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3. Meal-time glycaemia in adults with type 1 diabetes using multiple daily injections vs insulin pump therapy following carbohydrate-counting education and bolus calculator provision

Author

Lu, Jean C., Vogrin, Sara, McAuley, Sybil A., Lee, Melissa H., Paldus, Barbora, Bach, Leon A., Burt, Morton G., Clarke, Philip M., Cohen, Neale D., Colman, Peter G., de Bock, Martin I., Jane Holmes-Walker, D., Jenkins, Alicia J., Kaye, Joey, Keech, Anthony C., Kumareswaran, Kavita, MacIsaac, Richard J., McCallum, Roland W., Roem, Kerryn, Sims, Catriona, Stranks, Stephen N., Trawley, Steven, Ward, Glenn M., Sundararajan, Vijaya, Jones, Timothy W., and O'Neal, David N.

Published
2021
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6. Efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (DEPICT-1): 24 week results from a multicentre, double-blind, phase 3, randomised controlled trial

Author

Proietto, Joseph, Stranks, Stephen, Chen, Roger, O'Neal, David, Pape, Alexia, Forbes, Mark, Morbey, Claire, Luger, Anton, Hanusch, Ursula, Schnack, Christoph, Fliesser-Goerzer, Evelyn, Hoelzl, Bertram, Ebenbichler, Christoph, Prager, Rudolf, Van Gaal, Luc, Vercammen, Chris, Scheen, Andre, Mathieu, Chantal, Duyck, Francis, Nobels, Frank, Ruige, Johannes, Aggarwal, Naresh, Woo, Vincent, St-Pierre, Bruno, Dumas, Richard, Hramiak, Irene, Elliott, Thomas, Krarup Hansen, Troels, Henriksen, Jan Erik, Gram, Jeppe, Lihn, Aina, Bruun, Jens, Saltevo, Juha, Taurio, Jyrki, Strand, Jorma, Valle, Timo, Nieminen, Sakari, Pietilainen, Kirsi, Guerci, Bruno, Hadjadj, Samy, Cariou, Bertrand, Verges, Bruno, Borot, Sophie, Penfornis, Alfred, Schaum, Thomas, Tschoepe, Diethelm, Marck, Cornelia, Horacek, Thomas, Rose, Ludger, Klausmann, Gerhard, Luedemann, Joerg, Appelt, Steffi, Aigner, Ulrich, Goebel, Rolf, Behnke, Thomas, Ziegler, Anette-Gabriele, Peterfai, Eva, Kerenyi, Zsuzsanna, Oroszlan, Tamas, Kiss, Gyula G., Konyves, Laszlo, Piros, Gyorgyi, Phillip, Moshe, Mosenzon, Ofri, Shehadeh, Naim, Adawi, Faiad, Wainstein, Julio, Dotta, Francesco, Piatti, Piermarco, Genovese, Stefano, Consoli, Agostino, Di Bartolo, Paolo, Mannucci, Edoardo, Giordano, Carla, Lapolla, Annunziata, Aguilar, Carlos, Esteban, Alberto, Ruiz, Bazzoni, Ramirez, Guillermo Mondragon, Pelayo Orozco, Emilia, Alejandro, Carlos, de Alba, Stobschinski, Medina Pech, Carlos, Garza Ruiz, Jose, Sauque Reyna, Leobardo, Llamas Esperon, Guillermo, Nevarez Ruiz, Luis Alejandro, Vidrio Velazquez, Maricela, Flores Lozano, Fernando, Gonzalez Gonzalez, Jose Gerardo, Garcia-Hernandez, Pedro Alberto, Araujo-Silva, Roberto, Villeda - Espinosa, Efrain, Mistodie, Cristina, Popescu, Daniela, Constantin, Ciprian, Nicolau, Alina, Popa, Bogdan, Timar, Romulus, Serafinceanu, Cristian, Pintilei, Ella, Soto, Alfonso, Gimenez, Margarita, Merino-Torres, Juan Francisco, Morales, Cristobal, Mezquita, Pedro, Jendle, Johan, Tengmark, Bengt-Olov, Eriksson, Jan, Londahl, Magnus, Eliasson, Bjorn, Gunstone, Anthony, Heller, Simon, Darzy, Ken, Mansell, Peter, Davies, Melanie, Reed, Rory, Browne, Duncan, Courtney, Hamish, Turner, Wayne, Blagden, Mark, McCrimmon, Rory, Bergenstal, Richard, Lane, Wendy, Lucas, Kathryn, White, Alexander, Bao, Shichun, White, Judith, Jantzi, Curtis, Rasouli, Neda, Ervin, William, Lewy-Alterbaum, Lorena, Handelsman, Yehuda, Miranda-Palma, Bresta, Cleland, Alan, Fink, Raymond, Rodbard, Helena, Nakhle, Samer, Greenberg, Craig, Schorr, Alan, Bays, Harold, Simmons, Debra, Klein, Eric, Kane, Laurie, Fishman, Norman, Ipp, Eli, Garg, Satish, Bhargava, Anuj, Singh, Michelle Zaniewski, Rosenstock, Julio, Thrasher, James, Warren, Mark, Young, Laura, Aroda, Vanita, Pettus, Jeremy, Liljenquist, David, Busch, Robert, Dandona, Paresh, Wise, Jonathan, Kayne, David, Biggs, William, Hansen, Lars, Griffen, Steven C, Tschöpe, Diethelm, Thorén, Fredrik, Xu, John, and Langkilde, Anna Maria

Published
2017
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10. Management of type 2 diabetes in young adults aged 18–30 years: ADS/ADEA/APEG consensus statement

Author

Wong, Jencia, primary, Ross, Glynis P, additional, Zoungas, Sophia, additional, Craig, Maria E, additional, Davis, Elizabeth A, additional, Donaghue, Kim C, additional, Maple‐Brown, Louise J, additional, McGill, Margaret J, additional, Shaw, Jonathan E, additional, Speight, Jane, additional, Wischer, Natalie, additional, and Stranks, Stephen, additional

Published
2022
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11. Driving with type 1 diabetes: real-world evidence to support starting glucose level and frequency of monitoring during journeys

Author

Trawley, Steven, primary, Stephens, Amanda N, additional, McAuley, Sybil A, additional, Speight, Jane, additional, Hendrieckx, Christel, additional, Vogrin, Sara, additional, Lee, Melissa H, additional, Paldus, Barbora, additional, Bach, Leon A, additional, Burt, Morton G, additional, Cohen, Neale D, additional, Colman, Peter G., additional, Davis, Elizabeth A, additional, Holmes-Walker, D. Jane, additional, Jenkins, Alicia J, additional, Kaye, Joey, additional, Keech, Anthony C, additional, Kumareswaran, Kavita, additional, MacIsaac, Richard J., additional, McCallum, Roland W, additional, Sims, Catriona M., additional, Stranks, Stephen N, additional, Sundararajan, Vijaya, additional, Ward, Glenn M, additional, Jones, Timothy W, additional, and O'Neal, David N, additional

Published
2022
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12. An Assessment of Clinical Continuous Glucose Monitoring Targets for Older and High-Risk People Living with Type 1 Diabetes.

