232 results on '"Stucchi N. A."'
Search Results
2. The ReadFree tool for the identification of poor readers: a validation study based on a machine learning approach in monolingual and minority-language children
- Author
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Carioti, D, Stucchi, N, Toneatto, C, Masia, M, Del Monte, M, Stefanelli, S, Travellini, S, Marcelli, A, Tettamanti, M, Vernice, M, Guasti, M, Berlingeri, M, Carioti D., Stucchi N. A., Toneatto C., Masia M. F., Del Monte M., Stefanelli S., Travellini S., Marcelli A., Tettamanti M., Vernice M., Guasti M. T., Berlingeri M., Carioti, D, Stucchi, N, Toneatto, C, Masia, M, Del Monte, M, Stefanelli, S, Travellini, S, Marcelli, A, Tettamanti, M, Vernice, M, Guasti, M, Berlingeri, M, Carioti D., Stucchi N. A., Toneatto C., Masia M. F., Del Monte M., Stefanelli S., Travellini S., Marcelli A., Tettamanti M., Vernice M., Guasti M. T., and Berlingeri M.
- Abstract
In this study, we validated the "ReadFree tool", a computerised battery of 12 visual and auditory tasks developed to identify poor readers also in minority-language children (MLC). We tested the task-specific discriminant power on 142 Italian-monolingual participants (8-13 years old) divided into monolingual poor readers (N = 37) and good readers (N = 105) according to standardised Italian reading tests. The performances at the discriminant tasks of the "ReadFree tool" were entered into a classification and regression tree (CART) model to identify monolingual poor and good readers. The set of classification rules extracted from the CART model were applied to the MLC's performance and the ensuing classification was compared to the one based on standardised Italian reading tests. According to the CART model, auditory go-no/go (regular), RAN and Entrainment(100bpm) were the most discriminant tasks. When compared with the clinical classification, the CART model accuracy was 86% for the monolinguals and 76% for the MLC. Executive functions and timing skills turned out to have a relevant role in reading. Results of the CART model on MLC support the idea that ad hoc standardised tasks that go beyond reading are needed.
- Published
- 2023
3. A ReadFree Tool for the identification of reading disorders in monolingual and minority language children: a validation study.
- Author
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Carioti, D, Stucchi, N, Toneatto, C, Stefanelli, S, Travellini, S, Tettamanti, M, Vernice, M, Guasti, M, Berlingeri, M, Carioti, D., Stucchi, N., Toneatto, C., Stefanelli, S., Travellini, S., Tettamanti, M. D. P., Vernice, M., Guasti, M. T., Berlingeri, M., Carioti, D, Stucchi, N, Toneatto, C, Stefanelli, S, Travellini, S, Tettamanti, M, Vernice, M, Guasti, M, Berlingeri, M, Carioti, D., Stucchi, N., Toneatto, C., Stefanelli, S., Travellini, S., Tettamanti, M. D. P., Vernice, M., Guasti, M. T., and Berlingeri, M.
- Published
- 2023
4. Rhythm as a language-independent marker of poor reading performances.
- Author
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Carioti, D, Taha, J, Stucchi, N, Stefanelli, S, Vernice, M, Sarti, D, De Salvatore, M, Berlingeri, M, Guasti, M, Carioti D., Taha J., Stucchi N., Stefanelli S., Vernice M., Sarti D., De Salvatore M., Berlingeri M., Guasti M. T., Carioti, D, Taha, J, Stucchi, N, Stefanelli, S, Vernice, M, Sarti, D, De Salvatore, M, Berlingeri, M, Guasti, M, Carioti D., Taha J., Stucchi N., Stefanelli S., Vernice M., Sarti D., De Salvatore M., Berlingeri M., and Guasti M. T.
- Published
- 2023
5. A ReadFree tool for the identification of reading disorders in monolingual and minority-language children.
- Author
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Carioti, D, Stucchi, N, Toneatto, C, Stefanelli, S, Del Monte, M, Travellini, S, Marcelli, A, Tettamanti, M, Vernice, M, Berlingeri, M, Carioti, D., Stucchi, N. A., Toneatto, C., Stefanelli, S., Del Monte, M., Travellini, S., Marcelli, A., Tettamanti, M. P. D., Vernice, M., Berlingeri, M. A., Carioti, D, Stucchi, N, Toneatto, C, Stefanelli, S, Del Monte, M, Travellini, S, Marcelli, A, Tettamanti, M, Vernice, M, Berlingeri, M, Carioti, D., Stucchi, N. A., Toneatto, C., Stefanelli, S., Del Monte, M., Travellini, S., Marcelli, A., Tettamanti, M. P. D., Vernice, M., and Berlingeri, M. A.
- Published
- 2023
6. Assessment of Exergames as Treatment and Prevention of Dysgraphia
- Author
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Borghese, N. A., Palmiotto, C., Essenziale, J., Mainetti, R., Granocchio, E., Molteni, B., Sarti, D., Guasti, T., Stucchi, N., Pedrocchi, A., Ferrante, S., Guglielmelli, Eugenio, Series editor, Ibáñez, Jaime, editor, González-Vargas, José, editor, Azorín, José María, editor, Akay, Metin, editor, and Pons, José Luis, editor
- Published
- 2017
- Full Text
- View/download PDF
7. Rapid Automatized Naming as a Universal Marker of Developmental Dyslexia in Italian Monolingual and Minority-Language Children
- Author
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Carioti, D, Stucchi, N, Toneatto, C, Masia, M, Broccoli, M, Carbonari, S, Travellini, S, Del Monte, M, Riccioni, R, Marcelli, A, Vernice, M, Guasti, M, Berlingeri, M, Carioti D., Stucchi N., Toneatto C., Masia M. F., Broccoli M., Carbonari S., Travellini S., Del Monte M., Riccioni R., Marcelli A., Vernice M., Guasti M. T., Berlingeri M., Carioti, D, Stucchi, N, Toneatto, C, Masia, M, Broccoli, M, Carbonari, S, Travellini, S, Del Monte, M, Riccioni, R, Marcelli, A, Vernice, M, Guasti, M, Berlingeri, M, Carioti D., Stucchi N., Toneatto C., Masia M. F., Broccoli M., Carbonari S., Travellini S., Del Monte M., Riccioni R., Marcelli A., Vernice M., Guasti M. T., and Berlingeri M.
- Abstract
Rapid Automatized Naming (RAN) is considered a universal marker of developmental dyslexia (DD) and could also be helpful to identify a reading deficit in minority-language children (MLC), in which it may be hard to disentangle whether the reading difficulties are due to a learning disorder or a lower proficiency in the language of instruction. We tested reading and rapid naming skills in monolingual Good Readers (mGR), monolingual Poor Readers (mPR), and MLC, by using our new version of RAN, the RAN-Shapes, in 127 primary school students (from 3rd to 5th grade). In line with previous research, MLC showed, on average, lower reading performances as compared to mGR. However, the two groups performed similarly to the RAN-Shapes task. On the contrary, the mPR group underperformed both in the reading and the RAN tasks. Our findings suggest that reading difficulties and RAN performance can be dissociated in MLC; consequently, the performance at the RAN-Shapes may contribute to the identification of children at risk of a reading disorder without introducing any linguistic bias, when testing MLC.
- Published
- 2022
8. Identifying the risk of dyslexia in bilingual children: The potential of language-dependent and language-independent tasks
- Author
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Taha, J, Carioti, D, Stucchi, N, Chailleux, M, Granocchio, E, Sarti, D, De Salvatore, M, Guasti, M, Taha J., Carioti D., Stucchi N., Chailleux M., Granocchio E., Sarti D., De Salvatore M., Guasti M. T., Taha, J, Carioti, D, Stucchi, N, Chailleux, M, Granocchio, E, Sarti, D, De Salvatore, M, Guasti, M, Taha J., Carioti D., Stucchi N., Chailleux M., Granocchio E., Sarti D., De Salvatore M., and Guasti M. T.
- Abstract
This study investigates the linguistic processing and non-linguistic cognitive abilities of monolingual and bilingual children with and without reading difficulties and examines the relationship between these skills and reading. There were 72 Italian-speaking children: 18 monolingual good readers (MONO-GR, Mage = 10;4), 19 monolingual poor readers (MONO-PR, Mage = 10;3), 21 bilingual good readers (BI-GR, Mage = 10;6), and 16 bilingual poor readers (BI-PR, Mage = 10;6). All bilingual children spoke Italian as their L2. Children completed a battery of standardized Italian reading tests, language-dependent tasks: nonword repetition (NWR), sentence repetition (SR), and phonological awareness (PA), and language-independent tasks: timing anticipation, beat synchronization, inhibition control, auditory reaction time, and rapid automatized naming (RAN). Poor readers scored below good readers on the language-dependent tasks, including NWR, PA, and SR. Beat synchronization was the only language-independent task sensitive to reading ability, with poor readers showing greater variability than good readers in tapping to fast rhythms. SR was the only task influenced by language experience as bilinguals underperformed monolinguals on the task. Moreover, there were weak to moderate correlations between performance on some language-dependent tasks (NWR, PA), language-independent tasks (inhibition control, RAN), and reading measures. Performance on the experimental tasks (except for RAN) was not associated with the length of exposure to Italian. The results highlight the potential of NWR, PA, SR, and beat synchronization tasks in identifying the risk of dyslexia in bilingual populations. Future research is needed to validate these findings and to establish the tasks’ diagnostic accuracy.
- Published
- 2022
9. Using HoloLens Mixed Reality to research correlations between language and movement: a case study
- Author
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Beccaluva, E, Vona, F, Di Gioia, F, Patti, A, Guzzo, A, Cappella, I, Ma, Y, Stucchi, N, Garzotto, F, Beccaluva E. A., Vona F., Di Gioia F., Patti A., Guzzo A., Cappella I., Ma Y., Stucchi N., Garzotto F., Beccaluva, E, Vona, F, Di Gioia, F, Patti, A, Guzzo, A, Cappella, I, Ma, Y, Stucchi, N, Garzotto, F, Beccaluva E. A., Vona F., Di Gioia F., Patti A., Guzzo A., Cappella I., Ma Y., Stucchi N., and Garzotto F.
