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1. NMR metabolomics-guided DNA methylation mortality predictors

Author

Geleijnse, J.M., Boersma, E., van Spil, W.E., van Greevenbroek, M.M.J., Stehouwer, C.D.A., van der Kallen, C.J.H., Arts, I.C.W., Rutters, F., Beulens, J.W.J., Muilwijk, M., Elders, P.J.M., 't Hart, L.M., Ghanbari, M., Ikram, M.A., Netea, M.G., Kloppenburg, M., Ramos, Y.F.M., Bomer, N., Meulenbelt, I., Stronks, K., Snijder, M.B., Zwinderman, A.H., Heijmans, B.T., Lumey, L.H., Wijmenga, C., Fu, J., Zhernakova, A., Deelen, J., Mooijaart, S.P., Beekman, M., Slagboom, P.E., Onderwater, G.L.J., van den Maagdenberg, A.M.J.M., Terwindt, G.M., Thesing, C., Bot, M., Penninx, B.W.J.H., Trompet, S., Jukema, J.W., Sattar, N., van der Horst, I.C.C., van der Harst, P., So-Osman, C., van Hilten, J.A., Nelissen, R.G.H.H., Höfer, I.E., Asselbergs, F.W., Scheltens, P., Teunissen, C.E., van der Flier, W.M., van Dongen, J., Pool, R., Willemsen, A.H.M., Boomsma, D.I., Suchiman, H.E.D., Barkey Wolf, J.J.H., Cats, D., Mei, H., Slofstra, M., Swertz, M., Reinders, M.J.T., van den Akker, E.B., Bizzarri, Daniele, Reinders, Marcel J.T., Kuiper, Lieke, Beekman, Marian, Deelen, Joris, van Meurs, Joyce B.J., van Dongen, Jenny, Pool, René, Boomsma, Dorret I., Ghanbari, Mohsen, Franke, Lude, Slagboom, Pieternella E., and van den Akker, Erik B.

Published
2024
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7. Estimating the contribution of overweight and obesity to ethnic inequalities in cardio-metabolic diseases in the Netherlands:a simulation study

Author

Nusselder, W. J., Long, D., Waterlander, W. E., Stronks, K., Boshuizen, H. C., Nusselder, W. J., Long, D., Waterlander, W. E., Stronks, K., and Boshuizen, H. C.

Abstract

Objectives: Overweight and obesity (OWOB) starts in childhood, influences adult cardiovascular risk, and is not equally distributed across ethnic groups. It is unclear which effects can be expected from reductions in OWOB across the life course on inequalities in cardio-metabolic diseases in a multi-ethnic population. This study aims to estimate the effects of three scenarios of changes in OWOB (the Normal-Weight-for-All scenario, the No-Ethnic-Difference-over-the-Life-Course scenario, the and No-Ethnic-Differences-in-Childhood scenario). Study design: A simulation study. Methods: We combine data from multiple data sources and use the Dynamic Modeling for Health Impact Assessment (DYNAMO-HIA) model to estimate the effects of three scenarios on the cumulative incidence of diabetes mellitus, ischaemic heart disease (IHD) and stroke between 18 and 70 years in the five largest ethnic groups in the Netherlands. Results: In the scenario where all individuals have normal weight, the cumulative incidence decreased in all ethnic minority groups for all diseases, with largest decreases among South-Asian Surinamese, where the reduction of diabetes incidence exceeded 50%. In the scenario where the prevalence of OWOB in each ethnic-minority group was reduced to the current level among the Dutch-origin population, ethnic inequalities in cardio-metabolic diseases were substantially reduced, particularly when lowered prevalence of OWOB persisted across the lifespan. Reductions were the largest for diabetes and for the Asian Surinamese population. Conclusions: A substantial part of the well-known ethnic inequalities in incidence of diabetes, IHD, and stroke can be attributed to OWOB. Interventions aimed at reducing OWOB have clear potential to reduce the health inequalities in these outcomes, especially for diabetes, in particular when they have an impact across the lifespan.

