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1. Cost-benefit analysis of Canada's Prison Needle Exchange Program for the prevention of hepatitis C and injection-related infections

Author

Houdroge, Farah, Kronfli, Nadine, Stoove, Mark, and Scott, Nick

Subjects
Cost benefit analysis -- Methods, Infection -- Prevention, Prisons -- Health aspects, Hepatitis C -- Prevention, Cost benefit analysis, Health
Abstract

Background: Needle exchange programs are effective public health interventions that reduce blood-borne infections, including hepatitis C, and injection-related infections. We sought to assess the return on investment of existing Prison Needle Exchange Programs (PNEPs) in Canadian federal prisons and their expansion to all 43 institutions. Methods: We developed a stochastic compartmental model that estimated hepatitis C and injection-related infections under different PNEP scenarios in Canadian federal prisons. Scenarios projected for 2018-2030 were no PNEP, status quo (actual PNEP implementation 2018-2022, with coverage maintained to 2030), and PNEP scale-up (coverage among people who inject drugs in prison increasing over 2025-2030 to reach 50% by 2030). We calculated the benefit-cost ratio as benefits from health care savings, divided by PNEP costs. Results: By 2019, PNEPs were implemented in 9 of 43 federal prisons, with uptake reaching 10% of people who injected drugs in prison in 2022. Compared with no PNEP, this was estimated to cost Can$0.45 (uncertainty interval [UI] $0.32 to $0.98) million and avert 37 (UI 25 to 52) hepatitis C and 8 (UI -1 to 16) injection-related infections over 2018-2030, with a benefit-cost ratio of 1.9 (UI 0.56-3.0). Compared with the status quo, the PNEP scale-up scenario cost an additional $2.7 (UI $1.8 to $7.0) million and prevented 224 (UI 218 to 231) hepatitis C and 77 (UI 74 to 80) injection-related infections, with a benefit-cost ratio of 2.0 (UI 0.57 to 3.3). Interpretation: Every dollar invested in the current PNEP or its expansion is estimated to save $2 in hepatitis C and injection-related infection treatment costs. This return on investment strongly supports ongoing maintenance and scale-up of the PNEP in Canada from an economic perspective., The World Health Organization's Global Health Sector Strategies for 2022-2030 includes 2030 hepatitis C elimination targets of reducing new infections to fewer than 2 per 100 people who inject drugs [...]

Published
2024
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4. Developing Health Promotion Interventions on Social Networking Sites: Recommendations from The FaceSpace Project

Author

Gold, Judy, Pedrana, Alisa E, Stoove, Mark A, Chang, Shanton, Howard, Steve, Asselin, Jason, Ilic, Olivia, Batrouney, Colin, and Hellard, Margaret E

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

Online social networking sites offer a novel setting for the delivery of health promotion interventions due to their potential to reach a large population and the possibility for two-way engagement. However, few have attempted to host interventions on these sites, or to use the range of interactive functions available to enhance the delivery of health-related messages. This paper presents lessons learnt from “The FaceSpace Project”, a sexual health promotion intervention using social networking sites targeting two key at-risk groups. Based on our experience, we make recommendations for developing and implementing health promotion interventions on these sites. Elements crucial for developing interventions include establishing a multidisciplinary team, allowing adequate time for obtaining approvals, securing sufficient resources for building and maintaining an online presence, and developing an integrated process and impact evaluation framework. With two-way interaction an important and novel feature of health promotion interventions in this medium, we also present strategies trialled to generate interest and engagement in our intervention. Social networking sites are now an established part of the online environment; our experience in developing and implementing a health promotion intervention using this medium are of direct relevance and utility for all health organizations creating a presence in this new environment.

Published
2012
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5. Syphilis testing, incidence, and reinfection among gay and bisexual men in Australia over a decade spanning HIV PrEP implementation: an analysis of surveillance data from 2012 to 2022

Author

Traeger, Michael W., Guy, Rebecca, Taunton, Caroline, Chow, Eric P.F., Asselin, Jason, Carter, Allison, Aung, Htein Linn, Bloch, Mark, Fairley, Christopher K., McNulty, Anna, Cornelisse, Vincent J., Read, Phillip, Owen, Louise, Ryder, Nathan, Templeton, David J., O'Donnell, Darryl, Donovan, Basil, Hellard, Margaret E., and Stoové, Mark A.

