hemert, Th. J. E., van der Horn, Johan A., Steerneman, Antonius G. M., de Jong-van den Berg, Lolkje T. W., de Wit, M. E. c., Stricker, B. H. Ch., Porsius, A. J., Peters, E. Th. J., van der Werf, G. Th., Hoek, R., Ottervanger, J. P., van der Velden, J., Egberts, A. C. G., Mayboom, R. H. B., de Koning, G. H. P., van Ermen, M. C., Roisin, T., Kurz, X., Rikken, Floor, Vos, Rein, Herings, R. M. C., Leufkens, H. G. M., Porsius, A., Valkenburg, H. A., Grobbee, D. E., Bakker, A., Sturmans, F., Heerdink, Eibert R., Leufkens, Hubert G., Strieker, Bruno H. C., Gribnau, F., Urquhart, John, van Kraaij, D. J. W., Bruijns, E., Jansen, R. W. M. M., Gribnau, F. W. J., Hoefhagels, W. H. L., Heerdink, Eibert R., Boysen, Meindert H., de Smet, Peter A. G. M., Porsius, Arijan, Bakker, Albert, Teeuw, K. Bart, and Stewart, R.

Published
1995
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3. Abstracts of papers and posters

Author

Anthonio, R. L., Willemsen, A. T. M., Visser, T., van Waarde, A., Elzinga, P., Weemaes, A., Meeder, J. G., Pruim, J., Visser, G., Blanksma, P. K., Vaalburg, W., Bloemen, P. G. M., Henricks, P. A. J., van Bloois, L., van den Tweel, M. C., Nijkamp, F. P., Crommelin, D. J. A., Storm, G., de Boer, A. H., Winter, H. M. I., Lerk, C. F., de Boer, J., Meurs, H., Bottone, A. E., Koopal, M., Visser, J. C., Zaagsma, J., Borger P., Kauffman H. F., Vijgen J. L. J., Postma D. S., Vellenga E., Buckley, Theresa L., Buikema, H., van Gilst, W. H., van Veldhuisen, D. J., de Smet, B. J. G. L., Scholtens, E., Lie, K. I., Wesseling, H., Cheung, P. K., Dijkhuis, F. W. D., Bakker, W. W., Visser, J., Coopes, R. P., Benthem, L., van der Leest, J., Roffel, A. F., Coppes, R. P., Zeilstra, L. J. W., Vissink, A., Konings, A. W. T., Dijkstra, M., Veld, G. In't, Müller, M., van den Berg, G. J., Kuipers, F., Vonk, R. J., Elsinga, P. H., Franssen, E. J. F., van der Graaf, W. T. A., de Vries, E. G. E., Visser, G. M., Vos, M. G., Braker, A. H., Visser, T. J., Visser, G. M., Engels, F., van Houwelingen, A. H., van de Velde, M. J., Gansevoort, R. T., Sluiter, W. J., Hemmelder, M. H., de Zeeuw, D., de Jong, P. E., Gelissen, H. P. M. M., Henning, R. H., Epema, A. H., van Eekeren, J., Hennis, P. J., Den Hertog, A., de Graaf, S. S. N., Kellie, S. J., Bloemhof, H., Johnston, I., Besser, M., Chaseling, R. W., Ouvrier, R. A., Uqes, D. R. A., De Haan, A., Geerligs, H. J., Huchshorn, J. P., Van Scharenburg, G. J. M., Wilschut, J., Haas, M., Kluppel, C. A., Meijer, D. K. F., Moolenaar, F., Heerdink, Eibert R., Leufkens, Hubert G., Herings, Ron M. C., Stricker, Bruno H. Ch., Bakker, Albert, Heesen W. F., Beltman F. W., Smit A. J., May J. F., Meyboom-de Jong B., Duin, M., van den Akker, J., te Pas, M. F. W., van Popta, J. P., Nelemans, S. A., van der Linde, H. J., de Boer, A., Sturmans, F., Hessel, E. M., Van Oosterhout, A. J. M., Hofstra, C. L., Garssen, J., van Loveren, H., Savelkoul, H. F. J., Hoekstra, Y., Weersink, E. J. M., de Jong, J. W., van der Belt-Gritter, B., Jonkman, Lisa M., Kemner, Chantal, Koelega, Harry S., van Engeland, Herman, Verbaten, Marinus N., Kalivianakis, M., Zijlstra, I., Verkade, H. J., Elzinga, H., Stellaard, F., Kamps, J. A. A. M., Swart, P. J., Morselt, H., Scherphof, G. L., Kenemans, J. L., Lorist, M. M., Koopen, N. R., Kraneveld, A. D., Koster, A. Si., Kuipers, M. E., Groenink, M., Huisman, H., Schuitemaker, H., Lau, H. S., van den Broek, I. J. P. M., van Dijk, A., Oostinga, J., Porsius, A. J., Lin, Y., Havinga, R., Meijer, R. J., van der Mark, Th. W., Koëter, G. H., Michels, A. A., Nguyen, V. -T., Bensaude, O., Kampinga, H. H., Mohede, Inge C. M., Van Antoon J. M., Molema, Grietje, Edgington, Thomas S., Thorpe, Philip E., Olinga, P., Sandker, G. W., Slooff, M. J. H., Merema, M. T., Groothuis, G. M. M., Hofman, G., Van Ark, I., Paulussen, J. J. C., Fischer, M. J. E., de Mol, N. J., Janssen, L. H. M., Peters, E. Th. J., van der Werf, G. Th., Haaijer-Ruskamp, F. M., Pinto, Yigal M., Rooks, Gerrit, Grandjean, Jean G., Ebels, Tjark, Schunkert, H., Redegeld, Frank A., Garssen, Johan, van Loveren, Henk, Rigter, Irma M., van Groningen, Muck, Boks, Gertjan J., Tollenaere, Jan P., Trollope, Keith I., Vinter, Jeremy G., Hashjin, Gudarz Sadeghi, Folkerts, Gert, van de Loo, Peet G. F., Santing, R. E., Olymulder, C. G., van der Molen, K., Pasman, Y., Scheerens, Heleen, Van Loveren, Henk, Seppenwoolde-Waasdorp, T. J. A., de Boer, P., Van Engelen, H. M. J., Thijssen, J. H. H., Maes, R. A. A., Smit, J., Smit, J. W., Steen, H., Steurs, M. H., Kuks, P. F. M., Leusink, J. A., Szabó, Balázs M., Crijns, Harry J. G. M., Wiesfeld, Ans C. P., Talsma, H., Borchert, J. C. H., van Steenbergen, M. J., Hennink, W. E., Teeuw, K. B., Cromheecke, H., Schreudering, A., Teisman, B. C. H., Maselbas, W., Wolters-Keulemans, G. T. P., Tieleman, R. G., de Langen, C. D. J., Bel, K., Crijns, H. J. G. M., Grandjean, J., Wijffels, M., Klimp, A. H., van de Meer, P. F., Allessie, M. A., van Patot, H. A. Tissot, de Jongh, B. M., Tuininga, Y. S., Brouwer, J., Haaksma, J., Man in't Veld, A. J., Blomjous, F. J., Vingerhoeds, M. H., Belliot, S. O., Haisma, H. J., Visscher, C. A., Huisman, R. M., Navis, G. J., de Vlieger, J. F., van den Wijngaard, P., Wilting, J., van Heuven-Nolsen, D., Voors, A. A., van Brussel, B. L., Plokker, H. W. M., Van Waardenburg R. C. A. M., Meijer, Prins J., De Vries, C., Mulder N. H., Wierenga, P. K., Wilschut J., Schoen P., and Bron R.