Published
2024

8. NMR metabolomics-guided DNA methylation mortality predictors

Author

Bizzarri, Daniele, Reinders, Marcel J.T., Kuiper, Lieke, Beekman, Marian, Deelen, Joris, van Meurs, Joyce B.J., van Dongen, Jenny, Pool, René, Boomsma, D. I., Ghanbari, M., Franke, Lude, Geleijnse, J. M., Boersma, E., van Spil, W. E., van Greevenbroek, M. M.J., Stehouwer, C. D.A., van der Kallen, C. J.H., Arts, I. C.W., Rutters, F., Beulens, J. W.J., Muilwijk, M., Elders, P. J.M., 't Hart, L. M., Ikram, M. A., Netea, M. G., Kloppenburg, M., Ramos, Y. F.M., Bomer, N., Meulenbelt, I., Stronks, K., Snijder, M. B., Zwinderman, A. H., Heijmans, B. T., Lumey, L. H., Fu, J., Deelen, J., Mooijaart, S. P., Beekman, M., Bot, M., Trompet, S., van der Horst, I. C.C., So-Osman, C., Nelissen, R. G.H.H., Teunissen, C. E., van Dongen, J., Willemsen, A. H.M., Mei, H., Reinders, M. J.T., van den Akker, E. B., Bizzarri, Daniele, Reinders, Marcel J.T., Kuiper, Lieke, Beekman, Marian, Deelen, Joris, van Meurs, Joyce B.J., van Dongen, Jenny, Pool, René, Boomsma, D. I., Ghanbari, M., Franke, Lude, Geleijnse, J. M., Boersma, E., van Spil, W. E., van Greevenbroek, M. M.J., Stehouwer, C. D.A., van der Kallen, C. J.H., Arts, I. C.W., Rutters, F., Beulens, J. W.J., Muilwijk, M., Elders, P. J.M., 't Hart, L. M., Ikram, M. A., Netea, M. G., Kloppenburg, M., Ramos, Y. F.M., Bomer, N., Meulenbelt, I., Stronks, K., Snijder, M. B., Zwinderman, A. H., Heijmans, B. T., Lumey, L. H., Fu, J., Deelen, J., Mooijaart, S. P., Beekman, M., Bot, M., Trompet, S., van der Horst, I. C.C., So-Osman, C., Nelissen, R. G.H.H., Teunissen, C. E., van Dongen, J., Willemsen, A. H.M., Mei, H., Reinders, M. J.T., and van den Akker, E. B.

Abstract

Background: 1H-NMR metabolomics and DNA methylation in blood are widely known biomarkers predicting age-related physiological decline and mortality yet exert mutually independent mortality and frailty signals. Methods: Leveraging multi-omics data in four Dutch population studies (N = 5238, ∼40% of which male) we investigated whether the mortality signal captured by 1H-NMR metabolomics could guide the construction of DNA methylation-based mortality predictors. Findings: We trained DNA methylation-based surrogates for 64 metabolomic analytes and found that analytes marking inflammation, fluid balance, or HDL/VLDL metabolism could be accurately reconstructed using DNA-methylation assays. Interestingly, a previously reported multi-analyte score indicating mortality risk (MetaboHealth) could also be accurately reconstructed. Sixteen of our derived surrogates, including the MetaboHealth surrogate, showed significant associations with mortality, independent of relevant covariates. Interpretation: The addition of our metabolic analyte-derived surrogates to the well-established epigenetic clock GrimAge demonstrates that our surrogates potentially represent valuable mortality signal. Funding: BBMRI-NL, X-omics, VOILA, Medical Delta, NWO, ERC.

Published
2024

9. 9 Organisatie en financiering van de gezondheidszorg: een analytisch kader

Author

Stronks, K., Polder, J.J., Klazinga, N.S., Anema, J.R., van den Berg, M.J., van den Brink, W., Brug, J., Burdorf, A., Cornel, M.C., Das, C., Essink-Bot, M.L., Feron, F.J.M., Hulshof, C.T.J., Jeurissen, P.P.T., Klazinga, N.S., de Koning, H.J., Legemaate, J., Mackenbach, J.P., van Mechelen, W., van de Mheen, D., Middelkoop, B.J.C., Polder, J.J., Reijnders, U.J.L., Reijneveld, S.A., Richardus, J.H., Smit, H.A., Soethout, M.B.M., Stronks, K., van der Velden, J., Verhoeff, A.P., Westert, G.P., Wind, H., Mackenbach, Johan P., editor, and Stronks, Karien, editor

Published
2016
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10. 10 De Nederlandse gezondheidszorg: werking en prestaties

