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1. Development and Validation of a Quantitative Coronary CT Angiography Model for Diagnosis of Vessel-Specific Coronary Ischemia

Author

Heo, Ran, Park, Hyung-Bok, Marques, Hugo, Stuijfzand, Wijnand J., Choi, Jung Hyun, Doh, Joon-Hyung, Her, Ae-Young, Koo, Bon-Kwon, Nam, Chang-Wook, Shin, Sang-Hoon, Cole, Jason, Gimelli, Alessia, Khan, Muhammad Akram, Lu, Bin, Gao, Yang, Nabi, Faisal, Al-Mallah, Mouaz H., Nakazato, Ryo, Schoepf, U. Joseph, Thompson, Randall C., Jang, James J., Ridner, Michael, Rowan, Chris, Avelar, Erick, Généreux, Philippe, de Waard, Guus A., Sprengers, Ralf W., Raijmakers, Pieter G., Nurmohamed, Nick S., Danad, Ibrahim, Jukema, Ruurt A., de Winter, Ruben W., de Groot, Robin J., Driessen, Roel S., Bom, Michiel J., van Diemen, Pepijn, Pontone, Gianluca, Andreini, Daniele, Chang, Hyuk-Jae, Katz, Richard J., Stroes, Erik S.G., Wang, Hao, Chan, Chung, Crabtree, Tami, Aquino, Melissa, Min, James K., Earls, James P., Bax, Jeroen J., Choi, Andrew D., Knaapen, Paul, and van Rosendael, Alexander R.

Published
2024
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2. Relation of Gender to Atherosclerotic Plaque Characteristics by Differing Angiographic Stenosis Severity

Author

Jonas, Rebecca, Patel, Toral, Crabtree, Tami R., Jennings, Robert S., Heo, Ran, Park, Hyung-Bok, Marques, Hugo, Chang, Hyuk-Jae, Stuijfzand, Wijnand J., van Rosendael, Alexander R., Choi, Jung Hyun, Doh, Joon-Hyung, Her, Ae-Young, Koo, Bon-Kwon, Nam, Chang-Wook, Shin, Sang-Hoon, Cole, Jason, Gimelli, Alessia, Khan, Muhammad Akram, Lu, Bin, Gao, Yang, Nabi, Faisal, Al-Mallah, Mouaz H., Nakazato, Ryo, Schoepf, U. Joseph, Driessen, Roel S., Bom, Michiel J., Thompson, Randall C., Jang, James J., Ridner, Michael, Rowan, Chris, Avelar, Erick, Généreux, Philippe, Knaapen, Paul, de Waard, Guus A., Pontone, Gianluca, Andreini, Daniele, Bax, Jeroen J., Choi, Andrew D., Earls, James P., Hoffmann, Udo, Min, James K., and Villines, Todd C.

Published
2023
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3. Age- and sex-related features of atherosclerosis from coronary computed tomography angiography in patients prior to acute coronary syndrome: results from the ICONIC study

Author

Conte, Edoardo, Dwivedi, Aeshita, Mushtaq, Saima, Pontone, Gianluca, Lin, Fay Y, Hollenberg, Emma J, Lee, Sang-Eun, Bax, Jeroen, Cademartiri, Filippo, Chinnaiyan, Kavitha, Chow, Benjamin JW, Cury, Ricardo C, Feuchtner, Gudrun, Hadamitzky, Martin, Kim, Yong-Jin, Baggiano, Andrea, Leipsic, Jonathon, Maffei, Erica, Marques, Hugo, Plank, Fabian, Raff, Gilbert L, van Rosendael, Alexander R, Villines, Todd C, Weirich, Harald G, Al’Aref, Subhi J, Baskaran, Lohendran, Cho, Iksung, Danad, Ibrahim, Han, Donghee, Heo, Ran, Lee, Ji Hyun, Stuijfzand, Wijnand J, Gransar, Heidi, Lu, Yao, Sung, Ji Min, Park, Hyung-Bok, Al-Mallah, Mouaz H, de Araújo Gonçalves, Pedro, Berman, Daniel S, Budoff, Matthew J, Samady, Habib, Shaw, Leslee J, Stone, Peter H, Virmani, Renu, Narula, Jagat, Min, James K, Chang, Hyuk-Jae, and Andreini, Daniele

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Heart Disease, Atherosclerosis, Biomedical Imaging, Aging, Clinical Research, Heart Disease - Coronary Heart Disease, Cardiovascular, Acute Coronary Syndrome, Aged, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Female, Humans, Male, Plaque, Atherosclerotic, atherosclerosis, gender medicine, cardiac CT, high-risk plaque features, CCTA, Cardiovascular medicine and haematology
Abstract

AimsAlthough there is increasing evidence supporting coronary atherosclerosis evaluation by coronary computed tomography angiography (CCTA), no data are available on age and sex differences for quantitative plaque features. The aim of this study was to investigate sex and age differences in both qualitative and quantitative atherosclerotic features from CCTA prior to acute coronary syndrome (ACS).Methods and resultsWithin the ICONIC study, in which 234 patients with subsequent ACS were propensity matched 1:1 with 234 non-event controls, our current subanalysis included only the ACS cases. Both qualitative and quantitative advance plaque analysis by CCTA were performed by a core laboratory. In 129 cases, culprit lesions identified by invasive coronary angiography at the time of ACS were co-registered to baseline CCTA precursor lesions. The study population was then divided into subgroups according to sex and age (

