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6. The My Active and Healthy Aging (My-AHA) ICT platform to detect and prevent frailty in older adults: Randomized control trial design and protocol

Author

Vercelli, A.E., Rainero, I., Caglio, M., Carbone, C., Rubino, E., Sousa, I., Vasconcelos, M.J.M., Madureira, P., Ribeiro, J., Cardoso, N., Giannouli, E., Zijlstra, W., Alonso, S., Mönter, M., Schnieder, S., Roelen, S.D., Kächele, L., Krajewski, J., de Rosario, H., Laparra, J., Serrano, J.F., Medina, E., López, A., Pedrero, J.F., Martínez, Ú., Bazzani, M., Cogerino, C., Toso, G.M., Tommasone, G., Frisello, A., Aumayr, G., Haider, G., Bleier, D., Sturm, N., Kaartinen, N., Kern, A., Bandelow, S., Niederstrasser, N.G., Vaziri, D., Tabatabaei, A., Gouverneur, P., Lagodzinski, P., Wieching, R., Grzegorek, M., Shariat Yazdi, H., Shirahama, K., Wulf, V., Cho, Y., Kawashima, R., Burin, D., Nouchi, R., Summers, M.J., Ciferri, L., Summers, Mathew J., Rainero, Innocenzo, Vercelli, Alessandro E., Aumayr, Georg, de Rosario, Helios, Mönter, Michaela, and Kawashima, Ryuta

Published
2018
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11. The influence of partnership status on fertility intentions of childless women and men across European countries

Author

Sturm, N., Koops, J.C., Rutigliano, R., Sturm, N., Koops, J.C., and Rutigliano, R.

Abstract

Item does not contain fulltext, The absence of a suitable partner is the most frequently given reason for unmet fertility intentions across European countries while having a partner is positively associated with the intention to have a child. However, once this relationship is framed within a life-course approach, existing evidence is mixed and inconclusive. The norm to have children within a stable relationship and norms regarding the timing of childbirth are acknowledged in many contemporary societies. Therefore, the presence of a partner might have a stronger effect on fertility intentions around the social deadline for fertility, which could explain the mixed findings in previous research. This article analyses how fertility intentions are influenced by partnership status and how this relationship varies by age and across countries. We use data from the first wave of the Generations and Gender Survey to analyse a sample of childless men and women aged 18-45 years from 12 European countries. We implement logistic regression models to investigate the influence of having a partner on fertility intentions during the life course. Previous studies found that the positive influence of having a partner either decreases across the life course or does not vary significantly. This study reveals that the positive association between partnership and fertility intentions increases from the age of 18, proving that whether someone is in a partnership becomes more influential at later stages in life. After a certain age threshold, which varies across countries and gender, this positive association either turns insignificant, remains positive, or reverses.

Published
2023

13. Industry-Scale Orchestrated Federated Learning for Drug Discovery

Author

Oldenhof, M, Acs, G, Pejo, B, Schuffenhauer, A, Holway, N, Sturm, N, Dieckmann, A, Fortmeier, O, Boniface, E, Mayer, C, Gohier, A, Schmidtke, P, Niwayama, R, Kopecky, D, Mervin, L, Rathi, PC, Friedrich, L, Formanek, A, Antal, P, Rahaman, J, Zalewski, A, Heyndrickx, W, Oluoch, E, Stossel, M, Vanco, M, Endico, D, Gelus, F, de Boisfosse, T, Darbier, A, Nicollet, A, Blottiere, M, Telenczuk, M, Nguyen, VT, Martinez, T, Boillet, C, Moutet, K, Picosson, A, Gasser, A, Djafar, I, Simon, A, Arany, Ádám, Simm, J, Moreau, Yves, Engkvist, O, Ceulemans, H, Marini, C, and Galtier, M

Subjects
FOS: Computer and information sciences, Computer Science - Machine Learning, Statistics - Machine Learning, Machine Learning (stat.ML), Machine Learning (cs.LG)
Abstract

To apply federated learning to drug discovery we developed a novel platform in the context of European Innovative Medicines Initiative (IMI) project MELLODDY (grant n{\deg}831472), which was comprised of 10 pharmaceutical companies, academic research labs, large industrial companies and startups. The MELLODDY platform was the first industry-scale platform to enable the creation of a global federated model for drug discovery without sharing the confidential data sets of the individual partners. The federated model was trained on the platform by aggregating the gradients of all contributing partners in a cryptographic, secure way following each training iteration. The platform was deployed on an Amazon Web Services (AWS) multi-account architecture running Kubernetes clusters in private subnets. Organisationally, the roles of the different partners were codified as different rights and permissions on the platform and administrated in a decentralized way. The MELLODDY platform generated new scientific discoveries which are described in a companion paper., Comment: 9 pages, 4 figures, to appear in AAAI-23 ([IAAI-23 track] Deployed Highly Innovative Applications of AI)

