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2. Operational Research: Methods and Applications

Author

Petropoulos, Fotios, Laporte, Gilbert, Aktas, Emel, Alumur, Sibel A., Archetti, Claudia, Ayhan, Hayriye, Battarra, Maria, Bennell, Julia A., Bourjolly, Jean-Marie, Boylan, John E., Breton, Michèle, Canca, David, Charlin, Laurent, Chen, Bo, Cicek, Cihan Tugrul, Cox Jr, Louis Anthony, Currie, Christine S. M., Demeulemeester, Erik, Ding, Li, Disney, Stephen M., Ehrgott, Matthias, Eppler, Martin J., Erdoğan, Güneş, Fortz, Bernard, Franco, L. Alberto, Frische, Jens, Greco, Salvatore, Gregory, Amanda J., Hämäläinen, Raimo P., Herroelen, Willy, Hewitt, Mike, Holmström, Jan, Hooker, John N., Işık, Tuğçe, Johnes, Jill, Kara, Bahar Y., Karsu, Özlem, Kent, Katherine, Köhler, Charlotte, Kunc, Martin, Kuo, Yong-Hong, Lienert, Judit, Letchford, Adam N., Leung, Janny, Li, Dong, Li, Haitao, Ljubić, Ivana, Lodi, Andrea, Lozano, Sebastián, Lurkin, Virginie, Martello, Silvano, McHale, Ian G., Midgley, Gerald, Morecroft, John D. W., Mutha, Akshay, Oğuz, Ceyda, Petrovic, Sanja, Pferschy, Ulrich, Psaraftis, Harilaos N., Rose, Sam, Saarinen, Lauri, Salhi, Said, Song, Jing-Sheng, Sotiros, Dimitrios, Stecke, Kathryn E., Strauss, Arne K., Tarhan, İstenç, Thielen, Clemens, Toth, Paolo, Berghe, Greet Vanden, Vasilakis, Christos, Vaze, Vikrant, Vigo, Daniele, Virtanen, Kai, Wang, Xun, Weron, Rafał, White, Leroy, Van Woensel, Tom, Yearworth, Mike, Yıldırım, E. Alper, Zaccour, Georges, and Zhao, Xuying

Subjects
Mathematics - Optimization and Control
Abstract

Throughout its history, Operational Research has evolved to include a variety of methods, models and algorithms that have been applied to a diverse and wide range of contexts. This encyclopedic article consists of two main sections: methods and applications. The first aims to summarise the up-to-date knowledge and provide an overview of the state-of-the-art methods and key developments in the various subdomains of the field. The second offers a wide-ranging list of areas where Operational Research has been applied. The article is meant to be read in a nonlinear fashion. It should be used as a point of reference or first-port-of-call for a diverse pool of readers: academics, researchers, students, and practitioners. The entries within the methods and applications sections are presented in alphabetical order. The authors dedicate this paper to the 2023 Turkey/Syria earthquake victims. We sincerely hope that advances in OR will play a role towards minimising the pain and suffering caused by this and future catastrophes.

Published
2023
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11. Einsatz einer stützenden Herrenunterhose bei elektiven skrotalen Eingriffen: Eine prospektive, randomisierte Bewertung hinsichtlich postoperativer Komplikationsraten und gesundheitsbezogener Lebensqualität

Author

Baierl, Maxi Ann, Strauß, Arne, Uhlig, Annemarie, Hahn, Oliver, Reichert, Mathias, Schneider, Till Rasmus, Lüdecke, Jan, Mohr, Mirjam Naomi, Voß, Joost Wilhelm, von Knobloch, Hans-Christoph, Trojan, Lutz, Leitsmann, Conrad, and Leitsmann, Marianne

Published
2023
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21. Aufklärung in der Tumortherapie

Author

Heinrich, Elmar, Strauß, Arne, Trojan, Lutz, Section editor, Michel, Maurice Stephan, editor, W. Thüroff, Joachim, editor, Janetschek, Günter, editor, and Wirth, Manfred P., editor

Published
2023
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23. Personalized Treatment Strategy in “Low-Risk Prostate Cancer Active Surveillance Candidates” Using Irreversible Electroporation: Prospective Evaluation of Feasibility, Morbidity, Functional and Oncological Outcomes.