Published
2021

4. A Boosted Ensemble Algorithm for Determination of Plaque Stability in High-Risk Patients on Coronary CTA

Author

Al'Aref, Subhi J, Singh, Gurpreet, Choi, Jeong W, Xu, Zhuoran, Maliakal, Gabriel, van Rosendael, Alexander R, Lee, Benjamin C, Fatima, Zahra, Andreini, Daniele, Bax, Jeroen J, Cademartiri, Filippo, Chinnaiyan, Kavitha, Chow, Benjamin JW, Conte, Edoardo, Cury, Ricardo C, Feuchtner, Gudruf, Hadamitzky, Martin, Kim, Yong-Jin, Lee, Sang-Eun, Leipsic, Jonathon A, Maffei, Erica, Marques, Hugo, Plank, Fabian, Pontone, Gianluca, Raff, Gilbert L, Villines, Todd C, Weirich, Harald G, Cho, Iksung, Danad, Ibrahim, Han, Donghee, Heo, Ran, Lee, Ji Hyun, Rizvi, Asim, Stuijfzand, Wijnand J, Gransar, Heidi, Lu, Yao, Sung, Ji Min, Park, Hyung-Bok, Berman, Daniel S, Budoff, Matthew J, Samady, Habib, Stone, Peter H, Virmani, Renu, Narula, Jagat, Chang, Hyuk-Jae, Lin, Fay Y, Baskaran, Lohendran, Shaw, Leslee J, and Min, James K

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Cardiovascular, Clinical Research, Heart Disease, Heart Disease - Coronary Heart Disease, Atherosclerosis, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Algorithms, Case-Control Studies, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Coronary Stenosis, Humans, Plaque, Atherosclerotic, Predictive Value of Tests, Severity of Illness Index, acute coronary syndrome, coronary computed tomography angiography, diameter stenosis, machine learning, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectivesThis study sought to identify culprit lesion (CL) precursors among acute coronary syndrome (ACS) patients based on qualitative and quantitative computed tomography-based plaque characteristics.BackgroundCoronary computed tomography angiography (CTA) has been validated for patient-level prediction of ACS. However, the applicability of coronary CTA to CL assessment is not known.MethodsUtilizing the ICONIC (Incident COroNary Syndromes Identified by Computed Tomography) study, a nested case-control study of 468 patients with baseline coronary CTA, the study included ACS patients with invasive coronary angiography-adjudicated CLs that could be aligned to CL precursors on baseline coronary CTA. Separate blinded core laboratories adjudicated CLs and performed atherosclerotic plaque evaluation. Thereafter, the study used a boosted ensemble algorithm (XGBoost) to develop a predictive model of CLs. Data were randomly split into a training set (80%) and a test set (20%). The area under the receiver-operating characteristic curve of this model was compared with that of diameter stenosis (model 1), high-risk plaque features (model 2), and lesion-level features of CL precursors from the ICONIC study (model 3). Thereafter, the machine learning (ML) model was applied to 234 non-ACS patients with 864 lesions to determine model performance for CL exclusion.ResultsCL precursors were identified by both coronary angiography and baseline coronary CTA in 124 of 234 (53.0%) patients, with a total of 582 lesions (containing 124 CLs) included in the analysis. The ML model demonstrated significantly higher area under the receiver-operating characteristic curve for discriminating CL precursors (0.774; 95% confidence interval [CI]: 0.758 to 0.790) compared with model 1 (0.599; 95% CI: 0.599 to 0.599; p

Published
2020

6. Coronary Atherosclerotic Precursors of Acute Coronary Syndromes

Author

Chang, Hyuk-Jae, Lin, Fay Y, Lee, Sang-Eun, Andreini, Daniele, Bax, Jeroen, Cademartiri, Filippo, Chinnaiyan, Kavitha, Chow, Benjamin JW, Conte, Edoardo, Cury, Ricardo C, Feuchtner, Gudrun, Hadamitzky, Martin, Kim, Yong-Jin, Leipsic, Jonathon, Maffei, Erica, Marques, Hugo, Plank, Fabian, Pontone, Gianluca, Raff, Gilbert L, van Rosendael, Alexander R, Villines, Todd C, Weirich, Harald G, Al’Aref, Subhi J, Baskaran, Lohendran, Cho, Iksung, Danad, Ibrahim, Han, Donghee, Heo, Ran, Lee, Ji Hyun, Rivzi, Asim, Stuijfzand, Wijnand J, Gransar, Heidi, Lu, Yao, Sung, Ji Min, Park, Hyung-Bok, Berman, Daniel S, Budoff, Matthew J, Samady, Habib, Shaw, Leslee J, Stone, Peter H, Virmani, Renu, Narula, Jagat, and Min, James K

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Heart Disease, Atherosclerosis, Cardiovascular, Heart Disease - Coronary Heart Disease, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Acute Coronary Syndrome, Aged, Case-Control Studies, Cohort Studies, Coronary Artery Disease, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, acute coronary syndrome, atherosclerosis, clinical outcome, coronary artery disease, coronary computed tomography angiography, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundThe association of atherosclerotic features with first acute coronary syndromes (ACS) has not accounted for plaque burden.ObjectivesThe purpose of this study was to identify atherosclerotic features associated with precursors of ACS.MethodsWe performed a nested case-control study within a cohort of 25,251 patients undergoing coronary computed tomographic angiography (CTA) with follow-up over 3.4 ± 2.1 years. Patients with ACS and nonevent patients with no prior coronary artery disease (CAD) were propensity matched 1:1 for risk factors and coronary CTA-evaluated obstructive (≥50%) CAD. Separate core laboratories performed blinded adjudication of ACS and culprit lesions and quantification of baseline coronary CTA for percent diameter stenosis (%DS), percent cross-sectional plaque burden (PB), plaque volumes (PVs) by composition (calcified, fibrous, fibrofatty, and necrotic core), and presence of high-risk plaques (HRPs).ResultsWe identified 234 ACS and control pairs (age 62 years, 63% male). More than 65% of patients with ACS had nonobstructive CAD at baseline, and 52% had HRP. The %DS, cross-sectional PB, fibrofatty and necrotic core volume, and HRP increased the adjusted hazard ratio (HR) of ACS (1.010 per %DS, 95% confidence interval [CI]: 1.005 to 1.015; 1.008 per percent cross-sectional PB, 95% CI: 1.003 to 1.013; 1.002 per mm3 fibrofatty plaque, 95% CI: 1.000 to 1.003; 1.593 per mm3 necrotic core, 95% CI: 1.219 to 2.082; all p < 0.05). Of the 129 culprit lesion precursors identified by coronary CTA, three-fourths exhibited

Published
2018

7. Influence of symptom typicality for predicting MACE in patients without obstructive coronary artery disease: From the CONFIRM Registry (Coronary Computed Tomography Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry).