Published
2022

20. Risikofaktoren für eine invasive Langzeitbeatmung – ein Systematic Literature Review

Author

Trudzinski, F C, additional, Bornitz, F, additional, Müller, M M, additional, Weis, A, additional, Neetz, B, additional, Kronsteiner, D, additional, FJF, Herth, additional, Sturm, N, additional, Gassmann, V, additional, Joveš, B, additional, Neurohr, C, additional, Ghiani, A, additional, Schneider, A, additional, Szecsenyi, J, additional, von Schumann, S, additional, and Meis, J, additional

Published
2022
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22. Die spirituelle Anamnese in der Hausarztpraxis – eine Mixed-method-Studie zu den Erfahrungen von Hausärzten und MFAs im Rahmen des HoPES3-Projekts (Vortrag im Rahmen des HoPES3-Symposiums)

Author

Huperz, C, Frick, E, Maechler, R, Sturm, N, Schalhorn, F, Stolz, R, Joos, S, Valentini, J, and Straßner, C

Subjects
ddc: 610, Medicine and health
Abstract

Hintergrund: Spirituelle Bedürfnisse gewinnen insbesondere im Alter an Bedeutung und sollten im Rahmen einer ganzheitlichen, hausärztlichen Versorgung berücksichtigt werden. Im Rahmen des Projekts HoPES3 (Holistic Care Program for Elderly Patients to Integrate Spiritual needs, Social [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2021
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23. Stärkung sozialer Beziehungen älterer Patienten in der Hausarztpraxis – eine qualitative Studie zur Patientenperspektive im Rahmen des HoPES3-Projekts (Vortrag im Rahmen des HoPES3-Symposiums)

Author

Mächler, R, Frick, E, Sturm, N, Huperz, C, Stolz, R, Valentini, J, Joos, S, Schalhorn, F, and Straßner, C

Subjects
ddc: 610, Medicine and health
Abstract

Hintergrund: Soziale Beziehungen sind ein wichtiger Einflussfaktor für Gesundheit und Lebensqualität älterer Menschen. Im Rahmen des Forschungsprojekts HoPES3 (Holistic Care Program for Elderly Patients to Integrate Spiritual Needs, Social Activity and Self-Care into Disease Management [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2021
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26. Polarized Secretion of APRIL by the Tonsil Epithelium Upon Toll-Like Receptor Stimulation

Author

Sturm, N., Quinterot, M., Guyot, J.P., Righini, C., Daamen, W.F., Kuppevelt, T.H. van, Huard, B., Sturm, N., Quinterot, M., Guyot, J.P., Righini, C., Daamen, W.F., Kuppevelt, T.H. van, and Huard, B.

Abstract

Contains fulltext : 237750.pdf (Publisher’s version ) (Open Access), In mucosa such as tonsil, antibody-producing plasmocytes (PCs) lie in sub-epithelium space, which is thought to provide a suitable environment for their survival. A proliferation inducing ligand (APRIL) is one key survival factor for PCs present in this area. According to in situ staining, apical epithelial cells produced APRIL, and the secreted product had to migrate all through the stratified surface epithelium to reach basal cells. A similar process also occurred in the less-organized crypt epithelium. Tonsil epithelial cells captured secreted APRIL, thanks to their surface expression of the APRIL coreceptor, either syndecan-1 or -4 depending on their differentiation stage. In the most basal epithelial cells, secreted APRIL accumulated inside secretory lamp-1(+) vesicles in a polarized manner, facing the sub-epithelium. The tonsil epithelium upregulated APRIL production by apical cells and secretion by basal cells upon Toll-like receptor stimulation. Furthermore, LPS-stimulated epithelial cells sustained in vitro PC survival in a secreted APRIL-dependent manner. Taken together, our study shows that the tonsil epithelium responds to pathogen sensing by a polarized secretion of APRIL in the sub-epithelial space, wherein PCs reside.

Published
2021

27. Effektivität einer komplexen Intervention zur Stärkung von spirituellen Bedürfnissen, sozialer Aktivität und Selbstfürsorge in der hausärztlichen Versorgung - Ergebnisse einer Cluster-randomisierten kontrollierten Studie (Vortrag im Rahmen des HoPES3-Symposiums)

Author

Sturm, N, Krisam, J, Bentner, M, Frick, E, Mächler, R, Valentini, J, Joos, S, Stolz, R, Schalhorn, F, Straßner, C, Sturm, N, Krisam, J, Bentner, M, Frick, E, Mächler, R, Valentini, J, Joos, S, Stolz, R, Schalhorn, F, and Straßner, C

Published
2021

30. Temozolomide Treatment in Aggressive Pituitary Tumors and Pituitary Carcinomas: A French Multicenter Experience.

Author

Raverot, G, primary, Sturm, N, additional, DeFraipont, F, additional, Muller, M, additional, Salenave, S, additional, Caron, P, additional, Chabre, O, additional, Chanson, P, additional, Cortet-Rudelli, C, additional, Assaker, R, additional, Dufour, H, additional, Gaillard, S, additional, Francois, P, additional, Jouanneau, E, additional, Passagia, J.G., additional, Bernier, M, additional, Figarella-Branger, D, additional, Maurage, C.A., additional, Trouillas, J, additional, Borson-Chazot, F, additional, and Brue, T, additional