Author

Popeneciu, Ionel Valentin, Mohr, Mirjam Naomi, Strauß, Arne, Leitsmann, Conrad, Trojan, Lutz, and Reichert, Mathias

Subjects
ELECTROPORATION therapy, MAGNETIC resonance imaging, WATCHFUL waiting, PROSTATE-specific antigen, TREATMENT effectiveness, PROSTATE cancer
Abstract

Purpose: To evaluate the morbidity, functional and oncological outcome of irreversible electroporation (IRE) as a focal therapy for prostate cancer (PCa) when used in “active surveillance (AS)” candidates refusing standard treatment options. Materials and Methods: IRE was performed under general anaesthesia, and the transurethral catheter was removed one day after intervention in all patients. Pre- and post-interventional voiding parameters (measured by International Prostate Symptom Score Questionnaire [IPSS], uroflowmetry and post-void residue) were compared. Follow-up (FU) was observed over a minimum of six months, including oncological outcome (controlled by multiparametric magnetic resonance imaging, rebiopsy, prostate-specific antigen dynamic as well as the need and type of secondary treatment) and general functional outcome (International Index of Erectile Function Questionnaire, satisfaction of the procedure). Results: Twenty-four patients refusing AS or standard treatment with a median FU of 18.7 months were included. IPSS showed nine patients with mild, 12 with moderate and two with severe obstructive voiding symptoms pre-intervention (focal IRE). Median IPSS pre-IRE was 9 points, 8.5 (p=0.341) at six months and 10 (p=0.392) after 12 months, respectively. Pre-IRE maximum urinary flow (Qmax) (median: 16.1±8.0 mL/sec) and Qmax after catheter removal (16.2±7.6 mL/sec) did not differ significantly (p=0.904). Thirteen PCa recurrences occurred (54.2%). Out-of-lesion-PCa was found in 12/13 patients (92.3%), while 4/13 patients showed in-lesion-PCa recurrence simultaneously (30.8%). In one patient, there was an in-lesion-PCa recurrence only (7.7%). Six out of 24 patients (25.0%) received a secondary treatment. All patients were satisfied with the IRE procedure. Conclusions: Focal IRE underperforms regarding the overall oncological outcome and should not be offered as an equivalent therapy to established curative treatment strategies. Nevertheless, under a strict FU regimen, its lack of significant additional morbidity compared to an active surveillance strategy makes IRE a feasible alternative for low-risk PCa in highly selected patients as a personalised approach. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Efficacy and safety of erdafitinib in patients with locally advanced or metastatic urothelial carcinoma: long-term follow-up of a phase 2 study

