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4. Investigation into diseases in free-ranging ring-necked pheasants (Phasianus colchicus) in northwestern Germany during population decline with special reference to infectious pathogens

Author

Curland, N., Gethöffer, F., van Neer, A., Ziegler, L., Heffels-Redmann, U., Lierz, M., Baumgärtner, W., Wohlsein, P., Völker, I., Lapp, S., Bello, A., Pfankuche, V. M., Braune, S., Runge, M., Moss, A., Rautenschlein, S., Jung, A., Teske, L., Strube, C., Schulz, J., Bodewes, R., Osterhaus, A. D. M. E., and Siebert, U.

Published
2018
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10. Barriers and incentives for uptake of diagnostics for sustainable worm control by European dairy cattle farmers

Author

Vande Velde F, Hektoen L, Phythian CJ, Rinaldi L, Bosco A, Hinney B, Strube C, May K, Knubben-Schweizer G, Dourado Martins O, Mateus T, Simion V-E, Charlier J, Bartley D, Claerebout E, COMBAR, Vande Velde, F, Hektoen, L, Phythian, Cj, Rinaldi, L, Bosco, A, Hinney, B, Strube, C, May, K, Knubben-Schweizer, G, Dourado Martins, O, Mateus, T, Simion, V-E, Charlier, J, Bartley, D, and Claerebout, E

Published
2020

20. Health status of free-ranging ring-necked pheasant chicks (Phasianus colchicus) in North-Western Germany

Author

Liebing, J., primary, Völker, I., additional, Curland, N., additional, Wohlsein, P., additional, Baumgärtner, W., additional, Braune, S., additional, Runge, M., additional, Moss, A., additional, Rautenschlein, S., additional, Jung, A., additional, Ryll, M., additional, Raue, K., additional, Strube, C., additional, Schulz, J., additional, Heffels-Redmann, U., additional, Fischer, L., additional, Gethöffer, F., additional, Voigt, U., additional, Lierz, M., additional, and Siebert, U., additional

Published
2020
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34. AMPA and NMDA receptor localization in nucleus tractus solitarii neurons

Author

Strube, C., Balland, B., Lachamp, P., Baude, A., Jp, Kessler, Tell, F., Laboratoire de neurophysiologie cellulaire (LNPC), and Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS)

Subjects
ComputingMethodologies_GENERAL
Abstract

poster

Published
2005

37. Membrane cholesterol modulates dihydropyridine receptor function in mice fetal skeletal muscle cells

Author

Pouvreau, Sandrine, Berthier, Christine, Blaineau, Sylvie, Ansellem, Jacqueline, Coronado, Roberto, Strube, C., Physiologie intégrative, cellulaire et moléculaire (PICM), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Department of Physiology, and University of Wisconsin-Madison

Subjects
Cyclodextrins, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], Patch-Clamp Techniques, Calcium Channels, L-Type, Cell Membrane, Muscle Fibers, Skeletal, beta-Cyclodextrins, Action Potentials, Cell Separation, Research Papers, Electric Stimulation, Membrane Potentials, Mice, Cholesterol, Pregnancy, Image Processing, Computer-Assisted, Animals, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Calcium Channels, Calcium Signaling, Muscle, Skeletal, ComputingMilieux_MISCELLANEOUS
Abstract