Author

Lee, Ji Hyun, Han, Donghee, Hartaigh, Bríain Ó, Gransar, Heidi, Lu, Yao, Rizvi, Asim, Park, Mahn Won, Roudsari, Hadi Mirhedayati, Stuijfzand, Wijnand J, Berman, Daniel S, Callister, Tracy Q, DeLago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Al-Mallah, Mouaz H, Budoff, Matthew J, Kaufmann, Philipp A, Raff, Gilbert, Chinnaiyan, Kavitha, Cademartiri, Filippo, Maffei, Erica, Villines, Todd C, Kim, Yong-Jin, Leipsic, Jonathon, Feuchtner, Gudrun, Pontone, Gianluca, Andreini, Daniele, Marques, Hugo, Rubinshtein, Ronen, Achenbach, Stephan, Shaw, Leslee J, Chang, Hyuk-Jae, Bax, Jeroen, Chow, Benjamin, Cury, Ricardo C, Gomez, Millie, Jones, Erica C, Lin, Fay Y, Min, James K, and Peña, Jessica M

Subjects
Humans, Angina Pectoris, Angina, Unstable, Coronary Stenosis, Myocardial Infarction, Coronary Angiography, Prognosis, Severity of Illness Index, Registries, Proportional Hazards Models, Risk Factors, Prospective Studies, Predictive Value of Tests, Adult, Aged, Middle Aged, North America, Asia, Europe, Female, Male, Coronary Artery Disease, Kaplan-Meier Estimate, Asymptomatic Diseases, Multidetector Computed Tomography, Computed Tomography Angiography, Coronary Computed Tomographic Angiography, Major Adverse Cardiac Events, Symptom Typicality, Cardiovascular System & Hematology, Cardiorespiratory Medicine and Haematology
Abstract

Our objective was to assess the prognostic value of symptom typicality in patients without obstructive coronary artery disease (CAD), determined by coronary computed tomographic angiography (CCTA). We identified 4215 patients without prior history of CAD and without obstructive CAD (

Published
2018

8. Development and Validation of a Quantitative Coronary CT Angiography Model for Diagnosis of Vessel-Specific Coronary Ischemia

Author

Nurmohamed, Nick S., primary, Danad, Ibrahim, additional, Jukema, Ruurt A., additional, de Winter, Ruben W., additional, de Groot, Robin J., additional, Driessen, Roel S., additional, Bom, Michiel J., additional, van Diemen, Pepijn, additional, Pontone, Gianluca, additional, Andreini, Daniele, additional, Chang, Hyuk-Jae, additional, Katz, Richard J., additional, Stroes, Erik S.G., additional, Wang, Hao, additional, Chan, Chung, additional, Crabtree, Tami, additional, Aquino, Melissa, additional, Min, James K., additional, Earls, James P., additional, Bax, Jeroen J., additional, Choi, Andrew D., additional, Knaapen, Paul, additional, van Rosendael, Alexander R., additional, Heo, Ran, additional, Park, Hyung-Bok, additional, Marques, Hugo, additional, Stuijfzand, Wijnand J., additional, Choi, Jung Hyun, additional, Doh, Joon-Hyung, additional, Her, Ae-Young, additional, Koo, Bon-Kwon, additional, Nam, Chang-Wook, additional, Shin, Sang-Hoon, additional, Cole, Jason, additional, Gimelli, Alessia, additional, Khan, Muhammad Akram, additional, Lu, Bin, additional, Gao, Yang, additional, Nabi, Faisal, additional, Al-Mallah, Mouaz H., additional, Nakazato, Ryo, additional, Schoepf, U. Joseph, additional, Thompson, Randall C., additional, Jang, James J., additional, Ridner, Michael, additional, Rowan, Chris, additional, Avelar, Erick, additional, Généreux, Philippe, additional, de Waard, Guus A., additional, Sprengers, Ralf W., additional, and Raijmakers, Pieter G., additional

Published
2024
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9. Functional recovery after percutaneous revascularization of coronary chronic total occlusions: insights from cardiac magnetic resonance tissue tracking

Author

Everaars, Henk, Schumacher, Stefan P., Stuijfzand, Wijnand J., van Basten Batenburg, Martijn, Huynh, Jennifer, van Diemen, Pepijn A., Bom, Michiel J., de Winter, Ruben W., van de Ven, Peter M., van Loon, Ramon B., van Rossum, Albert C., Opolski, Maksymilian P., Nap, Alexander, and Knaapen, Paul

Published
2021
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12. Myocardial Blood Flow and Coronary Flow Reserve During 3 Years Following Bioresorbable Vascular Scaffold Versus Metallic Drug-Eluting Stent Implantation: The VANISH Trial

Author

Stuijfzand, Wijnand J., Schumacher, Stefan P., Driessen, Roel S., Lammertsma, Adriaan A., Bakker, Amber L., Rijnierse, Mischa T., van Rossum, Albert C., van de Ven, Peter M., Nap, Alexander, Appelman, Yolande, van Royen, Niels, van Leeuwen, Maarten A., Lemkes, Jorrit S., Raijmakers, Pieter G., and Knaapen, Paul

Published
2019
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13. The Predictive Value of Coronary Artery Calcium Scoring for Major Adverse Cardiac Events According to Renal Function (from the Coronary Computed Tomography Angiography Evaluation for Clinical Outcomes: An International Multicenter [CONFIRM] Registry)

Author

Lee, Ji Hyun, Rizvi, Asim, Hartaigh, Bríain Ó., Han, Donghee, Park, Mahn Won, Roudsari, Hadi Mirhedayati, Stuijfzand, Wijnand J., Gransar, Heidi, Lu, Yao, Callister, Tracy Q., Berman, Daniel S., DeLago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Al-Mallah, Mouaz H., Budoff, Matthew J., Kaufmann, Philipp A., Raff, Gilbert L., Chinnaiyan, Kavitha, Cademartiri, Filippo, Maffei, Erica, Villines, Todd C., Kim, Yong-Jin, Leipsic, Jonathon, Feuchtner, Gudrun, Pontone, Gianluca, Andreini, Daniele, Marques, Hugo, de Araújo Gonçalves, Pedro, Rubinshtein, Ronen, Achenbach, Stephan, Shaw, Leslee J., Chow, Benjamin J.W., Cury, Ricardo C., Bax, Jeroen J., Chang, Hyuk-Jae, Jones, Erica C., Lin, Fay Y., Min, James K., and Peña, Jessica M.