Author

Westert, G.P., Jeurissen, P.P.T., van den Berg, M.J., Stronks, K., Wammes, J.J.G., van der Hijden, E.J.E., Anema, J.R., van den Berg, M.J., van den Brink, W., Brug, J., Burdorf, A., Cornel, M.C., Das, C., Essink-Bot, M.L., Feron, F.J.M., Hulshof, C.T.J., Jeurissen, P.P.T., Klazinga, N.S., de Koning, H.J., Legemaate, J., Mackenbach, J.P., van Mechelen, W., van de Mheen, D., Middelkoop, B.J.C., Polder, J.J., Reijnders, U.J.L., Reijneveld, S.A., Richardus, J.H., Smit, H.A., Soethout, M.B.M., Stronks, K., van der Velden, J., Verhoeff, A.P., Westert, G.P., Wind, H., Mackenbach, Johan P., editor, and Stronks, Karien, editor

Published
2016
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11. 1 Inleiding

Author

Mackenbach, J.P., Stronks, K., Anema, J.R., van den Berg, M.J., van den Brink, W., Brug, J., Burdorf, A., Cornel, M.C., Das, C., Essink-Bot, M.L., Feron, F.J.M., Hulshof, C.T.J., Jeurissen, P.P.T., Klazinga, N.S., de Koning, H.J., Legemaate, J., Mackenbach, J.P., van Mechelen, W., van de Mheen, D., Middelkoop, B.J.C., Polder, J.J., Reijnders, U.J.L., Reijneveld, S.A., Richardus, J.H., Smit, H.A., Soethout, M.B.M., Stronks, K., van der Velden, J., Verhoeff, A.P., Westert, G.P., Wind, H., Mackenbach, Johan P., editor, and Stronks, Karien, editor

Published
2016
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12. Thema H Preventie in de spreekkamer van de huisarts en specialist

Author

Stronks, K., Anema, J.R., van den Brink, W., Brug, J., Burdorf, A., Das, C., HiraSing, R.A., Klazinga, N.S., van der Klink, J.J.L., de Koning, H.J., Legemaate, J., van der Maas, P.J., Mackenbach, J.P., van Mechelen, W., van de Mheen, D., Middelkoop, B.J.C., Polder, J.J., Reijneveld, S.A., Richardus, J.H., Smit, H.A., Soethout, M.B.M., Stronks, K., van der Velden, J., Westert, G.P., and Willems, J.H.B.M.

Published
2016
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13. Organisatie en financiering van de gezondheidszorg: een analytisch kader

Author

Stronks, K., Polder, J.J., Klazinga, N.S., Anema, J.R., van den Brink, W., Brug, J., Burdorf, A., Das, C., HiraSing, R.A., Klazinga, N.S., van der Klink, J.J.L., de Koning, H.J., Legemaate, J., van der Maas, P.J., Mackenbach, J.P., van Mechelen, W., van de Mheen, D., Middelkoop, B.J.C., Polder, J.J., Reijneveld, S.A., Richardus, J.H., Smit, H.A., Soethout, M.B.M., Stronks, K., van der Velden, J., Westert, G.P., and Willems, J.H.B.M.

Published
2016
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14. De Nederlandse gezondheidszorg: werking en prestaties

Author

Westert, G.P., Stronks, K., Klazinga, N.S., Polder, J.J., Anema, J.R., van den Brink, W., Brug, J., Burdorf, A., Das, C., HiraSing, R.A., Klazinga, N.S., van der Klink, J.J.L., de Koning, H.J., Legemaate, J., van der Maas, P.J., Mackenbach, J.P., van Mechelen, W., van de Mheen, D., Middelkoop, B.J.C., Polder, J.J., Reijneveld, S.A., Richardus, J.H., Smit, H.A., Soethout, M.B.M., Stronks, K., van der Velden, J., Westert, G.P., and Willems, J.H.B.M.

Published
2016
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15. Thema C Etnische verschillen in gezondheid en gezondheidszorg

Author

Stronks, K., Anema, J.R., van den Brink, W., Brug, J., Burdorf, A., Das, C., HiraSing, R.A., Klazinga, N.S., van der Klink, J.J.L., de Koning, H.J., Legemaate, J., van der Maas, P.J., Mackenbach, J.P., van Mechelen, W., van de Mheen, D., Middelkoop, B.J.C., Polder, J.J., Reijneveld, S.A., Richardus, J.H., Smit, H.A., Soethout, M.B.M., Stronks, K., van der Velden, J., Westert, G.P., and Willems, J.H.B.M.

