9 results on '"Sturm, P.D."'
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2. The Effect of Door Openings on Numbers of Colony Forming Units in the Operating Room during Hip Revision Surgery
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Mathijssen, N.M., Hannink, G.J., Sturm, P.D., Pilot, P., Bloem, R.M., Buma, P., Petit, P.L., Schreurs, B.W., Mathijssen, N.M., Hannink, G.J., Sturm, P.D., Pilot, P., Bloem, R.M., Buma, P., Petit, P.L., and Schreurs, B.W.
- Abstract
Item does not contain fulltext, BACKGROUND: The aim of this study was to investigate the effect of door opening rates on air quality in the operation room during hip revision surgery by measuring the number of colony forming units per cubic meter (CFU/m(3)). METHODS: During 70 hip revision operations the number of CFU/m(3) was measured at four time points. Factors that may influence air quality were recorded, including the number of persons present, duration of surgery, and door opening rates. The measured CFU/m(3) was dichotomized as either acceptable (20 CFU/m(3)). To determine whether door openings were associated with CFU/m(3) values, we used generalized linear mixed models to model the dichotomized repeatedly measured CFU/m(3) values. RESULTS: The median number of door openings per operation was eight (range, 0-72), the median duration of surgery was 145 min (range, 60-285), and the median number of persons present during surgery was eight (range, 5-10). Adjusted for number of persons in the operation room and duration of surgery, the number of door openings per operation was associated (odds ratio [OR] 1.05 [95% confidence interval {CI} 1.02-1.09]; p = 0.003) with an unacceptable number of CFU/m(3). CONCLUSIONS: In conclusion, a substantial association between number of door openings and an unacceptable number (>20) of CFU/m(3) was found. Adjusted for number of persons in the operation room and duration of surgery, every door opening increased the odds of unacceptable CFU/m(3) values by 5%. Number of persons present during surgery and duration of surgery were not related to CFU/m(3).
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- 2016
3. Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3
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Oosting, M., Buffen, K., Malireddi, S.R., Sturm, P.D., Verschueren, I., Koenders, M.I., Veerdonk, F.L. van de, Meer, J.W.M. van der, Netea, M.G., Kanneganti, T.D., and Joosten, L.A.
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Pathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1] ,Infection and autoimmunity Auto-immunity, transplantation and immunotherapy [NCMLS 1] - Abstract
Contains fulltext : 126874.pdf (Publisher’s version ) (Open Access)
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- 2012
4. Decontamination of cephalosporin-resistant Enterobacteriaceae during selective digestive tract decontamination in intensive care units
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Oostdijk, E.A., Smet, A.M. de, Kesecioglu, J., Bonten, M.J., Hoeven, J.G. van der, Pickkers, P., Sturm, P.D., Voss, A., Microbes in Health and Disease (MHD), Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Medical Microbiology and Infection Prevention, and CCA - Innovative therapy
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Microbiology (medical) ,Cefotaxime ,antibiotic resistance ,Iron metabolism Pathogenesis and modulation of inflammation [IGMD 7] ,Ceftazidime ,Antisepsis ,SDD ,beta-Lactam Resistance ,Microbiology ,Antibiotic resistance ,Enterobacteriaceae ,Intensive care ,ICUs ,selective decontamination ,polycyclic compounds ,medicine ,Tobramycin ,Humans ,Pharmacology (medical) ,Cephalosporin Resistance ,Pharmacology ,biology ,Enterobacteriaceae Infections ,Rectum ,Pathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1] ,biology.organism_classification ,Anti-Bacterial Agents ,Cephalosporins ,Gastrointestinal Tract ,Pathogenesis and modulation of inflammation [N4i 1] ,Intensive Care Units ,Infectious Diseases ,Ceftriaxone ,medicine.drug - Abstract
Item does not contain fulltext OBJECTIVES: Prevalences of cephalosporin-resistant Enterobacteriaceae are increasing globally, especially in intensive care units (ICUs). The effect of selective digestive tract decontamination (SDD) on the eradication of cephalosporin-resistant Enterobacteriaceae from the intestinal tract is unknown. We quantified eradication rates of cephalosporin-resistant and cephalosporin-susceptible Enterobacteriaceae during SDD in patients participating in a 13 centre cluster-randomized study and from a single-centre cohort. METHODS: All SDD patients colonized with Enterobacteriaceae in the intestinal tract at ICU admission were included. Cephalosporin resistance was defined as resistance to ceftazidime, cefotaxime or ceftriaxone and aminoglycoside resistance as resistance to tobramycin or gentamicin. Duration of rectal colonization was determined by screening twice weekly during ICU stay. Swabs were inoculated on selective medium supplemented with tobramycin or cefotaxime. RESULTS: Five hundred and seven (17%) of 2959 SDD patients with at least one rectal sample were colonized with Enterobacteriaceae at ICU admission: 77 (15%) with cephalosporin-resistant Enterobacteriaceae and 50 (10%) with aminoglycoside-resistant Enterobacteriaceae. Fifty-six (73%) patients colonized with cephalosporin-resistant Enterobacteriaceae were successfully decontaminated before ICU discharge, as were 343 (80%) patients colonized with cephalosporin-susceptible Enterobacteriaceae (P = 0.17). For aminoglycoside resistance, 31 (62%) patients were decontaminated, as were 368 patients (81%) colonized with aminoglycoside-susceptible Enterobacteriaceae (P < 0.01). On average, decolonization was demonstrated after 4 days if colonized with cephalosporin-susceptible Enterobacteriaceae and aminoglycoside-susceptible Enterobacteriaceae, and after 5 and 5.5 days if colonized with cephalosporin-resistant Enterobacteriaceae and aminoglycoside-resistant Enterobacteriaceae, respectively (log-rank test P = 0.053 for cephalosporin resistance and P = 0.03 for aminoglycoside resistance). If eradication failed, no associations were found with increased resistance in time (P > 0.05 for all comparisons). CONCLUSIONS: SDD can successfully eradicate cephalosporin-resistant Enterobacteriaceae from the intestinal tract.