Published
2019
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15. Corrigendum to ‘Relation of Gender to Atherosclerotic Plaque Characteristics by Differing Angiographic Stenosis Severity’ The American Journal of Cardiology, Volume 204, 1 October 2023, Pages 276-283

Author

Jonas, Rebecca, primary, Patel, Toral, additional, Crabtree, Tami R., additional, Jennings, Robert S., additional, Heo, Ran, additional, Park, Hyung-Bok, additional, Marques, Hugo, additional, Chang, Hyuk-Jae, additional, Stuijfzand, Wijnand J., additional, Rosendael, Alexander R. van, additional, Choi, Jung Hyun, additional, Doh, Joon-Hyung, additional, Her, Ae-Young, additional, Koo, Bon-Kwon, additional, Nam, Chang-Wook, additional, Shin, Sang-Hoon, additional, Cole, Jason, additional, Gimelli, Alessia, additional, Khan, Muhammad Akram, additional, Lu, Bin, additional, Gao, Yang, additional, Nabi, Faisal, additional, Al-Mallah, Mouaz H., additional, Nakazato, Ryo, additional, Schoepf, U. Joseph, additional, Driessen, Roel S., additional, Bom, Michiel J., additional, Thompson, Randall C., additional, Jang, James J., additional, Ridner, Michael, additional, Rowan, Chris, additional, Avelar, Erick, additional, Généreux, Philippe, additional, Knaapen, Paul, additional, de Waard, Guus A., additional, Pontone, Gianluca, additional, Andreini, Daniele, additional, Bax, Jeroen J., additional, Choi, Andrew D., additional, Earls, James P., additional, Hoffmann, Udo, additional, Min, James K., additional, and Villines, Todd C., additional

Published
2023
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16. Collateral grading systems in retrograde percutaneous coronary intervention of chronic total occlusions

Author

Somsen, Yvemarie B. O., primary, de Winter, Ruben W., additional, Giunta, Rocco, additional, Schumacher, Stefan P., additional, van Diemen, Pepijn A., additional, Jukema, Ruurt A., additional, Stuijfzand, Wijnand J., additional, Danad, Ibrahim, additional, Lissenberg – Witte, Birgit I., additional, Verouden, Niels J., additional, Nap, Alexander, additional, Kleijn, Sebastiaan A., additional, Galassi, Alfredo R., additional, Henriques, José P., additional, and Knaapen, Paul, additional

Published
2023
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17. Quantitative measurement of lipid rich plaque by coronary computed tomography angiography: A correlation of histology in sudden cardiac death

Author

Han, Donghee, Torii, Sho, Yahagi, Kazuyuki, Lin, Fay Y., Lee, Ji Hyun, Rizvi, Asim, Gransar, Heidi, Park, Mahn-Won, Roudsari, Hadi Mirhedayati, Stuijfzand, Wijnand J., Baskaran, Lohendran, ó Hartaigh, Bríain, Park, Hyung-bok, Lee, Sang-eun, Ali, Zabiullah, Kutys, Robert, Chang, Hyuk-Jae, Earls, James P., Fowler, David, Virmani, Renu, and Min, James K.

Published
2018
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21. IMPACT OF SEX-DIFFERENCES ON CHANGES IN MYOCARDIAL PERFUSION FOLLOWING PERCUTANEOUS CORONARY INTERVENTION OF CHRONIC TOTAL CORONARY OCCLUSIONS

Author

Somsen, Yvemarie, primary, De Winter, Ruben Willem, additional, Van Veelen, Anna, additional, Schumacher, Stefan, additional, Van Diemen, Pepijn, additional, Jukema, Ruurt, additional, Hoek, Roel, additional, Stuijfzand, Wijnand, additional, Danad, Ibrahim, additional, Verouden, Niels, additional, Nap, Alexander, additional, Appelman, Yolande, additional, Henriques, Jose, additional, and Knaapen, Paul, additional

Published
2023
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23. Diabetes, Atherosclerosis, and Stenosis by AI

Author

Jonas, Rebecca A., primary, Crabtree, Tami R., additional, Jennings, Robert S., additional, Marques, Hugo, additional, Katz, Richard J., additional, Chang, Hyuk-Jae, additional, Stuijfzand, Wijnand J., additional, van Rosendael, Alexander R., additional, Choi, Jung Hyun, additional, Doh, Joon-Hyung, additional, Her, Ae-Young, additional, Koo, Bon-Kwon, additional, Nam, Chang-Wook, additional, Park, Hyung-Bok, additional, Shin, Sang-Hoon, additional, Cole, Jason, additional, Gimelli, Alessia, additional, Khan, Muhammad Akram, additional, Lu, Bin, additional, Gao, Yang, additional, Nabi, Faisal, additional, Nakazato, Ryo, additional, Schoepf, U. Joseph, additional, Driessen, Roel S., additional, Bom, Michiel J., additional, Thompson, Randall C., additional, Jang, James J., additional, Ridner, Michael, additional, Rowan, Chris, additional, Avelar, Erick, additional, Généreux, Philippe, additional, Knaapen, Paul, additional, de Waard, Guus A., additional, Pontone, Gianluca, additional, Andreini, Daniele, additional, Al-Mallah, Mouaz H., additional, Guglielmo, Marco, additional, Bax, Jeroen J., additional, Earls, James P., additional, Min, James K., additional, Choi, Andrew D., additional, and Villines, Todd C., additional

Published
2023
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30. Optimizing Non-Invasive Detection of Coronary Artery Disease and Effects of Advanced Interventional Techniques for Patients with Stable Coronary Artery Disease

Author

Stuijfzand, Wijnand Jan Aloys, Knaapen, Paul, van Rossum, Bert, Raijmakers, Pieter, Nap, Alex, ACS - Atherosclerosis & ischemic syndromes, Cardiology, van Rossum, A.C., Raijmakers, P.G.H.M., and Nap, A.

