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1,106 results on '"Stummer, W."'

5. A magnetic resonance imaging based radiomics model to predict mitosis cycles in intracranial meningioma.

Author

Krähling, H., Musigmann, M., Akkurt, B.H., Sartoretti, T., Sartoretti, E., Henssen, D.J.H.A., Stummer, W., Heindel, W., Brokinkel, B., Mannil, M., Krähling, H., Musigmann, M., Akkurt, B.H., Sartoretti, T., Sartoretti, E., Henssen, D.J.H.A., Stummer, W., Heindel, W., Brokinkel, B., and Mannil, M.

Abstract

Item does not contain fulltext, The aim of this study was to develop a magnetic resonance imaging (MRI) based radiomics model to predict mitosis cycles in intracranial meningioma grading prior to surgery. Preoperative contrast-enhanced T1-weighted (T1CE) cerebral MRI data of 167 meningioma patients between 2015 and 2020 were obtained, preprocessed and segmented using the 3D Slicer software and the PyRadiomics plugin. In total 145 radiomics features of the T1CE MRI images were computed. The criterion on the basis of which the feature selection was made is whether the number of mitoses per 10 high power field (HPF) is greater than or equal to zero. Our analyses show that machine learning algorithms can be used to make accurate predictions about whether the number of mitoses per 10 HPF is greater than or equal to zero. We obtained our best model using Ridge regression for feature pre-selection, followed by stepwise logistic regression for final model construction. Using independent test data, this model resulted in an AUC (Area under the Curve) of 0.8523, an accuracy of 0.7941, a sensitivity of 0.8182, a specificity of 0.7500 and a Cohen's Kappa of 0.5576. We analyzed the performance of this model as a function of the number of mitoses per 10 HPF. The model performs well for cases with zero mitoses as well as for cases with more than one mitosis per 10 HPF. The worst model performance (accuracy = 0.6250) is obtained for cases with one mitosis per 10 HPF. Our results show that MRI-based radiomics may be a promising approach to predict the mitosis cycles in intracranial meningioma prior to surgery. Specifically, our approach may offer a non-invasive means of detecting the early stages of a malignant process in meningiomas prior to the onset of clinical symptoms.

Published
2023

6. Predicting Meningioma Resection Status: Use of Deep Learning.

Author

Akkurt, B.H., Wanderer, S., Schwyzer, L., Berberat, J., Henssen, D.J.H.A., Sartoretti, T., Sartoretti, E., Musigmann, M., Brokinkel, B., Stummer, W., Heindel, W., Remonda, L., Mannil, M., Akkurt, B.H., Wanderer, S., Schwyzer, L., Berberat, J., Henssen, D.J.H.A., Sartoretti, T., Sartoretti, E., Musigmann, M., Brokinkel, B., Stummer, W., Heindel, W., Remonda, L., and Mannil, M.

Abstract

01 juli 2023, Item does not contain fulltext

Published
2023

11. P11.15.B First multicentric real-life experience with the combination of lomustine and temozolomide in newly diagnosedMGMT promoter methylatedIDH wildtype glioblastoma

Author

Lazaridis, L, primary, Schmidt, T, additional, Agkatsev, S, additional, Blau, T, additional, Spille, D, additional, Heider, S, additional, Schulz, T, additional, Bumes, E, additional, Oster, C, additional, Feldheim, J, additional, Stummer, W, additional, Kessler, A, additional, Seidel, C, additional, Hau, P, additional, Sure, U, additional, Keyvani, K, additional, Herrlinger, U, additional, Kleinschnitz, C, additional, Stuschke, M, additional, Herrmann, K, additional, Deuschl, C, additional, Hattingen, E, additional, Scheffler, B, additional, Kebir, S, additional, and Glas, M, additional

Published
2022
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12. Prospective documentation and analysis of the pre- and early clinical management in severe head injury in Southern Bavaria at a population based level