Published
1994
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4. Self-rated health and mortality in a Lithuanian and a Dutch population

Author

Bosma, H., Appels, A., Grabauskas, V., Gostautas, A., and Sturmans, F.

Subjects
Mortality -- Research, Self-evaluation -- Health aspects, Lithuanians -- Health aspects, Dutch -- Health aspects, Health attitudes -- Analysis, Health, Social sciences
Abstract

The hypothesis that the evaluation of one's health as poor is associated with mortality, independent of the results of a standardized medical examination, was tested in the Kaunas-Rotterdam Follow-Up Study. In this study two cohorts, one consisting of 2452 Lithuanian males and one of 3365 Dutch males, aged 45-60, were screened for cardiovascular risk factors in 1973, using identical protocols, and were followed for about ten years. Self-rated health was assessed by two direct questions: 'How would you assess your own health?' and 'What do you think of your own health compared to that of other men of your age?' as well as by a Semantic Differential Test of 'My Health'. In both cohorts a negative evaluation of one's health was associated with mortality, controlling for past or present heart disease, cardiovascular risk factors, parental life span, socio-economic and marital status. Especially the data with regard to the comparative question indicate that self-rated health is associated with mortality in men living in two different socio-cultural systems. The data suggest that a weak sense of mastery may explain the association between health perception and mortality. Key words - self-rated health, mortality, coronary heart disease, negative explanatory style

Published
1996

6. Reproducibility of a food frequency questionnaire and stability of dietary habits determined from five annually repeated measurements

Author

Goldbohm, R.A., Veer, P. van't, Brandt, P.A. van den, Hof, M.A. van't, Brants, H.A.M., Sturmans, F., and Hermus, R.J.J.

Subjects
Questionnaires -- Usage, Nutrition -- Research, Food habits -- Research
Abstract

Food frequency questionnaires (FFQs) are utilized in the assessment of long-term dietary habits. A standard reference method of dietary assessment such as a diet record is used to validate the results of these questionnaires. Moreover, questionnaires are administered several times to evaluate their reproducibility. Dietary habits in the Netherlands Cohort Study on diet and cancer are assessed over a 5-year period with the help of a 150-item FFQ.

Published
1995

7. Validation of a dietary questionnaire used in a large-scale prospective cohort study on diet and cancer

Author

Goldbohm, R.A., Brandt, P.A. van den, Brants, H.A.M., Veer, P. van't, Al, M., Sturmans, F., and Hermus, R.J.J.

Subjects
Ingestion -- Analysis
Abstract

Evaluation of a self-administered 150-item food frequency questionnaire used in a cohort study on cancer and diet reveals that this method ranks subjects based on food group intake and nutrients. The study is conducted on a short subgroup comprising 59 men and 50 women. The results are compared with the questionnaire of a cohort random sample.