- Abstract
Communication can be defined as the understanding and exchanging of meaningful messages. The role of communication is central to the lives of human beings as, everyday, we use language to interact with the world around us. Linguistic skills play a fundamental role in this scenario and Language Disorders (LD) are impairments that limit the processing of linguistic information. Early and accurate identification of LD is thus essential to promote lifelong learning and well-being. From an evolutionary perspective, some human language constructs evolved from an ancestral motor system and share the same neural pathways in the Broca's area of the brain. This suggests a correlation between action and language. If such a relationship is well established and reliable, it would be possible to use the former as a marker of the latter. The hypothesis of our work, in a nutshell, is that movement can be a predictor of language. To study this correlation, we developed C(H)o(L)ordination, a Mixed Reality (MR) application for HoloLens 2. The application offers several activities based on visual stimuli involving motor movements, which tap on the same skills needed to perform some language tasks. We performed an exploratory study with N=22 users to test the application usability and user experience. The results suggest that C(H)o(L)ordination is a usable and powerful tool to gather insights on the ongoing debate about language evolution and language disorders.
- Published
- 2022
10. A Reading-Free Screening Tool: testare le abilità cognitive sottostanti la dislessia per identificare le difficoltà di lettura in bambini monolingue e bilingue.
- Author
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Carioti, D, Stucchi, N, Stefanelli, S, Toneatto, C, Masia, M, Travellini, S, Guasti, M, Vernice, M, Berlingeri, M, Carioti D., Stucchi N. A., Stefanelli S., C. Toneatto, M. F. Masia, Travellini S., M. T. Guasti, Vernice M., Berlingeri M., Carioti, D, Stucchi, N, Stefanelli, S, Toneatto, C, Masia, M, Travellini, S, Guasti, M, Vernice, M, Berlingeri, M, Carioti D., Stucchi N. A., Stefanelli S., C. Toneatto, M. F. Masia, Travellini S., M. T. Guasti, Vernice M., and Berlingeri M.
- Published
- 2022
11. The effect of the preferred hand on drawing movement
- Author
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Zarandi, Z, Stucchi, N, Fadiga, L, Pozzo, T, Zarandi, Zinat, Stucchi, Natale Adolfo, Fadiga, Luciano, Pozzo, Thierry, Zarandi, Z, Stucchi, N, Fadiga, L, Pozzo, T, Zarandi, Zinat, Stucchi, Natale Adolfo, Fadiga, Luciano, and Pozzo, Thierry
- Abstract
The observation that different effectors can execute the same movement suggests functional equivalences driven by limb independent representation of action in the central nervous system. A common invariant motor behavior is the speed and curvature coupling (the 1/3 power law), a low dimensional (abstract) descriptor of movement which is resilient to different sensorimotor contexts. Our purpose is to verify the consistency of such motor equivalence during a drawing task, by testing the effect of manual dominance and movement speed on motor performance. We hypothesize that abstract kinematic variables are not the most resistant to speed or limb effector changes. The results show specific effects of speed and hand side on the drawing task. Movement duration, speed-curvature covariation, and maximum velocity were not significantly affected by hand side, while geometrical features were strongly speed and limb dependent. However, intra-trial analysis performed over the successive drawing movements reveals a significant hand side effect on the variability of movement vigor and velocity-curvature relationship (the 1/3 PL). The identified effects of speed and hand dominance on the kinematic parameters suggest different neural strategies, in a pattern that does not go from the most abstract to the least abstract component, as proposed by the traditional hierarchical organization of the motor plan.
- Published
- 2023
12. Suggestions for interdisciplinary teaching in mathematics education: The case of the history of the concept of group
- Author
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Zudini V., Stucchi N., Zudini, V, Stucchi, N, Zudini, V., and Stucchi, N.
- Subjects
education ,history of mathematic ,history of psychology of perception ,mathematics education ,history of mathematics ,group ,teacher training - Abstract
The role of the history of mathematics in mathematics education, as a support in teaching, is widely acknowledged. It can serve to arouse students’ interest in mathematics as well as to stimulate reflection on mathematical concepts and methods. This work focuses on the group as “cross-concept”, in relation to its history from its origins in algebra to its applications in other areas. Given its very nature, the group should be adequately re-evaluated in an interdisciplinary approach, which may prove particularly captivating in linking the history of mathematics to the history of the psychology of perception. This historical interdisciplinary perspective may be useful in the context of university mathematics teaching, particularly teacher training.
- Published
- 2022
13. Alla base della Dislessia Evolutiva: testare e isolare le abilità cognitive sottostanti a lettura per lo screening delle difficoltà di apprendimento in bambini monolingue e bilingue.
- Author
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Carioti, D, Stucchi, N, Stefanelli, S, Toneatto, C, Masia, M, Travellini, S, Guasti, M, Vernice, M, Berlingeri, M, Carioti D., Stucchi N. A., Stefanelli S., C. Toneatto, M. F. Masia, Travellini S., M. T. Guasti, Vernice M., Berlingeri M., Carioti, D, Stucchi, N, Stefanelli, S, Toneatto, C, Masia, M, Travellini, S, Guasti, M, Vernice, M, Berlingeri, M, Carioti D., Stucchi N. A., Stefanelli S., C. Toneatto, M. F. Masia, Travellini S., M. T. Guasti, Vernice M., and Berlingeri M.
- Published
- 2021
14. Suggestions for interdisciplinary teaching in mathematics education: The case of the history of the concept of group
- Author
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Zudini, V, Stucchi, N, Zudini, V, and Stucchi, N
- Abstract
The role of the history of mathematics in mathematics education, as a support in teaching, is widely acknowledged. It can serve to arouse students’ interest in mathematics as well as to stimulate reflection on mathematical concepts and methods. This work focuses on the group as “cross-concept”, in relation to its history from its origins in algebra to its applications in other areas. Given its very nature, the group should be adequately re-evaluated in an interdisciplinary approach, which may prove particularly captivating in linking the history of mathematics to the history of the psychology of perception. This historical interdisciplinary perspective may be useful in the context of university mathematics teaching, particularly teacher training.
- Published
- 2022
15. The Poggendorff illusion in Ruben's Descent from the Cross in Antwerp: Does the illusion even matter?
- Author
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Daneyko, O, Stucchi, N, Zavagno, D, Daneyko, O, Stucchi, N, and Zavagno, D
- Abstract
Two experiments are described, the purpose of which was to investigate the presence of a misalignment illusion caused by Poggendorff-like conditions in two paintings by Peter Paul Rubens, both depicting the Descent from the Cross, one located in Antwerp (Belgium), the other in Lille (France). The first shows a geometrical misalignment made by Rubens in a minor detail, which is considered proof that the artist observed the Poggendorff illusion. The second painting, instead, shows a perfect geometrical alignment in a similar detail. In experiment 1, participants were asked to align a top segment to a lower one in two types of stimuli: a full-size digitally manipulated reproduction of the painting and a Poggendorff-like configuration that recalled the painting's lines displacement and tilt. Adjustments were performed from two distances, one up close (painting distance) and one from below and far (observation distance). Results confirmed the presence of the Poggendorff illusion, but mean adjustments significantly differed from the misalignment perpetrated by Rubens. Experiment 2 was set up in a similar fashion with the Lille painting. Results confirmed the presence of the Poggendorff illusion also in this painting; however, the alignment by Rubens coincides with the geometrical one. Results from both experiments do not support the claim that Rubens observed the Poggendorff illusion and therefore corrected for it in the Antwerp painting. An alternative account is discussed, which relates to the structural layout of the painting.
- Published
- 2022
16. Glomerular resistances predict long-term GFR decline in type 2 diabetic patients without overt nephropathy: a longitudinal subgroup analysis of the DEMAND trial
- Author
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Carrara, F, Ruggenenti, P, Perna, A, Iliev, I, Gaspari, F, Ferrari, S, Stucchi, N, Bossi, A, Trevisan, R, Remuzzi, G, Parvanova, A, Carrara, Fabiola, Ruggenenti, Piero, Perna, Annalisa, Iliev, Ilian Petrov, Gaspari, Flavio, Ferrari, Silvia, Stucchi, Nadia, Bossi, Antonio, Trevisan, Roberto, Remuzzi, Giuseppe, Parvanova, Aneliya, Carrara, F, Ruggenenti, P, Perna, A, Iliev, I, Gaspari, F, Ferrari, S, Stucchi, N, Bossi, A, Trevisan, R, Remuzzi, G, Parvanova, A, Carrara, Fabiola, Ruggenenti, Piero, Perna, Annalisa, Iliev, Ilian Petrov, Gaspari, Flavio, Ferrari, Silvia, Stucchi, Nadia, Bossi, Antonio, Trevisan, Roberto, Remuzzi, Giuseppe, and Parvanova, Aneliya
- Abstract
Aims: Investigating whether and to what extent changes in glomerular hemodynamic parameters, beyond glomerular hyperfiltration, could predict glomerular filtration rate (GFR) decline in hypertensive, non-proteinuric type 2 diabetic patients. Materials and methods: We estimated baseline afferent (Ra) and efferent (Re) arteriolar resistances and glomerular hydrostatic pressure in 60 consecutive patients from DEMAND study, using the Gomez’ equations. Baseline renal plasma flow was measured by para-aminohippurate plasma clearance, and GFR was measured by iohexol plasma clearance at baseline and every 6 months for a median of 4.0 years [IQR 3.5–4.0 years]. Patients with a GFR decline > or ≤ 3 mL/min/1.73 m2/year were categorized as “Progressors” and “Non-progressors,” respectively. Predictors of GFR decline were studied by univariable and multivariable logistic regression analysis. Results: •The GFR declined by a median [IQR] of 4.06 [5.46–2.00] mL/min/1.73 m2/year in the study group as a whole and by 5.35 [6.60–4.48] mL/min/1.73 m2/year and 1.71 [2.14–1.33] mL/min/1.73 m2/year in Progressors and Non-progressors, considered separately. Progressors had a higher baseline Ra (3487.3 ± 1349.3 dyne•sec•cm−5 vs. 2877.0 ± 668.9 dyne•sec•cm−5, p < 0.05) and higher Ra/Re ratio (1.4 ± 0.5 vs. 1.1 ± 0.3, p < 0.01) than Non-progressors. At multivariable logistic regression analysis, Ra/Re ratio and arterial hypertension duration were independently associated with GFR decline (odds ratio [95% CI] 8.50 [1.56–46.28] and 1.14 [1.01–1.28]), respectively. Conclusions: Increased Ra/Re ratio and arterial hypertension duration predict early GFR decline in hypertensive non-proteinuric type 2 diabetic patients. These findings could be explained by glomerular hypoperfusion and chronic ischemic injury related to pre-glomerular arteriolar narrowing. Clinical trial registration: DEMAND, NCT00157586, September 12, 2005.
