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1. Hart en vaten

Author

Danser, A. H. J., Smits, J. F. M., Struijker Boudier, H. A. J., van Zwieten, P. A., Cohen, A. F., editor, Danhof, M., editor, de Greef, H. J. M. M., editor, Ijzerman, A. P., editor, Kenter, M. J. H., editor, Schellens, J. H. M., editor, and Sitsen, J. M. A., editor

Published
2017
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5. Current and future initiatives for vascular health management in clinical practice

Author

Cameron JD, Asmar R, Struijker-Boudier H, Shirai K, Sirenko Y, Kotovskaya Y, and Topouchian J

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

James D Cameron,1 Roland Asmar,2 Harry Struijker-Boudier,3 Kohji Shirai,4 Yuriy Sirenko,5 Yulia Kotovskaya,6 Jirar Topouchian71Monash Cardiovascular Research Centre, Clayton, Melbourne, Victoria, Australia; 2Roland Asmar, Foundation Medical Research Institutes, Paris, France; 3Department of Pharmacology, Maastricht University, Maastricht, The Netherlands; 4Department of Vascular Function, Sakura Hospital, Toho University, Tokyo, Japan; 5Institute of Cardiology, Kiev, Ukraine; 6ESH Hypertension Excellence Center of Peoples Friendship University of Russia, Moscow, Russia; 7Department of Diagnosis and Therapeutics, Hôtel-Dieu University Hospital, Paris, FranceAbstract: Central arterial structure and function comprise a primary determinant of vascular health, and are integral to the important concept of ventriculo-vascular coupling or interaction. Central aortic stiffening is a major influence on central blood pressure, and directly relates to coronary perfusion. The joint session of the International Society of Vascular Health (Eastern Region) and the Ukrainian Congress of Cardiology was held in Kiev, Ukraine, on September 23, 2011; it provided an expert forum to discuss arterial evaluations, clinical applications, and progress toward translating arterial protection into cardiovascular benefits. The conclusions of the expert panel were:1. Aortic stiffness is not presently a treatment target but may be useful for substratifying cardiovascular risk in individuals in order to better target the intensity of conventional therapy, and it may be useful in assessing response to treatment.2. Crosstalk between macro- and microcirculation in hypertension has important implications for pharmacological treatment. An antihypertensive regimen should abolish the vicious cycle between the increased resistance in the microcirculation and the increased stiffness of the larger arteries. Such treatment should be based on drugs with multiple actions on the vascular tree, or on drug combinations that target the various segments of the arterial system.3. Several blood pressure-independent mechanisms of large artery stiffness exist. Future considerations for clinical understanding of large artery stiffness should involve new drugs and new evaluation methods – with a focus on vascular health, for the initiation of cardiovascular prevention, for newly designed studies for treatment evaluation, and for new studies of drug combinations.4. Arterial stiffening is a sign of cardiovascular aging and is a major factor affecting the biomechanics of large arteries. Arterial stiffness is an attractive therapeutic target in terms of vascular aging. Healthy lifestyle, physical exercise, and smoking cessation are the most effective ways of preventing and treating early vascular aging. Long-term effects of cardiovascular drugs on arterial stiffness need to be further investigated.5. The emerging clinical data on the cardio ankle vascular index (CAVI) technique of arterial health assessment is presented, showing that the CAVI is elevated in aging, coronary artery diseases, chronic kidney disease, hypertension, diabetes mellitus, smoking, and stress. The CAVI decreased with the administration of statins, angiotensin II receptor blocking agents, and calcium channel blockers. The CAVI is suggested as an important predictor of cardiovascular diseases.Future development of a clinical understanding of large artery stiffness is important and should include consideration of new drugs and new evaluation methods, with a focus on vascular health aimed at cardiovascular prevention.Keywords: arterial stiffness, cardiovascular protection, hypertension, arterial hemodynamic evaluation