Author

Wirth, A., Baethmann, A., Assal, A. J., Aydemir, S., Bayeff-Filloff, M., Beck, J., Belg, A., Boscher, A., Chapuis, D., Dietz, H.-G., Döffinger, J., Eisenmenger, W., Gerstner, W., Göbel, W.-E., Groβe, P., Grumme, T., Gutermuth, L., Hölzel, D., Höpner, F., Huf, R., Jaksche, H., Jensen, U., Kettemann, M., Ketterl, R., Kirmayer, U., Kolodziejcyk, D., Köstler, W., Kuznik, J., Lackner, C., Lenz, G., Lochbihler, H., Lumenta, C., Martin, S., Preisz, A., Prokscha, G., Regel, G., Reischl, H., Reulen, H.-J., Rothmeier, F., Sackerer, D., Schneck, S., Schweiberer, L., Sommer, F., Steiger, H.-J., Stolpe, E., Stummer, W., Tanner, P., Trappe, A., Twickel, J. v., Ueblacker, P., Wambach, W., Wengert, P., Zimmerer, S., Baethmann, A., editor, Eriskat, J., editor, Lehmberg, J., editor, and Plesnila, N., editor

Published
2004
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14. System Analysis of Patient Management During the Pre- and Early Clinical Phase in Severe Head Injury

Author

Baethmann, A., Chapuis, D., Wirth, A., Reulen, H.-J., Steiger, H.-J., Stummer, W., Hölzel, D., Lackner, Ch., Assal, J., Belg, A., Schrödel, M., Müller, N., Ueblacker, P., Chlistalla, A., Schneider, G., Schweiberer, L., Dietz, H.-G., Trappe, A., Göbel, W.-E., Jaksche, H., Messner, V., Grumme, Th., Wenger, P., Müller, H., Stolpe, E., Döffinger, J., Lumenta, Ch., Gerstner, W., Prokscha, G., Sackerer, D., Höfner, F., Eisenstein, T., Lenz, G., Preisz, A., Rothmeier, F., Kirmayer, U., Böhme, M., Horak, W., Weeß, Th., Reulen, H.-J., editor, Steiger, H.-J., editor, Baethmann, Alexander, editor, Plesnila, Nikolaus, editor, Ringel, Florian, editor, and Eriskat, Jörg, editor

Published
1999
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15. Quality indicators in meningioma surgery – analysis of the suitability of currently suggested quality indicators

Author

Spille, DC, Lohmann, S, Schwake, M, Samer, ZA, Stummer, W, Brokinkel, B, and Schipmann-Miletic, S

Subjects
ddc: 610, Medicine and health
Abstract

Objective: Risk stratification based on standardized quality measures has become crucial in neurosurgery. Contemporary quality indicators have often been collectively developed for a wide range of neurosurgical procedures. While these indicators are easy to register, their accuracy for tumor inherent [for full text, please go to the a.m. URL]

Published
2022
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16. Virtual Reality based teaching – a paradigm shift in education?

Author

Junga, A, Kockwelp, P, Valkov, D, Marschall, B, Hartwig, S, Stummer, W, Risse, B, and Holling, M

Subjects
ddc: 610, education, Medicine and health
Abstract

Objective: Student teaching is an essential part of the training of future physicians and an integral component in the recruitment of young talent. The aim of the course was to expose students to brain death diagnostics in order to lower the inhibition threshold for non-neurosurgical junior staff in [for full text, please go to the a.m. URL]

Published
2022
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17. Fractionated intracavitary radioimmunotherapy with Lu-177 labeled 6A10 Fab fragments in patients with glioblastoma – first patient experience

Author

Müther, M, Roll, W, Böning, G, Delker, A, Warneke, N, Gildehaus, FJ, Schäfers, M, Stegger, L, Stummer, W, and Reulen, HJ

Subjects
ddc: 610, Medicine and health
Abstract

Objective: After surgical cytoreduction and standard radiochemotherapy of glioblastoma, approved maintenance therapies are lacking. In line with the infiltrative biology of this tumor type, most recurrences are seen around the resection cavity. Adjuvant radio-immunotherapy (RIT) with Lu-177 labeled [for full text, please go to the a.m. URL]

Published
2022
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18. Epigenetic characterisation of Hemangioblastomas

Author

Woltering, N, Thomas, C, Albers, A, Müther, M, Paulus, W, Stummer, W, and Holling, M

Subjects
ddc: 610, endocrine system diseases, Medicine and health, urologic and male genital diseases, neoplasms, female genital diseases and pregnancy complications
Abstract

Objective: Hemangioblastomas (HBs) of the central nervous system are rare tumors and occur sporadically or as a manifestation of von Hippel-Lindau (vHL) disease. Despite their benign nature, the clinical course is variable. Therefore, a better knowledge of molecular factors involved in HB tumor biology [for full text, please go to the a.m. URL]