- Published
- 2022
17. The ReadFree Tool: uno strumento per lo screening delle abilità cognitive sottostanti la lettura nei bambini monolingui e multilingui.
- Author
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Carioti, D, Stucchi, N, Stefanelli, S, Toneatto, C, Masia, M, Travellini, S, Guasti, M, Vernice, M, Berlingeri, M, Stucchi, NA, Masia, MF, Guasti, MT, Carioti, D, Stucchi, N, Stefanelli, S, Toneatto, C, Masia, M, Travellini, S, Guasti, M, Vernice, M, Berlingeri, M, Stucchi, NA, Masia, MF, and Guasti, MT
- Published
- 2022
18. Assessment of Exergames as Treatment and Prevention of Dysgraphia
- Author
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Borghese, N. A., primary, Palmiotto, C., additional, Essenziale, J., additional, Mainetti, R., additional, Granocchio, E., additional, Molteni, B., additional, Sarti, D., additional, Guasti, T., additional, Stucchi, N., additional, Pedrocchi, A., additional, and Ferrante, S., additional
- Published
- 2016
- Full Text
- View/download PDF
19. Impact of a complement factor H gene variant on renal dysfunction, cardiovascular events and response to ACE inhibitor therapy in type 2 diabetes
- Author
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Valoti, E, Noris, M, Perna, A, Rurali, E, Gherardi, G, Breno, M, Parvanova, A, Iliev, I, Bossi, A, Trevisan, R, Dodesini, A, Ferrari, S, Stucchi, N, Benigni, A, Remuzzi, G, Ruggenenti, P, Valoti E., Noris M., Perna A., Rurali E., Gherardi G., Breno M., Parvanova A. I., Iliev I. P., Bossi A., Trevisan R., Dodesini A. R., Ferrari S., Stucchi N., Benigni A., Remuzzi G., Ruggenenti P., Valoti, E, Noris, M, Perna, A, Rurali, E, Gherardi, G, Breno, M, Parvanova, A, Iliev, I, Bossi, A, Trevisan, R, Dodesini, A, Ferrari, S, Stucchi, N, Benigni, A, Remuzzi, G, Ruggenenti, P, Valoti E., Noris M., Perna A., Rurali E., Gherardi G., Breno M., Parvanova A. I., Iliev I. P., Bossi A., Trevisan R., Dodesini A. R., Ferrari S., Stucchi N., Benigni A., Remuzzi G., and Ruggenenti P.
- Abstract
Complement activation has been increasingly implicated in the pathogenesis of type 2 diabetes and its chronic complications. It is unknown whether complement factor H (CFH) genetic variants, which have been previously associated with complement-mediated organ damage likely due to inefficient complement modulation, influence the risk of renal and cardiovascular events and response to therapy with angiotensin-converting enzyme inhibitors (ACEi) in type 2 diabetic patients. Here, we have analyzed the c.2808G> T, (p.Glu936Asp) CFH polymorphism, which tags the H3 CFH haplotype associated to low plasma factor H levels and predisposing to atypical hemolytic uremic syndrome, in 1,158 type 2 diabetics prospectively followed in the Bergamo nephrologic complications of type 2 diabetes randomized, controlled clinical trial (BENEDICT) that evaluated the effect of the ACEi trandolapril on new onset microalbuminuria. At multivariable Cox analysis, the p.Glu936Asp polymorphism (Asp/Asp homozygotes, recessive model) was associated with increased risk of microalbuminuria [adjusted hazard ratio (HR) 3.25 (95% CI 1.46-7.24), P = 0.0038] and cardiovascular events [adjusted HR 2.68 (95% CI 1.23-5.87), P = 0.013]. The p.Glu936Asp genotype significantly interacted with ACEi therapy in predicting microalbuminuria. ACEi therapy was not nephroprotective in Asp/Asp homozygotes [adjusted HR 1.54 (0.18-13.07), P = 0.691 vs. non-ACEi-treated Asp/Asp patients], whereas it significantly reduced microalbuminuria events in Glu/Asp or Glu/Glu patients [adjusted HR 0.38 (0.24-0.60), P < 0.0001 vs. non-ACEi-treated Glu/Asp or Glu/Glu patients]. Among ACEi-treated patients, the risk of developing cardiovascular events was higher in Asp/Asp homozygotes than in Glu/Asp or Glu/Glu patients [adjusted HR 3.26 (1.29-8.28), P = 0.013]. Our results indicate that type 2 diabetic patients Asp/Asp homozygotes in the p.Glu936Asp CFH polymorphism are at increased risk of microalbuminuria and cardiovascular comp
- Published
- 2019
20. Arte come forma di comunicazione
- Author
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Stucchi, N and Stucchi, N
- Subjects
Psychology of Art, Perception, Communication ,M-PSI/01 - PSICOLOGIA GENERALE - Published
- 2020
21. Rhythmic and Morphosyntactic Predictions: The Anticipation Abilities of Italian Children with Developmental Dyslexia
- Author
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Persici, V, Stucchi, N, Arosio, F, Brown, M, Dailey, B, Persici, V, Stucchi, N, and Arosio, F
- Subjects
children ,Italian ,prediction ,Rhythm, Dyslexia, Morphosyntax, Prediction, Anticipation ,developmental dyslexia ,rhythm ,morphosyntax - Published
- 2019
22. Cluster analysis identifies distinct pathogenetic patterns in c3 glomerulopathies/immune complex–Mediated membranoproliferative GN
- Author
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Iatropoulos, P, Daina, E, Curreri, M, Piras, R, Valoti, E, Mele, C, Bresin, E, Gamba, S, Alberti, M, Breno, M, Perna, A, Bettoni, S, Sabadini, E, Murer, L, Vivarelli, M, Noris, M, Remuzzi, G, Bottanelli, L, Donadelli, R, Cuccarolo, P, Abbate, M, Carrara, C, Cannata, A, Ferrari, S, Gaspari, F, Stucchi, N, Bassani, C, Lena, M, Omati, G, Taruscia, D, Bellantuono, R, Giordano, M, Messina, G, Caruso, M, Gotti, E, Mescia, F, Perticucci, E, Schieppati, A, Verdoni, L, Berto, M, Baraldi, O, Montini, G, Pasini, A, Passler, W, Degasperi, T, Gaggiotti, M, Gregorini, G, Miglietti, N, Guarnieri, A, Cirami, L, Roperto, R, Di Giorgio, G, Barbano, G, Innocenti, M, Ghiggeri, G, Magnasco, A, Rolla, D, Casartelli, D, Lambertini, D, Maggio, M, Cosci, P, Conti, G, Amar, K, Ardissino, G, Marinosci, A, Sinico, R, Montoli, A, Bonucchi, D, Facchini, F, Furci, L, Ferretti, A, Nuzzi, F, Pecoraro, C, Visciano, B, Canavese, C, Radin, E, Stratta, P, Nordio, M, Benetti, E, Parolin, M, Alberici, F, Manenti, L, Brugnano, R, Manenti, F, Capitanini, A, Emma, F, Massella, L, Rosa, M, Mazzon, M, Basso, E, Besso, L, Lavacca, A, Mella, A, Bertero, M, Coppo, R, Peruzzi, L, Porcellini, M, Piccoli, G, Clari, R, Pasi, A, Gangemi, C, Alfandary, H, Dagan, A, Conceiçao, M, Sameiro, F, Croze, L, Malvezzi, P, Tsygin, A, Zelan, B, Nastasi, N, Iatropoulos, Paraskevas, Daina, Erica, Curreri, Manuela, Piras, Rossella, Valoti, Elisabetta, Mele, Caterina, Bresin, Elena, Gamba, Sara, Alberti, Marta, Breno, Matteo, Perna, Annalisa, Bettoni, Serena, Sabadini, Ettore, Murer, Luisa, Vivarelli, Marina, Noris, Marina, Remuzzi, Giuseppe, Bottanelli, L., Donadelli, R., Cuccarolo, P., Abbate, M., Carrara, C., Cannata, A., Ferrari, S., Gaspari, F., Stucchi, N., Bassani, C., Lena, M., Omati, G., Taruscia, D., Bellantuono, R., Giordano, M., Messina, G., Caruso, M., Gotti, E., Mescia, F., Perticucci, E., Schieppati, A., Verdoni, L., Berto, M., Baraldi, O., Montini, G., Pasini, A., Passler, W., Degasperi, T., Gaggiotti, M., Gregorini, G., Miglietti, N., Guarnieri, A., Cirami, L., Roperto, R. M., Di Giorgio, G., Barbano, G., Innocenti, M. L. D., Ghiggeri, G. M., Magnasco, A., Rolla, D., Casartelli, D., Lambertini, D., Maggio, M., Cosci, P. M., Conti, G., Amar, K., Ardissino, G., Marinosci, A., Sinico, R. A., Montoli, A., Bonucchi, D., Facchini, F., Furci, L., Ferretti, A., Nuzzi, F., Pecoraro, C., Visciano, B., Canavese, C., Radin, E., Stratta, P., Nordio, M., Benetti, E., Parolin, M., Alberici, F., Manenti, L., Brugnano, R., Manenti, F., Capitanini, A., Emma, F., Massella, L., Rosa, M., Mazzon, M., Basso, E., Besso, L., Lavacca, A., Mella, A., Bertero, M., Coppo, R., Peruzzi, L., Porcellini, M. G., Piccoli, G. B., Clari, R., Pasi, A., Gangemi, C., Alfandary, H., Dagan, A., Conceiçao, M., Sameiro, F. M., Croze, L., Malvezzi, P., Tsygin, A., Zelan, B., Nastasi, null, Iatropoulos, P, Daina, E, Curreri, M, Piras, R, Valoti, E, Mele, C, Bresin, E, Gamba, S, Alberti, M, Breno, M, Perna, A, Bettoni, S, Sabadini, E, Murer, L, Vivarelli, M, Noris, M, Remuzzi, G, Bottanelli, L, Donadelli, R, Cuccarolo, P, Abbate, M, Carrara, C, Cannata, A, Ferrari, S, Gaspari, F, Stucchi, N, Bassani, C, Lena, M, Omati, G, Taruscia, D, Bellantuono, R, Giordano, M, Messina, G, Caruso, M, Gotti, E, Mescia, F, Perticucci, E, Schieppati, A, Verdoni, L, Berto, M, Baraldi, O, Montini, G, Pasini, A, Passler, W, Degasperi, T, Gaggiotti, M, Gregorini, G, Miglietti, N, Guarnieri, A, Cirami, L, Roperto, R, Di