Published
2013

16. Abstracts of papers and posters Pharmacological Meeting

Author

Adan, Roger A. H., Peter, J., Burbach, H., Gispen, Willem -Hendrik, Bax, Willem A., Saxena, Pramod R., Beenen, O. H. M., Pfaffendorf, M., van Zwieten, P. A., Biewenga, G. Ph., Nicastia, A. J., Haenen, G. R. M. M., Bast, A., Bouwknecht, J. A., Molewijk, H. E., van der Poel, A. M., Mos, J., Olivier, B., Broersen, L. M., Heinsbroek, R. P. W., de Bruin, J. P. C., Brouwers, D. L., Nelissen-Vrancken, H. J. M. G., Smits, J. F. M., Bruning, T. A., Kemme, M. J. B., Chang, P. C., Muizert, Y., Buckley, Theresa L., Nijkamp, Frans P., Cappendijk, S. L. T., Duval, S. Y., De Vries, R., Dzoljic, M. R., Compaan, J. C., Groenink, L., van der Gugten, J., Cox, E. H., van Hemert, A. G. N., de Jong, E., Danhof, M., Crijns, F. R. L., Wolffenbuttel, B. H. R., van Essen, H., Boudier, H. A. J. Struijker, Dam, J. P. M., Doornekamp, F. N. G., Velema, E., Post, M. J., Borst, C., de Boer, J., Meurs, H., Bottone, A. E., Koopal, M., Visser, J. C., Zaagsma, J., de Lannoy, L. M., Danser, A. H. J., Bouhuizen, A. M. B., Schoemaker, R. G., Saxena, P. R., Schalekamp, M. A. D. H., de Vlieger, J. F., van den Wijngaard, P., Koster, A. Sj., Buckley, T. L., Wilting, J., van Heuven-Nolsen, D., Nijkamp, F., Du, X. Y., Bos, E., Dubois, E. A., Vermeulen, R. J., Janssen, A. F. M., van Royen, E. A., Gaillard, P. J., de Boer, A. G., Breimer, D. D., Garrelds, I. M., de Graaf-in't Veld, C., van Wijk, R. Gerth, Zijlstra, F. J., Gerrits, Mirjam A. F. M., Patkina, Nadezda, Zvartau, Edwin E., van Ree, Jan M., Gho, B. C. G., Verdouw, P. D., Gingras, M. A., Cools, A. R., Gommans, J., Hijzen, T., Maes, R. A., Verdouw, P. M., Herremans, A. H. J., Hijzen, T. H., Slangen, J. L., Hoiting, B. H., Schuiling, M., Elzinga, C. R. S., Hoogstraate, A. J., Verhoef, J., Schrijvers, A. H. G. J., Pijpers, A., van Leengoed, L. A. M. G., Verheijden, J. H. M., Junginger, H. E., Boddé, H. E., Hüsken, B. C. P., Joordens, R. J. E., Kalkman, E. A. J., Bilgin, M. Y., Kam, K. L., Kraneveld, A. D., Muis, T., Nijkamp, F. P., Madretsma, G. S., van Dijk, A. P. M., Wilson, J. H. P., Mohede, C. M., Van Oosterhout, J. M., Niikamp, F. P., Nestby, P., Visser, D., Wardeh, G., Hogenboom, F., Mulder, A. H., Schoffelmeer, A. N. M., Oosting, J., Struijker Boudier, H. A. J., Janssen, B. J. A., Passier, P. C. J. J., Verluyten, M. J. A., Drexler, H., Daemen, M. J. A. P., Hashjin, Gudarz Sadeghi, Henricks, Paul A. J., Folkerts, Gert, Shirmohammadi, Mahnaz, Niikamp, Frans P., Santing, R. E., Olymulder, C. G., van der Molen, K., Scheerens, Heleen, Van Loveren, Henk, Sipma, H., den Hertog, A., Nelemans, A., Smit, J., Coppes, R. P., Tintelen, E. J. J. v., Roffel, A. F., Smit, M. J., Leurs, Rob, Timmerman, H., Stam, W. B., Avezaat, C. J. J., Stolte, J., Schiffers, P. M. H., Boudier, H. A. J. Struyker, ten Berge, R. E. J., Krikke, M., Teisman, B. C. H., Tjon, G. H. K., Michiels, N., Voorn, P., van Bergen, P., De Wildt, D. J., Versteeg, D. H. G., van den Tweel, M. C., Bloemen, P. G. M., Henricks, P. A. J., Engels, F., Blomjous, F. J., van der Geest, R., van Laar, T., Roos, R. A. C., van de Velde, M. J., van Kats, J. P., Sassen, L. M. A., Polak, M. P. J., Derkx, F. H. M., van Kesteren, C. A. M., Lamers, J. M. J., van Heugten, H. A. A., van Meeteren, N. L. U., Frankhuyzen-Sierevogel, A., Brakkee, J. H., Wiegant, V. M., Gispen, W. H., Vroom, M. B., van Wezel, H. B., Timmenga, E. J. F., van der Horst, C. M. A. M., Winkler Prins, E. A., Zwavelina, J., Maas, A., Zhang, J., Zwaveling, J., Jansen, F. P., Mochizuki, T., Yamatodani, A., Masereeuw, R., Moons, W. M., Russel, F. G. M., van de Meent, H., van den Berg, C., Wemer, J., Vleeming, W., Kasbergen, C. M., van der Aa, E. M., Wouterse, A. C., Peereboom-Stegeman, J. H. J. Copius, Hessel, E. M., Van Oosterhout, A. J. M., de Bie, J. J., Hofman, G., and Van Loveren, H.