Author

O'Neal, David N., Cohen, Ohad, Vogrin, Sara, Vigersky, Robert A., Jenkins, Alicia J., McAuley, Sybil A, Lee, Melissa H., Paldus, Barbora, Sims, Catriona M., MacIsaac, Richard J., Ward, Glenn M., Colman, Peter G., Cohen, Neale D., Bach, Leon A., Kumareswaran, Kavita, Stranks, Stephen N., Burt, Morton G., Holmes-Walker, D. Jane, McCallum, Roland W., and Kaye, Joey

Published
2023
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19. Six-months of hybrid closed-loop versus manual insulin delivery with finger-prick blood glucose monitoring in adults with type 1 diabetes: a randomized, controlled trial

Author

McAuley, Sybil A, primary, Lee, Melissa H, primary, Paldus, Barbora, primary, Vogrin, Sara, primary, Bock, Martin I de, primary, Abraham, Mary B, primary, Bach, Leon A, primary, Burt, Morton G, primary, Cohen, Neale D, primary, Colman, Peter G, primary, Davis, Elizabeth A, primary, Hendrieckx, Christel, primary, Holmes-Walker, D Jane, primary, Kaye, Joey, primary, Keech, Anthony C, primary, Kumareswaran, Kavita, primary, MacIsaac, Richard J, primary, McCallum, Roland W, primary, Sims, Catriona M, primary, Speight, Jane, primary, Stranks, Stephen N, primary, Sundararajan, Vijaya, primary, Trawley, Steven, primary, Ward, Glenn M, primary, Jenkins, Alicia J, primary, Jones, Timothy W, primary, O’Neal, David N, primary, and Group, the Australian JDRF Closed-Loop Research, primary

Published
2020
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20. 999-P: Six Months At-Home Hybrid Closed-Loop vs. Manual Insulin Delivery with Finger-Stick Blood Glucose Monitoring in Adults with Type 1 Diabetes: A Randomized Controlled Trial

Author

MCAULEY, SYBIL A., primary, LEE, MELISSA H., additional, PALDUS, BARBORA, additional, VOGRIN, SARA, additional, ABRAHAM, MARY B., additional, BACH, LEON, additional, BURT, MORTON, additional, COHEN, NEALE, additional, COLMAN, PETER G., additional, DAVIS, ELIZABETH A., additional, HENDRIECKX, CHRISTEL, additional, BOCK, MARTIN DE, additional, HOLMES-WALKER, JANE, additional, KAYE, JOEY, additional, KUMARESWARAN, KAVITA, additional, MACISAAC, RICHARD, additional, MCCALLUM, ROLAND W., additional, SIMS, CATRIONA M., additional, SPEIGHT, JANE, additional, STRANKS, STEPHEN, additional, TRAWLEY, STEVEN, additional, SUNDARARAJAN, VIJAYA, additional, WARD, GLENN, additional, KEECH, ANTHONY C., additional, JENKINS, ALICIA, additional, JONES, TIM, additional, and ONEAL, DAVID N., additional

Published
2020
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21. A safety and pharmacodynamics study of temelimab, an antipathogenic human endogenous retrovirus type W envelope monoclonal antibody, in patients with type 1 diabetes

Author

Curtin, Francois, primary, Champion, Bernard, additional, Davoren, Peter, additional, Duke, Sally, additional, Ekinci, Elif I., additional, Gilfillan, Chris, additional, Morbey, Claire, additional, Nathow, Thomas, additional, O'Moore‐Sullivan, Trisha, additional, O'Neal, David, additional, Roberts, Adam, additional, Stranks, Stephen, additional, Stuckey, Bronwyn, additional, Vora, Parind, additional, Malpass, Sam, additional, Lloyd, David, additional, Maëstracci‐Beard, Nicole, additional, Buffet, Bénédicte, additional, Kornmann, Gabrielle, additional, Bernard, Corinne, additional, Porchet, Hervé, additional, and Simpson, Richard, additional

Published
2020
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23. Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR):a double-blind, randomised, placebo-controlled trial

Author

Heerspink, Hiddo J.L., Parving, Hans Henrik, Andress, Dennis L., Bakris, George, Correa-Rotter, Ricardo, Hou, Fan Fan, Kitzman, Dalane W., Kohan, Donald, Makino, Hirofumi, McMurray, John J.V., Melnick, Joel Z., Miller, Michael G., Pergola, Pablo E., Perkovic, Vlado, Tobe, Sheldon, Yi, Tingting, Wigderson, Melissa, de Zeeuw, Dick, Elbert, Alicia, Vallejos, Augusto, Alvarisqueta, Andres, Maffei, Laura, Juncos, Luis, de Arteaga, Javier, Greloni, Gustavo, Farias, Eduardo, Zucchini, Alfredo, Vogel, Daniel, Cusumano, Ana, Santos, Juan, Fraenkel, Margaret, Gallagher, Martin, Davis, Tim, Acharya, Shamasunder, Cooke, Duncan, Suranyi, Michael, Roger, Simon, Toussaint, Nigel, Pollock, Carol, Chan, Doris, Stranks, Stephen, MacIsaac, Richard, Endre, Zoltan, Schmidt, Alice, Prager, Rudolf, Mayer, Gert, Warling, Xavier, Jadoul, Michel, Egstrup, Kenneth, Oczachowska-Kulik, Anna Ewa, Rossing, Peter, Ono, Yasuhirov, Yalcin, Murat, Karim, Shahana, Heerspink, Hiddo J.L., Parving, Hans Henrik, Andress, Dennis L., Bakris, George, Correa-Rotter, Ricardo, Hou, Fan Fan, Kitzman, Dalane W., Kohan, Donald, Makino, Hirofumi, McMurray, John J.V., Melnick, Joel Z., Miller, Michael G., Pergola, Pablo E., Perkovic, Vlado, Tobe, Sheldon, Yi, Tingting, Wigderson, Melissa, de Zeeuw, Dick, Elbert, Alicia, Vallejos, Augusto, Alvarisqueta, Andres, Maffei, Laura, Juncos, Luis, de Arteaga, Javier, Greloni, Gustavo, Farias, Eduardo, Zucchini, Alfredo, Vogel, Daniel, Cusumano, Ana, Santos, Juan, Fraenkel, Margaret, Gallagher, Martin, Davis, Tim, Acharya, Shamasunder, Cooke, Duncan, Suranyi, Michael, Roger, Simon, Toussaint, Nigel, Pollock, Carol, Chan, Doris, Stranks, Stephen, MacIsaac, Richard, Endre, Zoltan, Schmidt, Alice, Prager, Rudolf, Mayer, Gert, Warling, Xavier, Jadoul, Michel, Egstrup, Kenneth, Oczachowska-Kulik, Anna Ewa, Rossing, Peter, Ono, Yasuhirov, Yalcin, Murat, and Karim, Shahana

Abstract

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR

Published
2019

24. Niche oral agents in type 2 diabetes.

Author

JALLEH, RYAN and STRANKS, STEPHEN

Subjects
*GLUCOSIDASE inhibitors, *THIAZOLIDINEDIONES, *ACARBOSE, *GLUCOSE, *ROSIGLITAZONE
Abstract

The article discusses the alpha-glucosidase inhibitors and thiazolidinediones that are older classes of oral type 2 diabetes medication. Topics discussed include acarbose that is an alpha-glucosidase inhibitor available in Australia, diagnosis of impaired glucose tolerance, and safety concerns which were raised about the use of rosiglitazone.