Giorgio, G, Barbano, G, Innocenti, M, Ghiggeri, G, Magnasco, A, Rolla, D, Casartelli, D, Lambertini, D, Maggio, M, Cosci, P, Conti, G, Amar, K, Ardissino, G, Marinosci, A, Sinico, R, Montoli, A, Bonucchi, D, Facchini, F, Furci, L, Ferretti, A, Nuzzi, F, Pecoraro, C, Visciano, B, Canavese, C, Radin, E, Stratta, P, Nordio, M, Benetti, E, Parolin, M, Alberici, F, Manenti, L, Brugnano, R, Manenti, F, Capitanini, A, Emma, F, Massella, L, Rosa, M, Mazzon, M, Basso, E, Besso, L, Lavacca, A, Mella, A, Bertero, M, Coppo, R, Peruzzi, L, Porcellini, M, Piccoli, G, Clari, R, Pasi, A, Gangemi, C, Alfandary, H, Dagan, A, Conceiçao, M, Sameiro, F, Croze, L, Malvezzi, P, Tsygin, A, Zelan, B, Nastasi, N, Iatropoulos, Paraskevas, Daina, Erica, Curreri, Manuela, Piras, Rossella, Valoti, Elisabetta, Mele, Caterina, Bresin, Elena, Gamba, Sara, Alberti, Marta, Breno, Matteo, Perna, Annalisa, Bettoni, Serena, Sabadini, Ettore, Murer, Luisa, Vivarelli, Marina, Noris, Marina, Remuzzi, Giuseppe, Bottanelli, L., Donadelli, R., Cuccarolo, P., Abbate, M., Carrara, C., Cannata, A., Ferrari, S., Gaspari, F., Stucchi, N., Bassani, C., Lena, M., Omati, G., Taruscia, D., Bellantuono, R., Giordano, M., Messina, G., Caruso, M., Gotti, E., Mescia, F., Perticucci, E., Schieppati, A., Verdoni, L., Berto, M., Baraldi, O., Montini, G., Pasini, A., Passler, W., Degasperi, T., Gaggiotti, M., Gregorini, G., Miglietti, N., Guarnieri, A., Cirami, L., Roperto, R. M., Di Giorgio, G., Barbano, G., Innocenti, M. L. D., Ghiggeri, G. M., Magnasco, A., Rolla, D., Casartelli, D., Lambertini, D., Maggio, M., Cosci, P. M., Conti, G., Amar, K., Ardissino, G., Marinosci, A., Sinico, R. A., Montoli, A., Bonucchi, D., Facchini, F., Furci, L., Ferretti, A., Nuzzi, F., Pecoraro, C., Visciano, B., Canavese, C., Radin, E., Stratta, P., Nordio, M., Benetti, E., Parolin, M., Alberici, F., Manenti, L., Brugnano, R., Manenti, F., Capitanini, A., Emma, F., Massella, L., Rosa, M., Mazzon, M., Basso, E., Besso, L., Lavacca, A., Mella, A., Bertero, M., Coppo, R., Peruzzi, L., Porcellini, M. G., Piccoli, G. B., Clari, R., Pasi, A., Gangemi, C., Alfandary, H., Dagan, A., Conceiçao, M., Sameiro, F. M., Croze, L., Malvezzi, P., Tsygin, A., Zelan, B., and Nastasi, null
- Abstract
Membranoproliferative GN (MPGN) was recently reclassified as alternative pathway complement–mediated C3 glomerulopathy (C3G) and immune complex–mediated membranoproliferative GN (IC-MPGN). However, genetic and acquired alternative pathway abnormalities are also observed in IC-MPGN. Here, we explored the presence of distinct disease entities characterized by specific pathophysiologic mechanisms. We performed unsupervised hierarchical clustering, a data-driven statistical approach, on histologic, genetic, and clinical data and data regarding serum/plasma complement parameters from 173 patients with C3G/IC-MPGN. This approach divided patients into four clusters, indicating the existence of four different pathogenetic patterns. Specifically, this analysis separated patients with fluid-phase complement activation (clusters 1–3) who had low serum C3 levels and a high prevalence of genetic and acquired alternative pathway abnormalities from patients with solid-phase complement activation (cluster 4) who had normal or mildly altered serum C3, late disease onset, and poor renal survival. In patients with fluid-phase complement activation, those in clusters 1 and 2 had massive activation of the alternative pathway, including activation of the terminal pathway, and the highest prevalence of subendothelial deposits, but those in cluster 2 had additional activation of the classic pathway and the highest prevalence of nephrotic syndrome at disease onset. Patients in cluster 3 had prevalent activation of C3 convertase and highly electron-dense intramembranous deposits. In addition, we provide a simple algorithm to assign patients with C3G/IC-MPGN to specific clusters. These distinct clusters may facilitate clarification of disease etiology, improve risk assessment for ESRD, and pave the way for personalized treatment.
- Published
- 2018
23. The rhythm of handwriting, response to Prof. Vivian Cook comment on Children's first handwriting productions show a timing structure
- Author
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Guasti, M, Stucchi, N, Pagliarini, E, Guasti, M. T., Stucchi, N., Pagliarini E., Guasti, M, Stucchi, N, Pagliarini, E, Guasti, M. T., Stucchi, N., and Pagliarini E.
- Published
- 2018
24. Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective observational study and embedded randomised placebo-controlled trial
- Author
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Tofte, N. Lindhardt, M. Adamova, K. Bakker, S.J.L. Beige, J. Beulens, J.W.J. Birkenfeld, A.L. Currie, G. Delles, C. Dimos, I. Francová, L. Frimodt-Møller, M. Girman, P. Göke, R. Havrdova, T. Heerspink, H.J.L. Kooy, A. Laverman, G.D. Mischak, H. Navis, G. Nijpels, G. Noutsou, M. Ortiz, A. Parvanova, A. Persson, F. Petrie, J.R. Ruggenenti, P.L. Rutters, F. Rychlík, I. Siwy, J. Spasovski, G. Speeckaert, M. Trillini, M. Zürbig, P. von der Leyen, H. Rossing, P. Zimmermann, S. Rädisch, B. Hävemeier, A. Busmann, A. Wittkop, U. Neuhaus, B. Ax-Smolarski, R. Zieglschmid, V. Bollweber, E. Wölk, H. Curovic, V.R. Tougaard, N.H. Eickhoff, M.K. Pilemann-Lyberg, S. Winther, S.A. Rosenlund, S.V. Hansen, T.W. von Scholten, B.J. Hansen, C.S. Zobel, E.H. Laursen, J.C. Theilade, S. Jelstrup, L. Juhl, T.R. Riis, D. Hermann, J.A. Lundgaard, A.G. Halkjær, M.L.D. Aabo, L. Frost Lerche, T. Lajer, M. Stefansen, R.J. Campbell, M.A. Durban, A. Raad, J. Prigge, M. Schiemann, M. Wilson, R. Kean, S. Douglas, E. Surtees, P. Gant, C. Yeung, S.M.H. Hagedoorn, I. Flynn, J. Galloway, J. Brooksbank, K. Aparicio, C. Iliev, I.P. Nones, F. Lo Bue, F. Melacini, D. Cugini, D. Prandini, S. Lecchi, V. Yakymchuk, S. Gherardi, G. Villa, A. Villa, D. Gaspari, F. Cannata, A.N. Ferrari, S. Stucchi, N. Albrechtová, Š. Eldeik, E. Amanaki, R. Fernandez-Fernandez, B. Sanchez-Rodriguez, J. Vázquez, C. Sanz, A.B. Sanchez-Niño, M.D. Ramos, A.M. Gonzalo, M.Á. Schmidt, U. Selim, G. Gjorgovski, T. Stratrova, S.S. Stojceva-Taneva, O. Schutten-Westerneng, P. Wierbos, B. Huvers, F. De Bruin, A.K. Lapauw, B. de Man, E. Rokegem, K. Inion, S. Kreutzmann, K. Dewettinck, I. Boukens-de Graaf, C. Clerc-de Jong, F. Entius, J. Nannings, M. van Steenderen, S. Petry, F.W. Kilic, C. PRIORITY investigators
- Abstract
Background: Microalbuminuria is an early sign of kidney disease in people with diabetes and indicates increased risk of cardiovascular disease. We tested whether a urinary proteomic risk classifier (CKD273) score was associated with development of microalbuminuria and whether progression to microalbuminuria could be prevented with the mineralocorticoid receptor antagonist spironolactone. Methods: In this multicentre, prospective, observational study with embedded randomised controlled trial (PRIORITY), we recruited people with type 2 diabetes, normal urinary albumin excretion, and preserved renal function from 15 specialist centres in ten European countries. All participants (observational cohort) were tested with the CKD273 classifier and classified as high risk (CKD273 classifier score >0·154) or low risk (≤0·154). Participants who were classified as high risk were entered into a randomised controlled trial and randomly assigned (1:1), by use of an interactive web-response system, to receive spironolactone 25 mg once daily or matched placebo (trial cohort). The primary endpoint was development of confirmed microalbuminuria in all individuals with available data (observational cohort). Secondary endpoints included reduction in incidence of microalbuminuria with spironolactone (trial cohort, intention-to-treat population) and association between CKD273 risk score and measures of impaired renal function based on estimated glomerular filtration rate (eGFR; observational cohort). Adverse events (particularly gynaecomastia and hyperkalaemia) and serious adverse events were recorded for the intention-to-treat population (trial cohort). This study is registered with the EU Clinical Trials Register (EudraCT 20120-004523-4) and ClinicalTrials.gov (NCT02040441) and is completed. Findings: Between March 25, 2014, and Sept 30, 2018, we enrolled and followed-up 1775 participants (observational cohort), 1559 (88%) of 1775 participants had a low-risk urinary proteomic pattern and 216 (12%) had a high-risk pattern, of whom 209 were included in the trial cohort and assigned to spironolactone (n=102) or placebo (n=107). The overall median follow-up time was 2·51 years (IQR 2·0–3·0). Progression to microalbuminuria was seen in 61 (28%) of 216 high-risk participants and 139 (9%) of 1559 low-risk participants (hazard ratio [HR] 2·48, 95% CI 1·80–3·42; p
- Published
- 2020
25. Experimental silica nanoparticles products for the consolidation of silica stones
- Author
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Stucchi, N. M. E., Tesser, E., Antonelli, F., Benedetti, A, and Zaccariello, G.