Published
1994
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30. 2007 ESH‐ESC Guidelines for the management of arterial hypertension

Author

Mancia, G., DE BACIKER, G., Dominiczak, A., Cifikova, R., Fagard, R., Germano', Giuseppe Italo Walter, Grassi, G., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., Narkiewicz, K., Ruilope, L., Rynikiewicz, . A., Schmieder, R. E., STRUIJKER BOUDIER, H. A., ZANCHETTIi EUROPEAN SOCIETY OF HYPERTENSION, . A., EUROPEAN SOCIETY OF CARDIOLOGY, Mancia, G, De Backer, G, Dominiczak, A, Cifkova, R, Fagard, R, Germano, G, Grassi, G, Heagerty, A, Kjeldsen, S, Laurent, S, Narkiewicz, K, Ruilope, L, Rynkiewicz, A, Schmieder, R, Boudier, H, and Zanchetti, A

Subjects
arterial hypertension, medicine.medical_specialty, Ambulatory blood pressure, Risk Factors, Internal Medicine, Humans, Medicine, Hypertension diagnosis, Antihypertensive Agents, Evidence-Based Medicine, Task force, business.industry, General Medicine, Target organ damage, Coronary heart disease, monitoring, Intima-media thickness, Hypertension complications, Hypertension, Isolated systolic hypertension, Emergency medicine, Guidelines BP control, MED/09 - MEDICINA INTERNA, Cardiology and Cardiovascular Medicine, business, Risk Reduction Behavior
Published
2007

32. Erectiele disfunctie

Author

van Zwieten, P. A., Sitsen, J. M. A., Cohen, A. F., Franson, K. L., Smits, P., Struijker Boudier, H. A. J., van Bortel, L. M., and Cardiothoracic Surgery

Published
2009

33. Antiarrhythmica

Author

van Zwieten, P. A., Sitsen, J. M. A., Cohen, A. F., Franson, K. L., Smits, P., Struijker Boudier, H. A. J., van Bortel, L. M., and Cardiothoracic Surgery

Published
2009

34. Onderzoek naar de tijdelijke behandeling van hoog-normale bloeddruk ter voorkoming van hypertensie en met hypertensie samenhangende orgaanschade: de TIResiAS-studie

Author

van den Bogaard, B., Baumann, M., van Weert, H. C. P. M., Struijker Boudier, H. A. J., van Montfrans, G. A., van den Born, B. J. H., Intensive Care Medicine, General practice, Amsterdam Cardiovascular Sciences, General Internal Medicine, and Vascular Medicine

Abstract

A recent study from the Framingham cohort showed that persons with high normal blood pressure, also known as prehypertension, are at increased risk for cardiovascular complications and have a 10% annual risk to progress to hypertension. Studies in spontaneous hypertensive rats have demonstrated that it is possible to postpone the development of hypertension and hypertensive organ damage by a temporary anti-hypertensive intervention if started early in life. Recently the TROPHY study showed that treatment with an angiotensin receptor blocker for 2 years was able to delay the progress to hypertension. In a randomized trial in relatively young (age 18-40 years) prehypertensive persons, we aim to investigate whether temporary treatment with an angiotensin-converting enzyme inhibitor, for one year, reduces blood pressure and left ventricular mass two years after cessation of treatment compared to placebo

Published
2007

35. Practice guidelines 2007 for the treatment of arterial hypertension

Author

Mancia, G., DE BACKER, G., Dominiczak, A., Cifkova, R., Fagard, R., Germano', Giuseppe Italo Walter, Grassi, G., Am:, Heagerty, Kjeldsen, S. E., Laurent, S., Narkiewicz, K., Ruilope, L., Rynkiewicz, A., Schmieder, R. E., STRUIJKER BOUDIER, H. A., Zanchetti, A., Vahanian, A., Camm, J., DE CATERINA, R., Dean, V., Dickstein, K., Fllippatos, G., FUNCK BRENTANO, C., Hellemans, L., Kristensen, S. D., Mcgregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsiky, P., Zamorano, J. L., Erdine, S., Kiowski, W., Agabiti¬rosei, E., Ambrosioni, E., Lindholm, L. H., Manolis, A., Nilsson, P. M., Redon, J., Vilgimaa, M., LINEE GUIDA DELLA SOCI ETA' EUROPEA DI IPERTENSIONE ARTERIOSA, and SOCIETA' EUROPEA DI CARDIOLOGIA

