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Your search keyword '"Stubbs, Amy M."' showing total 8 results
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8 results on '"Stubbs, Amy M."'

1. Effectiveness of a bivalent mRNA vaccine dose against symptomatic SARS-CoV-2 infection among U.S. Healthcare personnel, September 2022–May 2023

Author

Plumb, Ian D., primary, Briggs Hagen, Melissa, additional, Wiegand, Ryan, additional, Dumyati, Ghinwa, additional, Myers, Christopher, additional, Harland, Karisa K., additional, Krishnadasan, Anusha, additional, James Gist, Jade, additional, Abedi, Glen, additional, Fleming-Dutra, Katherine E., additional, Chea, Nora, additional, Lee, Jane E., additional, Kellogg, Melissa, additional, Edmundson, Alexandra, additional, Britton, Amber, additional, Wilson, Lucy E., additional, Lovett, Sara A., additional, Ocampo, Valerie, additional, Markus, Tiffanie M., additional, Smithline, Howard A., additional, Hou, Peter C., additional, Lee, Lilly C., additional, Mower, William, additional, Rwamwejo, Fernand, additional, Steele, Mark T., additional, Lim, Stephen C., additional, Schrading, Walter A., additional, Chinnock, Brian, additional, Beiser, David G., additional, Faine, Brett, additional, Haran, John P., additional, Nandi, Utsav, additional, Chipman, Anne K., additional, LoVecchio, Frank, additional, Eucker, Stephanie, additional, Femling, Jon, additional, Fuller, Matthew, additional, Rothman, Richard E., additional, Curlin, Marcel E., additional, Talan, David A., additional, Mohr, Nicholas M., additional, Watts, Christopher, additional, McCullough, Matthew, additional, Nyanseor, Sankan, additional, Licherdell, Erin, additional, Peebles, Alexander, additional, Nadle, Joelle, additional, Johnston, Helen, additional, Brackney, Monica, additional, Fridkin, Scott, additional, Marceaux-Galli, Kaytlynn, additional, Lynfield, Ruth, additional, Pierce, Rebecca, additional, Keipp Talbot, H., additional, Tozloski, Jillian, additional, Hashimoto, Dean M., additional, Bahamon, Monica, additional, Krebs, Elizabeth, additional, Stubbs, Amy M., additional, Huber, Michelle, additional, Crosby, James C., additional, Roy, Sara, additional, Volturo, Gregory, additional, Galbraith, James, additional, Fuentes, Megan, additional, Smith, Jennifer, additional, Olivia Hopkins, Leslie, additional, Stuppy, Joseph, additional, Dashler, Gaby, additional, and Wahedi, Mastura, additional

Published
2023
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2. 531. Clinical Evaluation of the BioFire® FilmArray® Gastrointestinal (GI) Panel for use with Rectal Swab Specimens in Cary-Blair Media

Author

Goos, Jared, primary, Neff, Crissy, additional, Holmberg, Kristen, additional, Lyons, Annie, additional, Monroe, Nicole, additional, Selvarangan, Rangaraj, additional, Banerjee, Dithi, additional, Hueschen, Leslie A, additional, Chapin, Kimberle, additional, Tansarli, Giannoula, additional, Silbert, Suzane, additional, Lima, Amorce, additional, Connor, Bradley A, additional, Rogova, Marina, additional, Steele, Mark, additional, Stubbs, Amy M, additional, Bard, Jennifer Dien, additional, Flores-Vazquez, Jessica, additional, and Andjelic, Cynthia, additional

Published
2022
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4. Performance of PCR/electrospray ionization-mass spectrometry on whole blood for detection of bloodstream microorganisms in patients with suspected sepsis

Author

Strålin, Kristoffer, Rothman, Richard E., Özenci, Volkan, Barkataki, Kieron, Brealey, David, Dhiman, Neelam, Poling, Lara, Kurz, Michael C., Limaye, Ajit P., LoVecchio, Frank, Lowery, Kristin, Miller, Loren G., Moran, Gregory J., Overcash, J. Scott, Parekh, Amisha, Peacock, W. Frank, Rivers, Emanuel P., Sims, Matthew, Stubbs, Amy M., Sundqvist, Martin, Ullberg, Måns, Carroll, Karen C., Strålin, Kristoffer, Rothman, Richard E., Özenci, Volkan, Barkataki, Kieron, Brealey, David, Dhiman, Neelam, Poling, Lara, Kurz, Michael C., Limaye, Ajit P., LoVecchio, Frank, Lowery, Kristin, Miller, Loren G., Moran, Gregory J., Overcash, J. Scott, Parekh, Amisha, Peacock, W. Frank, Rivers, Emanuel P., Sims, Matthew, Stubbs, Amy M., Sundqvist, Martin, Ullberg, Måns, and Carroll, Karen C.