- Published
- 2020
26. Timing anticipation in adults and children with Developmental Dyslexia: evidence of an inefficient mechanism
- Author
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Pagliarini, E, Scocchia, L, Granocchio, E, Sarti, D, Stucchi, N, Guasti, M, Pagliarini, Elena, Scocchia, Lisa, Granocchio, Elisa, Sarti, Daniela, Stucchi, Natale, Guasti, Maria Teresa, Pagliarini, E, Scocchia, L, Granocchio, E, Sarti, D, Stucchi, N, Guasti, M, Pagliarini, Elena, Scocchia, Lisa, Granocchio, Elisa, Sarti, Daniela, Stucchi, Natale, and Guasti, Maria Teresa
- Abstract
Developmental Dyslexia (DD) is a learning disorder characterized by specific difficulties in learning to read accurately and fluently, which has been generally explained in terms of phonological deficits. Recent research has shown that individuals with DD experience timing difficulties in the domains of language, music perception and motor control, probably due to impaired rhythmic perception, suggesting that timing deficit might be a key underlying factor to explain such a variety of difficulties. The present work presents two experiments aimed at assessing the anticipatory ability on a given rhythm of 9-year old Italian children and Italian adults with and without DD. Both adults and children with DD displayed a greater timing error and were more variable than controls in high predictable stimuli. No difference between participants with and without DD was found in the control condition, in which the uncertain timing of the beat did not permit the extraction of regularities. These results suggest that both children and adults with DD are unable to exploit temporal regularities to efficiently anticipate the next sensory event whereas control participants easily are. By showing that the anticipatory timing system of individuals with Developmental Dyslexia appears affected, this study adds another piece of evidence to the multifaceted reality of Developmental Dyslexia.
- Published
- 2020
27. A Tablet App for Handwriting Skill Screening at the Preliteracy Stage: Instrument Validation Study
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Dui, L, Lunardini, F, Termine, C, Matteucci, M, Stucchi, N, Borghese, N, Ferrante, S, Dui, Linda Greta, Lunardini, Francesca, Termine, Cristiano, Matteucci, Matteo, Stucchi, Natale Adolfo, Borghese, Nunzio Alberto, Ferrante, Simona, Dui, L, Lunardini, F, Termine, C, Matteucci, M, Stucchi, N, Borghese, N, Ferrante, S, Dui, Linda Greta, Lunardini, Francesca, Termine, Cristiano, Matteucci, Matteo, Stucchi, Natale Adolfo, Borghese, Nunzio Alberto, and Ferrante, Simona
- Abstract
Background: Difficulties in handwriting, such as dysgraphia, impact several aspects of a child’s everyday life. Current methodologies for the detection of such difficulties in children have the following three main weaknesses: (1) they are prone to subjective evaluation; (2) they can be administered only when handwriting is mastered, thus delaying the diagnosis and the possible adoption of countermeasures; and (3) they are not always easily accessible to the entire community. Objective: This work aims at developing a solution able to: (1) quantitatively measure handwriting features whose alteration is typically seen in children with dysgraphia; (2) enable their study in a preliteracy population; and (3) leverage a standard consumer technology to increase the accessibility of both early screening and longitudinal monitoring of handwriting difficulties. Methods: We designed and developed a novel tablet-based app Play Draw Write to assess potential markers of dysgraphia through the quantification of the following three key handwriting laws: isochrony, homothety, and speed-accuracy tradeoff. To extend such an approach to a preliteracy age, the app includes the study of the laws in terms of both word writing and symbol drawing. The app was tested among healthy children with mastered handwriting (third graders) and those at a preliterate age (kindergartners). Results: App testing in 15 primary school children confirmed that the three laws hold on the tablet surface when both writing words and drawing symbols. We found significant speed modulation according to size (P<.001), no relevant changes to fraction time for 67 out of 70 comparisons, and significant regression between movement time and index of difficulty for 44 out of 45 comparisons (P<.05, R2>0.28, 12 degrees of freedom). Importantly, the three laws were verified on symbols among 19 kindergartners. Results from the speed-accuracy exercise showed a significant evolution with age of the global movement time
- Published
- 2020
28. Association of high-risk coronary atherosclerosis at CCTA with clinical and circulating biomarkers: Insight from CAPIRE study
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Conte, Edoardo, primary, Andreini, Daniele, additional, Magnoni, Marco, additional, Masson, Serge, additional, Mushtaq, Saima, additional, Berti, Sergio, additional, Canestrari, Mauro, additional, Casolo, Giancarlo, additional, Gabrielli, Domenico, additional, Latini, Roberto, additional, Marraccini, Paolo, additional, Moccetti, Tiziano, additional, Modena, Maria Grazia, additional, Pontone, Gianluca, additional, Gorini, Marco, additional, Maggioni, Aldo P., additional, Maseri, Attilio, additional, Maseri, A., additional, Andreini, D., additional, Berti, S., additional, Canestrari, M., additional, Casolo, G., additional, Gabrielli, D., additional, Latini, R., additional, Magnoni, M., additional, Marraccini, P., additional, Masson, S., additional, Moccetti, T., additional, Modena, M.G., additional, Pontone, G., additional, Gaspari, F., additional, Ferrari, S., additional, Cannata, A., additional, Stucchi, N., additional, Fois, M., additional, Bernasconi, R., additional, Balconi, G., additional, Vago, T., additional, Letizia, T., additional, Bottazzi, B., additional, Leone, R., additional, Suliman, I., additional, Sommaruga, M., additional, Gremigni, P., additional, Olivieri, R., additional, Pennacchietti, L., additional, Magnacca, M., additional, Rossi, M.G., additional, Pasotti, E., additional, Clemente, A., additional, Mushtaq, S., additional, Mauro, E., additional, Rossi, R., additional, Pigazzani, F., additional, Faggioni, L., additional, Ciardetti, M., additional, and Puppato, M., additional
- Published
- 2021
- Full Text
- View/download PDF
29. Language, Reading, and Motor Control: Get Rhythm!
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Guasti, MT, Pagliarini, E, Stucchi, N, Guasti, M, Pagliarini, E, and Stucchi, N
- Subjects
lcsh:Language and Literature ,Linguistics and Language ,dyslexia, motor deficts, subject-verb agreenebt ,Dyslexia, rhythmic organization, language ,Developmental Dyslexia, morphology, rhythm, language development, reading ,Developmental Dyslexia ,Experimental and Cognitive Psychology ,rhythm ,Language and Linguistics ,lcsh:Philology. Linguistics ,lcsh:P1-1091 ,reading ,motor deficts ,dyslexia ,morphology ,lcsh:P ,subject-verb agreenebt ,language development ,L-LIN/01 - GLOTTOLOGIA E LINGUISTICA - Published
- 2018
30. Rhythmic and morphosyntactic predictions in Italian children with DD
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Persici, V, Stucchi, N, Arosio, F, Persici, V, Stucchi, N, and Arosio, F
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children ,Italian ,prediction ,developmental dyslexia ,rhythm ,morphosyntax - Published
- 2018
31. The rhythm of handwriting, response to Prof. Vivian Cook comment on Children's first handwriting productions show a timing structure
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Guasti, M. T., Stucchi, N., Pagliarini E., Guasti, M, Stucchi, N, and Pagliarini, E
- Subjects
dyslexia, prediction - Published
- 2018
32. Synthesis and characterization of nanosilica products for the consolidation of stones
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Stucchi, N. M. E., Tesser, E., Antonelli, F., and Benedetti, A.
- Subjects
Settore CHIM/02 - Chimica Fisica - Published
- 2019
33. Music Education at School: Too Little and Too Late? Evidence From a Longitudinal Study on Music Training in Preadolescents
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Carioti, D, Danelli, L, Guasti, M, Gallucci, M, Perugini, M, Steca, P, Stucchi, N, Maffezzoli, A, Majno, M, Berlingeri, M, Paulesu, E, Desiré Carioti, Laura Danelli, Maria Teresa Guasti, Marcello Gallucci, Marco Perugini, Patrizia Steca, Natale Stucchi, Angelo Maffezzoli, Maria Majno, Manuela Berlingeri, Eraldo Paulesu, Carioti, D, Danelli, L, Guasti, M, Gallucci, M, Perugini, M, Steca, P, Stucchi, N, Maffezzoli, A, Majno, M, Berlingeri, M, Paulesu, E, Desiré Carioti, Laura Danelli, Maria Teresa Guasti, Marcello Gallucci, Marco Perugini, Patrizia Steca, Natale Stucchi, Angelo Maffezzoli, Maria Majno, Manuela Berlingeri, and Eraldo Paulesu
- Abstract
It is widely believed that intensive music training can boost cognitive and visuo-motor skills. However, this evidence is primarily based on retrospective studies; this makes it difficult to determine whether a cognitive advantage is caused by the intensive music training, or it is instead a factor influencing the choice of starting a music curriculum. To address these issues in a highly ecological setting, we tested longitudinally 128 students of a Middle School in Milan, at the beginning of the first class and, 1 year later, at the beginning of the second class. 72 students belonged to a Music curriculum (30 with previous music experience and 42 without) and 56 belonged to a Standard curriculum (44 with prior music experience and 12 without). Using a Principal Component Analysis, all the cognitive measures were grouped in four high-order factors, reflecting (a) General Cognitive Abilities, (b) Speed of Linguistic Elaboration, (c) Accuracy in Reading and Memory tests, and (d) Visuospatial and numerical skills. The longitudinal comparison of the four groups of students revealed that students from the Music curriculum had better performance in tests tackling General Cognitive Abilities, Visuospatial skills, and Accuracy in Reading and Memory tests. However, there were no significant curriculum-by-time interactions. Finally, the decision to have a musical experience before entering middle school was more likely to occur when the cultural background of the families was a high one. We conclude that a combination of family-related variables, early music experience, and pre-existent cognitive make-up is a likely explanation for the decision to enter a music curriculum at middle school.