Published
2021

25. Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Author

Heerspink, Hiddo J L, primary, Parving, Hans-Henrik, additional, Andress, Dennis L, additional, Bakris, George, additional, Correa-Rotter, Ricardo, additional, Hou, Fan-Fan, additional, Kitzman, Dalane W, additional, Kohan, Donald, additional, Makino, Hirofumi, additional, McMurray, John J V, additional, Melnick, Joel Z, additional, Miller, Michael G, additional, Pergola, Pablo E, additional, Perkovic, Vlado, additional, Tobe, Sheldon, additional, Yi, Tingting, additional, Wigderson, Melissa, additional, de Zeeuw, Dick, additional, Elbert, Alicia, additional, Vallejos, Augusto, additional, Alvarisqueta, Andres, additional, Maffei, Laura, additional, Juncos, Luis, additional, de Arteaga, Javier, additional, Greloni, Gustavo, additional, Farias, Eduardo, additional, Zucchini, Alfredo, additional, Vogel, Daniel, additional, Cusumano, Ana, additional, Santos, Juan, additional, Fraenkel, Margaret, additional, Gallagher, Martin, additional, Davis, Tim, additional, Acharya, Shamasunder, additional, Cooke, Duncan, additional, Suranyi, Michael, additional, Roger, Simon, additional, Toussaint, Nigel, additional, Pollock, Carol, additional, Chan, Doris, additional, Stranks, Stephen, additional, MacIsaac, Richard, additional, Endre, Zoltan, additional, Schmidt, Alice, additional, Prager, Rudolf, additional, Mayer, Gert, additional, Warling, Xavier, additional, Jadoul, Michel, additional, Hougardy, Jean, additional, Vercammen, Chris, additional, Van Vlem, Bruno, additional, Gillard, Pieter, additional, Costa e Forti, Adriana, additional, Borges, Joao Lindolfo, additional, Santos Canani, Luis, additional, Eliaschewitz, Freddy, additional, Leite, Silmara, additional, Fraige Filho, Fadlo, additional, Paschoalin, Raphael, additional, Moura Neto, Jose Andrade, additional, Deboni, Luciane, additional, de Lourdes Noronha, Irene, additional, Cercato, Cintia, additional, Prompt, Carlos Alberto, additional, Zanella, Maria, additional, Rassi, Nelson, additional, D'Avila, Domingos, additional, Milagres, Rosangela, additional, Felicio, Joao, additional, Pecoits Filho, Roberto, additional, Riella, Miguel Carlos, additional, Salles, Joao, additional, Keitel, Elizete, additional, Draibe, Sergio, additional, Amodeo, Celso, additional, Youmbissi, Joseph, additional, Roy, Louise, additional, Cournoyer, Serge, additional, Jolly, Shivinder, additional, Pichette, Vincent, additional, Nesrallah, Gihad, additional, Bajaj, Harpreet Singh, additional, Khandwala, Hasnain, additional, Aronson, Ronnie, additional, Goluch, Richard, additional, Tam, Paul, additional, Rabbat, Christian, additional, Bailey, Gordon, additional, Chow, Stephen, additional, Castillo, Alvaro, additional, Danin Vargas, Alfredo, additional, Gonzalez, Fernando, additional, Munoz, Rodrigo, additional, Gutierrez, Vicente, additional, Godoy, Gonzalo, additional, Zhao, Hongwen, additional, Liu, Zhangsuo, additional, Zhao, Minghui, additional, Guo, Xiaohui, additional, Su, Benli, additional, Fu, Shuxia, additional, Xu, Yan, additional, Yang, Jinkui, additional, Shi, Bingyin, additional, Xiao, Guanqing, additional, Shi, Wei, additional, Hao, Chuanming, additional, Xing, Changying, additional, Hou, Fanfan, additional, Luo, Qun, additional, Li, Yuxiu, additional, Ji, Linong, additional, Zuo, Li, additional, Wang, Song, additional, Ni, Zhaohui, additional, Ding, Guohua, additional, Chen, Nan, additional, Zhao, Jiajun, additional, Jia, Weiping, additional, Yu, Shengqiang, additional, Weng, Jian, additional, Xu, Gang, additional, Fu, Ping, additional, Sun, Shiren, additional, Liu, Bicheng, additional, Ding, Xiaoqiang, additional, Rychlik, Ivan, additional, Oplustilova, Alexandra, additional, Bartaskova, Dagmar, additional, Honova, Vaclava, additional, Chmelickova, Hana, additional, Petr, Martin, additional, Bucek, Petr, additional, Tesar, Vladimir, additional, Zahumensky, Emil, additional, Povlsen, Johan, additional, Egstrup, Kenneth, additional, Oczachowska-Kulik, Anna, additional, Rossing, Peter, additional, Lahtela, Jorma, additional, Strand, Jorma, additional, Kantola, Ilkka, additional, Petit, Catherine, additional, Combe, Christian, additional, Zaoui, Philippe, additional, Esnault, Vincent, additional, Urena Torres, Pablo, additional, Halimi, Jean-Michel, additional, Dussol, Bertrand, additional, Bieler, Tasso, additional, Budde, Klemens, additional, Dellanna, Frank, additional, Segiet, Thomas, additional, Kosch, Christine, additional, Schmidt-Guertler, Hans, additional, Schenkenberger, Isabelle, additional, Vielhauer, Volker, additional, Pistrosch, Frank, additional, Alscher, Mark, additional, Hasslacher, Christoph, additional, Hugo, Christian, additional, Muehlfeld, Anja, additional, Wanner, Christoph, additional, Passadakis, Ploumis, additional, Apostolou, Theofanis, additional, Tentolouris, Nikolaos, additional, Stefanidis, Ioannis, additional, Mavromatidis, Konstantinos, additional, Liakopoulos, Vasilios, additional, Goumenos, Dimitrios, additional, Siamopoulos, Konstantinos, additional, Yeung, Vincent, additional, Ozaki, Risa, additional, Fung, Samuel, additional, Tan, Kathryn, additional, Tang, Sydney, additional, Lui, Sing Leung, additional, Cheung, Siu Fai, additional, Sreenan, Seamus, additional, Eustace, Joseph, additional, O'Shea, Donal, additional, Lavin, Peter, additional, Stack, Austin, additional, Yagil, Yoram, additional, Wainstein, Julio, additional, Knobler, Hilla, additional, Cohen, Josef, additional, Kenis, Irina, additional, Daoud, Deeb, additional, Bar-Dayan, Yosefa, additional, Frajewicki, Victor, additional, Adawi, Faiad, additional, Gesualdo, Loreto, additional, Santoro, Domenico, additional, Marino, Francesco, additional, Galfre, Andrea, additional, Brunati, Chiara, additional, Ruggenenti, Piero, additional, Rombola, Giuseppe, additional, Pugliese, Giuseppe, additional, Ravera, Maura, additional, Malberti, Fabio, additional, Pontoriero, Giuseppe, additional, Rampino, Teresa, additional, De