Subjects
Chronic total occlusion, Bioresorbable vascular scaffold, SDG 3 - Good Health and Well-being, Coronary computed tomography angiography, Positron emiision tomography, Percutaneous coronary intervention
Abstract

The aim of this thesis was to (1) further optimize non-invasive detection of hemodynamically significant coronary artery disease (CAD) with coronary computed tomography angiography (CCTA) and myocardial perfusion imaging (MPI) and to examine (2) the effect of implantation of the bioresorbable vascular scaffold (BVS) and (3) chronic total occlusion percutaneous coronary intervention (CTO PCI). Part I showed that angiographic characteristics such as volumetric measures as well as morphological aspects of atherosclerosis as assessed by CCTA are of interest when considering the hemodynamic consequences of atherosclerosis. These findings add to luminal stenosis grading alone and aid in increasing the diagnostic accuracy of CCTA to predict hemodynamically significant CAD determined by invasive FFR. The main results of Part II indicate that implantation of the BVS is feasible however no benefit with regard to myocardial perfusion is observed during hyperemia or cold pressor testing. These findings do not support the use of BVS instead of metallic DES, especially since large randomized trials have illustrated that there is an increased risk in scaffold thrombosis during the first three years. Still, long-term outcome (>3 years) has yet to become available. The results of the studies in Part III indicate that the vast majority of patients with a CTO have significantly impaired myocardial perfusion with great effect of successful CTO PCI on recovery of myocardial perfusion and decrease of ischemic burden. Patient selection for CTO PCI should be based on expected patient benefit rather than lesion complexity.

Published
2021

31. Abstract 10176: Absolute Perfusion Increase in Remote Myocardium Following Chronic Total Coronary Occlusion Percutaneous Coronary Intervention

Author

de Winter, Ruben W, primary, Schumacher, Stefan P, additional, van Diemen, Pepijn A, additional, Jukema, Ruurt A, additional, Somsen, Yvemarie B, additional, Stuijfzand, Wijnand J, additional, Driessen, Roel S, additional, Bom, Michiel J, additional, Everaars, Henk, additional, Van Rossum, Albert C. C, additional, van de Ven, Peter M, additional, Verouden, Niels J, additional, Danad, Ibrahim, additional, Raijmakers, Pieter G, additional, Alexander, Nap, additional, and Knaapen, Paul, additional

Published
2021
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32. Early versus late acute coronary syndrome risk patterns of coronary atherosclerotic plaque.

Author

Hoogen, Inge J van den, Stuijfzand, Wijnand J, Gianni, Umberto, Rosendael, Alexander R van, Bax, A Maxim, Lu, Yao, Tantawy, Sara W, Hollenberg, Emma J, Andreini, Daniele, Al-Mallah, Mouaz H, Cademartiri, Filippo, Chinnaiyan, Kavitha, Chow, Benjamin J W, Conte, Edoardo, Cury, Ricardo C, Feuchtner, Gudrun, Gonçalves, Pedro de Araújo, Hadamitzky, Martin, Kim, Yong Jin, and Leipsic, Jonathon

Subjects
RESEARCH, PATIENT aftercare, BLOOD vessels, PATHOLOGICAL anatomy, ACUTE coronary syndrome, CORONARY angiography, COMPARATIVE studies, CORONARY artery disease, DESCRIPTIVE statistics, COMPUTED tomography, LONGITUDINAL method, DISEASE risk factors, DISEASE complications
Abstract

Aims The temporal instability of coronary atherosclerotic plaque preceding an incident acute coronary syndrome (ACS) is not well defined. We sought to examine differences in the volume and composition of coronary atherosclerosis between patients experiencing an early (≤90 days) versus late ACS (>90 days) after baseline coronary computed tomography angiography (CCTA). Methods and results From a multicenter study, we enrolled patients who underwent a clinically indicated baseline CCTA and experienced ACS during follow-up. Separate core laboratories performed blinded adjudication of ACS events and quantification of CCTA including compositional plaque volumes by Hounsfield units (HU): calcified plaque >350 HU, fibrous plaque 131–350 HU, fibrofatty plaque 31–130 HU and necrotic core <30 HU. In 234 patients (mean age 62 ± 12 years, 36% women), early and late ACS occurred in 129 and 105 patients after a mean of 395 ± 622 days, respectively. Patients with early ACS had a greater maximal diameter stenosis and maximal cross-sectional plaque burden as compared to patients with late ACS (P  < 0.05). Larger total, fibrous, fibrofatty, and necrotic core volumes were observed in the early ACS group (P  < 0.05). Findings for total, fibrous, fibrofatty, and necrotic core volumes were reproduced in an external validation cohort (P  < 0.05). Conclusions Volumetric differences in composition of coronary atherosclerosis exist between ACS patients according to their timing antecedent to the acute event. These data support that a large burden of non-calcified plaque on CCTA is strongly associated with near-term plaque instability and ACS risk. [ABSTRACT FROM AUTHOR]

Published
2022
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33. Viability and functional recovery after chronic total occlusion percutaneous coronary intervention

Author

Schumacher, Stefan P., primary, Everaars, Henk, additional, Stuijfzand, Wijnand J., additional, Diemen, Pepijn A., additional, Driessen, Roel S., additional, Bom, Michiel J., additional, Winter, Ruben W., additional, Somsen, Yvemarie B. O., additional, Huynh, Jennifer W., additional, Loon, Ramon B., additional, Ven, Peter M., additional, Rossum, Albert C., additional, Opolski, Maksymilian P., additional, Nap, Alexander, additional, and Knaapen, Paul, additional

Published
2021
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34. Coronary Collateral Flow Index Is Correlated With the Palmar Collateral Flow Index Indicating Systemic Collateral Coherence in Individual Patients-Brief Report