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- 2012
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5. New Diagnostic Microarray (Check-KPC ESBL) for Detection and Identification of Extended-Spectrum Beta-Lactamases in Highly Resistant Enterobacteriaceae
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Willemsen, I., Overdevest, I., Naiemi, N. Al, Rijnsburger, M., Savelkoul, P., Vandenbroucke-Grauls, C., Kluytmans, J., Lommerse, E., Spanjaard, L., Vlaminckx, B., Voss, A., Wulf, M.W., Vos, M., Wintermans, R., Andriese, G., Zeijl, J. van, Vorm, E. van der, Buiting, A., Sturm, P.D., Blok, H., Troelstra, A., Medical Microbiology and Infection Prevention, and CCA - Immuno-pathogenesis
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Microbiology (medical) ,Genetics ,Bacteriological Techniques ,Genotype ,biology ,Microarray ,Enterobacteriaceae Infections ,Microarray analysis techniques ,Bacteriology ,Pathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1] ,Microarray Analysis ,biology.organism_classification ,Sensitivity and Specificity ,Enterobacteriaceae ,beta-Lactamases ,Microbiology ,FAMILY ENTEROBACTERIACEAE ,Genes, Bacterial ,Drug Resistance, Bacterial ,Humans ,Diagnostic microarray ,Netherlands - Abstract
The performance of a microarray for the detection of extended-spectrum beta-lactamases was determined on a collection of 638 highly resistant members of the family Enterobacteriaceae collected from patients in 18 hospitals in The Netherlands. The microarray had a significantly higher specificity than the phenotypic assays. It also detects carbapenemases and characterizes the resistance genes, providing epidemiological insight.
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- 2011
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6. Dutch patients, retail chicken meat and poultry share the same ESBL genes, plasmids and strains
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Leverstein-van Hall, M.A., Dierikx, C.M., Cohen Stuart, J., Voets, G.M., Munckhof, M.P. van den, Essen-Zandbergen, A. van, Platteel, T., Fluit, A.C., Sande-Bruinsma, N. van de, Scharinga, J., Bonten, M.J., Mevius, D.J., Sturm, P.D., Advances in Veterinary Medicine, and Dep Infectieziekten Immunologie
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Veterinary medicine ,spectrum beta-lactamases ,Antibiotic resistance ,Epidemiology ,medicine.disease_cause ,multi-locus sequence typing ,Polymerase Chain Reaction ,Poultry ,law.invention ,Plasmid ,law ,Zoonoses ,polycyclic compounds ,Cluster Analysis ,infections ,humans ,Escherichia coli Infections ,Polymerase chain reaction ,Netherlands ,Antibacterial agent ,Molecular Epidemiology ,food and beverages ,General Medicine ,Bacterial Typing Techniques ,Infectious Diseases ,salmonella-enterica ,Carrier State ,Plasmids ,trends ,Microbiology (medical) ,Meat ,Genotype ,Bioinformatica & Diermodellen ,prevalence ,Biology ,beta-Lactamases ,diversity ,Microbiology ,plasmid ,Bio-informatics & Animal models ,Escherichia coli ,medicine ,Animals ,Humans ,emergence ,Epidemiology, Bio-informatics & Animal models ,human ,Typing ,Genotyping ,Epidemiologie ,resistant escherichia-coli ,Molecular epidemiology ,Pathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1] ,zoonosis ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,Molecular Typing ,extended-spectrum ,Epidemiologie, Bioinformatica & Diermodellen ,Multilocus sequence typing ,bacteria ,Multilocus Sequence Typing - Abstract
Item does not contain fulltext Intestinal carriage of extended-spectrum beta-lactamase (ESBL) -producing bacteria in food-producing animals and contamination of retail meat may contribute to increased incidences of infections with ESBL-producing bacteria in humans. Therefore, distribution of ESBL genes, plasmids and strain genotypes in Escherichia coli obtained from poultry and retail chicken meat in the Netherlands was determined and defined as 'poultry-associated' (PA). Subsequently, the proportion of E. coli isolates with PA ESBL genes, plasmids and strains was quantified in a representative sample of clinical isolates. The E. coli were derived from 98 retail chicken meat samples, a prevalence survey among poultry, and 516 human clinical samples from 31 laboratories collected during a 3-month period in 2009. Isolates were analysed using an ESBL-specific microarray, sequencing of ESBL genes, PCR-based replicon typing of plasmids, plasmid multi-locus sequence typing (pMLST) and strain genotyping (MLST). Six ESBL genes were defined as PA (bla(CTX-M-1) , bla(CTX-M-2) , bla(SHV-2) , bla(SHV-12) , bla(TEM-20) , bla(TEM-52) ): 35% of the human isolates contained PA ESBL genes and 19% contained PA ESBL genes located on IncI1 plasmids that were genetically indistinguishable from those obtained from poultry (meat). Of these ESBL genes, 86% were bla(CTX-M-1) and bla(TEM-52) genes, which were also the predominant genes in poultry (78%) and retail chicken meat (75%). Of the retail meat samples, 94% contained ESBL-producing isolates of which 39% belonged to E. coli genotypes also present in human samples. These findings are suggestive for transmission of ESBL genes, plasmids and E. coli isolates from poultry to humans, most likely through the food chain. 01 juni 2011
