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Your search keyword '"Struyker-Boudier, Harry A.J."' showing total 35 results
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35 results on '"Struyker-Boudier, Harry A.J."'

1. Cardiac function in a rat model of chronic aortic stiffness

Author

Lartaud-Idjouadiene, Isabelle, Niederhoffer, Nathalie, Debets, Jack J.M., Struyker-Boudier, Harry A.J., Atkinson, Jeffrey, and Smits, Jos F.M.

Subjects
Aorta -- Physiological aspects, Hypertension -- Physiological aspects, Rats as laboratory animals -- Physiological aspects, Cardiovascular system -- Physiological aspects, Biological sciences
Abstract

The effects of aortic stiffness on cardiac function were analyzed in VDN rats treated with vitamin D3 and nicotine. VDN rat models of aortic elastocalcinosis exhibited impaired cardiovascular reflexes due to increased arterial PCO2 and hypotensive hemorrhage. However, prolonged exposure to increased aortic stiffness and pulsatile load in normotensive VDN rats did not modify intrinsic cardiac control mechanisms. Furthermore, increased stiffness of the large diameter vessels close to the heart increased ventricular overload and modified cardiac performance.

Published
1997

20. A functional morphometric study of the cremaster muscle microcirculation in young spontaneously hypertensive rats

Author

Noble, Jos L M L L. M. L le, Tangelder, Geert J., Slaaf, Dick W., van Essen, Helma, Reneman, Robert S., and Struyker-Boudier, Harry A.J.

Abstract

Increased vascular resistance in spontaneous hypertension has been attributed to a reduced arteriolar lumen and a decrease in the number of arterioles and capillaries. In the present study, microvascular mechanisms for increased resistance were investigated in the cremaster muscle of 5-6-week-old spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto rats (WKY) using intravital microscopy. Vessels were classified on the basis of their location in the network relative to their branching order and function (A1—A4). In each preparation, one vessel of each category was observed for its side-branches, using bright-field microscopy. By comparing the number of side-branches seen under control conditions and after maximal vasodilatation (10~3mol/l adenosine, topically) we assessed their functional reserve. Capillary density was investigated using incident fluorescence microscopy. Both under control conditions and after vasodilatation, mean arterial pressure and heart rate were increased in SHR (mean arterial pressure SHR 103±4mmHg, WKY 89 ± 3mmHg, P<0.05; heart rate SHR 380 ± 16 beats/min, WKY 343 ± 12 beats/min, P<0.05). Arterioles (A1-A4) of SHR and WKY were equal in diameter (SHR 75.8 ± 3.2, 48.7 ± 1.1, 21.4 ± 0.9, 10.0 ± 0.04 ^m; WKY 71.6 ± 2.4, 48.9 ± 1.1, 18.5 ± 0.9, 9.8 ± 0.3 urn; A1-A4, respectively). After adenosine, the relative increase in diameter was similar in both groups. The number of side-branches under control conditions was similar in A1 and A2 vessels. SHR had fewer A3 vessels per A2 and fewer A4 vessels per A3 (per unit length), indicating a diminished arteriolar reserve. SHR capillary density was lower under control conditions (SHR 33.1 ± 1.2 mm/mm2; WKY 44.9 ± 1.7 mm/mm2; P<0.05). No capillary recruitment occurred during adenosine administration. We conclude that, in the early phase of spontaneous hypertension, a structurally diminished functional arteriolar reserve and a reduced capillary density, rather than a decreased dilating capacity or a reduced vessel lumen, are the primary mechanisms leading to the increased vascular resistance in cremaster muscle.

Published
1990

21. In vivo DNA synthesis is not uniformly increased in arterial smooth muscle of young spontaneously hypertensive rats

Author

Mey, Jo G.R. De, Daemen, Mat J.A.P., Boonen, Harrie C.M., Bosman, Fre T., Dijkstra, Ellis H., Fazzi, Gregorio E., Janssen, Ger M.J., Schiffers, Paul M.H., Struyker-Boudier, Harry A.J., and Vrijdag, Marian J.J.F.

Abstract

We compared the distribution of DNA synthesis over the arterial tree of young normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) with marginally elevated blood pressure. Six-week-old male SHR and WKY rats were therefore infused with 5-bromo-2'-deoxyuridine (BrdUrd) for 2 days and the nuclear incorporation of the thymidine analogue in the media of various arteries was determined by immunohistochemistry. In WKY rats, 2.5 of the arterial smooth muscle nuclei in elastic, muscular and resistance arteries incorporated BrdUrd. In SHR, DNA synthesis was more marked in large arteries than in resistance arteries. It was in addition significantly larger in the aorta, superior mesenteric, renal and femoral arteries of the SHR than in those of the WKY rats. However, nuclear incorporation of BrdUrd in vivo did not differ between SHR and WKY rats in aortic endothelium, carotid arterial smooth muscle, nor in mesenteric or renal resistance arteries. Between 6 and 20 weeks of age, the number of nuclear profiles per media cross-section did not increase in large arteries of WKY rats and SHR. During this period of time, however, carotid artery and thoracic aorta weight and DNA content increased. SHR large arteries gained more DNA than those of WKY rats. These data indicate that DNA synthesis is uniformly distributed over the arterial system in young WKY rats and that DNA synthesis is elevated in the smooth muscle of large arteries of 6-week-old SHR but not in their resistance arteries.

Published
1991

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