Cosmo, Salvatore, additional, Esposito, Ciro, additional, Nappi, Felice, additional, Abaterusso, Cataldo, additional, Conte, Giuseppe, additional, Panichi, Vincenzo, additional, Lauro, Davide, additional, Capasso, Giovambattista, additional, Russo, Domenico, additional, Anzai, Jiichi, additional, Naka, Motoji, additional, Ato, Keita, additional, Tsujimoto, Tetsuro, additional, Nimura, Toshinori, additional, Nakashima, Eitaro, additional, Takeda, Tetsuro, additional, Fujii, Shinya, additional, Kobayashi, Kunihisa, additional, Iwaoka, Hideaki, additional, Nagayama, Koji, additional, Harada, Hiroyuki, additional, Maeda, Hajime, additional, Kishimoto, Rui, additional, Iitsuka, Tadashi, additional, Itabashi, Naoki, additional, Furuya, Ryuichi, additional, Maeda, Yoshitaka, additional, Yamada, Daishiro, additional, Sasaki, Nobuhiro, additional, Sasaki, Hiromitsu, additional, Ueda, Shinichiro, additional, Kashihara, Naoki, additional, Watanabe, Shuichi, additional, Nakamura, Takehiro, additional, Kanai, Hidetoshi, additional, Makita, Yuichiro, additional, Ono, Keiko, additional, Iehara, Noriyuki, additional, Goto, Daisuke, additional, Kosuge, Keiichiro, additional, Tsuchida, Kenichi, additional, Sato, Toshiaki, additional, Sekikawa, Takashi, additional, Okamoto, Hideki, additional, Tanaka, Tsuyoshi, additional, Ikeda, Naoko, additional, Tadika, Takenobu, additional, Mukasa, Koji, additional, Osonoi, Takeshi, additional, Hirano, Fuminori, additional, Nishimura, Motonobu, additional, Yambe, Yuko, additional, Tanaka, Yukio, additional, Ujihara, Makoto, additional, Sakai, Takashi, additional, Imura, Mitsuo, additional, Umayahara, Yutaka, additional, Makino, Shinya, additional, Nakazawa, Jun, additional, Yamaguchi, Yukinari, additional, Kashine, Susumu, additional, Miyaoka, Hiroaki, additional, Suzuki, Katsunori, additional, Inoue, Toshihiko, additional, Nagai, Sou, additional, Sato, Nobuyuki, additional, Yamamoto, Masahiro, additional, Taya, Noriyasu, additional, Fujita, Akira, additional, Matsutani, Akira, additional, Shibagaki, Yugo, additional, Sato, Yuichi, additional, Yamauchi, Akira, additional, Tsutsui, Masahiro, additional, Ishiko, Tamayo, additional, Kaneko, Shizuka, additional, Azuma, Nobuyuki, additional, Matsuda, Hirofumi, additional, Hashiguchi, Yasuhiro, additional, Onishi, Yukiko, additional, Tokui, Mikiya, additional, Matsuhisa, Munehide, additional, Kiyosue, Arihiro, additional, Shinoda, Junji, additional, Ishikawa, Kazuo, additional, Ahmad, Ghazali, additional, Vijayasingham, Shalini, additional, Aziz, Nor Azizah, additional, Hussein, Zanariah, additional, Fung, Yin Khet, additional, Hassan, Wan Hasnul Halimi Wan, additional, Wong, Hin Seng, additional, Goh, Bak Leong, additional, Ali, Norhaliza Mohd, additional, Merican, Nor Shaffinaz Yusuf Azmi, additional, Vaithilingam, Indralingam, additional, Nik Ahmad, Nik Nur Fatnoon, additional, Adam, Noor, additional, Sukor, Norlela, additional, Vengadasalam, V Paranthaman P, additional, Abdul Kadir, Khalid, additional, Mohamed, Mafauzy, additional, Renoirte Lopez, Karina, additional, Leguizamo-Dimas, Aniceto, additional, Chew Wong, Alfredo, additional, Chevaile-Ramos, Jose, additional, Gonzalez Gonzalez, Jose, additional, Rico Hernandez, Raul, additional, Nino-Cruz, Jose, additional, Sauque Reyna, Leobardo, additional, Gonzalez-Galvez, Guillermo, additional, Madero Rovalo, Magdalena, additional, Bochicchio-Ricardelli, Tomasso, additional, Aldrete, Jorge, additional, Carranza-Madrigal, Jaime, additional, Vogt, Liffert, additional, Smak Gregoor, Peter, additional, Barendregt, JNM, additional, Luik, Peter, additional, Gansevoort, Ronald, additional, Laverman, Gozewijn, additional, Pilmore, Helen, additional, Lunt, Helen, additional, Baker, John, additional, Miller, Steven, additional, Rabindranath, Kannaiyan, additional, Zapata-Rincon, Luis, additional, Vargas-Gonzales, Rolando, additional, Calderon Ticona, Jorge, additional, Dextre Espinoza, Augusto, additional, Burga Nunez, Jose, additional, Zea-Nunez, Carlos Antonio, additional, Herrada Orue, Benjamin, additional, Medina-Santander, Boris, additional, Delgado-Butron, Cesar, additional, Farfan-Aspilcueta, Julio, additional, Mazur, Stanislaw, additional, Necki, Miroslaw, additional, Wruk, Michal, additional, Klodawska, Katarzyna, additional, Popenda, Grazyna, additional, Skokowska, Ewa, additional, Arciszewska, Malgorzata, additional, Wiecek, Andrzej, additional, Ciechanowski, Kazimierz, additional, Nowicki, Michal, additional, Birne, Rita, additional, Cabrita, Antonio, additional, Ramos, Aura, additional, Antunes Ferreira, Manuel Anibal, additional, Matta Fontanet, Evelyn, additional, Alcantara-Gonzalez, Altagracia Aurora, additional, Comulada-Rivera, Angel, additional, Galindo Ramos, Eugenia, additional, Cangiano, Jose, additional, Quesada-Suarez, Luis, additional, Calderon Ortiz, Ricardo, additional, Vazquez-Tanus, Jose, additional, Burgos-Calderon, Rafael, additional, Rosado, Carlos, additional, Hancu, Nicolae, additional, Pintilei, Ella, additional, Mistodie, Cristina, additional, Bako, Gabriel, additional, Ionutiu, Lavinia, additional, Petrica, Ligia, additional, Timar, Romulus, additional, Tuta, Liliana, additional, Duma, Livia, additional, Tutescu, Adriana, additional, Ivanova, Svetlana, additional, Essaian, Ashot, additional, Zrazhevskiy, Konstantin, additional, Tomilina, Natalia, additional, Smolyarchuk, Elena, additional, Kuzin, Anatoly, additional, Lantseva, Olga, additional, Karpova, Irina, additional, Shamkhalova, Minara, additional, Liberanskaya, Natalia, additional, Yavdosyuk, Andrey, additional, Shvarts, Yuri, additional, Bardymova, Tatiana, additional, Blagoveshchenskaya, Olga, additional, Solovev, Oleg, additional, Rechkova, Elena, additional, Pikalova, Natalia, additional, Pavlova, Maria, additional, Kolmakova, Elena, additional, Sayfutdinov, Rustam, additional, Villevalde, Svetlana, additional, Koziolova, Natalya, additional, Martynenko, Vladimir, additional, Marasaev, Vyacheslav, additional, Maksudova, Adelya, additional, Sigitova, Olga, additional, Mordovin, Viktor, additional, Klimontov, Vadim, additional, Samoylova, Yulia, additional, Karonova, Tatiana, additional, Yeoh, Lee Ying, additional, Teo, Boon Wee, additional, Foo, Marjorie Wai Yin, additional, Liew, Adrian, additional, Tkac, Ivan, additional, Oroszova, Aniko, additional, Fekete, Jozef, additional, Rosenberger, Jaroslav, additional, Obetkova, Ida, additional, Fulopova, Alla, additional, Kolesarova, Eva, additional, Raslova, Katarina, additional, Smolko, Peter, additional, Oksa, Adrian, additional, Distiller, Larry, additional, Trokis, Julien, additional, Adams, Luthando, additional, Makan, Hemant, additional, Ramlachan, Padaruth, additional, Mitha, Essack, additional, Coetzee, Kathleen, additional, Punt, Zelda, additional, Bhorat, Qasim, additional, Naiker, Puvenesvari, additional, Ellis, Graham, additional, Van Zyl, Louis, additional, Lee, Kwan Woo, additional, Kim, Min Seon, additional, Yoo, Soon-Jib, additional, Yoon, Kun Ho, additional, Cho, Yong-Wook, additional, Park, Tae-Sun, additional, Kim, Sang Yong, additional, Choi, Moon-Gi, additional, Oh, Tae Keun, additional, Lee, Kang-Wook, additional, Shon, Ho Sang, additional, Suh, Sung Hwan, additional, Kim, Byung-Joon, additional, Doo-Man, Kim, additional, Yi, Joo Hark, additional, Lee, Sang Ah, additional, Cho, Ho Chan, additional, Kim, Sin-Gon, additional, Cha, Dae-Ryong, additional, Seo, Ji A, additional, Choi, Kyung Mook, additional, Woo, Jeong-Taek, additional, Ahn, Kyu Jeung, additional, Lee, Jae Hyuk, additional, Kim, In-Joo, additional, Lee, Moon-Kyu, additional, Jang, Hak Chul, additional, Park, Kyong-Soo, additional, Kim, Beom Seok, additional, Mok, Ji Oh, additional, Shin, Mijung, additional, Yoon, Sun Ae, additional, Nam-Goong, Il-Seong, additional, Chung, Choon Hee, additional, Yu, Tae Yang, additional, Lee, Hyoung Woo, additional, Soto