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12. Infections after Transplantation of Bone Marrow or Peripheral Blood Stem Cells from Unrelated Donors

Author

Young, Jo-Anne H., Logan, Brent R., Wu, Juan, Wingard, John R., Weisdorf, Daniel J., Mudrick, Cathryn, Knust, Kristin, Horowitz, Mary M., Confer, Dennis L., Dubberke, Erik R., Pergam, Steven A., Marty, Francisco M., Strasfeld, Lynne M., Brown, Janice (Wes) M., Langston, Amelia A., Schuster, Mindy G., Kaul, Daniel R., Martin, Stanley I., and Anasetti, Claudio

Published
2016
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17. Bloodstream Infections in Hematologic Malignancy Patients With Fever and Neutropenia: Are Empirical Antibiotic Therapies in the United States Still Effective?

Author

Zimmer, Andrea J, primary, Stohs, Erica, additional, Meza, Jane, additional, Arnold, Christopher, additional, Baddley, John W, additional, Chandrasekar, Pranatharthi, additional, El Boghdadly, Zeinab, additional, Gomez, Carlos A, additional, Maziarz, Eileen K, additional, Montoya, Jose G, additional, Pergam, Steven, additional, Rolston, Kenneth V, additional, Satlin, Michael J, additional, Satyanarayana, Gowri, additional, Shoham, Shmuel, additional, Strasfeld, Lynne, additional, Taplitz, Randy, additional, Walsh, Thomas J, additional, Young, Jo-Anne H, additional, Zhang, Yuning, additional, and Freifeld, Alison G, additional

Published
2022
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22. Maribavir prophylaxis for prevention of cytomegalovirus disease in recipients of allogeneic stem-cell transplants: a phase 3, double-blind, placebo-controlled, randomised trial

Author

Marty, Francisco M, Ljungman, Per, Papanicolaou, Genovefa A, Winston, Drew J, Chemaly, Roy F, Strasfeld, Lynne, Young, Jo-Anne H, Rodriguez, Tulio, Maertens, Johan, Schmitt, Michael, Einsele, Hermann, Ferrant, Augustin, Lipton, Jeffrey H, Villano, Stephen A, Chen, Hongzi, and Boeckh, Michael

Published
2011
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32. Donor derived hepatitis B virus infection: Analysis of the Organ Procurement & Transplantation Network/United Network for Organ Sharing Ad Hoc Disease Transmission Advisory Committee

Author

Theodoropoulos, Nicole M., primary, La Hoz, Ricardo M., additional, Wolfe, Cameron, additional, Vece, Gabriel, additional, Bag, Remzi, additional, Berry, Gerald J., additional, Bucio, Jamie, additional, Danziger‐Isakov, Lara, additional, Florescu, Diana F., additional, Goldberg, David, additional, Ho, Chak‐Sum, additional, Lilly, Kathleen, additional, Malinis, Maricar, additional, Mehta, Aneesh K., additional, Nalesnik, Michael A., additional, Sawyer, Robert, additional, Strasfeld, Lynne, additional, Wood, R. Patrick, additional, and Michaels, Marian G., additional

Published
2020
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36. 88. Public Health Service (PHS) Increased-Risk Factors in Organ Donors: A Review of the OPTN Ad hoc Disease Transmission Advisory Committee (DTAC)

Author

Vece, Gabe, primary, La Hoz, Ricardo M, additional, Wolfe, Cameron R, additional, Ward, Emily G, additional, Wood, R Patrick, additional, Strasfeld, Lynne, additional, Sawyer, Rob, additional, Rana, Meenakshi, additional, Marboe, Charles, additional, Malinis, Maricar, additional, Liliy, Kathleen, additional, Ho, Sam, additional, Florescu, Diana F, additional, Danziger-Isakov, Lara, additional, Bucio, Jamie, additional, Berry, Gerald, additional, Bag, Remzi, additional, Aslam, Saima, additional, and Michaels, Marian G, additional

