Search

Your search keyword '"Stuart Elborn J"' showing total 46 results
Start Over Author "Stuart Elborn J"
46 results on '"Stuart Elborn J"'

3. Failure to conceive in women with CF is associated with pancreatic insufficiency and advancing age

Author

Shteinberg, Michal, Lulu, Adi Ben, Downey, Damian G., Blumenfeld, Zeev, Rousset-Jablonski, Christine, Perceval, Marie, Colombo, Alessandra, Stein, Nili, Livnat, Galit, Gur, Michal, Bentur, Lea, Mussaffi, Huda, Blau, Hannah, Sarouk, Ifat, Dagan, Adi, Kerem, Eitan, Aviram, Micha, Picard, Elie, Aliberti, Stefano, Álvarez, Antonio, Miranda, Javier Perez, Polverino, Eva, Durieu, Isabelle, Stuart Elborn, J., and Cohen-Cymberknoh, Malena

Published
2019
Full Text
View/download PDF

10. Placebo effects in pharmaceutical clinical trials in bronchiectasis: an EMBARC study

Author

Gao, Yonghua, primary, Lonergan, Mike, additional, Abo-Leyah, Hani, additional, Aliberti, Stefano, additional, Menendez, Rosario, additional, Blasi, Francesco, additional, Regis-Burgel, Pierre, additional, Ringshausen, Felix, additional, De Soyza, Anthony, additional, Vendrell, Montserrat, additional, Polverino, Eva, additional, Skrgat, Sabina, additional, Van Der Eerden, Menno, additional, Boersma, Wim, additional, Sibila, Oriol, additional, Mcdonnell, Melissa, additional, Kauppi, Paula, additional, Botnaru, Victor, additional, Van Braeckel, Eva, additional, Lorent, Natalie, additional, Rademacher, Jessica, additional, Haworth, Charles, additional, Dimakou, Katerina, additional, Loebinger, Michael R, additional, Torres, Antoni, additional, Welte, Tobias, additional, Stuart Elborn, J, additional, Crichton, Megan L, additional, Goeminne, Pieter C, additional, Shteinberg, Michal, additional, Shoemark, Amelia, additional, Altenburg, Josje, additional, and Chalmers, James D, additional

Published
2020
Full Text
View/download PDF

11. Antimicrobial resistance in cystic fibrosis: a Delphi approach to defining best practices

Author

Zemanick, E, Burgel, P-R, Taccetti, G, Holmes, A, Ratjen, F, Byrnes, CA, Waters, VJ, Bell, SC, VanDevanter, DR, Stuart Elborn, J, Flume, PA, Antimicrobial Resistance International Working Group in Cystic Fibrosis, and National Institute for Health Research

Subjects
Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Consensus, Delphi Technique, Systematic survey, International Cooperation, Best practice, ERADICATION, Respiratory System, MEDLINE, Delphi method, Microbial Sensitivity Tests, MRSA, Antimicrobial resistance, Cystic fibrosis, Antibiotic resistance, Drug Resistance, Bacterial, INFECTION, medicine, Humans, Child, Intensive care medicine, Antimicrobial Resistance International Working Group in Cystic Fibrosis, Science & Technology, business.industry, Patient Selection, 1103 Clinical Sciences, medicine.disease, Response to treatment, Anti-Bacterial Agents, Treatment Outcome, Infectious disease (medical specialty), Pediatrics, Perinatology and Child Health, Critical Pathways, business, Life Sciences & Biomedicine, Procedures and Techniques Utilization
Abstract

Background Antimicrobial susceptibility testing (AST) is a cornerstone of infection management in cystic fibrosis. However, there is little evidence that AST predicts the clinical outcome of CF antimicrobial treatment. It has been suggested there is a need for careful consideration of current AST use by the CF community. Methods We engaged a group of experts consisting of pulmonary (adult and pediatric) and infectious disease clinicians, microbiologists, and pharmacists representing a broad international experience. We conducted an iterative systematic survey (Delphi) to determine and quantify consensus regarding key questions facing CF clinicians in the use of respiratory culture results including what tests to order, when to obtain them, and how to act upon the results of the testing. Results Consensus was reached for many questions but there was not universal agreement to the questions that were addressed. There were some differences with respect to cultures obtained for surveillance compared to when there is clinical worsening. Areas of general consensus include when and how respiratory cultures should be performed, what information should be reported, and when AST should be performed. A key finding is that clinical response to treatment is used to guide treatment decisions rather than AST results. Conclusions Recommendations are presented regarding questions related to microbiology testing for patients with CF. We have also offered recommendations for priority research questions.

Published
2019

12. Anaerobic bacteria cultured from cystic fibrosis airways correlate to milder disease: A multisite study

Author

Thomas, S.D., Gilligan, P.H., Gotman, N., Lavelle, G., Mirkovic, B., Muhlebach, M.S., McGrath, S.J., Gilipin, D.F., Hatch, J.E., Einarsson, G.G., Tunney, M.M., McElvaney, N.G., McNally, P., Wolfgang, M.C., Stuart Elborn, J., Boucher, R.C., and Murray, M.A.

