1. Group B Streptococcus and Intraamniotic Inflammation and Infection.
- Author
-
Afsari M, White A, and Adhikari EH
- Subjects
- Humans, Pregnancy, Female, Streptococcal Vaccines, Infant, Newborn, Streptococcal Infections diagnosis, Streptococcal Infections drug therapy, Streptococcal Infections prevention & control, Streptococcus agalactiae, Antibiotic Prophylaxis methods, Pregnancy Complications, Infectious drug therapy, Pregnancy Complications, Infectious microbiology, Pregnancy Complications, Infectious prevention & control, Anti-Bacterial Agents therapeutic use, Chorioamnionitis microbiology, Chorioamnionitis drug therapy
- Abstract
Intraamniotic inflammation and infection complicate 2% to 5% of term deliveries. Group B Streptococcus (GBS) is a common cause of intraamniotic infection associated with invasive neonatal disease and maternal morbidity. Universal vaginal-rectal screening for GBS colonization is recommended between 36 and 37 weeks. Intrapartum antibiotic prophylaxis is recommended for individuals with positive GBS screens and other risk factors. Intravenous penicillin is the preferred antimicrobial agent. Individuals with penicillin allergies may receive cefazolin for low-risk allergies and either clindamycin or vancomycin for high-risk allergies, depending on their antimicrobial susceptibilities. Clinical trials are underway to evaluate the safety and immunogenicity of maternal anti-GBS vaccine candidates., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2024
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