Published
2019
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37. 2686. strong>Bloodstream Infection Survey in High-Risk Oncology Patients (BISHOP) with Fever and Neutropenia (FN): Viridans Group Streptococcus Emerges as an Important Pathogen

Author

Stohs, Erica, primary, Zimmer, Andrea, additional, Fey, Paul, additional, Handke, Luke D, additional, Zhang, Yuning, additional, Arnold, Christopher, additional, Baddley, John W, additional, Chandrasekar, Pranatharthi, additional, Boghdadly, Zeinab El, additional, Gomez, Carlos A, additional, Maziarz, Eileen K, additional, Montoya, Jose G, additional, Pergam, Steven A, additional, Rolston, Kenneth, additional, Satlin, Michael J, additional, Satyanarayana, Gowri, additional, Shoham, Shmuel, additional, Strasfeld, Lynne, additional, Taplitz, Randy, additional, Walsh, Thomas J, additional, Young, Jo-Anne H, additional, and Freifeld, Alison, additional

Published
2019
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41. 1016. Bloodstream Infection Survey in High-Risk Oncology Patients (BISHOP) With Fever and Neutropenia (FN): Predictors for Morbidity and Mortality

Author

Freifeld, Alison G, primary, Zimmer, Andrea, additional, Arnold, Christopher, additional, Baddley, John W, additional, Chandrasekar, Pranatharthi, additional, El Boghdadly, Zeinab, additional, Maziarz, Eileen K, additional, Montoya, Jose G, additional, Pergam, Steven, additional, Rolston, Kenneth V, additional, Satyanarayana, Gowri, additional, Shoham, Shmuel, additional, Strasfeld, Lynne, additional, Taplitz, Randy, additional, Walsh, Thomas J, additional, Young, Jo-Anne, additional, Zhang, Yuning, additional, and Meza, Jane, additional

Published
2018
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42. Antimicrobial Prophylaxis for Adult Patients With Cancer-Related Immunosuppression: ASCO and IDSA Clinical Practice Guideline Update

Author

Taplitz, Randy A., primary, Kennedy, Erin B., additional, Bow, Eric J., additional, Crews, Jennie, additional, Gleason, Charise, additional, Hawley, Douglas K., additional, Langston, Amelia A., additional, Nastoupil, Loretta J., additional, Rajotte, Michelle, additional, Rolston, Kenneth V., additional, Strasfeld, Lynne, additional, and Flowers, Christopher R., additional

Published
2018
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43. Donor derived hepatitis B virus infection: Analysis of the Organ Procurement & Transplantation Network/United Network for Organ Sharing Ad Hoc Disease Transmission Advisory Committee.

Author

Theodoropoulos, Nicole M., La Hoz, Ricardo M., Wolfe, Cameron, Vece, Gabriel, Bag, Remzi, Berry, Gerald J., Bucio, Jamie, Danziger‐Isakov, Lara, Florescu, Diana F., Goldberg, David, Ho, Chak‐Sum, Lilly, Kathleen, Malinis, Maricar, Mehta, Aneesh K., Nalesnik, Michael A., Sawyer, Robert, Strasfeld, Lynne, Wood, R. Patrick, and Michaels, Marian G.

Subjects
HEPATITIS B virus, INFECTIOUS disease transmission, VIRUS diseases, TRANSPLANTATION of organs, tissues, etc., UNUNITED fractures, BK virus, CELL surface antigens
Abstract