Gonzalez, Alfonso, additional, Almirall, Jaume, additional, Egido, Jesus, additional, Calero Gonzalez, Francesca, additional, Fernandez Fresnedo, Gema, additional, Valera Cortes, Ildefonso, additional, Praga Terente, Manuel, additional, Garcia Mendez, Isabel, additional, Navarro Gonzalez, Juan, additional, Herrero Calvo, Jose, additional, Cigarran Guldris, Secundino, additional, Prieto Velasco, Mario, additional, Minguela Pesquera, Jose Ignacio, additional, Galan, Antonio, additional, Pascual, Julio, additional, Marques Vidas, Maria, additional, Martins Munoz, Judith, additional, Rodriguez-Perez, Jose, additional, Castro-Alonso, Cristina, additional, Bonet Sol, Josep, additional, Seron, Daniel, additional, Fernandez Giraldez, Elvira, additional, Arrieta Lezama, Javier, additional, Montero, Nuria, additional, Hernandez-Jaras, Julio, additional, Santamaria Olmo, Rafael, additional, Molas Coten, Jose Ramon, additional, Hellberg, Olof, additional, Fellstrom, Bengt, additional, Bock, Andreas, additional, Pei, Dee, additional, Lin, Ching-Ling, additional, Tien, Kai-Jen, additional, Chen, Ching-Chu, additional, Huang, Chien-Ning, additional, Jiang, Ju-Ying, additional, Wu, Du-An, additional, Chu, Chih-Hsun, additional, Tseng, Shih-Ting, additional, Chen, Jung-Fu, additional, Bau, Cho-Tsan, additional, Sheu, Wayne, additional, Wu, Mai-Szu, additional, Sari, Ramazan, additional, Sezer, Siren, additional, Yildiz, Alaattin, additional, Satman, Ilhan, additional, Kalender, Betul, additional, Mankovskyy, Borys, additional, Fushtey, Ivan, additional, Stanislavchuk, Mykola, additional, Kolenyk, Mykola, additional, Dudar, Iryna, additional, Zolotaikina, Viktoriia, additional, Abrahamovych, Orest, additional, Kostynenko, Tetyana, additional, Petrosyan, Olena, additional, Kuskalo, Petro, additional, Galushchak, Olga, additional, Legun, Oleg, additional, Topchii, Ivan, additional, Martynyuk, Liliya, additional, Stryzhak, Vasyl, additional, Panina, Svitlana, additional, Tkach, Sergii, additional, Korpachev, Vadym, additional, Maxwell, Peter, additional, Gnudi, Luigi, additional, Kon, Sui Phin, additional, Tindall, Hilary, additional, Kalra, Phillip, additional, Mark, Patrick, additional, Patel, Dipesh, additional, El-Shahawy, Mohamed, additional, Bai, Liqun, additional, Nica, Romanita, additional, Lien, Yeong-Hau, additional, Menefee, Judson, additional, Busch, Robert, additional, Miller, Alan, additional, Ahmed, Azazuddin, additional, Arif, Ahmed, additional, Lee, Joseph, additional, Desai, Sachin, additional, Bansal, Shweta, additional, Bentsianov, Marie, additional, Belledonne, Mario, additional, Jere, Charles, additional, Gaona, Raul, additional, Greenwood, Gregory, additional, Brusco, Osvaldo, additional, Boiskin, Mark, additional, Belo, Diogo, additional, Minasian, Raffi, additional, Atray, Naveen, additional, Lawrence, Mary, additional, Taliercio, John, additional, Pergola, Pablo, additional, Scott, David, additional, Alvarez, German, additional, Marder, Bradley, additional, Powell, Thomas, additional, Bakdash, Wa'el, additional, Stoica, George, additional, McFadden, Christopher, additional, Rendell, Marc, additional, Wise, Jonathan, additional, Jones, Audrey, additional, Jardula, Michael, additional, Madu, Ivy-Joan, additional, Varghese, Freemu, additional, Tulloch, Brian, additional, Ahmed, Ziauddin, additional, Hames, Melanie, additional, Nazeer, Imran, additional, Shahid, Newman, additional, John, Rekha, additional, Montero, Manuel, additional, Fitz-Patrick, David, additional, Phillips, Lawrence, additional, Guasch, Antonio, additional, Christofides, Elena, additional, Gundroo, Aijaz, additional, Amin, Mohammad, additional, Bowman-Stroud, Cynthia, additional, Link, Michael, additional, Mulloy, Laura, additional, Nammour, Michael, additional, Lalwani, Tarik, additional, Hanson, Lenita, additional, Whaley-Connell, Adam, additional, Herman, Lee, additional, Chatha, Rupi, additional, Osama, Sayed, additional, Liss, Kenneth, additional, Kayali, Zeid, additional, Bhargava, Anuj, additional, Israel, Ezra, additional, Peguero-Rivera, Alfredo, additional, Fang, Michael, additional, Slover, Judith, additional, Barengolts, Elena, additional, Flores, Jose, additional, Muoneke, Rosemary, additional, Savin, Virginia, additional, Awua-Larbi, Stella, additional, Levine, Andrew, additional, Newman, George, additional, Golestaneh, Laden, additional, Bohm, Guillermo, additional, Reisin, Efrain, additional, Cruz, Lucita, additional, Weiss, Robert, additional, Zieve, Franklin, additional, Horwitz, Edward, additional, Chuang, Peale, additional, Mersey, James, additional, Manley, John, additional, Graf, Ronald, additional, Bedros, Fadi, additional, Joshi, Sudhir, additional, Frias, Juan, additional, Assefi, Ali, additional, O'Shaughnessy, Andrew, additional, Brantley, Roman, additional, Minga, Todd, additional, Tietjen, David, additional, Kantor, Samuel, additional, Jamal, Aamir, additional, Guadiz, Ramon, additional, Hershon, Kenneth, additional, Bressler, Peter, additional, Kopyt, Nelson, additional, Cathcart, Harold, additional, Bloom, Scott, additional, Reichel, Ronald, additional, Nakhle, Samer, additional, Dulude, Emily, additional, Tarkan, Joshua, additional, Baker, Penelope, additional, Zeig, Steven, additional, Moya Hechevarria, Jaynier, additional, Ropero-Cartier, Armando, additional, De la Calle, Gilda, additional, Doshi, Ankur, additional, Saba, Fadi, additional, Sligh, Teresa, additional, Shaw, Sylvia, additional, Kumar, Jayant, additional, Szerlip, Harold, additional, Bayliss, George, additional, Perlman, Alan, additional, Sakhrani, Lakhi, additional, Gouge, Steven, additional, Argoud, Georges, additional, Acosta, Idalia, additional, Elder, John, additional, Joshi, Sucharit, additional, Sensenbrenner, John, additional, Vicks, Steven, additional, Mangoo-Karim, Roberto, additional, Galphin, Claude, additional, Leon-Forero, Carlos, additional, Gilbert, John, additional, Brown, Eric, additional, Ijaz, Adeel, additional, Butt, Salman, additional, Markell, Mariana, additional, Arauz-Pacheco, Carlos, additional, Sloan, Lance, additional, Alvarado, Odilon, additional, Jabbour, Serge, additional, Simon, Eric, additional, Rastogi, Anjay, additional, James, Sam, additional, Hall, Karen, additional, Melish, John, additional, Dixon, Brad, additional, Adolphe, Allen, additional, Kovesdy, Csaba, additional, Beddhu, Srinivasan, additional, Solomon, Richard, additional, Fernando, Ronald, additional, Levin, Ellis, additional, Thakar, Charuhas, additional, Robey, Brooks, additional, Goldfarb, David, additional, Fried, Linda, additional, Maddukuri, Geetha, additional, Thomson, Stephen, additional, Annand, Andrew, additional, Kronfli, Saeed, additional, Kalirao, Paramjit, additional, Schmidt, Rebecca, additional, Dahl, Neera, additional, Blumenthal, Samuel, additional, Weinstein, Debra, additional, Ostergaard, Ove, additional, Weinstein, Talia, additional, Ono, Yasuhiro, additional, Yalcin, Murat, additional, and Karim, Shahana, additional