Published
1994

8. Agreement between interview data and a self-administered questionnaire on dietary supplement use

Author

Dorant, E., Brandt, P.A. van den, Goldbohm, R.A., Hermus, R.J.J., and Sturmans, F.

Subjects
Dietary supplements -- Surveys
Abstract

The effectiveness of an open-ended questionnaire on dietary supplement intake is analyzed. The questionnaire had a sensitivity of 65.9%, specificity of 98.5% and kappa, a measure of agreement, of 0.69%. Women users of not less than three supplements, prolonged supplement users and older age groups exhibited a good degree of recall. Specific supplement intake recall was 77.8% for garlic preparations and 11.8% for other supplements.

Published
1994

11. Mortality of workers exposed to acrylonitrile

Author

Swaen, G.M.H., Bloemen, L.J.N., Twisk, J., Scheffers, T., Slangen, J.J.M., and Sturmans, F.

Subjects
Netherlands -- Health aspects, Acrylonitrile -- Health aspects, Workplace accidents -- Patient outcomes, Business, Health care industry
Published
1992

17. Abstracts of papers Rational use of drugs: 18th European Symposium on Clinical Pharmacy

Author

Dukes, M. N. G., Elenbaas, Robert M., Tognoni, G., Smith, Dorothy L., Lunde, Inga, Leufkens, H. G. M., Hekster, Y. A., Bakker, A., Ostino, G., Petri, H., Sturmans, F., Banta, H. D., Rutten, F. F. H., Martens, L. L., Noyce, P. R., Merkus, F. W. H. M., de Jong-v.d.Berg, Lolkje, Haaijer-Ruskamp, Flora, Dukes, Graham, Vidgren, B. -M., Vidgren, S., Martini, N., Sala, M. L., Scroccaro, G., Olivencia, P., McLcod, D. C., Coln, W. G., Hartzcma, A. G., Thaver, C. F., Rodriguez-Sasiain, J. M., Sangroniz, B., Mauleon, M. D., Wood, M. A., Martinez, M. J., Leinebø, O., Saugen, J. N., Marini, P., Olivato, R., Alberola, C., Cruz-Martos, E., Cruz, T., Marfagon, N., de Tejada, A. Herreros, Denig, P., Haaijer-Ruskamp, F. M., Wesseling, H., Versluis, A., Gascón, M. P., Horne, Robert, Hough, Jane, Klazinga, N. S., van Everdingen, J. J. -E., van den Broek, P. J., Roberts, D. K., Veitch, G. B. A., Tan K. K. C., Holland D. A., Allwood M. C., Nicholls, A., Astobieta, A., Calvo, R., Rodriquez-Sasiain, J. M., Barriquand, D., Pochon, C., Aulagner, G., Vial, A., Dumarest, C., Maire, P. H., Jelliffe, R. W., Brouwers, J. R. B. J., Cramer, K., Gulyas, J., vd Kam, H. J., Sijtsma, J., Donadio, C., Tramonti, G., Garcea, G., Costagli, M., Lucchetti, A., Giordani, R., Paizis, G., Pierotti, R., Falcone, G., Bianchi, C., Gallastegui C., Farré R., Jiménez I., Mangues M. A., Guasch E., Ginovart G., Sagrera X., Raspall F., Queralto J. M., Kovarik, J. M., Rademaker, C. M. A., Verhoef, J., Silvestri, L., Caputo, M., Andrew, M., Toverud, E. -L., Jimenez I., Castro I., Alvarez E., Altimiras J., van de Leur, J. J. J. P. M., Muller, N. F., Van Turnhout, J. M., Mendizabal, L., Sasiain, J. M. Rodriguez, Morana, G., Ofstad, K. Moss, Timenes, A. -M., Vroom, J. K. F., de Jong-van den Berg, L. T. W., van den Berg, P. B., de Gier, J. J., Ferres J., Recoder O., Sanchez Rio T., Garcia M. P., Julia A., Balet A., Farre R., Manques M. A., Berod, T., Dufay, E., Naveau, C., Combe, M., Sauvageon, A., Hansen, Erik Wind, Christensen, Jens Dencker, Lie-A-Huen, L., Kinqma, J. H., Meijer, D. K. P., Le Meur, F., Isoard, P., Salek, M. S., Finlay, A. Y., Khan, G. K., Luscombe, D. K., Stuurman, A., Boidin, M. P., Wallenius, K., Ojala, R., Kariluoto, A., Ikonen, M., Paes, A. H. P., Blom, A. Th. G., Bakker, A., Wallenius, S., Enlund, H., Vainio, K., Codina, C., Roca, M., Sardà, P., Corominas, N., Massó, J., Ribas, J., Kentra, K., Myllyntausta, M., Saarenpää, M., Airaksinen, M. S. A., Mendarte, L., Rimola, A., Meisters, R., Hekster, Y., Janssen, W., Cox, A., Kempen, R., Aerdts, S. J. A., van Dalen, R., Clasener, H. A. L., Festen, J., Schjphorst, PP, Benraad, HB, van Asten, P., de Wit, R., Muller, N. F., Limbeek, R. J. G., Nagel, H. G. M., Mgyboom, R. H. B., Stricker, B. H. C., van den Berg, B. A. M., Nelen, T. H. A., Tijssen, T. A. G., Wassink, P., Wassink-L'Ortije, M. J. E., Gascón, P., Selva, C., Bassons, T., Pardo, C., Mas, M. P., Saqalés, M., Sánchez, F., Mercade, V., Pujol, R., Agustí, C., Cano, M., Gurrera, T., Gorchs, M., Fabregas, X., Murgui, L. L., Verdaguer, A., Witjes, W. P. J., Vollaard, E. J., Crul, B. J. P., Limpens, C., Ahonen, K., Klaukka, T., Vohlonen, I., Martikainen, J., Goldenberg, Daniel, Brodsky, Andres, Aparici, Ines, Argeri, Cecilia, Goldenberg D., Saidman C., Sevinski L., Allevato N., Mujico B., Ubogui J., Dorfman P., Rodriguez Lupo L., Varela M., Higa J., Fourrier, Annie, Larrouturou, Philippe, Samarran, Claire, Huchet, Jacqueline, Barber, N. D., Party, N., Wilson, P., Eide, Grethe, Horvei, Kari, Kruse-Jensen, Angelika, Wold, Ingrid, Møark, Turid, Barrett, C. W., Tugwell, A. C., Søndergaard, B., Rasmussen, M., Davidsen, F., Hey, H., Kierkeby, L., Riis, L., Korhonen, M., Vidgren, P., Ojanen, T., Vidqren, M., Ferrés J., Sanchez T., Gallastequi C., Julià A., Herings, R. M. C., Stricker, B. H. Ch., Janssen, A. J. H. H., Dinter, Heike, Janssen, A. J. H. M., Barbaut, X., Proust, S., Amlagner, G., Eskens, F. A. L. M., Clasener, H. A. L., Vollaard, E. J., Arnoldussen, E., Sieradzki, E., Wanat-Słupska, E., Zlółkowska, M., Pankowska, I., Mazur, R., Ksiazkiewicz, B., Jankowski, A., Marzec, A., Marzec, C., Marzec, M. O., Marzec, J. P., Marzec, A., Mungall, D. R., Portnoy, Lynne, Lucas, F., Kadir, F., Pijpers, A., Vulto, A., Zuidema, J., Tan, K. K. C., Sutton, P., Samu, Antal, Murphy, John E., Chapman, Ronnie, Wieringa, Nicolien, de Gier, J. J., Rolloos, J., Voesten, M. T. P. J., de Meijer, P. J. J., de Koning, G. H. P., Salek, S., Reerink, E., Mungall, D. R., Farrow, L., Raskob G., Rosenbloom D., Hull R., Ferres J., Torras A., Farre R., Recorder O., Garcia M. P., Torras C., Cubellsl J., Font, M., Madridejos, R., Catalán, A., Huguet, M., Franquesa, N., Gratacós, J., Martinez, M., Saltó, A., van der Kleijn, E., ter Wee, R. J. M., Holmberg, N., and Brenninkmeijer, R. F.