Author

Necchi, Andrea, Loriot, Yohann, Park, Se Hoon, Tagawa, Scott, Flechon, Aude, Alexeev, Boris, Varlamov, Sergey, Huddart, Robert, Burgess, Earle, Rezazadeh, Arash, Siefker-Radtke, Arlene, Vano, Yann, Gasparro, Donatello, Hamzaj, Alketa, Kopyltsov, Eugeniy, Gracia Donas, Jesus, Mellado, Begona, Parikh, Omi, Schatteman, Peter, Culine, Stephane, Houédé, Nadine, Zanetta, Sylvie, Facchini, Gaetano, Scagliotti, Giorgio, Schinzari, Giovanni, Lee, Jae Lyun, Shkolnik, Mikhail, Fleming, Mark, Joshi, Monica, O'Donnell, Peter, Stöger, Herbert, Decaestecker, Karel, Dirix, Luc, Machiels, Jean Pascal, Borchiellini, Dephine, Delva, Remy, Rolland, Frederic, Hadaschik, Boris, Retz, Margitta, Rosenbaum, Eli, Basso, Umberto, Mosca, Alessandra, Lee, Hyo Jin, Shin, Dong Bok, Cebotaru, Cristina, Duran, Ignacio, Moreno, Victor, Perez Gracia, Jose Luis, Pinto, Alvaro, Su, Wen-Pin, Wang, Shian-Shiang, Hainsworth, John, Schnadig, Ian, Srinivas, Sandhya, Vogelzang, Nicholas, Loidl, Wolfgang, Meran, Johannes, Gross Goupil, Marine, Joly, Florence, Imkamp, Florian, Klotz, Theodor, Krege, Susanne, May, Matthias, Schultze-Seemann, Wolfgang, Strauss, Arne, Zimmermann, Uwe, Keizman, Daniel, Peer, Avivit, Sella, Avishai, Berardi, Rossana, De Giorgi, Ugo, Sternberg, Cora Nanette, Rha, Sun Young, Bulat, Iurie, Izmailov, Adel, Matveev, Vsevolod, Vladimirov, Vladimir, Carles, Joan, Font, Albert, Saez, Maribel, Syndikus, Isabel, Tarver, Kathryn, Appleman, Leonard, Burke, John, Dawson, Nancy, Jain, Sharad, Zakharia, Yousef, Siefker-Radtke, Arlene O, García-Donas, Jesús, Huddart, Robert A, Burgess, Earle F, Fleming, Mark T, Rezazadeh Kalebasty, Arash, Mellado, Begoña, Varlamov, Sergei, Joshi, Monika, Tagawa, Scott T, Akapame, Sydney, Santiago-Walker, Ademi E, Monga, Manish, and O'Hagan, Anne

Published
2022
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30. Operational research: methods and applications