Published
2019
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27. Effect of 6 months of hybrid closed-loop insulin delivery in adults with type 1 diabetes: a randomised controlled trial protocol

Author

McAuley, Sybil A, primary, de Bock, Martin I, additional, Sundararajan, Vijaya, additional, Lee, Melissa H, additional, Paldus, Barbora, additional, Ambler, Geoff R, additional, Bach, Leon A, additional, Burt, Morton G, additional, Cameron, Fergus J, additional, Clarke, Philip M, additional, Cohen, Neale D, additional, Colman, Peter G, additional, Davis, Elizabeth A, additional, Fairchild, Jan M, additional, Hendrieckx, Christel, additional, Holmes-Walker, D Jane, additional, Horsburgh, Jodie C, additional, Jenkins, Alicia J, additional, Kaye, Joey, additional, Keech, Anthony C, additional, King, Bruce R, additional, Kumareswaran, Kavita, additional, MacIsaac, Richard J, additional, McCallum, Roland W, additional, Nicholas, Jennifer A, additional, Sims, Catriona, additional, Speight, Jane, additional, Stranks, Stephen N, additional, Trawley, Steven, additional, Ward, Glenn M, additional, Vogrin, Sara, additional, Jones, Timothy W, additional, and O’Neal, David N, additional

Published
2018
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28. Efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (DEPICT-1): 24 week results from a multicentre, double-blind, phase 3, randomised controlled trial

Author

Dandona, Paresh, primary, Mathieu, Chantal, additional, Phillip, Moshe, additional, Hansen, Lars, additional, Griffen, Steven C, additional, Tschöpe, Diethelm, additional, Thorén, Fredrik, additional, Xu, John, additional, Langkilde, Anna Maria, additional, Proietto, Joseph, additional, Stranks, Stephen, additional, Chen, Roger, additional, O'Neal, David, additional, Pape, Alexia, additional, Forbes, Mark, additional, Morbey, Claire, additional, Luger, Anton, additional, Hanusch, Ursula, additional, Schnack, Christoph, additional, Fliesser-Goerzer, Evelyn, additional, Hoelzl, Bertram, additional, Ebenbichler, Christoph, additional, Prager, Rudolf, additional, Van Gaal, Luc, additional, Vercammen, Chris, additional, Scheen, Andre, additional, Duyck, Francis, additional, Nobels, Frank, additional, Ruige, Johannes, additional, Aggarwal, Naresh, additional, Woo, Vincent, additional, St-Pierre, Bruno, additional, Dumas, Richard, additional, Hramiak, Irene, additional, Elliott, Thomas, additional, Krarup Hansen, Troels, additional, Henriksen, Jan Erik, additional, Gram, Jeppe, additional, Lihn, Aina, additional, Bruun, Jens, additional, Saltevo, Juha, additional, Taurio, Jyrki, additional, Strand, Jorma, additional, Valle, Timo, additional, Nieminen, Sakari, additional, Pietilainen, Kirsi, additional, Guerci, Bruno, additional, Hadjadj, Samy, additional, Cariou, Bertrand, additional, Verges, Bruno, additional, Borot, Sophie, additional, Penfornis, Alfred, additional, Schaum, Thomas, additional, Tschoepe, Diethelm, additional, Marck, Cornelia, additional, Horacek, Thomas, additional, Rose, Ludger, additional, Klausmann, Gerhard, additional, Luedemann, Joerg, additional, Appelt, Steffi, additional, Aigner, Ulrich, additional, Goebel, Rolf, additional, Behnke, Thomas, additional, Ziegler, Anette-Gabriele, additional, Peterfai, Eva, additional, Kerenyi, Zsuzsanna, additional, Oroszlan, Tamas, additional, Kiss, Gyula G., additional, Konyves, Laszlo, additional, Piros, Gyorgyi, additional, Mosenzon, Ofri, additional, Shehadeh, Naim, additional, Adawi, Faiad, additional, Wainstein, Julio, additional, Dotta, Francesco, additional, Piatti, Piermarco, additional, Genovese, Stefano, additional, Consoli, Agostino, additional, Di Bartolo, Paolo, additional, Mannucci, Edoardo, additional, Giordano, Carla, additional, Lapolla, Annunziata, additional, Aguilar, Carlos, additional, Esteban, Alberto, additional, Ruiz, Bazzoni, additional, Ramirez, Guillermo Mondragon, additional, Pelayo Orozco, Emilia, additional, Alejandro, Carlos, additional, de Alba, Stobschinski, additional, Medina Pech, Carlos, additional, Garza Ruiz, Jose, additional, Sauque Reyna, Leobardo, additional, Llamas Esperon, Guillermo, additional, Nevarez Ruiz, Luis Alejandro, additional, Vidrio Velazquez, Maricela, additional, Flores Lozano, Fernando, additional, Gonzalez Gonzalez, Jose Gerardo, additional, Garcia-Hernandez, Pedro Alberto, additional, Araujo-Silva, Roberto, additional, Villeda - Espinosa, Efrain, additional, Mistodie, Cristina, additional, Popescu, Daniela, additional, Constantin, Ciprian, additional, Nicolau, Alina, additional, Popa, Bogdan, additional, Timar, Romulus, additional, Serafinceanu, Cristian, additional, Pintilei, Ella, additional, Soto, Alfonso, additional, Gimenez, Margarita, additional, Merino-Torres, Juan Francisco, additional, Morales, Cristobal, additional, Mezquita, Pedro, additional, Jendle, Johan, additional, Tengmark, Bengt-Olov, additional, Eriksson, Jan, additional, Londahl, Magnus, additional, Eliasson, Bjorn, additional, Gunstone, Anthony, additional, Heller, Simon, additional, Darzy, Ken, additional, Mansell, Peter, additional, Davies, Melanie, additional, Reed, Rory, additional, Browne, Duncan, additional, Courtney, Hamish, additional, Turner, Wayne, additional, Blagden, Mark, additional, McCrimmon, Rory, additional, Bergenstal, Richard, additional, Lane, Wendy, additional, Lucas, Kathryn, additional, White, Alexander, additional, Bao, Shichun, additional, White, Judith, additional, Jantzi, Curtis, additional, Rasouli, Neda, additional, Ervin, William, additional, Lewy-Alterbaum, Lorena, additional, Handelsman, Yehuda, additional, Miranda-Palma, Bresta, additional, Cleland, Alan, additional, Fink, Raymond, additional, Rodbard, Helena, additional, Nakhle, Samer, additional, Greenberg, Craig, additional, Schorr, Alan, additional, Bays, Harold, additional, Simmons, Debra, additional, Klein, Eric, additional, Kane, Laurie, additional, Fishman, Norman, additional, Ipp, Eli, additional, Garg, Satish, additional, Bhargava, Anuj, additional, Singh, Michelle Zaniewski, additional, Rosenstock, Julio, additional, Thrasher, James, additional, Warren, Mark, additional, Young, Laura, additional, Aroda, Vanita, additional, Pettus, Jeremy, additional, Liljenquist, David, additional, Busch, Robert, additional, Dandona, Paresh, additional, Wise, Jonathan, additional, Kayne, David, additional, and Biggs, William, additional