Published
1989
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20. Assessment of evidence for screening community-dwelling older people

Author

Drewes, Y.M., Gussekloo, J., Meer, V. van der, Rigter, H., Dekker, J.H., Goumans, M.J.B.M., Metsemakers, J.F.M., Overbeek, R. van, Rooij, S.E. de, Schers, H.J., Schuurmans, M.J., Sturmans, F., Vries, K. de, Westendorp, R.G.J., Wind, A.W., and Assendelft, W.J.J.

Published
2010

21. Evolution of epidemiology in society

Author

van 't Veer, P., Sturmans, F., van Oers, J.A.M., and Tranzo, Scientific center for care and wellbeing

Subjects
Nutrition and Disease, Voeding en Ziekte, Life Science, VLAG
Published
2010

26. Assessment of appropriateness of screening community-dwelling older people to prevent functional decline.

Author

Drewes, Y.M., Gussekloo, J., Meer, V. van der, Rigter, H., Dekker, J.H., Goumans, M.J., Metsemakers, J.F.M., Overbeek, R. van, Rooij, S.E. De, Schers, H.J., Schuurmans, M.J., Sturmans, F., Vries, K. de, Westendorp, R.G.J., Wind, A.W., Assendelft, W.J.J., Drewes, Y.M., Gussekloo, J., Meer, V. van der, Rigter, H., Dekker, J.H., Goumans, M.J., Metsemakers, J.F.M., Overbeek, R. van, Rooij, S.E. De, Schers, H.J., Schuurmans, M.J., Sturmans, F., Vries, K. de, Westendorp, R.G.J., Wind, A.W., and Assendelft, W.J.J.