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- 2011
7. Antibiotic mixing through impacted bone grafts does not seem indicated in two-stage cemented hip revisions for septic loosening
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Elbers, J.B., Leijtens, B., Werven, H.E. van, Sturm, P.D., Kullberg, B.J., Schreurs, B.W., Elbers, J.B., Leijtens, B., Werven, H.E. van, Sturm, P.D., Kullberg, B.J., and Schreurs, B.W.
- Abstract
Item does not contain fulltext, Impaction bone grafts (IBG) in two-stage revision for prosthetic hip infection (PHI) might be more susceptible for infection, therefore antibiotic mixing through these grafts has been suggested. However, outcomes have not been compared with IBG without antibiotics and no long-term results are available. Therefore, we evaluated long-term infection-free outcome after the use of IBG without antibiotic supplement in two-stage revision for PHI. Patients were divided into positive (group 1, n = 8) and negative (group 2, n = 28) cultures at re-implantation and followed up to 18 years after re-implantation. Five of 36 patients died from non-orthopaedic causes (median 37, range 24-149 months). Five patients had a re-operation not related to infection (median 39, range 7-140 months). These were censored in the Kaplan-Meier estimator at the last outpatient evaluation. We found an overall re-infection rate of 2.8% within two years, which matches comparative studies in which antibiotic impregnated bone grafts had been used. In group 1, there was one re-infection after 44 months. In group 2, all three infections occurred within 56 months with an estimated infection-free percentage at 10 years of 87% (95% CI 66-96). Follow-up should be extended beyond two years and randomised clinical trials are needed for further comparison with IBG impregnated with antibiotics.
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- 2014
8. Shiga toxin-producing Escherichia coli isolated from patients with diarrhoea in Bangladesh
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Islam, M.A., Heuvelink, A.E., de Boer, E., Sturm, P.D., Beumer, R.R., Zwietering, M.H., Faruque, A.S.G., Haque, R., Sack, D.A., Talukder, K.A., Islam, M.A., Heuvelink, A.E., de Boer, E., Sturm, P.D., Beumer, R.R., Zwietering, M.H., Faruque, A.S.G., Haque, R., Sack, D.A., and Talukder, K.A.
- Abstract
The prevalence of Shiga toxin-producing Escherichia coli (STEC) and its characteristics were determined among hospitalized patients with diarrhoea and children with diarrhoea in an urban slum community of Dhaka city using sensitive culture and PCR methods. Stool samples were collected from 410 patients with diarrhoea enrolled in the 2 % surveillance system (every 50th patient attending the hospital with diarrhoeal disease is included) at the ICDDR,B hospital and from 160 children of 2¿5 years of age with diarrhoea living in an urban slum in Dhaka, between September 2004 and April 2005. Shiga toxin genes (stx) were detected by multiplex PCR in the enrichment broth of nine samples (2.2 %) from hospitalized patients and 11 samples (6.9 %) from the community patients. STEC was isolated from five stool samples with positive PCR results using a colony patch technique. All five isolates were positive in the Vero cell assay and PCR fragments of stx genes were confirmed by sequencing. Two isolates were positive for the E. coli attaching-and-effacing (eae) gene and four were positive for the enterohaemolysin (hlyEHEC) gene and enterohaemolysin production. The five isolates belonged to five different serotypes: O32 : H25, O2 : H45, O76 : H19, ONT : H25 and ONT : H19. It can be concluded that STEC is not a common pathogen in Bangladesh among hospitalized patients with diarrhoea nor among mild cases of diarrhoea in the community.
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- 2007
9. Long-term follow-up of patients with benign extrahepatic biliary stenosis who harbor a K-ras codon 12 mutation in their endobillary brush cytology
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Heek, T.N., Sturm, P.D., Rauws, E.A., Caspers, E., Drillenburg, P., Gouma, D.J., and Offerhaus, J.A.
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- 2001
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