Abstract

Blood culture (BC) often fails to detect bloodstream microorganisms in sepsis. However, molecular diagnostics hold great potential. The molecular method PCR/electrospray ionization-mass spectrometry (PCR/ESI-MS) can detect DNA from hundreds of different microorganisms in whole blood. The aim of the present study was to evaluate the performance of this method in a multicenter study including 16 teaching hospitals in the USA (n=13) and Europe (n=3). First, on 2,754 contrived whole blood samples, with or without spiked microorganisms, PCR/ESI-MS produced 99.1% true positive and 97.2% true negative results. Secondly, among 1,460 patients with suspected sepsis (sepsis-2 definition), BC and PCR/ESI-MS on whole blood were positive in 14.6% and 25.6% of cases, respectively, with the following result combinations: BC+/PCR/ESI-MS-, 4.3%; BC+/PCR/ESI-MS+, 10.3%; BC-/PCR/ESI-MS+, 15.3%; and BC-/PCR/ESI-MS-, 70.1%. Compared with BC, PCR/ESI-MS showed the following sensitivities (coagulase-negative staphylococci not included): Gram-positive bacteria, 58%; Gram-negative bacteria, 78%; and Candida species, 83%. The specificities were > 94% for all individual species. Patients treated with prior antimicrobial medications (n=603) had significantly increased PCR/ESI-MS positivity rates compared with patients without prior antimicrobial treatment, 31% vs 22% (p<0.0001), with pronounced differences for Gram-negative bacteria and Candida species. In conclusion, PCR/ESI-MS showed excellent performance on contrived samples. On clinical samples, it showed high specificities, moderately high sensitivities for Gram-negative bacteria and Candida species, and elevated positivity rates during antimicrobial treatment. These promising results encourage further development of molecular diagnostics on whole blood for detection of bloodstream microorganisms in sepsis., Funding Agencies:Ibis Biosciences, a division of Abbott Abbott LaboratoriesCepheid ContraFect Nabriva Therapeutics AG Lajolla Pharmaceuticals Alere Corporation Spectral Diagnostics Ferring Pharmaceuticals Inflammix VICTASm Sanofi Pasteur Inc. Curetis GmbH PfizerMerck & CompanyCidara Therapeutics Inc. Shire Aridis Pharmaceuticals Inc. Epigenomics Inc. Roche Holding GenentechFinch Therapeutics Seres Therapeutics Inc. Diasorin Molecular Janssen Research and Development NeuMoDx Molecular Iterum Therapeutics International

Published
2020
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5. Emergence of Extended-Spectrum β-Lactamase Urinary Tract Infections Among Hospitalized Emergency Department Patients in the United States

Author

Talan, David A., primary, Takhar, Sukhjit S., additional, Krishnadasan, Anusha, additional, Mower, William R., additional, Pallin, Daniel J., additional, Garg, Manish, additional, Femling, Jon, additional, Rothman, Richard E., additional, Moore, Johanna C., additional, Jones, Alan E., additional, Lovecchio, Frank, additional, Jui, Jonathan, additional, Steele, Mark T., additional, Stubbs, Amy M., additional, Chiang, William K., additional, and Moran, Gregory J., additional

Published
2021
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6. Performance of PCR/Electrospray Ionization-Mass Spectrometry on Whole Blood for Detection of Bloodstream Microorganisms in Patients with Suspected Sepsis

Author

Strålin, Kristoffer, primary, Rothman, Richard E., additional, Özenci, Volkan, additional, Barkataki, Kieron, additional, Brealey, David, additional, Dhiman, Neelam, additional, Poling, Lara, additional, Kurz, Michael C., additional, Limaye, Ajit P., additional, LoVecchio, Frank, additional, Lowery, Kristin, additional, Miller, Loren G., additional, Moran, Gregory J., additional, Overcash, J. Scott, additional, Parekh, Amisha, additional, Peacock, W. Frank, additional, Rivers, Emanuel P., additional, Sims, Matthew, additional, Stubbs, Amy M., additional, Sundqvist, Martin, additional, Ullberg, Måns, additional, and Carroll, Karen C., additional

Published
2020
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8. Initial approach to the patient with impaired consciousness.

Author

Stubbs AM

Subjects
Airway Resistance, Consciousness Disorders therapy, Diagnosis, Differential, Glasgow Coma Scale, Humans, Hypotension, Prognosis, Risk Factors, Time Factors, Consciousness Disorders diagnosis
Abstract

Patients presenting with impaired consciousness are often challenging to diagnose and treat. Etiologies are multiple and varied. Obtaining an accurate history and physical exam is often difficult with the altered patient. It is essential for the physician initially evaluating the patient to have a prioritized, systematic approach. The primary goals are to stabilize the patient, rapidly recognize and treat reversible causes, and disposition the patient appropriately to avoid potential morbidity and mortality.

Published
2008

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