Author

Hollander, M.R., Jansen, Matthijs F., Schumacher, Stefan P., Stuijfzand, Wijnand J., Leeuwen, Maarten A.H. van, Ven, Peter M. van de, Knaapen, Paul, Royen, N. van, Hollander, M.R., Jansen, Matthijs F., Schumacher, Stefan P., Stuijfzand, Wijnand J., Leeuwen, Maarten A.H. van, Ven, Peter M. van de, Knaapen, Paul, and Royen, N. van

Abstract

Contains fulltext : 233467.pdf (Publisher’s version ) (Closed access)

Published
2021

35. Optimizing Non-Invasive Detection of Coronary Artery Disease and Effects of Advanced Interventional Techniques for Patients with Stable Coronary Artery Disease: It is All about Myocardial Perfusion

Author

Stuijfzand, Wijnand Jan Aloys and Stuijfzand, Wijnand Jan Aloys

Abstract

The aim of this thesis was to (1) further optimize non-invasive detection of hemodynamically significant coronary artery disease (CAD) with coronary computed tomography angiography (CCTA) and myocardial perfusion imaging (MPI) and to examine (2) the effect of implantation of the bioresorbable vascular scaffold (BVS) and (3) chronic total occlusion percutaneous coronary intervention (CTO PCI). Part I showed that angiographic characteristics such as volumetric measures as well as morphological aspects of atherosclerosis as assessed by CCTA are of interest when considering the hemodynamic consequences of atherosclerosis. These findings add to luminal stenosis grading alone and aid in increasing the diagnostic accuracy of CCTA to predict hemodynamically significant CAD determined by invasive FFR. The main results of Part II indicate that implantation of the BVS is feasible however no benefit with regard to myocardial perfusion is observed during hyperemia or cold pressor testing. These findings do not support the use of BVS instead of metallic DES, especially since large randomized trials have illustrated that there is an increased risk in scaffold thrombosis during the first three years. Still, long-term outcome (>3 years) has yet to become available. The results of the studies in Part III indicate that the vast majority of patients with a CTO have significantly impaired myocardial perfusion with great effect of successful CTO PCI on recovery of myocardial perfusion and decrease of ischemic burden. Patient selection for CTO PCI should be based on expected patient benefit rather than lesion complexity.

Published
2021

37. THE IMPACT OF CORONARY REVASCULARIZATION ON REGIONAL VESSEL-SPECIFIC CORONARY FLOW CAPACITY: A SERIAL [15O]H2O POSITRON EMISSION TOMOGRAPHY PERFUSION IMAGING STUDY

Author

De Winter, Ruben Willem, primary, Jukema, Ruurt, additional, Van Diemen, Pepijn, additional, Schumacher, Stefan, additional, Driessen, Roel, additional, Stuijfzand, Wijnand, additional, Bom, Michiel, additional, Everaars, Henk, additional, van Rossum, Albert, additional, van de Ven, Peter, additional, Verouden, Niels, additional, Nap, Alexander, additional, Danad, Ibrahim, additional, Raijmakers, Pieter, additional, and Knaapen, Paul, additional

Published
2021
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38. A 7-YEAR WARRANTY PERIOD FOR CHEST PAIN PATIENTS WITH A NORMAL QUANTITATIVE [15O] H2O PET MYOCARDIAL PERFUSION SCAN

Author

Jukema, Ruurt, primary, Van Diemen, Pepijn, additional, Driessen, Roel, additional, Stuijfzand, Wijnand, additional, Bom, Michiel, additional, Schumacher, Stefan, additional, Everaars, Henk, additional, Raijmakers, Pieter, additional, de Winter, Ruben, additional, van de Ven, Peter, additional, van Rossum, Albert, additional, Knaapen, Paul, additional, and Danad, Ibrahim, additional

Published
2021
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39. Identification and Quantification of Cardiovascular Structures From CCTA: An End-to-End, Rapid, Pixel-Wise, Deep-Learning Method

Author

Baskaran, Lohendran, Maliakal, Gabriel, Al'Aref, Subhi J., Singh, Gurpreet, Xu, Zhuoran, Michalak, Kelly, Dolan, Kristina, Gianni, Umberto, van Rosendael, Alexander, van den Hoogen, Inge, Han, Donghee, Stuijfzand, Wijnand, Pandey, Mohit, Lee, Benjamin C., Lin, Fay, Pontone, Gianluca, Knaapen, Paul, Marques, Hugo, Bax, Jeroen, Berman, Daniel, Chang, Hyuk-Jae, Shaw, Leslee J., Min, James K., Cardiology, and ACS - Atherosclerosis & ischemic syndromes

Subjects
Male, Heart Diseases, Computed Tomography Angiography, Reproducibility of Results, deep learning, Settore MED/11 - Malattie dell'Apparato Cardiovascolare, Middle Aged, Coronary Angiography, quantification, Predictive Value of Tests, Multidetector Computed Tomography, Humans, Radiographic Image Interpretation, Computer-Assisted, Female, Prospective Studies, Registries, coronary computed tomography angiography, Aged
Abstract

OBJECTIVES This study designed and evaluated an end-to-end deep learning solution for cardiac segmentation and quantification.BACKGROUND Segmentation of cardiac structures from coronary computed tomography angiography (CCTA) images is laborious. We designed an end-to-end deep-learning solution.METHODS Scans were obtained from multicenter registries of 166 patients who underwent clinically indicated CCTA. Left ventricular volume (LVV) and right ventricular volume (RVV), left atrial volume (LAV) and right atrial volume (RAV), and left ventricular myocardial mass (LVM) were manually annotated as ground truth. A U-Net-inspired, deep-learning model was trained, validated, and tested in a 70:20:10 split.RESULTS Mean age was 61.1 +/- 8.4 years, and 49% were women. A combined overall median Dice score of 0.9246 (interquartile range: 0.8870 to 0.9475) was achieved. The median Dice scores for LVV, RVV, LAV, RAV, and LVM were 0.938 (interquartile range: 0.887 to 0.958), 0.927 (interquartile range: 0.916 to 0.946), 0.934 (interquartile range: 0.899 to 0.950), 0.915 (interquartile range: 0.890 to 0.920), and 0.920 (interquartile range: 0.811 to 0.944), respectively. Model prediction correlated and agreed well with manual annotation for LVV (r = 0.98), RVV (r = 0.97), LAV (r = 0.78), RAV (r = 0.97), and LVM (r = 0.94) (p < 0.05 for all). Mean difference and limits of agreement for LVV, RVV, LAV, RAV, and LVM were 1.20 ml (95% CI: -7.12 to 9.51), -0.78 ml (95% CI: -10.08 to 8.52), -3.75 ml (95% CI: -21.53 to 14.03), 0.97 ml (95% CI: -6.14 to 8.09), and 6.41 g (95% CI: -8.71 to 21.52), respectively.CONCLUSIONS A deep-learning model rapidly segmented and quantified cardiac structures. This was done with high accuracy on a pixel level, with good agreement with manual annotation, facilitating its expansion into areas of research and clinical import. (C) 2020 by the American College of Cardiology Foundation.

