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260 results on '"Stramer, S."'

1. Use of U.S. Blood Donors for National Serosurveillance of SARS-CoV-2 Antibodies: Basis for an Expanded National Donor Serosurveillance Program

Author

Stone, Mars, Di Germanio, Clara, Wright, David J, Sulaeman, Hasan, Dave, Honey, Fink, Rebecca V, Notari, Edward P, Green, Valerie, Strauss, Donna, Kessler, Debbie, Destree, Mark, Saa, Paula, Williamson, Phillip C, Simmons, Graham, Stramer, Susan L, Opsomer, Jean, Jones, Jefferson M, Kleinman, Steven, Busch, Michael P, Cassetti, C, Gerber, S, Patton, M, Havers, F, Basavaraju, S, Williams, AE, Anderson, S, Haynes, J, McCain, L, Hui, A, Samuels, C, Tanner, H, Kaidarova, Z, B, MP, Norris, PJ, S, M, Mathew, SM, Stramer, S, Kessler, D, Konkle, BA, Custer, B, Ness, PM, Kleinman, SH, Josephson, CD, Glynn, SA, and Malkin, K

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Prevention, Pneumonia, Pneumonia & Influenza, Biodefense, Cancer, Vaccine Related, Infectious Diseases, Emerging Infectious Diseases, Good Health and Well Being, Antibodies, Viral, Blood Donors, COVID-19, Child, Cross-Sectional Studies, Humans, SARS-CoV-2, Seroepidemiologic Studies, COVID-19 srological testing, seroprevalence, NHLBI Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundThe Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P) Epidemiology, Surveillance and Preparedness of the Novel SARS-CoV-2 Epidemic (RESPONSE) seroprevalence study conducted monthly cross-sectional testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in blood donors in 6 US metropolitan regions to estimate the extent of SARS-CoV-2 infections over time.MethodsDuring March-August 2020, approximately ≥1000 serum specimens were collected monthly from each region and tested for SARS-CoV-2 antibodies using a well-validated algorithm. Regional seroprevalence estimates were weighted based on demographic differences compared with the general population. Seroprevalence was compared with reported coronavirus disease 2019 (COVID-19) case rates over time.ResultsFor all regions, seroprevalence was

Published
2022

2. Transfusion‐transmissible coinfections among US blood donors.

Author

Conti, Galen, Notari, Edward P., Dodd, Roger Y., Gorlin, Jed, Custer, Brian, Reik, Rita, Hailu, Benyam, Whitaker, Barbee I., Stramer, Susan L., Notari, E., Stramer, S., Dodd, R., Conti, G., Fayed, R., Nelson, D., Townsend, R., Foster, G., Haynes, J., Crawford, E., and Huseynova, E.

Subjects
MIXED infections, BLOOD donors, SYPHILIS, DEMOGRAPHIC characteristics, LOGISTIC regression analysis
Abstract

Background: Transfusion‐transmissible infection (TTI) prevalence among US blood donors has been widely documented. Here we estimate the prevalence of donors presenting with ≥2 TTIs (multiple infections past or present referred to as coinfections) and describe their demographics and associations. Methods: Data from the Transfusion‐Transmissible Infections Monitoring System were compiled for October 2020–September 2023 (3 years). Prevalence per million donations (pmd) was calculated for each TTI coinfection combination with demographic characteristics summarized. The odds of each TTI coinfection combination were estimated using logistic regression. Reactivity by NAT and/or serology (HIV, HBV, and HCV) defined donors as consensus positive (CP) for each infection while serology‐based algorithms defined syphilis CP and the subset with active syphilis infections (ASIs). Results: About 22 million donations were included, with 212 coinfections (9.7 pmd). Around 2% of donations positive for any TTI (n = 10,516) were coinfections. Coinfection prevalence per TTI combination ranged from 0.3 pmd for HIV CP and HCV CP, to 4.3 pmd for HIV CP and syphilis CP. There were high proportions of coinfections from donors who were male, aged 25–54 years, white or black, first time, and residing in the southern US Census Region. The odds of a second TTI occurring in an individual donor with a TTI ranged from 23 (95% CI: 13, 41) times more likely for HBV CP and ASI to 395 (95% CI: 298, 524) times more likely for HIV CP and ASI. Conclusions: Coinfections are relatively uncommon among blood donors in the United States; however, associations exist among HIV, HBV, HCV, and syphilis infections. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Infectious disease agents and their potential threat to transfusion safety (an update to the 2009 Transfusion supplement).

Author

Katz, L. M., Dodd, Roger Y., Saa, Paula, Gorlin, J. B., Palmer, K., Hollinger, F. B., and Stramer, S. L.

Subjects
COMMUNICABLE diseases, DENGUE hemorrhagic fever, BLOOD transfusion reaction, EMERGING infectious diseases, BREAKTHROUGH infections, CREUTZFELDT-Jakob disease
Abstract

The article discusses the publication of an updated supplement to the 2009 Transfusion journal, which provides fact sheets on 68 emerging infectious disease agents that could potentially pose a risk to transfusion medicine. The fact sheets aim to assist clinicians in identifying and investigating agents responsible for transfusion-transmitted infections, as well as educate readers about the risks of emerging infections. The supplement includes revisions and new fact sheets, with a focus on monitoring changes in pathogen epidemiology and implementing interventions. The fact sheets adhere to a common structure and provide information on agent description, disease associations, transmission, prevention measures, and more. The article emphasizes the need for early identification and response to new threats, as well as the importance of ongoing research and interventions to ensure transfusion safety. [Extracted from the article]

Published
2024
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30. International survey on NAT testing of blood donations: expanding implementation and yield from 1999 to 2009

Author

Roth, W. K., Busch, M. P., Schuller, A., Ismay, S., Cheng, A., Seed, C. R., Jungbauer, C., Minsk, P. M., Sondag-Thull, D., Wendel, S., Levi, J. E., Fearon, M., Delage, G., Xie, Y., Jukic, I., Turek, P., Ullum, H., Tefanova, V., Tilk, M., Reimal, R., Castren, J., Naukkarinen, M., Assal, A., Jork, C., Hourfar, M. K., Michel, P., Offergeld, R., Pichl, L., Schmidt, M., Schottstedt, V., Seifried, E., Wagner, F., Weber-Schehl, M., Politis, C., Lin, C. K., Tsoi, W. C., OʼRiordan, J., Gottreich, A., Shinar, E., Yahalom, V., Velati, C., Satake, M., Sanad, N., Sisene, I., Bon, A. H., Koppelmann, M., Flanagan, P., Flesland, O., Brojer, E., Lętowska, M., Nascimento, F., Zhiburt, E., Chua, S. S., Teo, D., Stezinar, Levicnik S., Vermeulen, M., Reddy, R., Park, Q., Castro, E., Eiras, A., Gonzales Fraile, I., Torres, P., Ekermo, B., Niederhauser, C., Chen, H., Oota, S., Brant, L. J., Eglin, R., Jarvis, L., Mohabir, L., Brodsky, J., Foster, G., Jennings, C., Notari, E., Stramer, S., Kessler, D., Hillyer, C., Kamel, H., Katz, L., Taylor, C., Panzer, S., and Reesink, H. W.

Published
2012
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