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8 results on '"Storm P.B."'

5. Evaluation of Pedal Lymphangiography in Staging Non-Seminomatous Testicular Carcinoma

Author

Storm, P.B., Kern, A., Loening, S.A., Brown, R.C., and Culp, D.A.

Abstract

An analysis is presented on 45 patients undergoing pedal lymphangiography followed by retroperitoneal lymphadenectomy for non-seminomatous testicular carcinoma. Retroperitoneal node metastases were predicted correctly with the lymphangiogram in 10 of 20 patients (50 per cent). The over-all predictive accuracy was 62 per cent.

Published
1977
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6. Human "memories" can be evoked by stimulation of the lateral temporal cortex after ipsilateral medial temporal lobe resection

Author

Moriarity, J.L., Boatman, D., Krauss, G.L., Storm, P.B., and Lenz, F.A.

Abstract

A patient with medically intractable seizures and mesial temporal sclerosis underwent a left anterior temporal lobectomy and amygdalohippocampectomy. After 4 months, his seizures recurred and a left temporal, subdural grid of electrodes was placed to localise his seizure focus. Stimulation through the grid evoked four distinct "memories", or experiential phenomena, despite absence of the ipsilateral medial temporal lobe. To our knowledge, this is the first documented case of experiential phenomena evoked by cortical stimulation in the absence of the ipsilateral medial temporal lobe.

Published
2001

8. MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

Author

Stéphanie Puget, Mariarita Santi, Daniel C. Bowers, Cynthia Hawkins, Rosemary E. Henn, Laura M. Urbanski, Jeremiah Wala, Mélanie Pagès, Azra H. Ligon, Anna Maria Buccoliero, Peleg M. Horowitz, Phillip B. Storm, Mirko Scagnet, Liliana Goumnerova, Matthew D. Ducar, Kristine Pelton, Pascale Varlet, Uri Tabori, Sabine Mueller, Pratiti Bandopadhayay, Yun Jee Kang, Rameen Beroukhim, Joanna J. Phillips, Adam C. Resnick, Payal Jain, Brenton R. Paolella, László Bognár, Mark W. Kieran, David S. Knoff, Yuankun Zhu, Rhamy Zeid, Shakti Ramkissoon, Charles G. Eberhart, Hayley Malkin, Adam Tracy, Katie Boucher, Amanda Silva, Lori A. Ramkissoon, Adrianne Gladden-Young, Keith L. Ligon, Nada Jabado, Jacques Grill, Daphne A. Haas-Kogan, Sandro Santagata, James E. Bradner, Charles D. Stiles, Alexander J. Federation, Harry J. Han, Almos Klekner, Angela J. Waanders, Sara Seepo, Ryan O’Rourke, Paul Van Hummelen, Namrata Choudhari, D. Ashley Hill, Fausto J. Rodriguez, Caterina Giannini, William J. Gibson, Alon Goren, Peter C. Burger, Guillaume Bergthold, Steven E. Schumacher, Bandopadhayay P., Ramkissoon L.A., Jain P., Bergthold G., Wala J., Zeid R., Schumacher S.E., Urbanski L., O'Rourke R., Gibson W.J., Pelton K., Ramkissoon S.H., Han H.J., Zhu Y., Choudhari N., Silva A., Boucher K., Henn R.E., Kang Y.J., Knoff D., Paolella B.R., Gladden-Young A., Varlet P., Pages M., Horowitz P.M., Federation A., Malkin H., Tracy A.A., Seepo S., Ducar M., Van Hummelen P., Santi M., Buccoliero A.M., Scagnet M., Bowers D.C., Giannini C., Puget S., Hawkins C., Tabori U., Klekner A., Bognar L., Burger P.C., Eberhart C., Rodriguez F.J., Hill D.A., Mueller S., Haas-Kogan D.A., Phillips J.J., Santagata S., Stiles C.D., Bradner J.E., Jabado N., Goren A., Grill J., Ligon A.H., Goumnerova L., Waanders A.J., Storm P.B., Kieran M.W., Ligon K.L., Beroukhim R., and Resnick A.C.

Subjects
0301 basic medicine, Oncogene Proteins, Fusion, Carcinogenesis, Angiocentric Glioma, Biology, medicine.disease_cause, Article, Oncogene Proteins v-myb, 03 medical and health sciences, Glioma, Cell Line, Tumor, Genetics, medicine, Humans, MYB, Exome, Epigenetics, Child, Carcinogenesi, Gene Rearrangement, Mutation, Comparative Genomic Hybridization, High-Throughput Nucleotide Sequencing, RNA-Binding Proteins, Gene rearrangement, medicine.disease, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Cancer research, Human
Abstract

Angiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent genetic drivers. We performed genomic analysis of new and published data from 249 PLGGs, including 19 angiocentric gliomas. We identified MYB-QKI fusions as a specific and single candidate driver event in angiocentric gliomas. In vitro and in vivo functional studies show that MYB-QKI rearrangements promote tumorigenesis through three mechanisms: MYB activation by truncation, enhancer translocation driving aberrant MYB-QKI expression and hemizygous loss of the tumor suppressor QKI. To our knowledge, this represents the first example of a single driver rearrangement simultaneously transforming cells via three genetic and epigenetic mechanisms in a tumor.

Published
2016

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