Published
2020

40. ASSOCIATION BETWEEN CORONARY COLLATERALS AND MYOCARDIAL VIABILITY IN PATIENTS WITH A CHRONIC TOTAL OCCLUSION

Author

Schumacher, Stefan, Everaars, Henk, Stuijfzand, Wijnand J., Huynh, Jennifer W., Van Diemen, Pepijn, Driessen, Roel, Bom, Michiel, De Winter, Ruben, van Loon, Ramon B., van de Ven, Peter, van Rossum, Albert, Opolski, Maksymilian, Nap, Alexander, Knaapen, Paul, Cardiology, ACS - Atherosclerosis & ischemic syndromes, Surgery, ACS - Heart failure & arrhythmias, Epidemiology and Data Science, and APH - Methodology

Published
2020

41. A Boosted Ensemble Algorithm for Determination of Plaque Stability in High-Risk Patients on Coronary CTA

Author

Al’Aref, Subhi J., primary, Singh, Gurpreet, additional, Choi, Jeong W., additional, Xu, Zhuoran, additional, Maliakal, Gabriel, additional, van Rosendael, Alexander R., additional, Lee, Benjamin C., additional, Fatima, Zahra, additional, Andreini, Daniele, additional, Bax, Jeroen J., additional, Cademartiri, Filippo, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J.W., additional, Conte, Edoardo, additional, Cury, Ricardo C., additional, Feuchtner, Gudruf, additional, Hadamitzky, Martin, additional, Kim, Yong-Jin, additional, Lee, Sang-Eun, additional, Leipsic, Jonathon A., additional, Maffei, Erica, additional, Marques, Hugo, additional, Plank, Fabian, additional, Pontone, Gianluca, additional, Raff, Gilbert L., additional, Villines, Todd C., additional, Weirich, Harald G., additional, Cho, Iksung, additional, Danad, Ibrahim, additional, Han, Donghee, additional, Heo, Ran, additional, Lee, Ji Hyun, additional, Rizvi, Asim, additional, Stuijfzand, Wijnand J., additional, Gransar, Heidi, additional, Lu, Yao, additional, Sung, Ji Min, additional, Park, Hyung-Bok, additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Samady, Habib, additional, Stone, Peter H., additional, Virmani, Renu, additional, Narula, Jagat, additional, Chang, Hyuk-Jae, additional, Lin, Fay Y., additional, Baskaran, Lohendran, additional, Shaw, Leslee J., additional, and Min, James K., additional

Published
2020
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42. Age- and sex-related features of atherosclerosis from coronary computed tomography angiography in patients prior to acute coronary syndrome: results from the ICONIC study

Author

Conte, Edoardo, primary, Dwivedi, Aeshita, additional, Mushtaq, Saima, additional, Pontone, Gianluca, additional, Lin, Fay Y, additional, Hollenberg, Emma J, additional, Lee, Sang-Eun, additional, Bax, Jeroen, additional, Cademartiri, Filippo, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J W, additional, Cury, Ricardo C, additional, Feuchtner, Gudrun, additional, Hadamitzky, Martin, additional, Kim, Yong-Jin, additional, Baggiano, Andrea, additional, Leipsic, Jonathon, additional, Maffei, Erica, additional, Marques, Hugo, additional, Plank, Fabian, additional, Raff, Gilbert L, additional, van Rosendael, Alexander R, additional, Villines, Todd C, additional, Weirich, Harald G, additional, Al’Aref, Subhi J, additional, Baskaran, Lohendran, additional, Cho, Iksung, additional, Danad, Ibrahim, additional, Han, Donghee, additional, Heo, Ran, additional, Lee, Ji Hyun, additional, Stuijfzand, Wijnand J, additional, Gransar, Heidi, additional, Lu, Yao, additional, Sung, Ji Min, additional, Park, Hyung-Bok, additional, Al-Mallah, Mouaz H, additional, de Araújo Gonçalves, Pedro, additional, Berman, Daniel S, additional, Budoff, Matthew J, additional, Samady, Habib, additional, Shaw, Leslee J, additional, Stone, Peter H, additional, Virmani, Renu, additional, Narula, Jagat, additional, Min, James K, additional, Chang, Hyuk-Jae, additional, and Andreini, Daniele, additional

Published
2020
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43. Ischaemic burden and changes in absolute myocardial perfusion after chronic total occlusion percutaneous coronary intervention

Author

Schumacher, Stefan P., primary, Kockx, Marly, additional, Stuijfzand, Wijnand J., additional, Driessen, Roel S., additional, van Diemen, Pepijn A., additional, Bom, Michiel J., additional, Everaars, Henk, additional, Raijmakers, Pieter G., additional, Boellaard, Ronald, additional, van Rossum, Albert C., additional, Opolski, Maksymilian P., additional, Nap, Alexander, additional, and Knaapen, Paul, additional

Published
2020
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44. Coronary collaterals and myocardial viability in patients with chronic total occlusions

Author

Schumacher, Stefan P., primary, Everaars, Henk, additional, Stuijfzand, Wijnand J., additional, Huynh, Jennifer W., additional, van Diemen, Pepijn A., additional, Bom, Michiel J., additional, de Winter, Ruben W., additional, van Loon, Ramon B., additional, van de Ven, Peter M., additional, van Rossum, Albert C., additional, Opolski, Maksymilian P., additional, Nap, Alexander, additional, and Knaapen, Paul, additional

