1. Adiposity and breast, endometrial, and colorectal cancer risk in postmenopausal women: Quantification of the mediating effects of leptin, C‐reactive protein, fasting insulin, and estradiol
- Author
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Dashti, S Ghazaleh, Simpson, Julie A, Viallon, Vivian, Karahalios, Amalia, Moreno‐Betancur, Margarita, Brasky, Theodore, Pan, Kathy, Rohan, Thomas E, Shadyab, Aladdin H, Thomson, Cynthia A, Wild, Robert A, Wassertheil‐Smoller, Sylvia, Ho, Gloria YF, Strickler, Howard D, English, Dallas R, and Gunter, Marc J
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Clinical Trials and Supportive Activities ,Nutrition ,Prevention ,Breast Cancer ,Digestive Diseases ,Aging ,Clinical Research ,Colo-Rectal Cancer ,Cancer ,Obesity ,Adiposity ,Body Mass Index ,Breast Neoplasms ,C-Reactive Protein ,Case-Control Studies ,Cohort Studies ,Colorectal Neoplasms ,Endometrial Neoplasms ,Estradiol ,Fasting ,Female ,Humans ,Insulin ,Leptin ,Postmenopause ,Risk Factors ,breast cancer ,causal mediation analysis ,colorectal cancer ,endometrial cancer ,estrogens ,inflammation ,insulin ,Biochemistry and Cell Biology ,Oncology and carcinogenesis - Abstract
BackgroundMechanisms underlying the adiposity-cancer relationship are incompletely understood. We quantified the mediating roles of C-reactive protein (CRP), leptin, fasting insulin, and estradiol in the effect of adiposity on estrogen receptor (ER)-positive breast, endometrial, and colorectal cancer risk in postmenopausal women.MethodsWe used a case-cohort study within the Women's Health Initiative Observational Study, analyzed as a cumulative sampling case-control study. The study included 188 breast cancer cases, 98 endometrial cancer cases, 193 colorectal cancer cases, and 285 controls. Interventional indirect and direct effects on the risk ratio (RR) scale were estimated using causal mediation analysis.ResultsFor breast cancer, the total effect RR for BMI ≥30 versus ≥18.5-
- Published
- 2022