Published
2016
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16. Inleiding

Author

Mackenbach, J.P., Stronks, K., Anema, J.R., van den Brink, W., Brug, J., Burdorf, A., Das, C., HiraSing, R.A., Klazinga, N.S., van der Klink, J.J.L., de Koning, H.J., Legemaate, J., van der Maas, P.J., Mackenbach, J.P., van Mechelen, W., van de Mheen, D., Middelkoop, B.J.C., Polder, J.J., Reijneveld, S.A., Richardus, J.H., Smit, H.A., Soethout, M.B.M., Stronks, K., van der Velden, J., Westert, G.P., and Willems, J.H.B.M.

Published
2016
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21. Preventie:wat is het, en hoe benutten we het optimaal?

Author

Stronks, K., Stronks, K., Burdorf, A., Mölenberg, F.J.M., Kiefte, J.C., Kremers, S., Assendelft, W.J.J., Mierau, J.O., Peters, L.L., de Wit, N.J., van der Ven, G.L., Ballak, D.B., Stronks, K., Stronks, K., Burdorf, A., Mölenberg, F.J.M., Kiefte, J.C., Kremers, S., Assendelft, W.J.J., Mierau, J.O., Peters, L.L., de Wit, N.J., van der Ven, G.L., and Ballak, D.B.

Published
2022

24. Individual mental health patterns and the role of lifestyle among ageing adults over 20 years - the Doetinchem Cohort Study

Author

Cardiometabolic Health, Circulatory Health, Global Public Health & Bioethics, JC onderzoeksprogramma Cardiovascular Health, Menassa, M, Wesenhagen, Kej, Stronks, K, Franco, O H, Verschuren, Wmm, Picavet, Hsj, Cardiometabolic Health, Circulatory Health, Global Public Health & Bioethics, JC onderzoeksprogramma Cardiovascular Health, Menassa, M, Wesenhagen, Kej, Stronks, K, Franco, O H, Verschuren, Wmm, and Picavet, Hsj