Author

Petropoulos, Fotios, Laporte, Gilbert, Archetti, Claudia, Ayhan, Hayriye, Battarra, Maria, Bennell, Julia A., Boylan, John E., Breton, Michèle, Canca, David, Charlin, Laurent, Chen, Bo, Cicek, Cihan Tugrul, Jr, Louis Anthony Cox, Currie, Christine S. M., Demeulemeester, Erik, Ding, Li, Disney, Stephen M., Ehrgott, Matthias, Eppler, Martin J., Erdoğan, Güneş, Fortz, Bernard, Franco, L. Alberto, Frische, Jens, Greco, Salvatore, Gregory, Amanda J., Hämäläinen, Raimo P., Herroelen, Willy, Hewitt, Mike, Holmström, Jan, Hooker, John N., Işık, Tuğçe, Johnes, Jill, Kara, Bahar Y., Karsu, Özlem, Kent, Katherine, Köhler, Charlotte, Kunc, Martin, Kuo, Yong-Hong, Lienert, Judit, Letchford, Adam N., Leung, Janny, Li, Dong, Li, Haitao, Ljubić, Ivana, Lodi, Andrea, Lozano, Sebastián, Lurkin, Virginie, Martello, Silvano, McHale, Ian G., Midgley, Gerald, Morecroft, John D. W., Mutha, Akshay, Oğuz, Ceyda, Petrovic, Sanja, Pferschy, Ulrich, Psaraftis, Harilaos N., Rose, Sam, Saarinen, Lauri, Salhi, Said, Song, Jing-Sheng, Sotiros, Dimitrios, Stecke, Kathryn E., Strauss, Arne K., Tarhan, İstenç, Thielen, Clemens, Toth, Paolo, Berghe, Greet Vanden, Vasilakis, Christos, Vaze, Vikrant, Vigo, Daniele, Virtanen, Kai, Wang, Xun, Weron, Rafał, White, Leroy, Woensel, Tom Van, Yearworth, Mike, Yıldırım, E. Alper, Zaccour, Georges, Zhao, Xuying, Petropoulos, Fotios, Laporte, Gilbert, Archetti, Claudia, Ayhan, Hayriye, Battarra, Maria, Bennell, Julia A., Boylan, John E., Breton, Michèle, Canca, David, Charlin, Laurent, Chen, Bo, Cicek, Cihan Tugrul, Jr, Louis Anthony Cox, Currie, Christine S. M., Demeulemeester, Erik, Ding, Li, Disney, Stephen M., Ehrgott, Matthias, Eppler, Martin J., Erdoğan, Güneş, Fortz, Bernard, Franco, L. Alberto, Frische, Jens, Greco, Salvatore, Gregory, Amanda J., Hämäläinen, Raimo P., Herroelen, Willy, Hewitt, Mike, Holmström, Jan, Hooker, John N., Işık, Tuğçe, Johnes, Jill, Kara, Bahar Y., Karsu, Özlem, Kent, Katherine, Köhler, Charlotte, Kunc, Martin, Kuo, Yong-Hong, Lienert, Judit, Letchford, Adam N., Leung, Janny, Li, Dong, Li, Haitao, Ljubić, Ivana, Lodi, Andrea, Lozano, Sebastián, Lurkin, Virginie, Martello, Silvano, McHale, Ian G., Midgley, Gerald, Morecroft, John D. W., Mutha, Akshay, Oğuz, Ceyda, Petrovic, Sanja, Pferschy, Ulrich, Psaraftis, Harilaos N., Rose, Sam, Saarinen, Lauri, Salhi, Said, Song, Jing-Sheng, Sotiros, Dimitrios, Stecke, Kathryn E., Strauss, Arne K., Tarhan, İstenç, Thielen, Clemens, Toth, Paolo, Berghe, Greet Vanden, Vasilakis, Christos, Vaze, Vikrant, Vigo, Daniele, Virtanen, Kai, Wang, Xun, Weron, Rafał, White, Leroy, Woensel, Tom Van, Yearworth, Mike, Yıldırım, E. Alper, Zaccour, Georges, and Zhao, Xuying

Abstract

Throughout its history, Operational Research has evolved to include methods, models and algorithms that have been applied to a wide range of contexts. This encyclopedic article consists of two main sections: methods and applications. The first summarises the up-to-date knowledge and provides an overview of the state-of-the-art methods and key developments in the various subdomains of the field. The second offers a wide-ranging list of areas where Operational Research has been applied. The article is meant to be read in a nonlinear fashion and used as a point of reference by a diverse pool of readers: academics, researchers, students, and practitioners. The entries within the methods and applications sections are presented in alphabetical order. The authors dedicate this paper to the 2023 Turkey/Syria earthquake victims. We sincerely hope that advances in OR will play a role towards minimising the pain and suffering caused by this and future catastrophes.

Published
2024

33. Sunitinib for metastatic renal cell carcinoma: Real world data from the STAR-TOR registry and detailed literature review

Author

Uhlig, Annemarie, primary, Bergmann, Lothar, additional, Bögemann, Martin, additional, Fischer, Thomas, additional, Goebell, Peter J., additional, Leitsmann, Marianne, additional, Reichert, Mathias, additional, Rink, Michael, additional, Schlack, Katrin, additional, Trojan, Lutz, additional, Uhlig, Johannes, additional, Woike, Michael, additional, and Strauß, Arne, additional

Published
2024
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34. Operational Research: methods and applications

