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Your search keyword '"Strelkova, Olga S."' showing total 18 results
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18 results on '"Strelkova, Olga S."'

1. Age-associated clonal B cells drive B cell lymphoma in mice

Author

Castro, José P., Shindyapina, Anastasia V., Barbieri, Alessandro, Ying, Kejun, Strelkova, Olga S., Paulo, João A., Tyshkovskiy, Alexander, Meinl, Rico, Kerepesi, Csaba, Petrashen, Anna P., Mariotti, Marco, Meer, Margarita V., Hu, Yan, Karamyshev, Alexander, Losyev, Grigoriy, Galhardo, Mafalda, Logarinho, Elsa, Indzhykulian, Artur A., Gygi, Steven P., Sedivy, John M., Manis, John P., and Gladyshev, Vadim N.

Published
2024
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4. Revisiting chromatin packaging in mouse sperm

Author

Yin, Qiangzong, primary, Yang, Chih-Hsiang, additional, Strelkova, Olga S., additional, Wu, Jingyi, additional, Sun, Yu, additional, Gopalan, Sneha, additional, Yang, Liyan, additional, Dekker, Job, additional, Fazzio, Thomas G., additional, Li, Xin Zhiguo, additional, Gibcus, Johan, additional, and Rando, Oliver J., additional

Published
2023
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5. Revisiting chromatin packaging in mouse sperm

Author

Yin, Qiangzong, primary, Yang, Chih-Hsiang, additional, Strelkova, Olga S., additional, Wu, Jingyi, additional, Sun, Yu, additional, Gopalan, Sneha, additional, Yang, Liyan, additional, Dekker, Job, additional, Fazzio, Thomas G., additional, Li, Xin Zhiguo, additional, Gibcus, Johan, additional, and Rando, Oliver J., additional

Published
2022
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6. Bifunctional Magnetite–Gold Nanoparticles for Magneto-Mechanical Actuation and Cancer Cell Destruction

Author

Garanina, Anastasiia S., primary, Efremova, Maria V., additional, Machulkin, Alexey E., additional, Lyubin, Evgeny V., additional, Vorobyeva, Natalia S., additional, Zhironkina, Oxana A., additional, Strelkova, Olga S., additional, Kireev, Igor I., additional, Alieva, Irina B., additional, Uzbekov, Rustem E., additional, Agafonov, Viatcheslav N., additional, Shchetinin, Igor V., additional, Fedyanin, Andrey A., additional, Erofeev, Alexander S., additional, Gorelkin, Peter V., additional, Korchev, Yuri E., additional, Savchenko, Alexander G., additional, and Abakumov, Maxim A., additional

Published
2022
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10. Integrative analyses uncover mechanisms by which aging drives B cell lymphoma

Author

Castro, José P., primary, Shindyapina, Anastasia V., additional, Barbieri, Alessandro, additional, Ying, Kejun, additional, Strelkova, Olga S., additional, Paulo, João A., additional, Tyshkovskiy, Alexander, additional, Meinl, Rico, additional, Kerepesi, Csaba, additional, Petrashen, Anna P., additional, Mariotti, Marco, additional, Meer, Margarita, additional, Hu, Yan, additional, Karamyshev, Alexander, additional, Losyev, Grigoriy, additional, Indzhykulian, Artur A., additional, Gygi, Steven P., additional, Sedivy, John M., additional, Manis, John P., additional, and Gladyshev, Vadim N., additional

Published
2021
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11. Evolution of platelet function in adult patients with chronic immune thrombocytopenia on romiplostim treatment

Author

Ignatova, Anastasia A., primary, Demina, Irina A., additional, Ptushkin, Vadim V., additional, Khaspekova, Svetlana G., additional, Shustova, Olga N., additional, Pankrashkina, Maria M., additional, Ryabykh, Aleksandr A., additional, Obydennyi, Sergei I., additional, Strelkova, Olga S., additional, Polokhov, Dmitry M., additional, Seregina, Elena A., additional, Poletaev, Aleksandr V., additional, Ataullakhanov, Fazoil I., additional, Kireev, Igor I., additional, Mazurov, Alexei V., additional, Maschan, Alexei A., additional, Novichkova, Galina A., additional, and Panteleev, Mikhail A., additional

Published
2019
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15. Magnetocontrollability of Fe7C3@C superparamagnetic nanoparticles in living cells

Author

Alieva, Irina B., primary, Kireev, Igor, additional, Garanina, Anastasia S., additional, Alyabyeva, Natalia, additional, Ruyter, Antoine, additional, Strelkova, Olga S., additional, Zhironkina, Oxana A., additional, Cherepaninets, Varvara D., additional, Majouga, Alexander G., additional, Davydov, Valery A., additional, Khabashesku, Valery N., additional, Agafonov, Viatcheslav, additional, and Uzbekov, Rustem E., additional

Published
2016
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16. Magnetocontrollability of Fe7C3@C superparamagnetic nanoparticles in living cells.