Abstract

01 januari 2012, Item does not contain fulltext, OBJECTIVES: To identify appropriate screening conditions, stratified according to age and vulnerability, to prevent functional decline in older people. DESIGN: A RAND/University of California at Los Angeles appropriateness method. SETTING: The Netherlands. PARTICIPANTS: A multidisciplinary panel of 11 experts. MEASUREMENTS: The panelists assessed the appropriateness of screening for 29 conditions mentioned in guidelines from four countries, stratified according to age (60-74, 75-84, >/=85) and health status (general, vital, and vulnerable) and received a literature overview for each condition, including the guidelines and up-to-date literature. After an individual rating round, panelists discussed disagreements and performed a second individual rating. The median of the second ratings defined the appropriateness of screening. RESULTS: The panel rated screening to be appropriate in three of the 29 conditions, indicating that screening was expected to prevent functional decline. Screening for insufficient physical activity was considered appropriate for all three age and health groups. Screening for cardiovascular risk factors and smoking was considered appropriate for the general and vital population aged 60 to 74. Of the 261 ratings, 63 (24%) were classified as uncertain, of which 42 (67%) concerned the vulnerable population. The panelists considered conditions inappropriate mainly because of lack of an adequate screening tool or lack of evidence of effective interventions for positive screened persons. CONCLUSION: The expert panel considered screening older people to prevent functional decline appropriate for insufficient physical activity and smoking and cardiovascular risk in specific groups. For other conditions, sufficient evidence does not support screening. Based on their experience, panelists expected benefit from developing tests and interventions, especially for vulnerable older people.

Published
2012

28. Injection therapy for subacute and chronic benign low back pain

Author

Nelemans, P. J., Bie, R. A., Henrica de Vet, and Sturmans, F.

Abstract

BACKGROUND: Injection with anaesthetics and/or steroids is one of the treatment modalities used in patients with chronic low back pain which needs evaluation with respect to the effectiveness on short and long term pain relief. OBJECTIVES: To evaluate the effectiveness of injection therapy in patients with low back pain lasting longer than one month. We distinguished between three injection sites: facet joint, epidural or local injections. SEARCH STRATEGY: We searched the Medline and Embase databases up to 1996 and other search methods as advocated by the Back Review Group search strategy. Abstracts and unpublished studies were not included. SELECTION CRITERIA: Randomized controlled trials of injection therapy for pain relief (although additional treatments were allowed) in patients with benign low back pain lasting longer than one month and not originating from cancer. DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed the trials for methodological quality. Subgroup analyses were made between trials with different control groups (placebo and active injections), with different injection site (facet joint, epidural and local injection), and timing of outcome measurement (short and long term). Within the resulting 12 subcategories of studies (2*3*2), the overall relative risks and corresponding 95% confidence intervals were estimated, using a random effects model (DerSimonian and Laird). In the case of trials in which control groups were active injections, we refrained from pooling the results. MAIN RESULTS: Twenty-one randomized trials were included in this review. All studies involved patients with low back pain lasting longer than one month. Only 11 studies compared injection therapy with placebo injections (explanatory trials). The methodologic quality of many studies was low: only 8 studies had a methodologic score of 50 or more points. There were only three well designed explanatory clinical trials: one on injections into the facet joints with a short-term RR of 0.89 (95% CI: 0.65-1.21) and a long-term RR of 0.90 (95% CI: 0.69-1.17); one on epidural injections with a short-term RR of 0.94 (95% CI: 0.76-1.15) and a long-term RR of 1.00 (95% CI: 0.71-1.41); and one on local injections with a long-term RR of 0.79 (95% CI: 0.65-0.96). Within the 6 subcategories of explanatory studies the pooled RRs with 95% confidence intervals were: facet joint, short-term: RR=0.89 (0.65-1.21); facet joint, long-term: RR=0.90 (0.69-1.17); epidural, short-term: RR=0.93 (0. 79-1.09); epidural, long-term: RR=0.92 (0.76-1.11); local, short-term: RR=0.80 (0.40-1.59); local, long-term: RR=0.79 (0.65-0. 96). REVIEWER'S CONCLUSIONS: Convincing evidence is lacking on the effects of injection therapies for low back pain. There is a need for more, well designed explanatory trials in this field.

Published
2000

29. Vegetable and fruit consumption and risks of colon and rectal cancer in a prospective cohort study

Author

Voorrips, L.E., Goldbohm, R.A., Poppel, G. van, Sturmans, F., Hermus, R.J.J., Brandt, P.A. van den, and Centraal Instituut voor Voedingsonderzoek TNO

Subjects
Adult, Male, Rectal neoplasms, Brassica, Major clinical study, Vegetable, Cancer risk, Age Distribution, Food intake, Vegetables, Humans, Prospective Studies, Prospective study, Sex Distribution, Eating habit, Nutrition, Aged, Netherlands, Likelihood Functions, Incidence, food and beverages, Middle Aged, Dietary fiber, Colon cancer, Fruit, Case-Control Studies, Rectum cancer, Colonic Neoplasms, Multivariate Analysis, Female, Risk factor, Food Habits, Cohort analysis, Human
Abstract

The relation between vegetable and fruit consumption and colorectal cancer risk was comprehensively assessed in the Netherlands Cohort Study on Diet and Cancer using a validated 150-item food frequency questionnaire. After 6.3 years of follow-up (1986-1992), over 1,000 incident cases of colorectal cancer were registered. Using case-cohort analysis, the authors calculated rate ratios and 95% confidence intervals adjusted for age, alcohol intake, and family history of colorectal cancer. For colon cancer, no statistically significant associations with total vegetable intake or total fruit intake were found. However, among women, an inverse association was observed with vegetables and fruits combined (for the highest quintile vs. the lowest, the rate ratio was 0.66 (95% confidence interval: 0.44, 1.01)). Brassica vegetables and cooked leafy vegetables showed inverse associations for both men and women. Among women and, to a lesser extent, among men, inverse associations were stronger for distal colonic tumors than for proximal colonic tumors. For rectal cancer, no statistically significant associations were found for vegetable consumption or fruit consumption or for specific groups of vegetables and fruits; only Brassica vegetables showed a positive association in women. As in other cohort studies, the observed inverse relation between vegetable and fruit consumption and occurrence of colorectal cancer was less strong than relations reported in case-control studies.