Published
2024
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9. Point-of-care HCV RNA testing improves hepatitis C testing rates and allows rapid treatment initiation among people who inject drugs attending a medically supervised injecting facility

Author

MacIsaac, Michael B, Whitton, Bradley, Anderson, Jenine, Cogger, Shelley, Vella-Horne, Dylan, Penn, Matthew, Weeks, Anthony, Elmore, Kasey, Pemberton, David, Winter, Rebecca J, Papaluca, Timothy, Howell, Jessica, Hellard, Margaret, Stoové, Mark, Wilson, David, Pedrana, Alisa, Doyle, Joseph S, Clark, Nicolas, Holmes, Jacinta A, and Thompson, Alexander J

Published
2024
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10. Changes in incidence of hepatitis C virus reinfection and access to direct-acting antiviral therapies in people with HIV from six countries, 2010–19: an analysis of data from a consortium of prospective cohort studies

Author

Hellard, Margaret E, Sacks-Davis, Rachel, van Santen, Daniela K, Stewart, Ashleigh, Ke, Tianhui, Zhang, Yanqin, Stoove, Mark, Guy, Rebecca, Pedrana, Alisa, Asselin, Jason, Dawe, Joshua, Wilkinson, Anna, Boyd, Anders, Smit, Colette, van der Valk, Marc, Schinkel, Janke, Wittkop, Linda, Salmon, Dominique, Sogni, Philippe, Esterle, Laure, Gilbert, Camille, Merchadou, Laurence, Gillet, Stephanie, Khan, Coralie, Bonnet, Fabrice, Leleux, Olivier, Le Marec, Fabien, Perrier, Adelaide, Matthews, Gail, Shaw, Ineke, Martinello, Marianne, Applegate, Tanya, Carson, Joanne, Doyle, Joseph S, Harney, Brendan, Bryant, Melissa, Jarrin Vera, Inmaculada, Berenguer, Juan, Alejos, Belen, Lazarus, Jeffrey V, Moreno, Cristina, Izquierdo, Rebecca, Rava, Marta, Klein, Marina, Wang, Shouao, Lumia, Jessica, Pexos, Costa, Peiris, Hansi, Saeed, Sahar, Moodie, Erica, Young, Jim, Pick, Neora, Conway, Brian, Hull, Mark, Wong, Alex, Gill, John, Barrett, Lisa, Cohen, Jeff, Cox, Joseph, Cote, Pierre, Haider, Shariq, Rouleau, Danielle, Vachon, Marie-Louise, Rachlis, Anita, Sandre, Roger, Walmsley, Sharon, Sadr, Aida, Cooper, Curtis, Sanche, Steve, Rauch, Andri, Mugglin, Catrina, Salazar-Viscaya, Luisa, Kusejko, Katharina, Prins, Maria, Hage, Kris, Lacombe, Karine, Requena, Maria-Bernada, Girard, Pierre-Marie, Brucker, Matthieu, Vincensini, Jean-Paul, Jarrin, Inmaculada, Requena, Maria-Bernarda, Matthews, Gail V, Martin, Natasha K, Spelman, Tim, and Hellard, Margaret

Published
2024
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12. Real-world trends in incidence of bacterial sexually transmissible infections among gay and bisexual men using HIV pre-exposure prophylaxis (PrEP) in Australia following nationwide PrEP implementation: an analysis of sentinel surveillance data

Author

Asselin, Jason, Bastian, Lisa, Bateson, Deborah, Bowden, Scott, Boyd, Mark, Callander, Denton, Carter, Allison, Cogle, Aaron, Costello, Jane, Dimech, Wayne, Dittmer, Jennifer, Donovan, Basil, El-Hayek, Carol, Ellard, Jeanne, Fairley, Christopher, Franklin, Lucinda, Guy, Rebecca, Hellard, Margaret, Hocking, Jane, Kim, Jules, McGill, Scott, Nolan, David, Patel, Prital, Pendle, Stella, Polkinghorne, Victoria, Nguyen, Long, Nguyen, Thi, O'Connor, Catherine, Reed, Philip, Roth, Norman, Ryder, Nathan, Selvey, Christine, Stoové, Mark, Traeger, Michael William, Vickers, Toby, Walker, Melanie, Watchirs-Smith, Lucy, West, Michael, Traeger, Michael W, Wright, Edwina J, Grulich, Andrew, McManus, Hamish, Fairley, Christopher K, Chow, Eric P F, McNulty, Anna, Finlayson, Robert, Bell, Charlotte, Owen, Louise, Marshall, Lewis, Russell, Darren, O'Donnell, Darryl, Hellard, Margaret E, and Stoové, Mark A

Published
2022
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13. Connecting patients notified with hepatitis C to treatment (CONNECT Study): A randomized controlled trial of active case management by a health department to support primary care practitioners

Author

Marukutira, Tafireyi, Barter, Rachel, Moore, Karen P., Hellard, Margaret E., Richmond, Jacqui, Turner, Kate, Pedrana, Alisa E., Melody, Shannon, Johnston, Fay H., Owen, Louise, Boom, Wijnand van Den, Scott, Nick, Thompson, Alexander, Iser, David M., Spelman, Timothy, Veitch, Mark, Stoové, Mark, and Doyle, Joseph S.