Published
2023

25. Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants

Author

Zhou, B, Lu, Y, Hajifathalian, K, Bentham, J, Di Cesare, M, Danaei, G, Bixby, H, Cowan, MJ, Ali, MK, Taddei, C, Lo, WC, Reis-Santos, B, Stevens, GA, Riley, LM, Miranda, JJ, Bjerregaard, P, Rivera, JA, Fouad, HM, Ma, G, Mbanya, JC, McGarvey, ST, Mohan, V, Onat, A, Pilav, A, Ramachandran, A, Romdhane, HB, Paciorek, CJ, Bennett, JE, Ezzati, M, Abdeen, ZA, Abdul Kadir, K, Abu-Rmeileh, NM, Acosta-Cazares, B, Adams, R, Aekplakorn, W, Aguilar-Salinas, CA, Agyemang, C, Ahmadvand, A, Al-Othman, AR, Alkerwi, A, Amouyel, P, Amuzu, A, Andersen, LB, Anderssen, SA, Anjana, RM, Aounallah-Skhiri, H, Aris, T, Arlappa, N, Arveiler, D, Assah, FK, Avdicová, M, Azizi, F, Balakrishna, N, Bandosz, P, Barbagallo, CM, Barceló, A, Batieha, AM, Baur, LA, Benet, M, Bernabe-Ortiz, A, Bharadwaj, S, Bhargava, SK, Bi, Y, Bjertness, E, Bjertness, MB, Björkelund, C, Blokstra, A, Bo, S, Boehm, BO, Boissonnet, CP, Bovet, P, Brajkovich, I, Breckenkamp, J, Brenner, H, Brewster, LM, Brian, GR, Bruno, G, Bugge, A, Cabrera de León, A, Can, G, Cândido, AP, Capuano, V, Carlsson, AC, Carvalho, MJ, Casanueva, FF, Casas, JP, Caserta, CA, Castetbon, K, Chamukuttan, S, Chaturvedi, N, Chen, CJ, Chen, F, Chen, S, Cheng, CY, Chetrit, A, Chiou, ST, Cho, Y, Chudek, J, Cifkova, R, Claessens, F, Concin, H, Cooper, C, Cooper, R, Costanzo, S, Cottel, D, Cowell, C, Crujeiras, AB, D'Arrigo, G, Dallongeville, J, Dankner, R, Dauchet, L, de Gaetano, G, De Henauw, S, Deepa, M, Dehghan, A, Deschamps, V, Dhana, K, Di Castelnuovo, AF, Djalalinia, S, Doua, K, Drygas, W, Du, Y, Dzerve, V, Egbagbe, EE, Eggertsen, R, El Ati, J, Elosua, R, Erasmus, RT, Erem, C, Ergor, G, Eriksen, L, Escobedo-de la Peña, J, Fall, CH, Farzadfar, F, Felix-Redondo, FJ, Ferguson, TS, Fernández-Bergés, D, Ferrari, M, Ferreccio, C, Feskens, EJ, Finn, JD, Föger, B, Foo, LH, Forslund, AS, Francis, DK, Franco Mdo, C, Franco, OH, Frontera, G, Furusawa, T, Gaciong, Z, Garnett, SP, Gaspoz, JM, Gasull, M, Gates, L, Geleijnse, JM, Ghasemian, A, Ghimire, A, Giampaoli, S, Gianfagna, F, Giovannelli, J, Giwercman, A, Gross, MG, González Rivas, JP, Gorbea, MB, Gottrand, F, Grafnetter, D, Grodzicki, T, Grøntved, A, Gruden, G, Gu, D, Guan, OP, Guerrero, R, Guessous, I, Guimaraes, AL, Gutierrez, L, Hambleton, IR, Hardy, R, Hari Kumar, R, Hata, J, He, J, Heidemann, C, Herrala, S, Hihtaniemi, IT, Ho, SY, Ho, SC, Hofman, A, Hormiga, CM, Horta, BL, Houti, L, Howitt, C, Htay, TT, Htet, AS, Htike, MM, Hu, Y, Hussieni, AS, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, AG, Ibrahim, MM, Ikeda, N, Ikram, MA, Irazola, VE, Islam, M, Iwasaki, M, Jacobs, JM, Jafar, T, Jamil, KM, Jasienska, G, Jiang, CQ, Jonas, JB, Joshi, P, Kafatos, A, Kalter-Leibovici, O, Kasaeian, A, Katz, J, Kaur, P, Kavousi, M, Keinänen-Kiukaanniemi, S, Kelishadi, R, Kengne, AP, Kersting, M, Khader, YS, Khalili, D, Khang, YH, Kiechl, S, Kim, J, Kolsteren, P, Korrovits, P, Kratzer, W, Kromhout, D, Kujala, UM, Kula, K, Kyobutungi, C, Laatikainen, T, Lachat, C, Laid, Y, Lam, TH, Landrove, O, Lanska, V, Lappas, G, Laxmaiah, A, Leclercq, C, Lee, J, Lehtimäki, T, Lekhraj, R, León-Muñoz, LM, Li, Y, Lim, WY, Lima-Costa, MF, Lin, HH, Lin, X, Lissner, L, Lorbeer, R, Lozano, JE, Luksiene, D, Lundqvist, A, Lytsy, P, Machado-Coelho, GL, Machi, S, Maggi, S, Magliano, DJ, Makdisse, M, Mallikharjuna