Search

Your search keyword '"Stoppa, Ian"' showing total 21 results
Start Over Author "Stoppa, Ian"
21 results on '"Stoppa, Ian"'

3. Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis

Author

Provera, Alessia, primary, Ramavath, Naresh Naik, additional, Gadipudi, Laila Lavanya, additional, Gigliotti, Casimiro Luca, additional, Boggio, Elena, additional, Vecchio, Cristina, additional, Stoppa, Ian, additional, Rolla, Roberta, additional, Boldorini, Renzo, additional, Pirisi, Mario, additional, Smirne, Carlo, additional, Albano, Emanuele, additional, Dianzani, Umberto, additional, and Sutti, Salvatore, additional

Published
2023
Full Text
View/download PDF

5. Use of Poly Lactic-co-glycolic Acid Nano and Micro Particles in the Delivery of Drugs Modulating Different Phases of Inflammation

Author

Puricelli, Chiara, primary, Gigliotti, Casimiro Luca, additional, Stoppa, Ian, additional, Sacchetti, Sara, additional, Pantham, Deepika, additional, Scomparin, Anna, additional, Rolla, Roberta, additional, Pizzimenti, Stefania, additional, Dianzani, Umberto, additional, Boggio, Elena, additional, and Sutti, Salvatore, additional

Published
2023
Full Text
View/download PDF

6. Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunctionassociated steatohepatitis.

Author

Provera, Alessia, Ramavath, Naresh Naik, Gadipudi, Laila Lavanya, Gigliotti, Casimiro Luca, Boggio, Elena, Vecchio, Cristina, Stoppa, Ian, Rolla, Roberta, Boldorini, Renzo, Pirisi, Mario, Smirne, Carlo, Albano, Emanuele, Dianzani, Umberto, and Sutti, Salvatore

Subjects
LECTINS, CELLULAR evolution, MYELOID cells, CHOLINE, FATTY liver, KUPFFER cells, HEPATIC fibrosis
Abstract

Background and aims: Inducible T-cell Co-Stimulator (ICOS) present on T-lymphocytes and its ligand ICOSL expressed by myeloid cells play multiple roles in regulating T-cell functions. However, recent evidence indicates that reverse signalling involving ICOSL is also important in directing the differentiation of monocyte-derived cells. In this study, we investigated the involvement of ICOS/ICOSL dyad in modulating macrophage functions during the evolution of metabolic dysfunction-associated steatohepatitis (MASH). Results: In animal models of MASH, ICOS was selectively up-regulated on CD8+ T-cells in parallel with an expansion of ICOSL-expressing macrophages. An increase in circulating soluble ICOSL was also evident in patients with MASH as compared to healthy individuals. ICOSL knockout (ICOSL-/-) mice receiving choline/methionine deficient (MCD) diet for 6 weeks had milder steatohepatitis than wild type mice. MASH improvement was confirmed in mice fed with cholesterol-enriched Western diet for 24 weeks in which ICOSL deficiency greatly reduced liver fibrosis along with the formation of crown-like macrophage aggregates producing the pro-fibrogenic mediators osteopontin (OPN) and galectin-3 (Gal-3). These effects associated with a selective shewing of F4-80+/CD11bhigh monocyte-derived macrophages (MoMFs) expressing the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) to CD11blow/F4-80+ cells positive for the Kupffer cell marker C-type lectin-like type 2 receptor (CLEC-2), thus indicating an increased MoMF maturation toward monocyte-derived Kupffer cells. Conclusions: These results suggest that CD8+ T-cells interaction with monocyte-derived macrophages through ICOS/ICOSL critically supports a specific subset of TREM2+-expressing cells contributing to the evolution of steatohepatitis. The data also point ICOS/ICOSL dyad as a possible target for therapeutic interventions in MASH. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

7. Genes and Microbiota Interaction in Monogenic Autoimmune Disorders

Author

Costa, Federica, primary, Beltrami, Eleonora, additional, Mellone, Simona, additional, Sacchetti, Sara, additional, Boggio, Elena, additional, Gigliotti, Casimiro Luca, additional, Stoppa, Ian, additional, Dianzani, Umberto, additional, Rolla, Roberta, additional, and Giordano, Mara, additional

Published
2023
Full Text
View/download PDF

8. Exploiting Nanomedicine for Cancer Polychemotherapy: Recent Advances and Clinical Applications

Author

Boggio, Elena, primary, Gigliotti, Casimiro Luca, additional, Stoppa, Ian, additional, Pantham, Deepika, additional, Sacchetti, Sara, additional, Rolla, Roberta, additional, Grattarola, Margherita, additional, Monge, Chiara, additional, Pizzimenti, Stefania, additional, Dianzani, Umberto, additional, Dianzani, Chiara, additional, and Battaglia, Luigi, additional

Published
2023
Full Text
View/download PDF

12. Parenteral Nanoemulsions Loaded with Combined Immuno- and Chemo-Therapy for Melanoma Treatment

Author

Monge, Chiara, primary, Stoppa, Ian, additional, Ferraris, Chiara, additional, Bozza, Annalisa, additional, Battaglia, Luigi, additional, Cangemi, Luigi, additional, Miglio, Gianluca, additional, Pizzimenti, Stefania, additional, Clemente, Nausicaa, additional, Gigliotti, Casimiro Luca, additional, Boggio, Elena, additional, Dianzani, Umberto, additional, and Dianzani, Chiara, additional