Published
2023
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17. HIV treatment-as-prevention and its effect on incidence of HIV among cisgender gay, bisexual, and other men who have sex with men in Australia: a 10-year longitudinal cohort study

Author

Callander, Denton, McManus, Hamish, Gray, Richard T, Grulich, Andrew E, Carr, Andrew, Hoy, Jennifer, Donovan, Basil, Fairley, Christopher K, Holt, Martin, Templeton, David J, Liaw, Siaw-Teng, McMahon, James H, Asselin, Jason, Petoumenos, Kathy, Hellard, Margaret, Pedrana, Alisa, Elliott, Julian, Keen, Phillip, Costello, Jane, Keane, Richard, Kaldor, John, Stoové, Mark, and Guy, Rebecca

Published
2023
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20. Treatment as prevention effect of direct-acting antivirals on primary hepatitis C virus incidence: findings from a multinational cohort between 2010 and 2019

Author

van Santen, Daniela K., Sacks-Davis, Rachel, Stewart, Ashleigh, Boyd, Anders, Young, Jim, van der Valk, Marc, Smit, Colette, Rauch, Andri, Braun, Dominique L., Jarrin, Inmaculada, Berenguer, Juan, Lazarus, Jeffrey V., Lacombe, Karine, Requena, Maria-Bernarda, Wittkop, Linda, Leleux, Olivier, Salmon, Dominique, Bonnet, Fabrice, Matthews, Gail, Doyle, Joseph S., Spelman, Tim, Klein, Marina B., Prins, Maria, Asselin, Jason, Stoové, Mark A., and Hellard, Margaret

Published
2023
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24. Hepatitis C incidence among patients attending primary care health services that specialise in the care of people who inject drugs, Victoria, Australia, 2009 to 2020

Author

Wilkinson, Anna Lee, van Santen, Daniela K, Traeger, Michael W, Sacks-Davis, Rachel, Asselin, Jason, Scott, Nick, Harney, Brendan L, Doyle, Joseph S, El-Hayek, Carol, Howell, Jessica, Bramwell, Fran, McManus, Hamish, Donovan, Basil, Stoové, Mark, Hellard, Margaret, and Pedrana, Alisa

Published
2022
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29. Improvements in transition times through the HIV cascade of care among gay and bisexual men with a new HIV diagnosis in New South Wales and Victoria, Australia (2012–19): a longitudinal cohort study

Author

Carr, Andrew, Elliot, Julian, Templeton, David J., Liaw, Teng, Wilson, David P., van Santen, Daniela K, Asselin, Jason, Haber, Noah A, Traeger, Michael W, Callander, Denton, Donovan, Basil, El-Hayek, Carol, McMahon, James H, Petoumenos, Kathy, McManus, Hamish, Hoy, Jennifer F, Hellard, Margaret, Guy, Rebecca, and Stoové, Mark

Published
2021
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33. HIV incidence in people receiving government-subsidised pre-exposure prophylaxis in Australia: a whole-of-population retrospective cohort study

Author

Medland, Nicholas A, McManus, Hamish, Bavinton, Benjamin R, Fraser, Doug, Traeger, Michael W, Grulich, Andrew E, Stoove, Mark A, McGregor, Skye, King, Jonathan M, Heath-Paynter, Dash, and Guy, Rebecca J

Abstract

HIV pre-exposure prophylaxis (PrEP) is highly effective and has been government subsidised in Australia since April, 2018. We examined HIV incidence over 5 years in a retrospective observational cohort of people who had received subsidised PrEP.

Published
2024
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34. Exploring opportunities for hepatitis C treatment uptake among people who inject drugs in Australia: a qualitative study.