Rao, K, Manios, Y, Manzato, E, Margozzini, P, Marques-Vidal, P, Martorell, R, Masoodi, SR, Mathiesen, EB, Matsha, TE, McFarlane, SR, McLachlan, S, McNulty, BA, Mediene-Benchekor, S, Meirhaeghe, A, Menezes, AM, Merat, S, Meshram, II, Mi, J, Miquel, JF, Mohamed, MK, Mohammad, K, Mohammadifard, N, Mohd Yusoff, MF, Møller, NC, Molnár, D, Mondo, CK, Morejon, A, Moreno, LA, Morgan, K, Moschonis, G, Mossakowska, M, Mostafa, A, Mota, J, Motta, J, Mu, TT, Muiesan, ML, Müller-Nurasyid, M, Mursu, J, Nagel, G, Námešná, J, Nang, EE, NangThetia, VB, Navarrete-Muñoz, EM, Ndiaye, NC, Nenko, I, Nervi, F, Nguyen, ND, Nguyen, QN, Nieto-Martínez, RE, Ning, G, Ninomiya, T, Noale, M, Noto, D, Nsour, MA, Ochoa-Avilés, AM, Oh, K, Ordunez, P, Osmond, C, Otero, JA, Owusu-Dabo, E, Pahomova, E, Palmieri, L, Panda-Jonas, S, Panza, F, Parsaeian, M, Peixoto, SV, Pelletier, C, Peltonen, M, Peters, A, Peykari, N, Pham, ST, Pitakaka, F, Piwonska, A, Piwonski, J, Plans-Rubió, P, Porta, M, Portegies, ML, Poustchi, H, Pradeepa, R, Price, JF, Punab, M, Qasrawi, RF, Qorbani, M, Radisauskas, R, Rahman, M, Raitakari, O, Rao, SR, Ramke, J, Ramos, R, Rampal, S, Rathmann, W, Redon, J, Reganit, PF, Rigo, F, Robinson, SM, Robitaille, C, Rodríguez-Artalejo, F, Rodriguez-Perez Mdel, C, Rodríguez-Villamizar, LA, Rojas-Martinez, R, Ronkainen, K, Rosengren, A, Rubinstein, A, Rui, O, Ruiz-Betancourt, BS, Russo Horimoto, RV, Rutkowski, M, Sabanayagam, C, Sachdev, HS, Saidi, O, Sakarya, S, Salanave, B, Salonen, JT, Salvetti, M, Sánchez-Abanto, J, Santos, D, dos Santos, RN, Santos, R, Saramies, JL, Sardinha, LB, Sarrafzadegan, N, Saum, KU, Scazufca, M, Schargrodsky, H, Scheidt-Nave, C, Sein, AA, Sharma, SK, Shaw, JE, Shibuya, K, Shin, Y, Shiri, R, Siantar, R, Sibai, AM, Simon, M, Simons, J, Simons, LA, Sjostrom, M, Slowikowska-Hilczer, J, Slusarczyk, P, Smeeth, L, Snijder, MB, So, HK, Sobngwi, E, Söderberg, S, Solfrizzi, V, Sonestedt, E, Soumare, A, Staessen, JA, Stathopoulou, MG, Steene-Johannessen, J, Stehle, P, Stein, AD, Stessman, J, Stöckl, D, Stokwiszewski, J, Stronks, K, Strufaldi, MW, Sun, CA, Sundström, J, Sung, YT, Suriyawongpaisal, P, Sy, RG, Tai, ES, Tamosiunas, A, Tang, L, Tarawneh, M, Tarqui-Mamani, CB, Taylor, A, Theobald, H, Thijs, L, Thuesen, BH, Tolonen, HK, Tolstrup, JS, Topbas, M, Torrent, M, Traissac, P, Trinh, OT, Tulloch-Reid, MK, Tuomainen, TP, Turley, ML, Tzourio, C, Ueda, P, Ukoli, FA, Ulmer, H, Uusitalo, HM, Valdivia, G, Valvi, D, van Rossem, L, van Valkengoed, IG, Vanderschueren, D, Vanuzzo, D, Vega, T, Velasquez-Melendez, G, Veronesi, G, Verschuren, WM, Verstraeten, R, Viet, L, Vioque, J, Virtanen, JK, Visvikis-Siest, S, Viswanathan, B, Vollenweider, P, Voutilainen, S, Vrijheid, M, Wade, AN, Wagner, A, Walton, J, Wan Mohamud, WN, Wang, F, Wang, MD, Wang, Q, Wang, YX, Wannamethee, SG, Weerasekera, D, Whincup, PH, Widhalm, K, Wiecek, A, Wijga, AH, Wilks, RJ, Willeit, J, Wilsgaard, T, Wojtyniak, B, Wong, TY, Woo, J, Woodward, M, Wu, FC, Wu, SL, Xu, H, Yan, W, Yang, X, Ye, X, Yoshihara, A, Younger-Coleman, NO, Zambon, S, Zargar, AH, Zdrojewski, T, Zhao, W, Zheng, Y, and Zuñiga Cisneros, J