Published
2022
Full Text
View/download PDF

13. ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis

Author

Alves, Gustavo Ferreira, primary, Stoppa, Ian, additional, Aimaretti, Eleonora, additional, Monge, Chiara, additional, Mastrocola, Raffaella, additional, Porchietto, Elisa, additional, Einaudi, Giacomo, additional, Collotta, Debora, additional, Bertocchi, Ilaria, additional, Boggio, Elena, additional, Gigliotti, Casimiro Luca, additional, Clemente, Nausicaa, additional, Aragno, Manuela, additional, Fernandes, Daniel, additional, Cifani, Carlo, additional, Thiemermann, Christoph, additional, Dianzani, Chiara, additional, Dianzani, Umberto, additional, and Collino, Massimo, additional

Published
2022
Full Text
View/download PDF

15. ICOSL Stimulation by ICOS-Fc Accelerates Cutaneous Wound Healing In Vivo

Author

Stoppa, Ian, primary, Gigliotti, Casimiro Luca, additional, Clemente, Nausicaa, additional, Pantham, Deepika, additional, Dianzani, Chiara, additional, Monge, Chiara, additional, Puricelli, Chiara, additional, Rolla, Roberta, additional, Sutti, Salvatore, additional, Renò, Filippo, additional, Boldorini, Renzo, additional, Boggio, Elena, additional, and Dianzani, Umberto, additional

Published
2022
Full Text
View/download PDF

16. Inducible T‐cell co‐stimulator (ICOS) and ICOS ligand are novel players in the multiple‐myeloma microenvironment

Author

Boggio, Elena, primary, Gigliotti, Casimiro Luca, additional, Moia, Riccardo, additional, Scotta, Annamaria, additional, Crespi, Ilaria, additional, Boggione, Paola, additional, De Paoli, Lorenzo, additional, Deambrogi, Clara, additional, Garzaro, Massimiliano, additional, Vidali, Matteo, additional, Chiocchetti, Annalisa, additional, Stoppa, Ian, additional, Rolla, Roberta, additional, Dianzani, Chiara, additional, Monge, Chiara, additional, Clemente, Nausicaa, additional, Gaidano, Gianluca, additional, and Dianzani, Umberto, additional

Published
2021
Full Text
View/download PDF

17. Inducible T‐cell co‐stimulator (ICOS) and ICOS ligand are novel players in the multiple‐myeloma microenvironment.

Author

Boggio, Elena, Gigliotti, Casimiro Luca, Moia, Riccardo, Scotta, Annamaria, Crespi, Ilaria, Boggione, Paola, De Paoli, Lorenzo, Deambrogi, Clara, Garzaro, Massimiliano, Vidali, Matteo, Chiocchetti, Annalisa, Stoppa, Ian, Rolla, Roberta, Dianzani, Chiara, Monge, Chiara, Clemente, Nausicaa, Gaidano, Gianluca, and Dianzani, Umberto

Subjects
T cells, MULTIPLE myeloma, CELL migration, PLASMA cells, TUMOR markers
Abstract

Summary: The inducible T‐cell co‐stimulator (ICOS) is a T‐cell receptor that, once bound to ICOS ligand (ICOSL) expressed on several cell types including the B‐cell lineage, plays a decisive role in adaptive immunity by regulating the interplay between B and T cells. In addition to its immunomodulatory functions, we have shown that ICOS/ICOSL signalling can inhibit the activity of osteoclasts, unveiling a novel mechanism of lymphocyte–bone cells interactions. ICOS and ICOSL can also be found as soluble forms, namely sICOS and sICOSL. Here we show that: (i) levels of sICOS and sICOSL are increased in multiple myeloma (MM) compared to monoclonal gammopathy of undetermined significance and smouldering MM; (ii) levels of sICOS and sICOSL variably correlate with several markers of tumour burden; and (iii) sICOS levels tend to be higher in Durie–Salmon stage II/III versus stage I MM and correlate with overall survival as an independent variable. Moreover, surface ICOS and ICOSL are expressed in both myeloma cells and normal plasma cells, where they probably regulate different functional stages. Finally, ICOSL triggering inhibits the migration of myeloma cell lines in vitro and the growth of ICOSL+ MOPC‐21 myeloma cells in vivo. These results suggest that ICOS and ICOSL represent novel markers and therapeutic targets for MM. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

21. Role of Alginates Combined with Natural Extracts to Prevent the Gastric Acid-Related Damage

Author

Uberti, Francesca, Secondini, Lorenzo, Stoppa, Ian, Catera, Mietta, and Molinari, Claudio

Subjects
Science / Life Sciences / Biochemistry
Abstract

The human stomach is extremely vulnerable to various attacks able to cause erosion and mucosal epithelium damage which lead to gastrointestinal tract bleeding and/or ulcer perforations and finally worsen the original disease. A prolonged exposition to strong acidic environment causes coagulation necrosis resulting from the desiccating action of the acid on proteins in exposed tissues with inflammation and accumulation of intracellular radical oxygen species. Therapeutic strategies aim to treat both symptoms and epithelial damage with chemical or mechanical approaches. In this context, alginates seem to have great importance, especially if combined with other molecules known to have some properties on gastric epithelial cells, for example, vitamin D3, extract of prickly pear and olive leaves, and a tyndalized probiotic. This natural composition is able to exert a gastroprotective effect to maintain or restore the integrity of gastric epithelium through an antioxidant pathway, inhibiting apoptosis and activating survival kinases better than other pharmacological or natural active principles.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results