Published
2020
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45. Identification and Quantification of Cardiovascular Structures From CCTA

Author

Baskaran, Lohendran, primary, Maliakal, Gabriel, additional, Al’Aref, Subhi J., additional, Singh, Gurpreet, additional, Xu, Zhuoran, additional, Michalak, Kelly, additional, Dolan, Kristina, additional, Gianni, Umberto, additional, van Rosendael, Alexander, additional, van den Hoogen, Inge, additional, Han, Donghee, additional, Stuijfzand, Wijnand, additional, Pandey, Mohit, additional, Lee, Benjamin C., additional, Lin, Fay, additional, Pontone, Gianluca, additional, Knaapen, Paul, additional, Marques, Hugo, additional, Bax, Jeroen, additional, Berman, Daniel, additional, Chang, Hyuk-Jae, additional, Shaw, Leslee J., additional, and Min, James K., additional

Published
2020
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46. Adverse Plaque Characteristics Relate More Strongly With Hyperemic Fractional Flow Reserve and Instantaneous Wave-Free Ratio Than With Resting Instantaneous Wave-Free Ratio

Author

Driessen, Roel S., primary, de Waard, Guus A., additional, Stuijfzand, Wijnand J., additional, Raijmakers, Pieter G., additional, Danad, Ibrahim, additional, Bom, Michiel J., additional, Min, James K., additional, Leipsic, Jonathon A., additional, Ahmadi, Amir, additional, van de Ven, Peter M., additional, Knuuti, Juhani, additional, van Rossum, Albert C., additional, Davies, Justin E., additional, van Royen, Niels, additional, Narula, Jagat, additional, and Knaapen, Paul, additional

Published
2020
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47. MACROVASCULAR ABNORMALITIES AND FFRCT IN ISCHEMIA WITH NONOBSTRUCTIVE CORONARY ARTERIES (INOCA): THE CREDENCE TRIAL

Author

Lin, Fay, primary, van Rosendael, Alexander, additional, Gianni, Umberto, additional, Stuijfzand, Wijnand, additional, Lu, Yao, additional, Bax, A. Maxim, additional, Hollenberg, Emma J., additional, van den Hoogen, Inge J., additional, Tantawy, Sara, additional, Pena, Jessica, additional, Al'Aref, Subhi, additional, Baskaran, Lohendran, additional, Dunham, Simon, additional, Kolli, Kranthi, additional, Chang, Hyuk-Jae, additional, Genereux, Philippe, additional, Pontone, Gianluca, additional, Leipsic, Jonathon, additional, Bax, Jeroen J., additional, Berman, Daniel S., additional, Narula, Jagat, additional, Knaapen, Paul, additional, Min, James, additional, and Shaw, Leslee J., additional

Published
2020
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48. FUNCTIONAL RECOVERY AFTER PERCUTANEOUS REVASCULARIZATION OF CORONARY CHRONIC TOTAL OCCLUSIONS: INSIGHTS FROM CARDIAC MAGNETIC RESONANCE TISSUE TRACKING

Author

Everaars, Henk, primary, Schumacher, Stefan, additional, Stuijfzand, Wijnand, additional, Batenburg, Martijn Basten, additional, Huynh, Jennifer, additional, van Diemen, Pepijn, additional, Bom, Michiel, additional, de Winter, Ruben, additional, Driessen, Roel, additional, van de Ven, Peter, additional, van Loon, R.B., additional, van Rossum, Albert, additional, Opolski, Maksymilian P., additional, Nap, Alexander, additional, and Knaapen, Paul, additional

Published
2020
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49. Association of High-Density Calcified 1K Plaque With Risk of Acute Coronary Syndrome

Author

van Rosendael, Alexander R., primary, Narula, Jagat, additional, Lin, Fay Y., additional, van den Hoogen, Inge J., additional, Gianni, Umberto, additional, Al Hussein Alawamlh, Omar, additional, Dunham, Patricia C., additional, Peña, Jessica M., additional, Lee, Sang-Eun, additional, Andreini, Daniele, additional, Cademartiri, Filippo, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J. W., additional, Conte, Edoardo, additional, Cury, Ricardo C., additional, Feuchtner, Gudrun, additional, Hadamitzky, Martin, additional, Kim, Yong-Jin, additional, Leipsic, Jonathon, additional, Maffei, Erica, additional, Marques, Hugo, additional, de Araújo Gonçalves, Pedro, additional, Plank, Fabian, additional, Pontone, Gianluca, additional, Raff, Gilbert L., additional, Villines, Todd C., additional, Weirich, Harald G., additional, Al’Aref, Subhi J., additional, Baskaran, Lohendran, additional, Cho, Iksung, additional, Danad, Ibrahim, additional, Han, Donghee, additional, Heo, Ran, additional, Lee, Ji Hyun, additional, Rivzi, Asim, additional, Stuijfzand, Wijnand J., additional, Gransar, Heidi, additional, Lu, Yao, additional, Sung, Ji Min, additional, Park, Hyung-Bok, additional, Samady, Habib, additional, Stone, Peter H., additional, Virmani, Renu, additional, Budoff, Matthew J., additional, Berman, Daniel S., additional, Chang, Hyuk-Jae, additional, Bax, Jeroen J., additional, Min, James K., additional, and Shaw, Leslee J., additional

Published
2020
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50. Myocardial Blood Flow and Coronary Flow Reserve During 3 Years Following Bioresorbable Vascular Scaffold Versus Metallic Drug-Eluting Stent Implantation

Author

Stuijfzand, Wijnand J., Schumacher, Stefan P., Driessen, Roel S., Lammertsma, Adriaan A., Bakker, Amber L., Rijnierse, Mischa T., Royen, N. van, Raijmakers, Pieter G., Knaapen, Paul, Stuijfzand, Wijnand J., Schumacher, Stefan P., Driessen, Roel S., Lammertsma, Adriaan A., Bakker, Amber L., Rijnierse, Mischa T., Royen, N. van, Raijmakers, Pieter G., and Knaapen, Paul

Abstract

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Published
2019

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