Published
2017
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37. Gonadotropin-releasing hormone pacemaker sensitivity to negative feedback inhibition by estradiol in women with hypothalamic amenorrhea**Supported by the National Health and Medical Research Council of Australia.

Author

Judd, Stephen, Stranks, Stephen, and Michailov, Lily

Abstract

To better understand the pathophysiology of hypothalamic amenorrhea (HA), the frequency of luteinizing hormone (LH) pulsatility and the LH response to gonadotropin-releasing hormone (GnRH) was assessed before and after clomiphene citrate (CC) in 18 women with HA and 10 normal women in the early follicular phase (EFP). The HA women showed a greater acceleration of LH pulsatility after CC than EFP women but there was a decrease in their LH response to GnRH. Naloxone caused an increase in LH pulsatility in HA but not EFP women, although this effect was less than that seen with CC. We conclude that, in HA women, the GnRH pacemaker, but not the pituitary, is inhibited by increased sensitivity to the negative feedback effect of estradiol and increased opiate tone.

Published
1989
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38. Exploration of barriers and enablers to diabetes care for Aboriginal people on rural Ngarrindjeri Country.

Author

Omodei‐James, Shanti, Wilson, Annabelle, Kropinyeri, Renee, Cameron, Darryl, Wingard, Sharon, Kerrigan, Caitlin, Scriven, Talia, Wilson, Stacy, Mendham, Amy E., Spaeth, Brooke, Stranks, Stephen, Kaambwa, Billingsley, Ullah, Shahid, Worley, Paul, and Ryder, Courtney

Subjects
*TYPE 2 diabetes, *PEOPLE with diabetes, *INDIGENOUS peoples, *RURAL health, *THEMATIC analysis
Abstract

Issues Addressed Methods Results Conclusions So What? Addressing the disproportionate burden of type 2 diabetes prevalence in Aboriginal communities is critical. Current literature on diabetes care for Aboriginal people is primarily focused on remote demographics and overwhelmingly dominated by Western biomedical models and deficit paradigms. This qualitative research project adopted a strengths‐based approach to explore the barriers and enablers to diabetes care for Aboriginal people on Ngarrindjeri Country in rural South Australia.Knowledge Interface methodology guided the research as Aboriginal and Western research methods were drawn upon. Data collection occurred using three yarning sessions held on Ngarrindjeri Country. Yarns were transcribed and deidentified before a qualitative thematic analysis was conducted, guided by Dadirri and a constructivist approach to grounded theory.A total of 15 participants attended the yarns. Major barriers identified by participants were underscored by the ongoing impacts of colonisation. This was combated by a current of survival as participants identified enablers to diabetes care, namely a history of healthy community, working at the knowledge interface, motivators for action, and an abundance of community skills and leadership.Despite the raft of barriers detailed by participants throughout the diabetes care journey, Aboriginal people on Ngarrindjeri Country were found to be uniquely positioned to address diabetes prevalence and management.Health promotion efforts with Aboriginal people on Ngarrindjeri Country must acknowledge the sustained impacts of colonisation, while building on the abundance of community enablers, skills and strengths. Opportunities present to do so by adopting holistic, community‐led initiatives that shift away from the dominant biomedical approach to diabetes care. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Efficacy of a basal bolus insulin protocol to treat prednisolone-induced hyperglycaemia in hospitalised patients

Author

Burt, MG, Drake, SM, Aguilar-Loza, NR, Esterman, A, Stranks, Stephen, and Roberts, GW

Subjects
Glucocorticoid, Hospitalised patient, Circadian rhythm, Hyperglycaemia, Insulin therapy
Abstract

Background/Aim: Few studies have specifically investigated treatment of prednisolone-induced hyperglycaemia. Aim: To determine if a basal bolus insulin (BBI) protocol for inpatient hyperglycaemia is effective in patients prescribed acute prednisolone for an inflammatory disease. Methods: In a cross-sectional study, 66 patients with type 2 diabetes admitted to a general medical ward and treated with BBI for up to 5 days were studied. Twenty-four patients were taking prednisolone ≥10 mg/day to treat an acute inflammatory disease. The remaining 42 patients were a control group. The primary outcome was mean daily blood glucose level. Results: There were no significant differences in glycosylated haemoglobin (8.1 ± 1.0 vs 8.1 ± 1.6%, P = 0.88), age (77 ± 11 vs 75 ± 14 years, P = 0.57), male sex (63 vs 60%, P = 0.81) or body mass index (30.0 ± 5.3 vs 30.2 ± 11.5 kg/m2, P = 0.90) between patients taking prednisolone and controls. Mean daily glucose concentration was higher in patients taking prednisolone than in controls (12.2 ± 0.3 vs 10.0 ± 0.1 mmol/L, P < 0.001). Blood glucose level was higher in patients on prednisolone at 1700 h (14.6 ± 0.6 vs 10.3 ± 0.3 mmol/L, P < 0.001) and 2100 h (14.5 ± 0.6 vs 10.5 ± 0.3 mmol/L, P < 0.001), with no significant differences at 0700 h and 1200 h. These findings occurred despite patients taking prednisolone receiving a higher daily insulin dose than controls (0.67–0.70 vs 0.61–0.65 U/kg, P = 0.001) because of higher doses of ultra-rapid-acting insulin at 1200 h and 1700 h. Conclusions: Hospitalised patients taking prednisolone had substantial afternoon and evening hyperglycaemia despite receiving BBI via a protocol for inpatient hyperglycaemia. Specific insulin regimens for prednisolone-induced hyperglycaemia are needed that recommend more insulin during this time period. Refereed/Peer-reviewed

Published
2015

40. Results of an Australian trial of an automated insulin delivery (AID) system and other studies support likely benefit of AID use for many Australian adults with type 1 diabetes.

