1. Urinary syndecan‐1 in dogs anesthetized with isoflurane or sevoflurane: A randomized, prospective study
- Author
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Stephanie Harris, Katherine Gerken, Stuart Clark‐Price, Ellan Hung, Tom Jukier, Amy Yanke, Kendon Kuo, and Maureen McMichael
- Subjects
canine ,endothelium ,glycocalyx ,glycosaminoglycans ,inhalant anesthesia ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Background Syndecan‐1 (SDC1) is an established marker of endothelial glycocalyx shedding. Most research on SDC1 has focused on plasma or serum concentrations, and little is known about urine concentrations. Objectives Measure urinary SDC1 concentrations in dogs undergoing anesthesia with either sevoflurane or isoflurane and assess the effects of anesthesia duration and IV crystalloids on urinary SDC1 concentrations. Animals Thirty‐one client‐owned dogs undergoing anesthesia for magnetic resonance imaging (MRI) with or without surgery for suspected intervertebral disk disease (IVDD) were used. Methods Dogs with suspected IVDD were randomized to undergo anesthesia with either sevoflurane or isoflurane. Urine was collected before and immediately after anesthesia for the analysis of SDC1. Urinary creatinine concentrations also were measured, and the ratio of urinary SDC1 to urinary creatinine (USCR) was used to account for dilution. Results Median (range) USCR was significantly higher after anesthesia compared with baseline for all groups combined (P
- Published
- 2024
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