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- 2019
34. Predicting the Future in Rhythm and Language: The Anticipation Abilities of a Group of Italian-Speaking Preschoolers.
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Guijarro-Fuentes, P, Suárez-Gómez, C, Persici, V, Stucchi, N, Arosio, F, Guijarro-Fuentes, P, Suárez-Gómez, C, Persici, V, Stucchi, N, and Arosio, F
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- 2019
35. Rhythmic and Morphosyntactic Predictions: The Anticipation Abilities of Italian Children with Developmental Dyslexia
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Brown, M, Dailey, B, Persici, V, Stucchi, N, Arosio, F, Brown, M, Dailey, B, Persici, V, Stucchi, N, and Arosio, F
- Published
- 2019
36. Cluster Analysis Identifies Distinct Pathogenetic Patterns in C3 Glomerulopathies/Immune Complex–Mediated Membranoproliferative GN
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Iatropoulos, Paraskevas, Daina, Erica, Curreri, Manuela, Piras, Rossella, Valoti, Elisabetta, Mele, Caterina, Bresin, Elena, Gamba, Sara, Alberti, Marta, Breno, Matteo, Perna, Annalisa, Bettoni, Serena, Sabadini, Ettore, Murer, Luisa, Vivarelli, Marina, Noris, Marina, Remuzzi, Giuseppe, Bottanelli, L., Donadelli, R., Cuccarolo, P., Abbate, M., Carrara, C., Cannata, A., Ferrari, S., Gaspari, F., Stucchi, N., Bassani, C., Lena, M., Omati, G., Taruscia, D., Bellantuono, R., Giordano, M., Messina, G., Caruso, M., Gotti, E., Mescia, F., Perticucci, E., Schieppati, A., Verdoni, L., Berto, M., Baraldi, O., Montini, G., Pasini, A., Passler, W., Degasperi, T., Gaggiotti, M., Gregorini, G., Miglietti, N., Guarnieri, A., Cirami, L., Roperto, R. M., Di Giorgio, G., Barbano, G., Innocenti, M. L. D., Ghiggeri, G. M., Magnasco, A., Rolla, D., Casartelli, D., Lambertini, D., Maggio, M., Cosci, P. M., Conti, G., Amar, K., Ardissino, G., Marinosci, A., Sinico, R. A., Montoli, A., Bonucchi, D., Facchini, F., Furci, L., Ferretti, A., Nuzzi, F., Pecoraro, C., Visciano, B., Canavese, C., Radin, E., Stratta, P., Nordio, M., Benetti, E., Parolin, M., Alberici, F., Manenti, L., Brugnano, R., Manenti, F., Capitanini, A., Emma, F., Massella, L., Rosa, M., Mazzon, M., Basso, E., Besso, L., Lavacca, A., Mella, A., Bertero, M., Coppo, R., Peruzzi, L., Porcellini, M. G., Piccoli, G. B., Clari, R., Pasi, A., Gangemi, C., Alfandary, H., Dagan, A., Conceiçao, M., Sameiro, F. M., Croze, L., Malvezzi, P., Tsygin, A., Zelan, B., Nastasi, null, Iatropoulos, P, Daina, E, Curreri, M, Piras, R, Valoti, E, Mele, C, Bresin, E, Gamba, S, Alberti, M, Breno, M, Perna, A, Bettoni, S, Sabadini, E, Murer, L, Vivarelli, M, Noris, M, Remuzzi, G, Bottanelli, L, Donadelli, R, Cuccarolo, P, Abbate, M, Carrara, C, Cannata, A, Ferrari, S, Gaspari, F, Stucchi, N, Bassani, C, Lena, M, Omati, G, Taruscia, D, Bellantuono, R, Giordano, M, Messina, G, Caruso, M, Gotti, E, Mescia, F, Perticucci, E, Schieppati, A, Verdoni, L, Berto, M, Baraldi, O, Montini, G, Pasini, A, Passler, W, Degasperi, T, Gaggiotti, M, Gregorini, G, Miglietti, N, Guarnieri, A, Cirami, L, Roperto, R, Di Giorgio, G, Barbano, G, Innocenti, M, Ghiggeri, G, Magnasco, A, Rolla, D, Casartelli, D, Lambertini, D, Maggio, M, Cosci, P, Conti, G, Amar, K, Ardissino, G, Marinosci, A, Sinico, R, Montoli, A, Bonucchi, D, Facchini, F, Furci, L, Ferretti, A, Nuzzi, F, Pecoraro, C, Visciano, B, Canavese, C, Radin, E, Stratta, P, Nordio, M, Benetti, E, Parolin, M, Alberici, F, Manenti, L, Brugnano, R, Manenti, F, Capitanini, A, Emma, F, Massella, L, Rosa, M, Mazzon, M, Basso, E, Besso, L, Lavacca, A, Mella, A, Bertero, M, Coppo, R, Peruzzi, L, Porcellini, M, Piccoli, G, Clari, R, Pasi, A, Gangemi, C, Alfandary, H, Dagan, A, Conceiçao, M, Sameiro, F, Croze, L, Malvezzi, P, Tsygin, A, Zelan, B, and Nastasi, N
- Subjects
0301 basic medicine ,Complement system ,Glomerulonephritis, Membranoproliferative ,membranoproliferative glomerulonephritis (MPGN) ,030232 urology & nephrology ,Disease ,Antigen-Antibody Complex ,Biology ,Kidney ,03 medical and health sciences ,0302 clinical medicine ,Glomerulopathy ,Clinical Research ,medicine ,Dense Deposit Disease ,Humans ,C3 glomerulopathy ,General Medicine ,Complement System Proteins ,C3 glomerulonephriti ,medicine.disease ,C3-convertase ,Immune complex ,030104 developmental biology ,Nephrology ,Immunology ,Alternative complement pathway ,Nephrotic syndrome ,Rare disease - Abstract
Membranoproliferative GN (MPGN) was recently reclassified as alternative pathway complement–mediated C3 glomerulopathy (C3G) and immune complex–mediated membranoproliferative GN (IC-MPGN). However, genetic and acquired alternative pathway abnormalities are also observed in IC-MPGN. Here, we explored the presence of distinct disease entities characterized by specific pathophysiologic mechanisms. We performed unsupervised hierarchical clustering, a data-driven statistical approach, on histologic, genetic, and clinical data and data regarding serum/plasma complement parameters from 173 patients with C3G/IC-MPGN. This approach divided patients into four clusters, indicating the existence of four different pathogenetic patterns. Specifically, this analysis separated patients with fluid-phase complement activation (clusters 1–3) who had low serum C3 levels and a high prevalence of genetic and acquired alternative pathway abnormalities from patients with solid-phase complement activation (cluster 4) who had normal or mildly altered serum C3, late disease onset, and poor renal survival. In patients with fluid-phase complement activation, those in clusters 1 and 2 had massive activation of the alternative pathway, including activation of the terminal pathway, and the highest prevalence of subendothelial deposits, but those in cluster 2 had additional activation of the classic pathway and the highest prevalence of nephrotic syndrome at disease onset. Patients in cluster 3 had prevalent activation of C3 convertase and highly electron-dense intramembranous deposits. In addition, we provide a simple algorithm to assign patients with C3G/IC-MPGN to specific clusters. These distinct clusters may facilitate clarification of disease etiology, improve risk assessment for ESRD, and pave the way for personalized treatment.
