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Your search keyword '"Stuckey, Bronwyn G.A."' showing total 34 results
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34 results on '"Stuckey, Bronwyn G.A."'

2. Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry

Author

Burns, Kharis, Mullin, Benjamin H., Moolhuijsen, Loes M.E., Laisk, Triin, Tyrmi, Jaakko S., Cui, Jinrui, Actkins, Ky’Era V., Louwers, Yvonne V., Davis, Lea K., Dudbridge, Frank, Azziz, Ricardo, Goodarzi, Mark O., Laivuori, Hannele, Mägi, Reedik, Visser, Jenny A., Laven, Joop S.E., Wilson, Scott G., Day, Felix R., Stuckey, Bronwyn G.A., Burns, Kharis, Mullin, Benjamin H., Moolhuijsen, Loes M.E., Laisk, Triin, Tyrmi, Jaakko S., Cui, Jinrui, Actkins, Ky’Era V., Louwers, Yvonne V., Davis, Lea K., Dudbridge, Frank, Azziz, Ricardo, Goodarzi, Mark O., Laivuori, Hannele, Mägi, Reedik, Visser, Jenny A., Laven, Joop S.E., Wilson, Scott G., Day, Felix R., and Stuckey, Bronwyn G.A.

Abstract

Background: Polycystic ovary syndrome (PCOS) is a complex multifactorial disorder with a substantial genetic component. However, the clinical manifestations of PCOS are heterogeneous with notable differences between lean and obese women, implying a different pathophysiology manifesting in differential body mass index (BMI). We performed a meta-analysis of genome-wide association study (GWAS) data from six well-characterised cohorts, using a case–control study design stratified by BMI, aiming to identify genetic variants associated with lean and overweight/obese PCOS subtypes. Results: The study comprised 254,588 women (5,937 cases and 248,651 controls) from individual studies performed in Australia, Estonia, Finland, the Netherlands and United States of America, and separated according to three BMI stratifications (lean, overweight and obese). Genome-wide association analyses were performed for each stratification within each cohort, with the data for each BMI group meta-analysed using METAL software. Almost half of the total study population (47%, n = 119,584) were of lean BMI (≤ 25 kg/m2). Two genome-wide significant loci were identified for lean PCOS, led by rs12000707 within DENND1A (P = 1.55 × 10–12) and rs2228260 within XBP1 (P = 3.68 × 10–8). One additional locus, LINC02905, was highlighted as significantly associated with lean PCOS through gene-based analyses (P = 1.76 × 10–6). There were no significant loci observed for the overweight or obese sub-strata when analysed separately, however, when these strata were combined, an association signal led by rs569675099 within DENND1A reached genome-wide significance (P = 3.22 × 10–9) and a gene-based association was identified with ERBB4 (P = 1.59 × 10–6). Nineteen of 28 signals identified in previous GWAS, were replicated with consistent allelic effect in the lean stratum. There were less replicated signals in the overweight and obese groups, and

Published
2024

9. 274-OR: Effect of Testosterone Treatment on Type 2 Diabetes Incidence in High-Risk Men Enrolled in a Lifestyle Program: A Two-Year Randomized Placebo-Controlled Trial

Author

WITTERT, GARY A., primary, ROBLEDO, KRISTY P., additional, GROSSMANN, MATHIS, additional, BRACKEN, KAREN, additional, YEAP, BU B., additional, STUCKEY, BRONWYN G.A., additional, MCLACHLAN, ROBERT I., additional, HANDELSMAN, DAVID J., additional, ALLAN, CAROLYN, additional, INDER, WARRICK, additional, JESUDASON, DAVID, additional, KEECH, ANTHONY C., additional, JENKINS, ALICIA, additional, TANG FUI, MARK NG, additional, and DANIEL, MARK, additional

Published
2020
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18. Erectile dysfunction, sildenafil and cardiovascular risk

Author

Chew, K. Kim, Stuckey, Bronwyn G.A., and Thompson, Peter L.

Subjects
Cardiovascular diseases -- Care and treatment, Impotence -- Drug therapy, Health
Abstract

Issues concerning the use of sildenafil for the treatment of erectile dysfunction are discussed. Particular emphasis is placed on the possible role of sildenafil in serious cardiovascular events. Care must be taken when prescribing sildenafil for patients receiving complicated multidrug antihypertensive therapy.

Published
2000

22. Premature ejaculation: a clinical update

Author

Palmer, Neil R. and Stuckey, Bronwyn G.A.

Subjects
Premature ejaculation -- Causes of, Premature ejaculation -- Diagnosis, Premature ejaculation -- Care and treatment, Health
Abstract

Premature ejaculation (PE) or ejaculation occurring without control shortly after vaginal penetration is the most common male sexual complaint and is quite distressing is studied. The symptoms, causes and treatment of PE are discussed.

Published
2008

23. Polycystic ovary syndrome and abnormal glucose tolerance

Author

Teede, Helena J. and Stuckey, Bronwyn G.A

Subjects
Diabetes -- Risk factors, Obesity -- Risk factors, Stein-Leventhal syndrome -- Distribution, Stein-Leventhal syndrome -- Prevention, Stein-Leventhal syndrome -- Care and treatment, Women -- Health aspects, Company distribution practices, Health
Abstract

The article discusses polycystic ovary syndrome, a common endocrine abnormality of women and a reproductive condition characterized by the appearance of the ovary on ultrasound.

Published
2007

26. Rapid, divergent changes in spinal and forearm bone density following short-term intravenous treatment of paget's disease with pamidronate disodium

Author

Price, Roger I., primary, Gutteridge, Donald H., additional, Stuckey, Bronwyn G.A., additional, Kent, G. Neil, additional, Retallack, Robert W., additional, Prince, Richard L., additional, Bhagat, Chotoo I., additional, Johnston, Christine A., additional, Nicholson, Geoffrey C., additional, and Stewart, Graeme O., additional

Published
2009
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