Caveolae and transverse (T-) tubules are membrane structures enriched in cholesterol and glycosphingolipids. They play an important role in receptor signalling and myogenesis. The T-system is also highly enriched in dihydropyridine receptors (DHPRs), which control excitation-contraction (E-C) coupling. Recent results have shown that a depletion of membrane cholesterol alters caveolae and T-tubules, yet detailed functional studies of DHPR expression are lacking. Here we studied electrophysiological and morphological effects of methyl-beta-cyclodextrin (MbetaCD), a cholesterol-sequestering drug, on freshly isolated fetal skeletal muscle cells. Exposure of fetal myofibres to 1-3 mM MbetaCD for 1 h at 37 degrees C led to a significant reduction in caveolae and T-tubule areas and to a decrease in cell membrane electrical capacitance. In whole-cell voltage-clamp experiments, the L-type Ca(2+) current amplitude was significantly reduced, and its voltage dependence was shifted approximately 15 mV towards more positive potentials. Activation and inactivation kinetics were slower in treated cells than in control cells and stimulation by a saturating concentration of Bay K 8644 was enhanced. In addition, intramembrane charge movement and Ca(2+) transients evoked by a depolarization were reduced without a shift of the midpoint, indicating a weakening of E-C coupling. In contrast, T-type Ca(2+) current was not affected by MbetaCD treatment. Most of the L-type Ca(2+) conductance reduction and E-C coupling weakening could be explained by a decrease of the number of DHPRs due to the disruption of caveolae and T-tubules. However, the effects on L-type channel gating kinetics suggest that membrane cholesterol content modulates DHPR function. Moreover, the significant shift of the voltage dependence of L-type current without any change in the voltage dependence of charge movement and Ca(2+) transients suggests that cholesterol differentially regulates the two functions of the DHPR.

Published
2004
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39. The value of a bulk-tank milk ELISA and individual serological and faecal examination for diagnosing (sub)clinical Dictyocaulus viviparus infection in dairy cows.

Author

Advances in Veterinary Medicine, Dep Infectieziekten Immunologie, Ploeger, H.W., Verbeek, P.C., Dekkers, C.H.W., Strube, C., van Engelen, E., Uiterwijk, M., Lam, T.J.G.M., Holzhauer, M., Advances in Veterinary Medicine, Dep Infectieziekten Immunologie, Ploeger, H.W., Verbeek, P.C., Dekkers, C.H.W., Strube, C., van Engelen, E., Uiterwijk, M., Lam, T.J.G.M., and Holzhauer, M.

Published
2012

43. A transcriptomic analysis of the adult stage of the bovine lungworm, Dictyocaulus viviparus

Author

Ranganathan, S, Nagaraj, SH, Hu, M, Strube, C, Schnieder, T, Gasser, RB, Ranganathan, S, Nagaraj, SH, Hu, M, Strube, C, Schnieder, T, and Gasser, RB

Abstract

BACKGROUND: Lungworms of the genus Dictyocaulus (family Dictyocaulidae) are parasitic nematodes of major economic importance. They cause pathological effects and clinical disease in various ruminant hosts, particularly in young animals. Dictyocaulus viviparus, called the bovine lungworm, is a major pathogen of cattle, with severe infections being fatal. In this study, we provide first insights into the transcriptome of the adult stage of D. viviparus through the analysis of expressed sequence tags (ESTs). RESULTS: Using our EST analysis pipeline, we estimate that the present dataset of 4436 ESTs is derived from 2258 genes based on cluster and comparative genomic analyses of the ESTs. Of the 2258 representative ESTs, 1159 (51.3%) had homologues in the free-living nematode C. elegans, 1174 (51.9%) in parasitic nematodes, 827 (36.6%) in organisms other than nematodes, and 863 (38%) had no significant match to any sequence in the current databases. Of the C. elegans homologues, 569 had observed 'non-wildtype' RNAi phenotypes, including embryonic lethality, maternal sterility, sterility in progeny, larval arrest and slow growth. We could functionally classify 776 (35%) sequences using the Gene Ontologies (GO) and established pathway associations to 696 (31%) sequences in Kyoto Encyclopedia of Genes and Genomes (KEGG). In addition, we predicted 85 secreted proteins which could represent potential candidates for developing novel anthelmintics or vaccines. CONCLUSION: The bioinformatic analyses of ESTs data for D. viviparus has elucidated sets of relatively conserved and potentially novel genes. The genes discovered in this study should assist research toward a better understanding of the basic molecular biology of D. viviparus, which could lead, in the longer term, to novel intervention strategies. The characterization of the D. viviparus transcriptome also provides a foundation for whole genome sequence analysis and future comparative transcriptomic analyses.

Published
2007

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