Abstract

Anaerobic and aerobic bacteria were quantitated in respiratory samples across three cystic fibrosis (CF) centres using extended culture methods. Subjects aged 1–69 years who were clinically stable provided sputum (n=200) or bronchoalveolar lavage (n=55). 18 anaerobic and 39 aerobic genera were cultured from 59% and 95% of samples, respectively; 16 out of 57 genera had a 5% prevalence across centres. Analyses of microbial communities using co-occurrence networks in sputum samples showed groupings of oral, including anaerobic, bacteria, whereas typical CF pathogens formed distinct entities. Pseudomonas was associated with worse nutrition and F508del genotype, whereas anaerobe prevalence was positively associated with pancreatic sufficiency, better nutrition and better lung function. A higher total anaerobe/ total aerobe CFU ratio was associated with pancreatic sufficiency and better nutrition. Subjects grouped by factor analysis who had relative dominance of anaerobes over aerobes had milder disease compared with a Pseudomonas-dominated group with similar proportions of subjects that were homozygous for F508del. In summary, anaerobic bacteria occurred at an early age. In sputum-producing subjects anaerobic bacteria were associated with milder disease, suggesting that targeted eradication of anaerobes may not be warranted in sputum-producing CF subjects.

Published
2018
Full Text
View/download PDF

13. British Thoracic Society Guideline for bronchiectasis in adults

Author

T Hill, Adam, primary, L Sullivan, Anita, additional, D Chalmers, James, additional, De Soyza, Anthony, additional, Stuart Elborn, J, additional, Andres Floto, R, additional, Grillo, Lizzie, additional, Gruffydd-Jones, Kevin, additional, Harvey, Alex, additional, S Haworth, Charles, additional, Hiscocks, Edwin, additional, R Hurst, John, additional, Johnson, Christopher, additional, Peter Kelleher, W, additional, Bedi, Pallavi, additional, Payne, Karen, additional, Saleh, Hashem, additional, J Screaton, Nicholas, additional, Smith, Maeve, additional, Tunney, Michael, additional, Whitters, Deborah, additional, Wilson, Robert, additional, and R Loebinger, Michael, additional

Published
2018
Full Text
View/download PDF

16. Mechanisms of reduced susceptibility and genotypic prediction of antibiotic resistance in Prevotella isolated from cystic fibrosis (CF) and non-CF patients

Author

Sherrard, Laura J, primary, Schaible, Bettina, additional, Graham, Kathryn A, additional, McGrath, Stef J, additional, McIlreavey, Leanne, additional, Hatch, Joseph, additional, Wolfgang, Matthew C, additional, Muhlebach, Marianne S, additional, Gilpin, Deirdre F, additional, Schneiders, Thamarai, additional, Stuart Elborn, J, additional, and Tunney, Michael M, additional

Published
2018
Full Text
View/download PDF

19. British Thoracic Society Guideline for bronchiectasis in adults

Author

T Hill, Adam, L Sullivan, Anita, D Chalmers, James, De Soyza, Anthony, Stuart Elborn, J, Andres Floto, R, Grillo, Lizzie, Gruffydd-Jones, Kevin, Harvey, Alex, S Haworth, Charles, Hiscocks, Edwin, R Hurst, John, Johnson, Christopher, Peter Kelleher, W, Bedi, Pallavi, Payne, Karen, Saleh, Hashem, J Screaton, Nicholas, Smith, Maeve, Tunney, Michael, Whitters, Deborah, Wilson, Robert, and R Loebinger, Michael

Published
2019
Full Text
View/download PDF

25. EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity

Author

Darrah, Rebecca, primary, McKone, Edward, additional, O'Connor, Clare, additional, Rodgers, Christine, additional, Genatossio, Alan, additional, McNamara, Sharon, additional, Gibson, Ronald, additional, Stuart Elborn, J., additional, Ennis, Madeleine, additional, Gallagher, Charles G., additional, Kalsheker, Noor, additional, Aitken, Moira, additional, Wiese, Dawn, additional, Dunn, John, additional, Smith, Paul, additional, Pace, Rhonda, additional, Londono, Douglas, additional, Goddard, Katrina A. B., additional, Knowles, Michael R., additional, and Drumm, Mitchell L., additional

Published
2010
Full Text
View/download PDF

26. No Evidence of Transmission of Bacteria Between Reptiles and a CF Patient - A Case Report of a Young Adult CF Patient and Reptiles

Author

Maeda, Y., primary, Stanley, T., additional, Stirling, J., additional, Griffiths, M., additional, Calvert, A., additional, Stuart Elborn, J., additional, Cherie Millar, B., additional, Goldsmith, C. E., additional, Rendall, J., additional, Loughrey, A., additional, Rooney, P. J., additional, and Moore, J. E., additional

Published
2009
Full Text
View/download PDF

28. Emergence of Scedosporium apiospermum in patients with cystic fibrosis

Author

Nagano, Yuriko, Millar, B. Cherie, Goldsmith, Colin E., Stuart Elborn, J., Rendall, Jackie, and Moore, John E.

