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38 results on '"Stupin, Igor"'

11. Early Detection of Aortic Degeneration in a Mouse Model of Sporadic Aortic Aneurysm and Dissection Using Nanoparticle Contrast-Enhanced Computed Tomography

Author

Ghaghada, Ketan B., primary, Ren, Pingping, additional, Devkota, Laxman, additional, Starosolski, Zbigniew, additional, Zhang, Chen, additional, Vela, Deborah, additional, Stupin, Igor V., additional, Tanifum, Eric A., additional, Annapragada, Ananth V., additional, Shen, Ying H., additional, and LeMaire, Scott A., additional

Published
2021
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14. Hyperphosphorylation, cytoskeleton and cell‐surface binding aptamers: Developing markers and understanding molecular changes in early stage Alzheimer’s disease

Author

Parekh, Parag A., primary, Mu, Qingshan, additional, Badchappe, Andrew, additional, Bhavane, Rohan, additional, Srivastava, Mayank, additional, Stupin, Igor, additional, Bhandari, Prajwal, additional, Devkota, Laxman, additional, Ghaghada, Ketan, additional, and Annapragada, Ananth, additional

Published
2020
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22. ACS/TIRVIM: Calibration and first results

Author

Shakun, Alexey, primary, Luginin, Michail, primary, Maturilli, Alessandro, primary, Grassi, Davide, primary, Ignatiev, Nikolay, primary, Grigoriev, Alexey, primary, Moshkin, Boris, primary, Korablev, Oleg, primary, Arnold, Gabriele E., primary, Kungurov, Andrey, primary, Makarov, Vladislav, primary, Martynovich, Fedor, primary, Maslov, Igor, primary, Merzlyakov, Dmitry, primary, Nikolskiy, Yuri, primary, Patsaev, Dmitry, primary, Santos-Skripko, Aleksandr, primary, Sazonov, Oleg, primary, Shashkin, Viktor, primary, Stupin, Igor, primary, and Zharkov, Alexander, primary

Published
2018
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24. Magnetic Resonance Imaging of Atherosclerotic Plaque at Clinically Relevant Field Strengths (1T) by Targeting the Integrin α4β1

Author

Woodside, Darren G., primary, Tanifum, Eric A., additional, Ghaghada, Ketan B., additional, Biediger, Ronald J., additional, Caivano, Amy R., additional, Starosolski, Zbigniew A., additional, Khounlo, Sayadeth, additional, Bhayana, Saakshi, additional, Abbasi, Shahrzad, additional, Craft, John W., additional, Maxwell, David S., additional, Patel, Chandreshkumar, additional, Stupin, Igor V., additional, Bakthavatsalam, Deenadayalan, additional, Market, Robert V., additional, Willerson, James T., additional, Dixon, Richard A. F., additional, Vanderslice, Peter, additional, and Annapragada, Ananth V., additional

Published
2018
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28. Fourier spectrometer TIRVIM/ACS aboard ExoMars 16 orbiter (Conference Presentation)

Author

Grigoriev, Alexei V., primary, Shakun, Alexey, additional, Moshkin, Boris E., additional, Patsaev, Dmitry V., additional, Zharkov, Alexander V., additional, Shashkin, Victor, additional, Kungurov, Andrey S., additional, Santos-Skripko, Alexander, additional, Martynovich, Fedor G., additional, Stupin, Igor A., additional, Merzlyakov, Dmitry, additional, Makarov, Vladislav, additional, Sazonov, Oleg M., additional, Nikolskyi, Yuryi, additional, Ignatiev, Nikolai I., additional, Maslov, Igor A., additional, Gorinov, Dmitry, additional, Efremenkova, Elena, additional, Terentiev, Alexander, additional, and Korablev, Oleg, additional

Published
2017
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29. ACS/TIRVIM: Calibration and first results.