- Published
- 2017
37. Effects of Sevelamer Carbonate in Patients With CKD and Proteinuria: The ANSWER Randomized Trial
- Author
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Ruggiero, Barbara, primary, Trillini, Matias, additional, Tartaglione, Lida, additional, Rotondi, Silverio, additional, Perticucci, Elena, additional, Tripepi, Rocco, additional, Aparicio, Carolina, additional, Lecchi, Veruska, additional, Perna, Annalisa, additional, Peraro, Francesco, additional, Villa, Davide, additional, Ferrari, Silvia, additional, Cannata, Antonio, additional, Mazzaferro, Sandro, additional, Mallamaci, Francesca, additional, Zoccali, Carmine, additional, Bellasi, Antonio, additional, Cozzolino, Mario, additional, Remuzzi, Giuseppe, additional, Ruggenenti, Piero, additional, Kohan, Donald E., additional, Perico, N., additional, Ruggenenti, P., additional, Remuzzi, G., additional, Ruggiero, B., additional, Trillini, M., additional, Aparicio, C., additional, Tartaglione, L., additional, Rotondi, S., additional, Prandini, S., additional, Lecchi, V., additional, Cugini, D., additional, Gherardi, G., additional, Zoccali, C., additional, Mallamaci, F., additional, Parlongo, G., additional, Panuccio, V., additional, Caridi, G., additional, Tripepi, R., additional, Rubis, N., additional, Diadei, O., additional, Villa, D., additional, Carminati, S., additional, Martinetti, D., additional, Giuliano, G.A., additional, Perna, A., additional, Peraro, F., additional, Celeste, A., additional, Gaspari, F., additional, Carrara, F., additional, Ferrari, S., additional, Stucchi, N., additional, Cannata, A., additional, Mazzaferro, S., additional, Fassino, V., additional, Boccardo, P., additional, and Peracchi, S., additional
- Published
- 2019
- Full Text
- View/download PDF
38. C5 Convertase Blockade in Membranoproliferative Glomerulonephritis: A Single-Arm Clinical Trial
- Author
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Ruggenenti, Piero, primary, Daina, Erica, additional, Gennarini, Alessia, additional, Carrara, Camillo, additional, Gamba, Sara, additional, Noris, Marina, additional, Rubis, Nadia, additional, Peraro, Francesco, additional, Gaspari, Flavio, additional, Pasini, Andrea, additional, Rigotti, Angelo, additional, Lerchner, Renelda M., additional, Santoro, Domenico, additional, Pisani, Antonio, additional, Pasi, Alessandra, additional, Remuzzi, Giuseppe, additional, Remuzzi, G., additional, Ruggenenti, P., additional, Mondo, E., additional, Rota, S., additional, Carrara, C., additional, Portalupi, V., additional, Pasini, A., additional, Monitini, G., additional, Monti, E., additional, Rigotti, A., additional, De Giovanni, F., additional, Giacon, B., additional, Lerchner, R.M., additional, Passler, W., additional, Santoro, D., additional, Visconti, L., additional, Pisani, A., additional, Riccio, E., additional, Pasi, A., additional, Dugo, M., additional, Tuono, C., additional, Emma, F., additional, Vivarelli, M., additional, Murer, L., additional, Benetti, E., additional, Coppo, R., additional, Amore, A., additional, Gambaro, G., additional, Passalacqua, S., additional, Ruggiero, B., additional, Daina, E., additional, Bresin, E., additional, Gamba, S., additional, Prandini, S., additional, Lecchi, V., additional, Cugini, D., additional, Gherardi, G., additional, Rubis, N., additional, Diadei, O., additional, Villa, A., additional, Villa, D., additional, Boccardo, P., additional, Peracchi, S., additional, Martinetti, D., additional, Perna, A., additional, Peraro, F., additional, Giuliano, G.A., additional, Gaspari, F., additional, Carrara, F., additional, Ferrari, S., additional, Stucchi, N., additional, Cannata, A., additional, Noris, M., additional, Bettoni, S., additional, Alberti, M., additional, Cuccarolo, P., additional, Rizzo, P., additional, Marchetti, G.F., additional, and Sonzogni, A., additional
- Published
- 2019
- Full Text
- View/download PDF
39. Rhythmic and morphosyntactic predictions: The anticipation abilities of Italian children with developmental dyslexia
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Persici, V, Stucchi, N, Arosio, F, Persici, V, Stucchi, N, and Arosio, F
- Published
- 2018
40. Repulsive Serial Effects in Visual Numerosity Judgments
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Valsecchi, M, Stucchi, N, Scocchia, L, SCOCCHIA, LISA GIORGIA, Valsecchi, M, Stucchi, N, Scocchia, L, and SCOCCHIA, LISA GIORGIA
- Abstract
We investigated how the approximate perceived numerosity of ensembles of visual elements is modulated by the numerosity of previously viewed ensembles depending on whether the first ensemble is held in visual working memory or not. We show that the numerosity of the previously seen ensemble has a repulsive effect, that is, a stimulus with high numerosity induces an underestimation of the following one and vice versa. This repulsive effect is present regardless of whether the first stimulus is memorized or not. While subtle changes of the experimental paradigm can have major consequences for the nature of interstimulus dependencies in perception, generally speaking the fact that we found such effects in a visual numerosity estimation task confirms that the process by which human observers produce estimates of the number of elements bears analogies to the processes that lead to the perception of visual dimensions such as orientation.
- Published
- 2018
41. Predicting the future in rhythm and language: The anticipation skills of a group of Italian children
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Persici, V, Stucchi, N, Arosio, F, Valentina Persici, Natale Stucchi, Fabrizio Arosio, Persici, V, Stucchi, N, Arosio, F, Valentina Persici, Natale Stucchi, and Fabrizio Arosio
- Published
- 2018
42. Effects of Manidipine and Delapril in Hypertensive Patients With Type 2 Diabetes Mellitus
- Author
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Ruggenenti, P, Lauria, G, Iliev, IP, Fassi, A, Ilieva, AP, Rota, S, Chiurchiu, C, Barlovic, DP, Sghirlanzoni, A, Lombardi, R, Penza, P, CAVALETTI, GUIDO ANGELO, Piatti, ML, Frigeni, B, Filipponi, M, Rubis, N, Noris, G, Motterlini, N, Ene Iordache, B, Gaspari, F, Perna, A, Zaletel, J, Bossi, A, Dodesini, AR, TREVISAN, ROBERTO, Remuzzi, G, DEMAND Study Investigators, Parvanova, IA, Petrov, II, Yakymchuk, S, Arnoldi, F, Prandini, S, Kocijancic, A, Pongrac, D, Prezelj, J, Gala, T, Kersnik, M, Trevisan, G, Lepore, G, Mondo, E, Inversi, F, Mangili, R, Bruno, S, Brusegan, V, Lecchi, V, Belviso, A, Genovese, S, Pareyson, D, Camozzi, F, Cavaletti, G, Marzorati, L, MARMIROLI, PAOLA LORENA, Mattavelli, L, Tadini, S, Gherardi, G, Calini, W, Diadei, O, Rossoni, D, Villa, D, Carminati, S, Agus, E, Remuzzi, A, Giuliano, GA, Ganeva, M, Cannata, AN, Carrara, F, Cella, C, Centemeri, E, Ferrari, S, Petrò, C, Savoldelli, E, Stucchi, N, Boccardo, P, Perico, N, Peracchi, S, Gelmi, S, Mecca, G, Imbimbo, B, Alberici, M, Gardini, F, Lauria, G., Ruggenenti, P, Lauria, G, Iliev, I, Fassi, A, Ilieva, A, Rota, S, Chiurchiu, C, Barlovic, D, Sghirlanzoni, A, Lombardi, R, Penza, P, Cavaletti, G, Piatti, M, Frigeni, B, Filipponi, M, Rubis, N, Noris, G, Motterlini, N, Ene Iordache, B, Gaspari, F, Perna, A, Zaletel, J, Bossi, A, Dodesini, A, Trevisan, R, Remuzzi, G, DEMAND Study, I, Parvanova, I, Petrov, I, Yakymchuk, S, Arnoldi, F, Prandini, S, Kocijancic, A, Pongrac, D, Prezelj, J, Gala, T, Kersnik, M, Trevisan, G, Lepore, G, Mondo, E, Inversi, F, Mangili, R, Bruno, S, Brusegan, V, Lecchi, V, Belviso, A, Genovese, S, Pareyson, D, Camozzi, F, Marzorati, L, Marmiroli, P, Mattavelli, L, Tadini, S, Gherardi, G, Calini, W, Diadei, O, Rossoni, D, Villa, D, Carminati, S, Agus, E, Remuzzi, A, Giuliano, G, Ganeva, M, Cannata, A, Carrara, F, Cella, C, Centemeri, E, Ferrari, S, Petrò, C, Savoldelli, E, Stucchi, N, Boccardo, P, Perico, N, Peracchi, S, Gelmi, S, Mecca, G, Imbimbo, B, Alberici, M, and Gardini, F
- Subjects
Adult ,Blood Glucose ,Male ,Dihydropyridines ,medicine.medical_specialty ,Diabetic neuropathy ,Urology ,Renal function ,Delapril ,Angiotensin-Converting Enzyme Inhibitors ,Kidney Function Tests ,Placebo ,Risk Assessment ,Severity of Illness Index ,Drug Administration Schedule ,Piperazines ,Body Mass Index ,Manidipine ,Double-Blind Method ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,Diabetic Nephropathies ,Nitrobenzenes ,Aged ,Dose-Response Relationship, Drug ,diabetes ,business.industry ,Hazard ratio ,Middle Aged ,Calcium Channel Blockers ,Prognosis ,medicine.disease ,Survival Rate ,Treatment Outcome ,Endocrinology ,Diabetes Mellitus, Type 2 ,Hypertension ,Indans ,Albuminuria ,Drug Therapy, Combination ,Female ,medicine.symptom ,business ,medicine.drug - Abstract
To assess whether angiotensin-converting enzyme inhibitors and third-generation dihydropyridine calcium channel blockers ameliorate diabetic complications, we compared glomerular filtration rate (GFR; primary outcome), cardiovascular events, retinopathy, and neuropathy in 380 hypertensive type 2 diabetics with albuminuria 2 (IQR: 0.16–0.50 mL/min per 1.73 m 2 ) on combined therapy, 0.36 mL/min per 1.73 m 2 (IQR: 0.18–0.53 mL/min per 1.73 m 2 ) on delapril, and 0.30 mL/min per 1.73 m 2 (IQR: 0.12–0.50 mL/min per 1.73 m 2 ) on placebo ( P =0.87 and P =0.53 versus combined therapy or delapril, respectively). Similar findings were observed when baseline GFR values were not considered for slope analyses. Albuminuria was stable in the 3 treatment groups. The hazard ratio (95% CI) for major cardiovascular events between combined therapy and placebo was 0.17 (0.04–0.78; P =0.023). Among 192 subjects without retinopathy at inclusion, the hazard ratio for developing retinopathy between combined therapy and placebo was 0.27 (0.07–0.99; P =0.048). Among 200 subjects with centralized neurological evaluation, the odds ratios for peripheral neuropathy at 3 years between combined therapy or delapril and placebo were 0.45 (0.24–0.87; P =0.017) and 0.52 (0.27–0.99; P =0.048), respectively. Glucose disposal rate decreased from 5.8±2.4 to 5.3±1.9 mg/kg per min on placebo ( P =0.03) but did not change on combined or delapril therapy. Treatment was well tolerated. In hypertensive type 2 diabetic patients, combined manidipine and delapril therapy failed to slow GFR decline but safely ameliorated cardiovascular disease, retinopathy, and neuropathy and stabilized insulin sensitivity.
- Published
- 2011
43. Spatial alignment and response hand in geometric and motion illusions
- Author
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Scocchia, L, Paroli, M, Stucchi, N, Sedda, A, SCOCCHIA, LISA, STUCCHI, NATALE ADOLFO, Sedda, A., Scocchia, L, Paroli, M, Stucchi, N, Sedda, A, SCOCCHIA, LISA, STUCCHI, NATALE ADOLFO, and Sedda, A.