Author

Petropoulos, Fotios, primary, Laporte, Gilbert, additional, Aktas, Emel, additional, Alumur, Sibel A., additional, Archetti, Claudia, additional, Ayhan, Hayriye, additional, Battarra, Maria, additional, Bennell, Julia A., additional, Bourjolly, Jean-Marie, additional, Boylan, John E., additional, Breton, Michèle, additional, Canca, David, additional, Charlin, Laurent, additional, Chen, Bo, additional, Cicek, Cihan Tugrul, additional, Cox, Louis Anthony, additional, Currie, Christine S.M., additional, Demeulemeester, Erik, additional, Ding, Li, additional, Disney, Stephen M., additional, Ehrgott, Matthias, additional, Eppler, Martin J., additional, Erdoğan, Güneş, additional, Fortz, Bernard, additional, Franco, L. Alberto, additional, Frische, Jens, additional, Greco, Salvatore, additional, Gregory, Amanda J., additional, Hämäläinen, Raimo P., additional, Herroelen, Willy, additional, Hewitt, Mike, additional, Holmström, Jan, additional, Hooker, John N., additional, Işık, Tuğçe, additional, Johnes, Jill, additional, Kara, Bahar Y., additional, Karsu, Özlem, additional, Kent, Katherine, additional, Köhler, Charlotte, additional, Kunc, Martin, additional, Kuo, Yong-Hong, additional, Letchford, Adam N., additional, Leung, Janny, additional, Li, Dong, additional, Li, Haitao, additional, Lienert, Judit, additional, Ljubić, Ivana, additional, Lodi, Andrea, additional, Lozano, Sebastián, additional, Lurkin, Virginie, additional, Martello, Silvano, additional, McHale, Ian G., additional, Midgley, Gerald, additional, Morecroft, John D.W., additional, Mutha, Akshay, additional, Oğuz, Ceyda, additional, Petrovic, Sanja, additional, Pferschy, Ulrich, additional, Psaraftis, Harilaos N., additional, Rose, Sam, additional, Saarinen, Lauri, additional, Salhi, Said, additional, Song, Jing-Sheng, additional, Sotiros, Dimitrios, additional, Stecke, Kathryn E., additional, Strauss, Arne K., additional, Tarhan, İstenç, additional, Thielen, Clemens, additional, Toth, Paolo, additional, Van Woensel, Tom, additional, Berghe, Greet Vanden, additional, Vasilakis, Christos, additional, Vaze, Vikrant, additional, Vigo, Daniele, additional, Virtanen, Kai, additional, Wang, Xun, additional, Weron, Rafał, additional, White, Leroy, additional, Yearworth, Mike, additional, Yıldırım, E. Alper, additional, Zaccour, Georges, additional, and Zhao, Xuying, additional

Published
2023
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48. Axitinib beyond first-line therapy of Metastatic Renal Cell Carcinoma: Real World Data from the STAR-TOR registry

Author

Uhlig, Annemarie, primary, Uhlig, Johannes, additional, Woike, Michael, additional, Fischer, Thomas, additional, Trojan, Lutz, additional, Bergmann, Lothar, additional, Bögemann, Martin, additional, Goebell, Peter J., additional, Rink, Michael, additional, Schlack, Katrin, additional, Leitsmann, Marianne, additional, and Strauß, Arne, additional

Published
2023
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50. Optimizing the structure of interdisciplinary tumor boards for effective cancer care

Author

Braulke, Friederike, primary, Kober, Kathrin, additional, Arndt, Andreas, additional, Papendick, Maximilian, additional, Strauss, Arne, additional, Kramm, Christof Maria, additional, Thoms, Kai-Martin, additional, König, Alexander, additional, Gaedcke, Jochen, additional, Gallwas, Julia, additional, Wulf, Svenja, additional, Szuszies, Christoph, additional, Wulf, Gerald, additional, Rödel, Ralph, additional, Wolfer, Susanne, additional, Malinova, Vesna, additional, Overbeck, Tobias R., additional, Hinterthaner, Marc, additional, Lotz, Joachim, additional, Nauck, Friedemann, additional, Ernst, Marielle, additional, Stadelmann, Christine, additional, Ströbel, Philipp, additional, Ellenrieder, Volker, additional, Asendorf, Thomas, additional, and Rieken, Stefan, additional

Published
2023
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