Published
2000

30. Vegetable and fruit consumption and lung cancer risk in the Netherlands Cohort Study on diet and cancer

Author

Voorrips, L.E., Goldbohm, R.A., Verhoeven, D.T.H., Poppel, G.A.F.C. van, Sturmans, F., Hermus, R.J.J., Brandt, P.A. van den, Epidemiologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, RS: CAPHRI School for Public Health and Primary Care, and Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding

Subjects
Adult, Male, Lung Neoplasms, Family history, Brassica, Major clinical study, Adenocarcinoma, Risk Assessment, Education, Cohort Studies, Cancer risk, Age, Age Distribution, Vegetables, Confidence Intervals, Humans, Prospective Studies, Sex Distribution, Nutrition, Aged, Netherlands, Questionnaire, Incidence, Smoking, Gender, Middle Aged, Nutrition Surveys, Confounding Factors (Epidemiology), Diet, Statistical concepts, Fruit, Multivariate Analysis, Female, Cohort analysis, Lung cancer, Model
Abstract

Objective: The purpose was to study the association between vegetable and fruit consumption and lung cancer incidence using 1074 cases after 6.3 years of follow-up in the Netherlands Cohort Study. Methods: Dietary intake was assessed using a 150-item food-frequency questionnaire. Multivariate models were used including age, sex, family history of lung cancer, highest educational level attained, and smoking history. Results: Statistically significant inverse associations were found with total vegetables and most vegetable groups. Rate ratios (RRs) based on consumption frequency showed the strongest effect of vegetables from the Brassica group (RR 0.5, 95% confidence interval (95% CI) 0.3-0.9, for consumption greater than or equal to 3 times per week versus less than or equal to once a month). RR of highest versus lowest quintile of total vegetable consumption was 0.7 (95% CI 0.5-1.0, p-trend 0.001). Statistically significant inverse associations were found for all fruits listed in the questionnaire. RRs for quintiles of total fruit intake were 1.0, 0.7, 0.6, 0.6 and 0.8 respectively (p-trend

Published
2000

31. A prospective cohort study on antioxidant and folate intake and male lung cancer risk

Author

Voorrips, L.E., Goldbohm, R.A., Brants, H.A.M., Poppel, G.A.F.C. van, Sturmans, F., Hermus, R.J.J., Brandt, P.A. van den, Epidemiologie, and RS: NUTRIM School of Nutrition and Translational Research in Metabolism

Subjects
Adult, Male, Lung Neoplasms, Folic acid, Zeaxanthin, Family history, Major clinical study, Adenocarcinoma, Vegetable, Risk Assessment, Antioxidants, Cohort Studies, Cancer risk, Lycopene, Cigarette smoking, Squamous cell carcinoma, Humans, Prospective Studies, Prospective study, Nutrition, Aged, Priority journal, Beta carotene, Dietary intake, Incidence, Xanthophyll, Smoking, food and beverages, Middle Aged, Diet, Fruit, Case-Control Studies, Alpha carotene, Food composition, Antioxidant, Cohort analysis, Lung cancer
Abstract

Many studies have reported inverse associations between vegetable and fruit consumption and lung cancer risk. The aim of the present study was to elucidate the role of several antioxidants and folate in this relationship. In the Netherlands Cohort Study on Diet and Cancer, 58,279 men of ages 55-69 Sears at baseline in 1986 returned a questionnaire including a 150-item food frequency questionnaire. After 6.3 years of follow-up, 939 male lung cancer cases were registered. A new Dutch carotenoid database was used to estimate intake of alpha-carotene, beta-carotene, lutein + zeaxanthin, beta-cryptoxanthin, and lycopene, completed with the antioxidant vitamins C and E and folate. Using case-cohort analysis, rate ratios were calculated, adjusted for age, smoking, educational level, and family history of lung cancer. Protective effects on lung cancer incidence were found for lutein + zeaxanthin, beta-cryptoxanthin, folate, and vitamin C. Other carotenoids (alpha-carotene, beta-carotene, and lycopene) and vitamin E did not show significant associations. After adjustment for vitamin C, only folate remained inversely associated, and after adjustment for folate, only beta-cryptoxanthin and vitamin C remained significantly associated. Inverse associations were strongest among current smokers and weaker for former smokers at baseline. Inverse associations with carotenes, lutein C zeaxanthin, and beta-cryptoxanthin seemed to be limited to small cell and squamous cell carcinomas. Only folate and vitamin C intake appeared to be inversely related to small cell and squamous cell carcinomas and adenocarcinomas. Folate, vitamin C, and beta-cryptoxanthin might be better protective agents against lung cancer in smokers than alpha-carotene, beta-carotene, lutein + zeaxanthin, and lycopene.

Published
2000

36. Gastcolumn

Author

Sturmans, F (Ferd) and Public Health

Published
1998

37. TSG: al 75 jaar vitaal

Author

Gulden, J.W.J. van der and Sturmans, F.