- Abstract
Perception of visual illusions is susceptible to manipulation of their spatial properties. Further, illusions can sometimes affect visually guided actions, especially the movement planning phase. Remarkably, visual properties of objects related to actions, such as affordances, can prime more accurate perceptual judgements. In spite of the amount of knowledge available on affordances and on the influence of illusions on actions (or lack of thereof), virtually nothing is known about the reverse: the influence of action-related parameters on the perception of visual illusions. Here, we tested a hypothesis that the response mode (that can be linked to action-relevant features) can affect perception of the Poggendorff (geometric) and of the Vanishing Point (motion) illusion. We explored the role of hand dominance (right dominant versus left non-dominant hand) and its interaction with stimulus spatial alignment (i.e., congruency between visual stimulus and the hand used for responses). Seventeen right-handed participants performed our tasks with their right and left hands, and the stimuli were presented in regular and mirror-reversed views. It turned out that the regular version of the Poggendorff display generates a stronger illusion compared to the mirror version, and that participants are less accurate and show more variability when they use their left hand in responding to the Vanishing Point. In summary, our results show that there is a marginal effect of hand precision in motion related illusions, which is absent for geometrical illusions. In the latter, attentional anisometry seems to play a greater role in generating the illusory effect. Taken together, our findings suggest that changes in the response mode (here: manual action-related parameters) do not necessarily affect illusion perception. Therefore, although intuitively speaking there should be at least unidirectional effects of perception on action, and possible interactions between the two systems, this sim
- Published
- 2017
44. Children's first handwriting productions show a rhythmic structure
- Author
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Pagliarini, E, Scocchia, L, Vernice, M, Zoppello, M, Ballottin, U, Bouamama, S, Guasti, M, Stucchi, N, VERNICE, MIRTA, GUASTI, MARIA TERESA, STUCCHI, NATALE ADOLFO, Pagliarini, E, Scocchia, L, Vernice, M, Zoppello, M, Ballottin, U, Bouamama, S, Guasti, M, Stucchi, N, VERNICE, MIRTA, GUASTI, MARIA TERESA, and STUCCHI, NATALE ADOLFO
- Abstract
Although much research has been concerned with the development of kinematic aspects of handwriting, little is known about the development along with age of two principles that govern its rhythmic organization: Homothety and Isochrony. Homothety states that the ratio between the durations of the single motor events composing a motor act remains invariant and independent from the total duration of the movement. Isochrony refers to the proportional relationship between the speed of movement execution and the length of its trajectory. The current study shows that children comply with both principles since their first grade of primary school. The precocious adherence to these principles suggests that an internal representation of the rhythm of handwriting is available before the age in which handwriting is performed automatically. Overall, these findings suggest that despite being a cultural acquisition, handwriting appears to be shaped by more general constraints on the timing planning of the movements.
- Published
- 2017
45. Predicting the future in rhythm and language: The anticipation abilities of a group of Italian-speaking preschoolers
- Author
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Persici, V, Stucchi, N, Arosio, F, PERSICI, VALENTINA, STUCCHI, NATALE ADOLFO, AROSIO, FABRIZIO, Persici, V, Stucchi, N, Arosio, F, PERSICI, VALENTINA, STUCCHI, NATALE ADOLFO, and AROSIO, FABRIZIO
- Published
- 2017
46. Assessment of exergames as treatment and prevention of dysgraphia
- Author
-
Ibáñez, J, González-Vargas, J, Azorín, J, Akay, M, Pons, J, Borghese, N, Palmiotto, C, Essenziale, J, Mainetti, R, Granocchio, E, Molteni, B, Sarti, D, Guasti, M, Stucchi, N, Pedrocchi, A, Ferrante, S, GUASTI, MARIA TERESA, STUCCHI, NATALE ADOLFO, Ferrante, S., Ibáñez, J, González-Vargas, J, Azorín, J, Akay, M, Pons, J, Borghese, N, Palmiotto, C, Essenziale, J, Mainetti, R, Granocchio, E, Molteni, B, Sarti, D, Guasti, M, Stucchi, N, Pedrocchi, A, Ferrante, S, GUASTI, MARIA TERESA, STUCCHI, NATALE ADOLFO, and Ferrante, S.
- Abstract
The dysgraphic disorder is usually underestimated and belatedly diagnosed. The need of prevention and early intervention focused on prewriting exercises emerges from the literature. We explore exergames to supply this need, together with an adequate assessment module of the training results. The exergames were designed in collaboration with clinicians and were tested on 16 kindergarten children. The movement data collected have allowed to provide some preliminary indexes of evaluation, that have shown to be consistent with the qualitative evaluation of the teachers. The use of the mobile application as a school exercise obtained positive feedback.
- Published
- 2017
47. Language, reading and motor control: get rhythm!
- Author
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Guasti, M, Pagliarini, E, Stucchi, N, Guasti, MT, Guasti, M, Pagliarini, E, Stucchi, N, and Guasti, MT
- Published
- 2017
48. Predicting the future in rhythm and language: The anticipation skills of a group of Italian-speaking children
- Author
-
Persici, V, Stucchi, N, Arosio, F, Persici, Valentina, Stucchi, Natale, Arosio, Fabrizio, Persici, V, Stucchi, N, Arosio, F, Persici, Valentina, Stucchi, Natale, and Arosio, Fabrizio
- Published
- 2017
49. The GFR and GFR decline cannot be accurately estimated in type 2 diabetics
- Author
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Gaspari, F, Ruggenenti, P, Porrini, E, Motterlini, N, Cannata, A, Carrara, F, Sosa, A, Cella, C, Ferrari, S, Stucchi, N, Parvanova, A, Iliev, I, Trevisan, R, Bossi, A, Zaletel, J, Remuzzi, G, Gaspari F, Ruggenenti P, Porrini E, Motterlini N, Cannata A, Carrara F, Sosa AJ, Cella C, Ferrari S, Stucchi N, Parvanova A, Iliev I, Trevisan R, Bossi A, Zaletel J, Remuzzi G, Gaspari, F, Ruggenenti, P, Porrini, E, Motterlini, N, Cannata, A, Carrara, F, Sosa, A, Cella, C, Ferrari, S, Stucchi, N, Parvanova, A, Iliev, I, Trevisan, R, Bossi, A, Zaletel, J, Remuzzi, G, Gaspari F, Ruggenenti P, Porrini E, Motterlini N, Cannata A, Carrara F, Sosa AJ, Cella C, Ferrari S, Stucchi N, Parvanova A, Iliev I, Trevisan R, Bossi A, Zaletel J, and Remuzzi G
- Abstract
There are no adequate studies that have formally tested the performance of different estimating formulas in patients with type 2 diabetes both with and without overt nephropathy. Here we evaluated the agreement between baseline GFRs, GFR changes at month 6, and long-term GFR decline measured by iohexol plasma clearance or estimated by 15 creatinine-based formulas in 600 type 2 diabetics followed for a median of 4.0 years. Ninety patients were hyperfiltering. The number of those identified by estimation formulas ranged from 0 to 24:58 were not identified by any formula. Baseline GFR was significantly underestimated and a 6-month GFR reduction was missed in hyperfiltering patients. Long-term GFR decline was also underestimated by all formulas in the whole study group and in hyper-, normo-, and hypofiltering patients considered separately. Five formulas generated positive slopes in hyperfiltering patients. Baseline concordance correlation coefficients and total deviation indexes ranged from 32.1% to 92.6% and from 0.21 to 0.53, respectively. Concordance correlation coefficients between estimated and measured long-term GFR decline ranged from -0.21 to 0.35. The agreement between estimated and measured values was also poor within each subgroup considered separately. Thus, our study questions the use of any estimation formula to identify hyperfiltering patients and monitor renal disease progression and response to treatment in type 2 diabetics without overt nephropathy.
- Published
- 2013
50. Measuring and estimating GFR and treatment effect in ADPKD patients: results and implications of a longitudinal cohort study
- Author
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Ruggenenti P, Gaspari F, Cannata A, Carrara F, Cella C, Ferrari S, Stucchi N, Prandini S, Ene Iordache B, Diadei O, Perico N, Ondei P, Buongiorno E, Messa P, Dugo M, Remuzzi G, GFR ADPKD Study Group, PISANI, ANTONIO, Ruggenenti, P, Gaspari, F, Cannata, A, Carrara, F, Cella, C, Ferrari, S, Stucchi, N, Prandini, S, Ene Iordache, B, Diadei, O, Perico, N, Ondei, P, Pisani, Antonio, Buongiorno, E, Messa, P, Dugo, M, Remuzzi, G, and GFR ADPKD Study, Group
- Subjects
Nephrology ,Adult ,Male ,medicine.medical_specialty ,Anatomy and Physiology ,Clinical Research Design ,Iohexol ,Science ,Urology ,Autosomal dominant polycystic kidney disease ,Renal function ,urologic and male genital diseases ,Cohort Studies ,chemistry.chemical_compound ,Internal medicine ,medicine ,Polycystic kidney disease ,Humans ,Biology ,Creatinine ,Multidisciplinary ,Models, Statistical ,business.industry ,urogenital system ,Reproducibility of Results ,Renal System ,Middle Aged ,medicine.disease ,Polycystic Kidney, Autosomal Dominant ,female genital diseases and pregnancy complications ,Endocrinology ,Treatment Outcome ,chemistry ,Research Design ,Disease Progression ,Medicine ,Female ,sense organs ,business ,medicine.drug ,Kidney disease ,Cohort study ,Research Article ,Glomerular Filtration Rate - Abstract
Trials failed to demonstrate protective effects of investigational treatments on glomerular filtration rate (GFR) reduction in Autosomal Dominant Polycystic Kidney Disease (ADPKD). To assess whether above findings were explained by unreliable GFR estimates, in this academic study we compared GFR values centrally measured by iohexol plasma clearance with corresponding values estimated by Chronic Kidney Disease Epidemiology Collaboration (CKD-Epi) and abbreviated Modification of Diet in Renal Disease (aMDRD) formulas in ADPKD patients retrieved from four clinical trials run by a Clinical Research Center and five Nephrology Units in Italy. Measured baseline GFRs and one-year GFR changes averaged 78.6±26.7 and 8.4±10.3 mL/min/1.73 m(2) in 111 and 71 ADPKD patients, respectively. CKD-Epi significantly overestimated and aMDRD underestimated baseline GFRs. Less than half estimates deviated by
- Published
- 2012
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