Published
2007

37. Onlangs gepubliceerde Europese en Amerikaanse richtlijnen voor hypertensiediagnostiek en -behandeling

Author

van Zwieten, P. A., Struijker Boudier, H. A., de Leeuw, P. W., and Cardiothoracic Surgery

Abstract

The European Society of Hypertension in conjunction with the European Society of Cardiology has published new guidelines on the management of hypertension. At about the same time, the Joint National Committee in the United States updated the American hypertension guidelines. Both guidelines agree on a number of issues, such as the importance of systolic blood pressure, the necessity to take into account additional risk factors and the growing emphasis on combination treatment. As far as pharmacotherapy is concerned, however, there are major differences between the guidelines. Whereas the European report permits a choice from among several classes of drugs for initial treatment, the American guidelines still consider diuretics to be the first choice

Published
2004

39. Anginex, a designed peptide that inhibits angiogenesis

Author

Griffioen, A W, van der Schaft, D W, Barendsz-Janson, A F, Cox, A, Struijker Boudier, H A, Hillen, H F, and Mayo, K H

Subjects
O-(Chloroacetylcarbamoyl)fumagillol, Magnetic Resonance Spectroscopy, Molecular Sequence Data, Neovascularization, Physiologic, Proteins, Plasminogen, Peptide Fragments, Endostatins, Thrombospondin 1, Cell Movement, Cyclohexanes, Cell Adhesion, Humans, Amino Acid Sequence, Collagen, Endothelium, Vascular, Peptides, Angiostatins, Sesquiterpenes, Cell Division, Cells, Cultured, Research Article
Abstract

Novel beta-sheet-forming peptide 33-mers, betapep peptides, have been designed by using a combination approach employing basic folding principles and incorporating short sequences from the beta-sheet domains of anti-angiogenic proteins. One of these designed peptides (betapep-25), named anginex, was observed to be potently anti-angiogenic. Anginex specifically inhibits vascular endothelial cell proliferation and induces apoptosis in these cells, as shown by flow-cytometric detection of sub-diploid cells, TUNEL (terminal deoxyribonucleotidyl transferase-mediated dUTP-nick-end labelling) analysis and cell morphology. Anginex also inhibits endothelial cell adhesion to and migration on different extracellular matrix components. Inhibition of angiogenesis in vitro is demonstrated in the sprout-formation assay and in vivo in the chick embryo chorio-allantoic membrane angiogenesis assay. Comparison of active and inactive betapep sequences allows structure-function relationships to be deduced. Five hydrophobic residues and two lysines appear to be crucial to activity. This is the first report of a designed peptide having a well-defined biological function as a novel cytokine, which may be an effective anti-angiogenic agent for therapeutic use against various pathological disorders, such as neoplasia, rheumatoid arthritis, diabetic retinopathy and restenosis.

Published
2001

45. Effects of individual risk factors on the incidence of cardiovascular event in the treated hypertensive patients of the Hypertension Optimal Treatment Study

Author

Struijker-Boudier H, Safar M, and van Bortel L

Subjects
Cardiovascular event, Individual risk factors, medicine.medical_specialty, Text mining, Physiology, business.industry, Optimal treatment, Internal medicine, Incidence (epidemiology), Internal Medicine, Medicine, Cardiology and Cardiovascular Medicine, business
Published
2001

46. Arterial Properties in Relation to Genetic Variations in the Adducin Subunits in a White Population

Author

Seidlerova, J., primary, Staessen, J. A., additional, Bochud, M., additional, Nawrot, T., additional, Casamassima, N., additional, Citterio, L., additional, Kuznetsova, T., additional, Jin, Y., additional, Manunta, P., additional, Richart, T., additional, Struijker-Boudier, H. A., additional, Fagard, R., additional, Filipovsky, J., additional, and Bianchi, G., additional

Published
2009
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47. Arterial properties in relation to genetic variation in α-adducin and the renin–angiotensin system in a White population

Author

Seidlerová, J, primary, Staessen, J A, additional, Nawrot, T, additional, Brand, E, additional, Brand-Herrmann, S-M, additional, Casamassima, N, additional, Citterio, L, additional, Hasenkamp, S, additional, Kuznetsova, T, additional, Li, Y, additional, Manunta, P, additional, Richart, T, additional, Struijker-Boudier, H A, additional, Fagard, R, additional, and Filipovskỳ, J, additional

Published
2008
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