Published
2016
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26. Dietary pattern derived by reduced rank regression and depressive symptoms in a multi-ethnic population: the HELIUS study

Author

Vermeulen, E., Stronks, K., Visser, M., Brouwer, I.A., Snijder, M.B., Mocking, R.J.T., and Derks, E.M.

Subjects
Depression, Mental -- Demographic aspects, Ethnic groups -- Food and nutrition -- Psychological aspects -- Health aspects, Diet -- Health aspects -- Demographic aspects, Food/cooking/nutrition, Health
Abstract

Background/Objectives: To investigate the association of dietary patterns derived by reduced rank regression (RRR) with depressive symptoms in a multi-ethnic population. Subjects/Methods: Cross-sectional data from the HELIUS study were used. In total, 4967 men and women (18-70 years) of Dutch, South-Asian Surinamese, African Surinamese, Turkish and Moroccan origin living in the Netherlands were included. Diet was measured using ethnic-specific food frequency questionnaires. Depressive symptoms were measured with the nine-item patient health questionnaire. Results: By performing RRR in the whole population and per ethnic group, comparable dietary patterns were identified and therefore the dietary pattern for the whole population was used for subsequent analyses. We identified a dietary pattern that was strongly related to eicosapentaenoic acid+docosahexaenoic acid, folate, magnesium and zinc (response variables) and which was characterized by milk products, cheese, whole grains, vegetables, legumes, nuts, potatoes and red meat. After adjustment for confounders, a statistically significant inverse association was observed in the whole population (B: -0.03, 95% CI: -0.06, -0.00, P=0.046) and among Moroccan (B: -0.09, 95% CI: -0.13, -0.04, P=0.027) and South-Asian Surinamese participants (B: -0.05, 95% CI: -0.09, -0.01, P= Conclusions: No consistent evidence was found that consumption of a dietary pattern, high in nutrients that are hypothesized to protect against depression, was associated with lower depressive symptoms across different ethnic groups., Author(s): E Vermeulen [sup.1] , K Stronks [sup.1] , M Visser [sup.2] [sup.3] , I A Brouwer [sup.2] , M B Snijder [sup.1] [sup.4] , R J T Mocking [sup.5] [...]

Published
2017
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33. Preventie:wat is het, en hoe benutten we het optimaal? (NFU paper)

Author

Stronks, K., Burdorf, A., Mölenberg, F.J.M., Kiefte, J.C., Kremers, S., Assendelft, W.J.J., Mierau, J.O., Peters, L.L., de Wit, N.J., van der Ven, G.L., Ballak, D.B., Stronks, K., Burdorf, A., Mölenberg, F.J.M., Kiefte, J.C., Kremers, S., Assendelft, W.J.J., Mierau, J.O., Peters, L.L., de Wit, N.J., van der Ven, G.L., and Ballak, D.B.

Published
2022

34. Gedragsexpertise is de sleutel tot effectief leefstijlbeleid : Gedragswetenschappers roepen op tot actie

Author

Evers, A., Empelen, P. van, Adriaanse, M., Brombacher, A., Burdorf, L., Gemert-Pijnen, L. van, Kremers, S., Roefs, A., Seidell, J., Soedamah-Muthu, S., Stronks, K., Vet, E. de, Evers, A., Empelen, P. van, Adriaanse, M., Brombacher, A., Burdorf, L., Gemert-Pijnen, L. van, Kremers, S., Roefs, A., Seidell, J., Soedamah-Muthu, S., Stronks, K., and Vet, E. de

Abstract

De rol van preventie en een gezonde leefstijl in de zorg en publieke gezondheid krijgt steeds prominenter aandacht in het volksgezondheidsbeleid, denk onder andere aan het Nationaal Preventie Akkoord. De noodzaak van preventie van ziekte door het bevorderen van een gezonde leefstijl is in de coronapandemie pijnlijk duidelijk geworden. Duurzaam gezond leven geeft het immuunsysteem een boost, vermindert het risico op een ernstig beloop van een COVID-19-infectie en kan chronische ziekten als hart- en vaatziekten, type 2 diabetes en chronische nierschade voorkomen of de ziektelast ervan verminderen. Een gezonde leefstijl vraagt echter van mensen die niet gezond leven dat ze hun gedrag veranderen, zoals meer gaan bewegen, gezonder gaan eten of bijvoorbeeld stoppen met roken. Dit maakt gedragsverandering—van mensen, patiënten, zorgprofessionals, beleidsmakers en professionals in het publieke domein—de sleutel tot het terugdringen van chronische aandoeningen en andere maatschappelijke uitdagingen, zoals arbeidsmarktkrapte en stijgende zorgkosten. Des te opvallender is het structurele gebrek aan de inzet van gedragswetenschappelijke expertise, terwijl deze essentieel is om tot effectief beleid en interventies te komen. Daarom roept een twaalftal gerenommeerde gedragsexperts op tot actie: Zet primair gedragsexpertise in bij de start van de ontwikkeling, implementatie en evaluatie van interventies en beleid op het gebied van leefstijl om te komen tot duurzaam gezondere mensen en daarmee een duurzamer gezond Nederland.