Author

Alieva, Irina B., Kireev, Igor, Garanina, Anastasia S., Alyabyeva, Natalia, Ruyter, Antoine, Strelkova, Olga S., Zhironkina, Oxana A., Cherepaninets, Varvara D., Majouga, Alexander G., Davydov, Valery A., Khabashesku, Valery N., Agafonov, Viatcheslav, and Uzbekov, Rustem E.

Subjects
SUPERPARAMAGNETIC materials, MAGNETIZATION, NANOPARTICLES, CYTOPLASM, MAGNETIC fields
Abstract

Background: A new type of superparamagnetic nanoparticles with chemical formula Fe7C3@C (MNPs) showed higher value of magnetization compared to traditionally used iron oxide-based nanoparticles as was shown in our previous studies. The in vitro biocompatibility tests demonstrated that the MNPs display high efficiency of cellular uptake and do not affect cyto-physiological parameters of cultured cells. These MNPs display effective magnetocontrollability in homogeneous liquids but their behavior in cytoplasm of living cells under the effect of magnetic field was not carefully analyzed yet. Results: In this work we investigated the magnetocontrollability of MNPs interacting with living cells in permanent magnetic field. It has been shown that cells were capable of capturing MNPs by upper part of the cell membrane, and from the surface of the cultivation substrate during motion process. Immunofluorescence studies using intracellular endosomal membrane marker showed that MNP agglomerates can be either located in endosomes or lying free in the cytoplasm. When attached cells were exposed to a magnetic field up to 0.15 T, the MNPs acquired magnetic moment and the displacement of incorporated MNP agglomerates in the direction of the magnet was observed. Weakly attached or non-attached cells, such as cells in mitosis or after cytoskeleton damaging treatments moved towards the magnet. During long time cultivation of cells with MNPs in a magnetic field gradual clearing of cells from MNPs was observed. It was the result of removing MNPs from the surface of the cell agglomerates discarded in the process of exocytosis. Conclusions: Our data allow us to conclude for the first time that the magnetic properties of the MNPs are sufficient for successful manipulation with MNP agglomerates both at the intracellular level, and within the whole cell. The structure of the outer shells of the MNPs allows firmly associate different types of biological molecules with them. This creates prospects for the use of such complexes for targeted delivery and selective removal of selected biological molecules from living cells. [ABSTRACT FROM AUTHOR]

Published
2016
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18. PKHD1L1 is required for stereocilia bundle maintenance, durable hearing function and resilience to noise exposure.

Author

Strelkova OS, Osgood RT, Tian CJ, Zhang X, Hale E, De-la-Torre P, Hathaway DM, and Indzhykulian AA

Abstract

Sensory hair cells of the cochlea are essential for hearing, relying on the mechanosensitive stereocilia bundle at their apical pole for their function. Polycystic Kidney and Hepatic Disease 1-Like 1 (PKHD1L1) is a stereocilia protein required for normal hearing in mice, and for the formation of the transient stereocilia surface coat, expressed during early postnatal development. While the function of the stereocilia coat remains unclear, growing evidence supports PKHD1L1 as a human deafness gene. In this study we carry out in depth characterization of PKHD1L1 expression in mice during development and adulthood, analyze hair-cell bundle morphology and hearing function in aging PKHD1L1-defficient mouse lines, and assess their susceptibility to noise damage. Our findings reveal that PKHD1L1-deficient mice display no disruption to bundle cohesion or tectorial membrane attachment-crown formation during development. However, starting from 6 weeks of age, PKHD1L1-defficient mice display missing stereocilia and disruptions to bundle coherence. Both conditional and constitutive PKHD1L1 knock-out mice develop high-frequency hearing loss progressing to lower frequencies with age. Furthermore, PKHD1L1-deficient mice are susceptible to permanent hearing loss following moderate acoustic overexposure, which induces only temporary hearing threshold shifts in wild-type mice. These results suggest a role for PKHD1L1 in establishing robust sensory hair bundles during development, necessary for maintaining bundle cohesion and function in response to acoustic trauma and aging.

Published
2024
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