Subjects
Saprophytes -- Identification and classification, Cystic fibrosis -- Complications and side effects, Cystic fibrosis -- Case studies
Published
2007

35. SMAD inhibition attenuates epithelial to mesenchymal transition by primary keratinocytes in vitro.

Author

O'Kane, Donal, Jackson, Megan V., Kissenpfennig, Adrien, Spence, Shaun, Damkat‐Thomas, Lindsay, Tolland, Julia P., Smyth, Anita E., Denton, Christopher P., Stuart Elborn, J., McAuley, Daniel F., and O'Kane, Cecilia M.

Subjects
EPITHELIAL cells, KERATINOCYTES, TRANSFORMING growth factors-beta, TUMOR necrosis factors, SCLERODERMA (Disease), HYPERTROPHIC scars, CYTOKINES
Abstract

Epithelial to mesenchymal transition ( EMT) is a process whereby epithelial cells undergo transition to a mesenchymal phenotype and contribute directly to fibrotic disease. Recent studies support a role for EMT in cutaneous fibrotic diseases including scleroderma and hypertrophic scarring, although there is limited data on the cytokines and signalling mechanisms regulating cutaneous EMT. We investigated the ability of TGF- β and TNF- α, both overexpressed in cutaneous scleroderma and central mediators of EMT in other epithelial cell types, to induce EMT in primary keratinocytes and studied the signalling mechanisms regulating this process. TGF- β induced EMT in normal human epidermal keratinocytes ( NHEK cells), and this process was enhanced by TNF- α. EMT was characterised by changes in morphology, proteome (down-regulation of E-cadherin and Zo-1 and up-regulation of vimentin and fibronectin), MMP secretion and COL1 α1 mRNA expression. TGF- β and TNF- α in combination activated SMAD and p38 signalling in NHEK cells. P38 inhibition with SB203580 partially attenuated EMT, whereas SMAD inhibition using SB431542 significantly inhibited EMT and also reversed established EMT. These data highlight the retained plasticity of adult keratinocytes and support further studies of EMT in clinically relevant in vivo models of cutaneous fibrosis and investigation of SMAD inhibition as a potential therapeutic intervention. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

38. No Evidence of Transmission of Bacteria Between Reptiles and a CF Patient - A Case Report of a Young Adult CF Patient and Reptiles Y. Maeda et al. Case Report of a Young Adult CF Patient and Reptiles.

Author

Maeda, Y., Stanley, T., Stirling, J., Griffiths, M., Calvert, A., Stuart Elborn, J., Cherie Millar, B., Goldsmith, C. E., Rendall, J., Loughrey, A., Rooney, P. J., and Moore, J. E.

Subjects
CYSTIC fibrosis, ATYPICAL mycobacteria, PSEUDOMONAS aeruginosa, GRAM-negative bacteria, ZOONOSES, HEALTH risk assessment, REPTILES as laboratory animals
Abstract

A microbiological study was undertaken to assess the risk of infection to a CF patient from a collection of pet reptiles, particularly atypical mycobacteria. This study helped to verify that the reptiles under the care of the CF patient did not harbour bacterial organisms that would normally be pathogenic to CF patients. However, the chronic carriage of Pseudomonas aeruginosa and other pathogens in the CF patient may constitute a greater risk of infection to the animals being handled. Therefore, we recommend stringent infection control precautions by CF patients and their pets, particularly adherence to hand washing and disinfection, when handling the animals, their litter or when working with their immediate environment, to potentially minimize the spread of bacterial and other pathogens from animal to human and vice versa. Detailed risk assessments therefore need to be undertaken by clinicians and veterinarians to detail working models that protect both animals and patients from pathogens originating from the other. [ABSTRACT FROM AUTHOR]

Published
2010
Full Text
View/download PDF

39. Advanced curriculum for cystic fibrosis: Integrating genomic-driven data into patient-centered treatment strategies

Author

Stuart Elborn, J., Sermet-Gaudelus, Isabelle, Flume, Patrick A., Madge, Susan, Cerny, Frank, P.Clancy, John, Bichl, Sandy, and Morton, Alison

Subjects
Cystic fibrosis -- Care and treatment, Business, international
Abstract

Abstract Owing to the high frequency and serious nature of cystic fibrosis, the development of targeted therapies for the management of this disease has been an active area of research. [...]

Published
2016

45. TACKLING ANTIMICROBIAL RESISTANCE (AMR) - IN VITRO EFFECT OF SODIUM CHLORIDE ON ANTIBIOTIC SUSCEPTIBILITY IN CLINICAL PSEUDOMONAS AERUGINOSA ISOLATED FROM PATIENTS WITH CYSTIC FIBROSIS (CF).

Author

Gramegna A, Cherie Millar B, Contarini M, Blasi F, Stuart Elborn J, Downey DG, and Moore JE

Subjects
Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Drug Resistance, Bacterial, Humans, Sodium Chloride, Cystic Fibrosis complications, Cystic Fibrosis drug therapy, Pseudomonas aeruginosa
Abstract

Competing Interests: DECLARATION OF INTERESTS: The authors have no interests to declare.

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results