Published
2010
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35. APRIL-mediated anti-inflammatory response of astrocytes in multiple sclerosis

Author

Baert, L., Benkhoucha, M., Popa, N., Ahmed, M., Manfroi, B., Boutonnat, J., Sturm, N., Raguenez, G., Tessier, M., Casez, Olivier, Marignier, R., Ahmadi, M., Broisat, A., Ghezzi, C., Rivat, C., Sonrier, C., Hahne, M., Baeten, D., Vives, R., Lortat-Jacob, Hugues, Marche, N., Schneider, P., Lassmann, H., Boucraut, J., Lalive, P., Huard, B., Chemical Sciences Division [LBNL Berkeley] (CSD), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), AGeing and IMagery (AGIM), Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Joseph Fourier - Grenoble 1 (UJF)-Université Pierre Mendès France - Grenoble 2 (UPMF), Centre Hospitalier Universitaire [Grenoble] (CHU), Chimie des polymères (LCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Parisien de Chimie Moléculaire (IPCM), Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Radiopharmaceutiques biocliniques (LRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Radiopharmaceutiques biocliniques, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut de Génétique Moléculaire de Montpellier (IGMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie structurale (IBS - UMR 5075 ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre de résonance magnétique biologique et médicale (CRMBM), and Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]
Abstract

International audience; OBJECTIVE:the two related TNF members APRIL and BAFF are currently targeted in autoimmune diseases as B-cell regulators. In multiple sclerosis (MS), combined APRIL/BAFF blockade led to an unexpected exacerbated inflammation in the central nervous system (CNS) of patients. Here, we investigate the role of the APRIL/BAFF axis in the CNS.METHODS:APRIL expression was analyzed in MS lesions by immunohistochemistry. The in vivo role of APRIL was assessed in the murine MS model, experimental autoimmune encephalitis (EAE). Functional in vitro studies were performed with human and mouse astrocytes.RESULTS:APRIL was expressed in lesions from EAE. In its absence, the disease was worst. Lesions from MS patients also showed APRIL expression upon infiltration of macrophages. Notably, all the APRIL secreted by these macrophages specifically targeted astrocytes. The upregulation of chondroitin sulfate proteoglycan (CSPG) bearing sometimes chondroitin sulfate of type E sugar moieties, binding APRIL, in reactive astrocytes explained the latter selectivity. Astrocytes responded to APRIL by producing sufficient amount of IL-10 to dampen antigen-specific T-cell proliferation and pathogenic cytokine secretion. Finally, an intraspinal delivery of recombinant APRIL before disease onset shortly reduced EAE symptoms. Repeated intravenous injections of recombinant APRIL before and even at disease onset had also an effect.INTERPRETATION:our data show that APRIL mediates an anti-inflammatory response from astrocytes in MS lesions. This protective activity is not shared with BAFF. This article is protected by copyright. All rights reserved.

Published
2019

48. Recurrent INHBE-GLI1 fusions in hepatocellular adenomas with sonic hedgehog pathway activation

Author

Nault, J.C., primary, Couchy, G., additional, Balabaud, C., additional, Morcrette, G., additional, Caruso, S., additional, Blanc, J.-F., additional, Bacq, Y., additional, Caldéraro, J., additional, Paradis, V., additional, Ramos, J., additional, Gnemmi, V., additional, Sturm, N., additional, Savier, E., additional, Chiche, L., additional, Selves, J., additional, Pilati, C., additional, Laurent, A., additional, DeMuret, A., additional, Lebail, B., additional, Rebouissou, S., additional, Imbeaud, S., additional, Bioulac-Sage, P., additional, Letouze, E., additional, and Zucman-Rossi, J., additional

Published
2017
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49. Treatment and prognosis of acute severe autoimmune hepatitis

Author

De Martin, E., primary, Coilly, A., additional, Houssel-Debry, P., additional, Ollivier-Hourmand, I., additional, Heurgue-Berlot, A., additional, Artru, F., additional, Barge, S., additional, Chazouilleres, O., additional, Silvain, C., additional, Duvoux, C., additional, Pageaux, G.-P., additional, Besch, C., additional, Bourlière, M., additional, Fontaine, H., additional, de Ledinghen, V., additional, Dumortier, J., additional, Conti, F., additional, Radenne, S., additional, Debette-Gratien, M., additional, Goria, O., additional, Boursier, J., additional, Peron, J.-M., additional, Durand, F., additional, Borrentain, P., additional, Potier, P., additional, Minello, A., additional, Abergel, A., additional, Perarnau, J.-M., additional, Nousbaum, J.-B., additional, Rudler, M., additional, Alric, L., additional, Anty, R., additional, Sturm, N., additional, Sebagh, M., additional, Agostini, H., additional, Samuel, D., additional, and Duclos-Vallée, J.-C., additional

Published
2017
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