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Your search keyword '"Strafella, Maria Stefania"' showing total 5 results
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5 results on '"Strafella, Maria Stefania"'

1. Henoch-Schönlein purpura and drug and vaccine use in childhood: A case-control study

Author

Da Dalt, Liviana, Zerbinati, Claudia, Strafella, Maria Stefania, Renna, Salvatore, Riceputi, Laura, Di Pietro, Pasquale, Barabino, Paola, Scanferla, Stefania, Raucci, Umberto, Mores, Nadia, Compagnone, Adele, Da Cas, Roberto, Menniti Ippolito, Francesca, and Chiappini, Elena

Subjects
Adverse drug reaction, Children, Henoch-Schönlein purpura, Vaccine, Pediatrics, Perinatology and Child Health
Published
2016

3. Henoch-Schönlein purpura and drug and vaccine use in childhood: a case-control study.

Author

Dalt, Liviana Da, Zerbinati, Claudia, Strafella, Maria Stefania, Renna, Salvatore, Riceputi, Laura, Di Pietro, Pasquale, Barabino, Paola, Scanferla, Stefania, Raucci, Umberto, Mores, Nadia, Compagnone, Adele, Da Cas, Roberto, and Menniti-Ippolito, Francesca

Subjects
PHARMACOEPIDEMIOLOGY, VACCINES, HOSPITAL care of children, CHILDREN'S hospitals, CONFIDENCE intervals, DRUG utilization, HOSPITAL emergency services, INTERVIEWING, PARENTS, PEDIATRICS, PUBLIC health surveillance, RISK assessment, MMR vaccines, CASE-control method, DESCRIPTIVE statistics, SCHOENLEIN-Henoch purpura, ODDS ratio, CHILDREN, DISEASE risk factors
Abstract

Background: Henoch-Schönlein purpura (HSP) is the most common vasculitis in childhood; nevertheless, its etiology and pathogenesis remain unknown despite the fact that a variety of factors, mainly infectious agents, drugs and vaccines have been suggested as triggers for the disease. The aim of this study was to estimate the association of HSP with drug and vaccine administration in a pediatric population. Methods: An active surveillance on drug and vaccine safety in children is ongoing in 11 clinical centers in Italy. All children hospitalized through the local Paediatric Emergency Department for selected acute clinical conditions of interest were enrolled in the study. Data on drug and vaccine use in children before the onset of symptoms leading to hospitalization were collected by parents interview. A case-control design was applied for risk estimates: exposure in children with HSP, included as cases, was compared with similar exposure in children with gastroduodenal lesions, enrolled as controls. HSP cases were validated according to EULAR/PRINTO/PRES criteria. Validation was conducted retrieving data from individual patient clinical record. Results: During the study period (November 1999-April 2013), 288 cases and 617 controls were included. No increased risk of HSP was estimated for any drug. Among vaccines, measles-mumps-rubella (MMR) vaccine showed an increased risk of HSP (OR 3.4; 95 % CI 1.2-10.0). Conclusions: This study provides further evidence on the possible role of MMR vaccine in HSP occurrence. [ABSTRACT FROM AUTHOR]

Published
2016
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5. Rhabdomyosarcoma in a Patient With CardioFacio-Cutaneous Syndrome

Author

Bisogno, Gianni, Murgia, Alessandra, Mammi, Isabella, Strafella, Maria Stefania, and Carli, Modesto

Abstract

A boy with characteristic facial features, pulmonary valvular stenosis, ectodermal abnormalities, growth failure, and mental retardation was admitted for intestinal occlusion at 20 months of age. Clinical findings were consistent with a diagnosis of cardio-facio-cutaneous syndrome (CFC-s), and a huge abdominal mass was evident on computed tomography scan. A biopsy was performed, and embryonal rhabdomyosarcoma was diagnosed. Molecular analysis was performed by reverse transcription (RT) polymerase chain reaction (PCR) on tumor RNA to seek the chimerical transcript of the most common soft tissue sarcoma translocations and analyze neurofibromatosis 1 (NF1) gene expression. Translocations involving 1;13, 2;13, and 11;22 were not found, and the specific transcripts of the NF1 gene were present. Chemotherapy was implemented, but the child died 7 months later of tumor progression. Few patients with CFC-s have been described, and their follow-up is not well known. The association of CFC-s with rhabdomyosarcoma has not been reported previously, but other neoplasms have been reported in patients with Noonan syndrome, a condition similar to CFC-s. More observations are needed, but this and other reports suggest there could be a higher risk of malignancy in patients with syndromes in the Noonan phenotype category.

Published
1999

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