Hepatitis B virus (HBV) can be transmitted from organ donor to recipient, but details of transmission events are not widely published. The Disease Transmission Advisory Committee (DTAC) evaluated 105 cases of potential donor derived transmission events of HBV between 2009‐2017. Proven, probable or possible transmission of HBV occurred in 25 (23.8%) cases. Recipients of liver grafts were most commonly infected (20 of 21 exposed recipients) compared to 9 of 21 exposed non‐hepatic recipients. Eleven of 25 donors were HBV core antibody (HBcAb) positive/HBV surface antigen (HBsAg) negative and infected 8/20 recipients. Of the 10 liver recipients and 1 liver‐kidney recipient who received organs from these donors: six were not given antiviral prophylaxis, two developed infection after antiviral prophylaxis was discontinued, two developed HBV while on lamivudine prophylaxis, one was on antiviral prophylaxis and did not develop HBV viremia or antigenemia. One recipient of a HBcAb positive/HBsAg negative kidney developed active HBV infection. Unexpected donor‐derived transmission of HBV was a rare event in reports to DTAC, but was often detected in the recipient late post‐transplant. Six of 11 recipients (54.5%) of a liver from a HBcAb positive donor did not receive prophylaxis; all of these were potentially preventable with the use of anti‐viral prophylaxis. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Infectious Complications

Author

Strasfeld, Lynne

Subjects
Treatment, surgical procedures, operative, chemical and pharmacologic phenomena, Stem cell transplant, Guidelines, Infection, Article
Abstract

Infections remain a cause of significant morbidity and mortality following hematopoietic stem cell transplantation (HSCT). The conditioning regimen (chemotherapy, radiation therapy), mucosal damage, type of transplant, immune suppressive therapy, and graft-versus-host disease (GVHD) all predispose the HSCT recipient to infection. Abnormal B- and T-lymphocyte function results in impaired humoral and cellular immunity, respectively. Neutrophil function is impaired by the use of corticosteroids and other medications. Hypogammaglobulinemia and functional asplenia are common. The occurrence of infections in an individual patient varies according to the phase of the transplant process and reflects the type(s) of immune defect(s), underlying disease, endogenous host flora, exposure history, and pre-treatment infections.

Published
2014

46. Cryptococcustransmission through solid organ transplantation in the United States: A report from the Ad Hoc Disease Transmission Advisory Committee

Author

Penumarthi, Lasya R., La Hoz, Ricardo M., Wolfe, Cameron R., Jackson, Brendan R., Mehta, Aneesh K., Malinis, Maricar, Danziger-Isakov, Lara, Strasfeld, Lynne, Florescu, Diana F., Vece, Gabriel, Basavaraju, Sridhar V., and Michaels, Marian G.

Abstract

Cryptococcusspecies can cause serious life-threatening infection in solid organ transplant recipients by reactivation of prior infection, posttransplant de novoinfection, or donor transmission from the transplanted organ. Although previously reported in the literature, the extent of donor-derived cryptococcosis in the United States has not been documented. We analyzed potential donor-derived Cryptococcustransmission events reported to the Organ Procurement and Transplantation Network (OPTN) for investigation by the Ad Hoc Disease Transmission Advisory Committee (DTAC). All reports between 2009 and 2019 in which transmission to recipients was designated proven or probable, or determined to be averted due to implementation of prophylaxis (intervention without disease transmission—“IWDT”) were included. During 2009–2019, 58 reports of potential donor-derived cryptococcosis were submitted to DTAC. Among these reports, 12 donors were determined to have resulted in proven or probable transmission to 23/34 (67.6%) recipients. Most of these donors (10/12 [83%]) exhibited central nervous system-related symptoms prior to death and 5/23 (22%) infected recipients died. For 11 different donors, prophylaxis, most often with fluconazole, was administered to 23/35 (65.7%) recipients. Clinicians should maintain awareness of donor-derived cryptococcosis and consider prompt prophylaxis or treatment followed by reporting to OPTN for further investigation.

Published
2021
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47. Impact of a Clostridioides DifficileTesting Computerized Clinical Decision Support Tool on an Adult Stem Cell Transplantation and Hematologic Malignancies Unit

Author

Nix, Chad D., Messer, William B., Hale, Molly L., Lewis, James S., and Strasfeld, Lynne M.

Abstract

•C difficile infection rates in hospitalized hematopoietic stem cell transplant (HSCT) recipients and paitents with hematologic malignancy (HM) are higher than in the general population.•Following implementation of a C difficile testing algorithm with computerized decision support tool on our HSCT/HM unit we observed a >2-fold decrease in C difficile incidence and oral vancomycin use.•Along wiht this decrease in oral vancomycin use we noted a corresponding decline in the incidence of vancomycin-resistant Enterococcus (VRE) colonization and VRE bloodstream infection.