Subjects
GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 24963___.PDF (Publisher’s version ) (Open Access)

Published
1997

38. Low diagnostic value of respiratory impedance measurements in children

Author

Cuijpers, CEJ, Wesseling, GJ, Kessels, AGH, Swaen, GMH, Mertens, PLJM, deKok, ME, Broer, J, Sturmans, F, and Wouters, EFM

Subjects
FORCED OSCILLATION TECHNIQUE, OSCILLOMETRY, SPECTRUM, asthma, SPIROMETRY, CHRONIC-BRONCHITIS, children, ASTHMATIC-CHILDREN, respiratory impedance, PRIMARY-SCHOOL CHILDREN, diagnostic value, OBSTRUCTION, REACTANCE, RESISTANCE
Abstract

The aim of this study was to determine whether impedance values in children with various chronic respiratory complaints differed from those observed in symptom-free children. Respiratory impedance was measured using the forced oscillation technique in 1,776 Dutch children aged 6-12 yrs. In addition to the commonly used parameters of resistance and reactance, further impedance parameters were obtained by using linear and quadratic regression to describe individual resistance and reactance curves as a function of frequency. Furthermore, the diagnostic value of the individual impedance parameters was evaluated by means of receiver operator characteristic (ROC) curves. Statistically significant differences in impedance values were found in girls with symptoms suggesting asthma compared to symptom-free girls, but not in boys. In children with chronic cough, impedance was not significantly different from the values of symptom-free children. The results obtained by the additional impedance parameters were comparable to those of the commonly used measures. We conclude that the diagnostic value of the impedance parameters appeared to be low, as no cut-off points were found to discriminate clearly between symptomatic and symptom-free children. These findings may reflect absence of functional abnormalities in symptomatic children at this age. (C)ERS Journals Ltd 1997.

Published
1997

43. Agreement between interview data and a self-administered questionnaire on dietary supplement use

Author

Elisabeth Dorant, Pa, Den Brandt, Ra, Goldbohm, Rj, Hermus, and Sturmans F

Subjects
Male, Plants, Medicinal, Reproducibility of Results, Vitamins, Middle Aged, Sensitivity and Specificity, Diet Records, Cohort Studies, Random Allocation, Surveys and Questionnaires, Food, Fortified, Mental Recall, Humans, Female, Prospective Studies, Garlic, Aged, Netherlands
Abstract

To study the relative validity of an open-ended question on the consumption of dietary supplements in the preceding five-year period, incorporated in a self-administered questionnaire used in the NLCS, The Netherlands Cohort Study on diet and cancer (120,852 men and women aged 55-69 years).Questionnaire data were compared with reference information from three personal interviews carried out within a period of 10 months.A randomly selected subgroup (59 men and 50 women) of the cohort living in 12 municipalities in the eastern and western regions of The Netherlands.The overall sensitivity of the questionnaire concerning the use of any dietary supplement was 65.9%, the specificity was 98.5%; kappa as measure of agreement was estimated at 0.69. A high percentage recall was observed among women, users of at least three types of dietary supplements, long-term supplement users and those in the oldest age group. Recall of intake of specific supplements ranged from 77.8% for garlic preparations to 11.8% for 'other' supplements. Estimates of consumption of specific supplements (garlic and vitamin preparations) may provide enough precision to correctly classify individuals as users or non-users of those supplements.

Published
1994

44. A prospective cohort study on the relation between meat consumption and the risk of colon cancer

Author

Ra, Goldbohm, Pa, Den Brandt, van 't Veer P, Ha, Brants, Elisabeth Dorant, Sturmans F, and Rj, Hermus

Subjects
Male, Meat, Age Factors, Fishes, Middle Aged, Dietary Fats, Cohort Studies, Risk Factors, Colonic Neoplasms, Animals, Humans, Female, Dietary Proteins, Prospective Studies, Energy Intake, Aged, Follow-Up Studies, Netherlands
Abstract

The high incidence of colon cancer in affluent societies has often been attributed to a high fat diet and, more in particular, the consumption of meat. The association of the consumption of meat and the intake of fat with risk of colon cancer was investigated in a prospective cohort study on diet and cancer, which is being conducted in the Netherlands since 1986 among 120,852 men and women, aged 55-69. The analysis was based on 215 incident cases of colon cancer (105 men and 110 women) accumulated in 3.3 years of follow-up, excluding cases diagnosed in the first year of follow-up. Dietary habits were assessed at baseline with a 150-item semiquantitative food frequency questionnaire. No trends in relative rates of colon cancer were detected for intake of energy or for the energy-adjusted intake of fats, protein, fat from meat, and protein from meat. Consumption of total fresh meat, beef, pork, minced meat, chicken, and fish was not associated with risk of colon cancer either. Processed meats, however, were associated with an increased risk in men and women (relative rate, 1.17 per increment of 15 g/day; 95% confidence interval, 1.03-1.33). The increased risk appeared to be attributable to one of the five questionnaire items on processed meat, which comprised mainly sausages. This study does not support a role of fresh meat and dietary fat in the etiology of colon cancer in this population. As an exception, some processed meats may increase the risk, but the mechanism is not yet clear.