Author

Jenkins AJ, Januszewski AS, Kirby A, Hendrieckx C, McAuley SA, Lee MH, Paldus B, Vogrin S, de Bock MI, Abraham MB, Bach LA, Burt MG, Cohen ND, Colman PG, Davis EA, Holmes-Walker DJ, Kaye J, Keech AC, Kumareswaran K, MacIsaac RJ, McCallum RW, Sims CM, Speight J, Stranks SN, Sundararajan V, Trawley S, Ward GM, Jones TW, and O'Neal DN

Abstract

Less than 20% of Australians with type 1 diabetes (T1D) meet recommended glucose targets. Technology use is associated with better glycaemia, with the most advanced being automated insulin delivery (AID) systems, which are now recommended as gold-standard T1D care. Our Australian AID trial shows a wide spectrum of adults with T1D can achieve recommended targets. Other studies, including lived experience data, are supportive. Insulin pumps are not subsidised for most Australian adults with T1D. We advocate change., (© 2024 Royal Australasian College of Physicians.)

Published
2024
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41. Less Nocturnal Hypoglycemia but Equivalent Time in Range Among Adults with Type 1 Diabetes Using Insulin Pumps Versus Multiple Daily Injections.

Author

McAuley SA, Vogrin S, Lee MH, Paldus B, Trawley S, de Bock MI, Abraham MB, Bach LA, Burt MG, Cohen ND, Colman PG, Davis EA, Hendrieckx C, Holmes-Walker DJ, Jenkins AJ, Kaye J, Keech AC, Kumareswaran K, MacIsaac RJ, McCallum RW, Sims CM, Speight J, Stranks SN, Sundararajan V, Ward GM, Jones TW, and O'Neal DN

Subjects
Adult, Australia, Blood Glucose, Blood Glucose Self-Monitoring, Glycated Hemoglobin analysis, Humans, Hypoglycemic Agents therapeutic use, Insulin therapeutic use, Insulin Infusion Systems, Diabetes Mellitus, Type 1 drug therapy, Hypoglycemia chemically induced
Abstract

Background: This prerandomization analysis from the Australian HCL-Adult trial (registration number: ACTRN12617000520336) compared masked continuous glucose monitoring (CGM) metrics among adults using insulin pumps versus multiple daily injections (MDIs), who were all self-monitoring blood glucose (SMBG). Methods: Adults with type 1 diabetes, using an insulin pump or MDIs without real-time CGM (and entering a trial of closed-loop technology), were eligible. MDI users were given an insulin dosage calculator. All participants received diabetes and carbohydrate-counting education, then wore masked CGM sensors for 3 weeks. Ethics Approval: HREC-D 088/16 Results: Adults using MDIs ( n  = 61) versus pump ( n  = 59) did not differ by age, sex, diabetes duration, insulin total daily dose, or HbA 1c at baseline. After education, median (interquartile range) CGM time in range (TIR) 70-180 mg/dL (3.9-10.0 mmol/L) was 54% (47, 62) for those using MDIs and 56% (48, 66) for those using pump ( P  = 0.40). All CGM metrics were equivalent for 24 h/day for MDI and pump users. Overnight, those using MDIs (vs. pump) spent more time with glucose <54 mg/dL (<3.0 mmol/L): 1.4% (0.1, 5.1) versus 0.5% (0.0, 2.0), respectively ( P  = 0.012). They also had more CGM hypoglycemia episodes (121 vs. 54, respectively; incidence rate ratio [95% confidence interval] 2.48 [1.51, 4.06]; P  < 0.001). Conclusions: Adults with type 1 diabetes using pumps versus MDIs in conjunction with SMBG experienced less nocturnal hypoglycemia, measured by masked CGM, after equivalent diabetes and dietary education in conjunction with insulin dosage calculator provision to all. However, both groups had equivalent TIR. This observation may reflect advantages afforded by flexibility in basal insulin delivery provided by pumps.

Published
2021
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42. Six Months of Hybrid Closed-Loop Versus Manual Insulin Delivery With Fingerprick Blood Glucose Monitoring in Adults With Type 1 Diabetes: A Randomized, Controlled Trial.

Author

McAuley SA, Lee MH, Paldus B, Vogrin S, de Bock MI, Abraham MB, Bach LA, Burt MG, Cohen ND, Colman PG, Davis EA, Hendrieckx C, Holmes-Walker DJ, Kaye J, Keech AC, Kumareswaran K, MacIsaac RJ, McCallum RW, Sims CM, Speight J, Stranks SN, Sundararajan V, Trawley S, Ward GM, Jenkins AJ, Jones TW, and O'Neal DN

Subjects
Adult, Aged, Blood Glucose drug effects, Blood Glucose metabolism, Blood Glucose Self-Monitoring instrumentation, Blood Glucose Self-Monitoring methods, Blood Specimen Collection adverse effects, Blood Specimen Collection methods, Blood Specimen Collection psychology, Female, Fingers, Glycated Hemoglobin analysis, Humans, Hypoglycemic Agents administration & dosage, Hypoglycemic Agents adverse effects, Injections, Insulin adverse effects, Male, Middle Aged, Needlestick Injuries blood, Personal Satisfaction, Blood Glucose analysis, Diabetes Mellitus, Type 1 blood, Diabetes Mellitus, Type 1 drug therapy, Insulin administration & dosage, Insulin Infusion Systems
Abstract

Objective: To investigate glycemic and psychosocial outcomes with hybrid closed-loop (HCL) versus user-determined insulin dosing with multiple daily injections (MDI) or insulin pump (i.e., standard therapy for most adults with type 1 diabetes)., Research Design and Methods: Adults with type 1 diabetes using MDI or insulin pump without continuous glucose monitoring (CGM) were randomized to 26 weeks of HCL (Medtronic 670G) or continuation of current therapy. The primary outcome was masked CGM time in range (TIR; 70-180 mg/dL) during the final 3 weeks., Results: Participants were randomized to HCL ( n = 61) or control ( n = 59). Baseline mean (SD) age was 44.2 (11.7) years, HbA 1c was 7.4% (0.9%) (57 [10] mmol/mol), 53% were women, and 51% used MDI. HCL TIR increased from (baseline) 55% (13%) to (26 weeks) 70% (10%) with the control group unchanged: (baseline) 55% (12%) and (26 weeks) 55% (13%) (difference 15% [95% CI 11, 19]; P < 0.0001). For HCL, HbA 1c was lower (median [95% CI] difference -0.4% [-0.6, -0.2]; -4 mmol/mol [-7, -2]; P < 0.0001) and diabetes-specific positive well-being was higher (difference 1.2 [95% CI 0.4, 1.9]; P < 0.0048) without a deterioration in diabetes distress, perceived sleep quality, or cognition. Seventeen (9 device-related) versus 13 serious adverse events occurred in the HCL and control groups, respectively., Conclusions: In adults with type 1 diabetes, 26 weeks of HCL improved TIR, HbA 1c , and their sense of satisfaction from managing their diabetes compared with those continuing with user-determined insulin dosing and self-monitoring of blood glucose. For most people living with type 1 diabetes globally, this trial demonstrates that HCL is feasible, acceptable, and advantageous., (© 2020 by the American Diabetes Association.)

Published
2020
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