Published
2024
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48. Isavuconazole Prophylaxis in Patients With Hematologic Malignancies and Hematopoietic Cell Transplant Recipients.

Author

Fontana, Lauren, Perlin, David S, Zhao, Yanan, Noble, Brie N, Lewis, James S, Strasfeld, Lynne, and Hakki, Morgan

Subjects
BLOOD disease treatment, ANTIFUNGAL agents, HEMATOPOIETIC stem cell transplantation, MEDICAL records, PREVENTIVE medicine, MYCOSES, NEUTROPENIA, PULMONARY aspergillosis, TRANSPLANTATION of organs, tissues, etc., ACUTE myeloid leukemia, TREATMENT effectiveness, RETROSPECTIVE studies, ACQUISITION of data methodology, DISEASE complications, EVALUATION
Abstract

Background Isavuconazole (ISA) is an attractive candidate for primary mold-active prophylaxis in high-risk patients with hematologic malignancies or hematopoietic cell transplant (HCT) recipients. However, data supporting the use of ISA for primary prophylaxis in these patients are lacking. Methods We conducted a retrospective review of breakthrough invasive fungal infections (bIFIs) among adult hematologic malignancy patients and HCT recipients who received ≥7 days of ISA primary prophylaxis between 1 September 2016 and 30 September 2018. The incidence of bIFIs in patients receiving ISA was compared to those receiving posaconazole (POS) and voriconazole (VOR) during the same time period. Results One hundred forty-five patients received 197 courses of ISA prophylaxis. Twelve bIFIs (Aspergillus fumigatus [5], Aspergillus species [2], Mucorales [2], Fusarium species [2], and Candida glabrata [1]) occurred, representing 8.3% of patients and 6.1% of courses, after a median duration of 14 days of ISA prophylaxis. All bIFIs occurred during periods of neutropenia. Seven patients (58.3%) died within 42 days of onset of bIFI. In addition, bIFIs complicated 10.2% of ISA, 4.1% of POS, and 1.1% of VOR courses among patients with de novo or relapsed/refractory acute myeloid leukemia during the study period, with invasive pulmonary aspergillosis (IPA) complicating 6.8% of ISA, 1.3% of POS, and zero VOR courses. Conclusions Although ISA has been approved for treatment of invasive Aspergillus and mucormycosis, we observed an increased rate of bIFI, notably IPA, using ISA for primary prophylaxis. These results support the need for further study to determine the role of ISA as primary prophylaxis. [ABSTRACT FROM AUTHOR]

Published
2020
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49. Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update

Author

Taplitz, Randy A., primary, Kennedy, Erin B., additional, Bow, Eric J., additional, Crews, Jennie, additional, Gleason, Charise, additional, Hawley, Douglas K., additional, Langston, Amelia A., additional, Nastoupil, Loretta J., additional, Rajotte, Michelle, additional, Rolston, Kenneth, additional, Strasfeld, Lynne, additional, and Flowers, Christopher R., additional

Published
2018
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50. Impact of a Clostridioides DifficileTesting Computerized Clinical Decision Support Tool on an Adult Stem Cell Transplantation and Hematologic Malignancies Unit

Author

Nix, Chad D., Messer, William B., Hale, Molly L., Lewis, James S., and Strasfeld, Lynne M.

Abstract

•C difficile infection rates in hospitalized hematopoietic stem cell transplant (HSCT) recipients and paitents with hematologic malignancy (HM) are higher than in the general population.•Following implementation of a C difficile testing algorithm with computerized decision support tool on our HSCT/HM unit we observed a >2-fold decrease in C difficile incidence and oral vancomycin use.•Along wiht this decrease in oral vancomycin use we noted a corresponding decline in the incidence of vancomycin-resistant Enterococcus (VRE) colonization and VRE bloodstream infection.

Published
2021
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