Author

Shakun, Alexey, Ignatiev, Nikolay, Luginin, Michail, Grigoriev, Alexey, Moshkin, Boris, Grassi, Davide, Arnold, Gabriele, Maturilli, Alessandro, Kungurov, Andrey, Makarov, Vladislav, Martynovich, Fedor, Maslov, Igor, Merzlyakov, Dmitry, Nikolskiy, Yuri, Patsaev, Dmitry, Santos-Skripko, Aleksandr, Sazonov, Oleg, Shashkin, Viktor, Stupin, Igor, and Zharkov, Alexander

Published
2018
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33. ACS/TIRVIM: Calibration and first results

Author

Strojnik, Marija, Kirk, Maureen S., Shakun, Alexey, Ignatiev, Nikolay, Luginin, Michail, Grigoriev, Alexey, Moshkin, Boris, Grassi, Davide, Arnold, Gabriele, Maturilli, Alessandro, Kungurov, Andrey, Makarov, Vladislav, Martynovich, Fedor, Maslov, Igor, Merzlyakov, Dmitry, Nikolskiy, Yuri, Patsaev, Dmitry, Santos-Skripko, Aleksandr, Sazonov, Oleg, Shashkin, Viktor, Stupin, Igor, Zharkov, Alexander, and Korablev, Oleg

Published
2018
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36. Abstract 11515: Early Detection of Aortic Wall Injury in a Mouse Model of Sporadic Aortic Aneurysm and Dissection Using Nanoparticle Contrast-enhanced Computed Tomography

Author

Ghaghada, Ketan, Ren, Pingping, Devkota, Laxman, Starosolski, Zbigniew, Stupin, Igor, Annapragada, Ananth, Shen, Ying H, and Lemaire, Scott A

Abstract

Introduction:Early detection of aortic degeneration is critical for improving outcomes in patients with aortic aneurysms and dissections (AAD). Although non-invasive imaging techniques exhibit high sensitivity for the detection of aortic enlargement, they are unable to detect aortic degeneration that occurs before changes in vessel diameter are evident. In this pre-clinical study, we investigated contrast-enhanced computed tomography (CECT) imaging using a liposomal-iodine (Lip-I) nanoparticle contrast agent, referred to as n-CECT, for early detection of AAD.Hypothesis:We hypothesize that n-CECT will enable early detection of aortic wall inflammation and degeneration.Methods:In a mouse model of sporadic AAD, 4 week-old C57BL/6 mice were challenged with high-fat diet for 8 weeks and angiotensin-II (Ang II) infusion during the last 4 weeks. Unchallenged mice received chow diet and were infused with saline. On days 5, 10, and 28 after initiation of infusion, CT angiogram (CTA) was performed to evaluate aortic dilatation, aneurysm, and dissection. Delayed CT (with Lip-I injection 4 days prior to CT scan) was acquired to determine aortic wall degeneration and inflammation. CT findings were compared with histology and immunofluorescence (IF) analysis of excised aorta.Results:CTA detected dilatation in ascending aorta (60% incidence), aortic arch (30%), and suprarenal abdominal aorta (SAA, 10%). Aneurysm was detected in descending thoracic aorta (DTA, 10%) and abdominal aorta (20%). Dissection was detected in DTA (10%) and SAA (10%). Delayed CT detected aortic wall signal enhancement in almost all the challenged mice including several mice that did not exhibit aortic enlargement in CTA. The incidence of mice showing aortic wall signal enhancement but not CTA findings was 30% in ascending aorta, 50% in aortic arch, 10% in DTA and 60% in SAA. None of the unchallenged mice showed aortic wall signal enhancement. Aortic wall signal detected in n-CECT correlated with aortic wall degeneration on histology and inflammation (macrophage accumulation) on IF staining.Conclusions:In mice, n-CECT is sensitive in detecting aortic wall degeneration and inflammation before aortic dilatation and dissection become evident in CT angiography.

Published
2019
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38. Silent myocardial ischemia: Current perspectives and future directions.

Author

Ahmed AH, Shankar K, Eftekhari H, Munir M, Robertson J, Brewer A, Stupin IV, and Casscells SW

Abstract

Silent myocardial ischemia (SMI) is increasingly being recognized as part of the spectrum of ischemic heart disease. The spectrum of SMI ranges from asymptomatic coronary artery disease to critical illness necessitating intensive care. Although many diagnostic tools have been used to identify low- and high-risk subgroups, their use is limited by modest sensitivities and specificities. The present review identifies current concepts in the management of SMI in various clinical settings, as well as emerging technologies that may simplify the diagnosis and treatment of this condition.

Published
2007

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