Published
1994

45. A prospective cohort study on the relation between meat consumption and the risk of colon cancer

Author

Goldbohm, R.A., van den Brandt, P.A., van 't Veer, P., Brants, A.M., Dorant, E., Sturmans, F., Hermus, R.J.J., Epidemiologie, and RS: NUTRIM School of Nutrition and Translational Research in Metabolism

Subjects
Vakgroep Gezondheidsleer, Life Science, food and beverages, Environmental and Occupational Health Group
Abstract

A prospective cohort study on the relation between meat consumption and the risk of colon cancer. Goldbohm RA, van den Brandt PA, van 't Veer P, Brants HA, Dorant E, Sturmans F, Hermus RJ. Department of Nutrition, TNO-Toxicology and Nutrition Institute, Zeist, The Netherlands. The high incidence of colon cancer in affluent societies has often been attributed to a high fat diet and, more in particular, the consumption of meat. The association of the consumption of meat and the intake of fat with risk of colon cancer was investigated in a prospective cohort study on diet and cancer, which is being conducted in the Netherlands since 1986 among 120,852 men and women, aged 55-69. The analysis was based on 215 incident cases of colon cancer (105 men and 110 women) accumulated in 3.3 years of follow-up, excluding cases diagnosed in the first year of follow-up. Dietary habits were assessed at baseline with a 150-item semiquantitative food frequency questionnaire. No trends in relative rates of colon cancer were detected for intake of energy or for the energy-adjusted intake of fats, protein, fat from meat, and protein from meat. Consumption of total fresh meat, beef, pork, minced meat, chicken, and fish was not associated with risk of colon cancer either. Processed meats, however, were associated with an increased risk in men and women (relative rate, 1.17 per increment of 15 g/day; 95% confidence interval, 1.03-1.33). The increased risk appeared to be attributable to one of the five questionnaire items on processed meat, which comprised mainly sausages. This study does not support a role of fresh meat and dietary fat in the etiology of colon cancer in this population. As an exception, some processed meats may increase the risk, but the mechanism is not yet clear

Published
1994

46. A prospective cohort study on selenium status and the risk of lung cancer

Author

Pa, Den Brandt, Ra, Goldbohm, van 't Veer P, Bode P, Elisabeth Dorant, Rj, Hermus, and Sturmans F

Subjects
Male, Lung Neoplasms, Time Factors, Ascorbic Acid, Adenocarcinoma, Education, Cohort Studies, Selenium, Sex Factors, Risk Factors, Surveys and Questionnaires, Humans, Prospective Studies, Carcinoma, Small Cell, Vitamin A, Aged, Netherlands, Incidence, Carcinoma, Smoking, Age Factors, Feeding Behavior, Middle Aged, Toes, beta Carotene, Carotenoids, Nails, Carcinoma, Squamous Cell, Female, Follow-Up Studies
Abstract

Selenium has been suggested to be anticarcinogenic and to play a role in the cellular defense against oxidative stress. The association between toenail selenium (a marker of long-term selenium status) and lung cancer was investigated in a cohort study of diet and cancer that started in 1986 among 120,852 Dutch men and women aged 55-69 years. After 3.3 years of follow-up, 550 incident cases of lung carcinoma were detected. Toenail selenium data were available for 370 lung cancer cases and 2459 members of a randomly selected subcohort. The rate ratio of lung cancer for subjects in the highest compared to the lowest quintile of toenail selenium, after controlling for age, gender, smoking, and education, was 0.50 (95% confidence interval, 0.30-0.81), with a significant inverse trend across quintiles (P = 0.006). The protective effect of selenium was concentrated in subjects with a relatively low dietary intake of beta-carotene or vitamin C. The rate ratio in the highest compared to the lowest quintile of selenium was 0.45 in the low beta-carotene group (95% confidence interval, 0.22-0.92; trend P = 0.028) and 0.36 in the low vitamin C group (95% confidence interval, 0.17-0.75; trend P0.001). The results of this study support an inverse association between selenium status and lung cancer and suggest a modification of the effect of selenium by the antioxidants beta-carotene and vitamin C.

Published
1993

47. Reproduceerbaarheid van een voedselfrequentielijst en stabilkiteit van voedingsgewoonten op basis van vijfjaarlijks herhaalde metingen

Author

Bausch-Goldbohm, R.A., Veer, P. van 't, Brandt, P.A. van den, Hof, M.A. van 't, Brants, H.A.M., Sturmans, F., Hermus, R.J.J., and TNO Preventie en Gezondheid

Subjects
Epidemiologie, Nederland, Workplace
Abstract

Congres van de Vereniging voor Epidemiologie 19e WEON-congres donderdag 15 april en vrijdag 16 april 1993 in et Academisch Centrum Amsterdam. Congres abstract.

Published
1993

49. Een prospectief cohortonderzoek naar seleniumstatus en het risico op kanker

Author

Brandt, P.A. van den, Bausch-Goldbohm, R.A., Veer, P. van 't, Bode, P., Dorant, E., Hermus, R.J.J., Sturmans, F., and TNO Preventie en Gezondheid

Subjects
Epidemiologie, Nederland, Workplace
Abstract

Congres van de Vereniging voor Epidemiologie 19e WEON-congres donderdag 15 april en vrijdag 16 april 1993 in et Academisch Centrum Amsterdam. Congres abstract.

Published
1993

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