Published
2022
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19. Resection of osteophytes in diffuse idiopathic skeletal hyperostosis (DISH) causing massive dysphagia

Author

Al Barim, B, Maragno, E, Schipmann, S, Stummer, W, and Schwake, M

Subjects
ddc: 610, Medicine and health
Abstract

Objective: Diffuse idiopathic skeletal hyperostosis (DISH) is a common condition, leading to anterior osteophytic fusion of vertebral bodies of the cervical spine. In rare cases, these osteophytes can cause dysphagia when they impinge on the pharyngoesophageal junction. The aim of this case series was [for full text, please go to the a.m. URL]

Published
2022
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20. The evaluation of neuroinflammatory mediators in human epileptic amygdala tissue

Author

Khaleghi Ghadiri, M, Gorji, A, Stummer, W, and Abdolahi, S

Subjects
ddc: 610, Medicine and health
Abstract

Objective: Multiple lines of evidence support the key role of neuroinflammation in the pathogenesis of epilepsy and associated comorbidities. The main aim of this investigation was to study the role of different inflammatory pathways in human epileptogenesis Methods: Using immunohistochemistry [for full text, please go to the a.m. URL]

Published
2022
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34. Symptomatic Oculomotor Nerve Cyst in a 3-Year-Old Child: Case Report With Emphasis on Surgical Management

Author

Müther, M. (Michael), Bruns, A. (Ann-Katrin), Fortmann, T. (Thomas), Brentrup, A. (Angela), Grenzebach, U. (Ulrike), Stummer, W. (Walter), and Universitäts- und Landesbibliothek Münster

Subjects
Medicine and health, Oculomotor nerve, Central nervous system, Cysts, Case report, ddc:610
Abstract

Background and Importance: Third nerve palsies in the pediatric population are most commonly caused by trauma, tumors, or vascular abnormalities. Cystic oculomotor nerve neuropathies, however, are rare. We report the case of a symptomatic cyst along and within the oculomotor nerve, which has not been described previously. Clinical Presentation: Here, we report a case of a 3-yr-old girl presenting with a progressive painless oculomotor nerve palsy. A magnetic resonance imaging revealed a cystic formation along the cisternal and cavernous course of the nerve. Due to lack of alternative treatment options, surgery was offered. Intraoperative direct nerve stimulation allowed for identification of a non-functional part of the cyst wall and open fenestration and biopsy were executed. Histopathology revealed neuritis. Serology was negative for various pathogens. The oculomotor palsy rapidly resolved. At a follow-up 5 yr after surgery, the girl is asymptomatic and the cisternal part of the cyst remains collapsed. Conclusion: This is the first report of a symptomatic cyst along and within the oculomotor nerve treated effectively with open fenestration and decompression highlighting the importance of intraoperative neuromonitoring in cranial nerve surgery. Uncertainty remains regarding the etiology of this disease.

Published
2022

43. Leukocyte-Endothelium Interactions in Global Cerebral Ischemia

Author

Beck, J., Stummer, W., Lehmberg, J., Baethmann, A., Uhl, E., Reulen, H.-J., editor, Steiger, H.-J., editor, James, Hector E., editor, Marshall, Lawrence F., editor, Raulen, Hans J., editor, Baethmann, Alexander, editor, Marmarou, Anthony, editor, Ito, Umeo, editor, Hoff, Julian T., editor, Kuroiwa, Toshihiko, editor, and Czernicki, Zbigniew, editor

Published
1997
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44. Evaluation of morphology and behaviour of microglia obtained from human glioma

Author

Khaleghi Ghadiri, M, Ghasemi, S, Labreze, Z, Folkens, S, Stummer, W, and Gorji, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Microglia, mono-nuclear cells distributed throughout the CNS, are key immune effector cells of the brain. The complex interactions between microglia and the other cell types in glioma play a crucial role in the development of novel treatments, presumably via the regulation of tumor progression[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Published
2021
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45. 5-ALA-induced porphyrin contents in various brain tumours – implications regarding imaging device design and their validation

Author

Suero Molina, E, Kaneko, S, Black, D, and Stummer, W

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Fluorescence-guidance with 5-Aminolevulinic Acid (5-ALA) has been approved for malignant glioma surgery by the European Medicine Agencies (EMA) in Europe and the Food and Drug Administration (FDA) in the USA. Multiple systems have since been developed for visualizing fluorescing Protoporphyrin[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Published
2021
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