Published
2022

36. Volksgezondheid en gezondheidszorg

Author

Anema, J.R., primary, van den Berg, M.J., additional, van den Brink, W., additional, Brug, J., additional, Burdorf, A., additional, Cornel, M.C., additional, Das, C., additional, Essink-Bot, M.L., additional, Feron, F.J.M., additional, Hulshof, C.T.J., additional, Jeurissen, P.P.T., additional, Klazinga, N.S., additional, de Koning, H.J., additional, Legemaate, J., additional, Mackenbach, J.P., additional, van Mechelen, W., additional, van de Mheen, D., additional, Middelkoop, B.J.C., additional, Polder, J.J., additional, Reijnders, U.J.L., additional, Reijneveld, S.A., additional, Richardus, J.H., additional, Smit, H.A., additional, Soethout, M.B.M., additional, Stronks, K., additional, van der Velden, J., additional, Verhoeff, A.P., additional, Westert, G.P., additional, and Wind, H., additional

Published
2016
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38. Deep phenotyping meets big data

Author

Lakerveld, J., Wagtendonk, A., Vaartjes, I., Karssenberg, D., Penninx, B., Beulens, J., Timmermans, E., Huisman, M., Kramer, S., van Wier, M., Boomsma, D., Willemsen, G., Schuengel, C., Oosterman, M., Stronks, K., Vermeulen, R., Koster, A., Stehouwer, C., van den Hurk, K., Koomen, E., de Mutsert, R., Have, M., Verschuren, M., Picavet, S., Beenackers, M., van Lenthe, F., Ikram, A., Jaddoe, V., Oldehinkel, T., de Jong, T., Mulder, S., Dotinga, A., Landdegradatie en aardobservatie, Landscape functioning, Geocomputation and Hydrology, Organizational Culture and Change, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Afd Pharmacology, Urban Accessibility and Social Inclusion, Geography and Education, Leerstoel Aken, UU LEG Research USG Public Matters, Spatial Economics, Sociology, The Social Context of Aging (SoCA), Biological Psychology, APH - Mental Health, APH - Methodology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Health Behaviors & Chronic Diseases, Clinical Child and Family Studies, LEARN! - Child rearing, APH - Aging & Later Life, RS: CAPHRI - R4 - Health Inequities and Societal Participation, Sociale Geneeskunde, MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, MUMC+: MA Reumatologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Hematologie (9), MUMC+: MA Maag Darm Lever (9), MUMC+: MA Endocrinologie (9), MUMC+: HVC Pieken Maastricht Studie (9), Interne Geneeskunde, MUMC+: MA Interne Geneeskunde (3), Public Health, Epidemiology, Erasmus MC other, Pediatrics, Epidemiology and Data Science, Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, APH - Societal Participation & Health, Otolaryngology / Head & Neck Surgery, APH - Quality of Care, APH - Digital Health, and Public and occupational health

Subjects
Earth science, Big data, 010501 environmental sciences, 01 natural sciences, Health informatics, DISEASE, Environmental data, Data science, Cohort Studies, 0302 clinical medicine, 030212 general & internal medicine, Netherlands, ASSOCIATIONS, Non-communicabledisease, Environmental exposure, Non-communicable disease, SDG 11 - Sustainable Cities and Communities, Exposome, Geography, Cohort, lcsh:R858-859.7, BURDEN, medicine.medical_specialty, General Computer Science, Health geography, GREEN, Environment, lcsh:Computer applications to medicine. Medical informatics, Exposure, 03 medical and health sciences, REGRESSION, medicine, Humans, 0105 earth and related environmental sciences, business.industry, Research, Public health, Prevention, Public Health, Environmental and Occupational Health, Environmental Exposure, AIR-POLLUTION, General Business, Management and Accounting, Earth Sciences, Upstream determinants, business, Cohorts, ENVIRONMENTS
Abstract

Environmental exposures are increasingly investigated as possible drivers of health behaviours and disease outcomes. So-called exposome studies that aim to identify and better understand the effects of exposures on behaviours and disease risk across the life course require high-quality environmental exposure data. The Netherlands has a great variety of environmental data available, including high spatial and often temporal resolution information on urban infrastructure, physico-chemical exposures, presence and availability of community services, and others. Until recently, these environmental data were scattered and measured at varying spatial scales, impeding linkage to individual-level (cohort) data as they were not operationalised as personal exposures, that is, the exposure to a certain environmental characteristic specific for a person. Within the Geoscience and hEalth Cohort COnsortium (GECCO) and with support of the Global Geo Health Data Center (GGHDC), a platform has been set up in The Netherlands where environmental variables are centralised, operationalised as personal exposures, and used to enrich 23 cohort studies and provided to researchers upon request. We here present and detail a series of personal exposure data sets that are available within GECCO to date, covering personal exposures of all residents of The Netherlands (currently about 17 M) over the full land surface of the country, and discuss challenges and opportunities for its use now and in the near future.

Published
2020
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