Author

Aung, Phyo, Goutzamanis, Stelliana, Douglass, Caitlin, Stoove, Mark, Hellard, Margaret, Dietze, Paul, and Higgs, Peter

Abstract

Background and objective: This study aims to understand the reasons people avoid or delay HCV treatment and identify potential pathways that can increase the uptake of HCV treatment from a health systems perspective. Methods: Semi-structured interviews with 15 participants who were HCV positive and had a history of active or recent injecting drug use were conducted. Thematic and framework analyses based on an integrated framework by Høj and colleagues were used to identify barriers and opportunities to HCV treatment. Results: The study identified barriers and enablers to HCV treatment at individual, socio-structural, and system levels. Competing priorities, unstable housing, and stigma were barriers, while engagement in opioid agonist therapy and peer support were enablers. Misinformation, limited OAT prescribers, and gaps in care coordination, especially within the prison system, were identified as missed opportunities at the system level, while organizational support and respectful relationships with service providers were key to engagement. Conclusions: Person-centered care addressing the specific needs of PWID, such as housing, and drug and alcohol treatment, should be enhanced, and HCV care embedded within these services. Strengthening care pathways, especially within and between prisons and other primary care services, is urgently needed. [ABSTRACT FROM AUTHOR]

Published
2025
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39. HIV incidence and factors associated with testing positive for HIV among men who have sex with men and transgender women in Myanmar: data from community-based HIV testing services

Author

Veronese, Vanessa, Traeger, Michael, Oo, Zaw M., Tun, Thet T., Oo, Nwe N., Maung, Htay, Hughes, Chad, Pedrana, Alisa, and Stoove, Mark

Subjects
Transgender people -- Sexual behavior, HIV tests, HIV -- Prevention, Epidemiology, Women -- Sexual behavior, Sexually transmitted disease prevention, Health
Abstract

Introduction: In Myanmar, men who have sex with men (MSM) and transgender women (TW) are disproportionately affected by HIV, despite national HIV program scale-up. However, limited HIV surveillance capacity prevents monitoring of epidemic trends and program impact. This study aimed to estimate HIV prevalence and incidence and explore associated sexual risk behaviours among MSM and TW clients attending HIV testing clinics in Myanmar. Methods: An electronic data management system was implemented in two community-based, MSM and TW -tailored HIV testing clinics in Myanmar in August 2016. Unique client identifiers enabled prospective monitoring of service engagement, testing frequency and outcomes. We estimated HIV incidence and rate of HIV diagnosis at baseline testing visit among clients over a 15 month period. Correlates of HIV diagnoses were identified using multivariable logistic regression. Results: 2794 MSM and TW were tested for HIV. At their baseline test, 38% of clients reported any previous testing and 93% reported being sexually active over the previous three months, with 74% reporting sex with casual male partners and 28% reporting consistent condom use with casual partners. 291 clients tested positive for HIV for the first time at baseline (10.4%; 95% CI: 9.3 to 11.6). Twelve incident cases were detected among 279 clients receiving [greater than or equal to]2 tests (incidence = 10.1 per 100 person-years; 95% CI: 5.73 to 17.8). HIV diagnosis at baseline was significantly associated with being a transgender woman or a non-openly disclosing man who has sex with men, age 26 to 39 years, and reporting no testing history. Conclusions: High HIV incidence and new diagnoses being associated with reporting no testing history points to undiagnosed HIV driving transmissions in Myanmar. Repeat testing was uncommon. HIV programs in Myanmar must focus on promoting frequent HIV testing alongside adequate coverage of education and primary prevention interventions among MSM and TW. Keywords: HIV prevention; men who have sex with men; transgender women; Myanmar; HIV epidemiology; HIV testing, (1) | INTRODUCTION Evidence of emergent HIV epidemics and prevalence estimates greater than 10% point to a disproportionate burden of HIV among men who have sex with men (MSM) and [...]

Published
2020
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40. HIV pre-exposure prophylaxis for female sex workers: ensuring women's family planning needs are not left behind

Author

Bowring, Anna L., Ampt, Frances H., Schwartz, Sheree, Stoove, Mark A., Luchters, Stanley, Baral, Stefan, and Hellard, Margaret

Subjects
International Conference on AIDS -- 2018 AD, Sexually transmitted diseases -- Prevention, Working women -- Social aspects -- Health aspects, Prophylaxis -- Social aspects -- Health aspects, HIV infections -- Prevention, Social services -- Social aspects -- Health aspects, Reproductive health -- Social aspects -- Health aspects, HIV -- Prevention, Condoms -- Social aspects -- Health aspects, Abortion -- Social aspects -- Health aspects, Sexually transmitted disease prevention -- Social aspects -- Health aspects, Sex oriented businesses -- Health aspects -- Social aspects, Health
Abstract

Introduction: Female sex workers (FSWs) experience overlapping burdens of HIV, sexually transmitted infections and unintended pregnancy. Pre-exposure prophylaxis (PrEP) is highly efficacious for HIV prevention. It represents a promising strategy to reduce HIV acquisition risks among FSWs specifically given complex social and structural factors that challenge consistent condom use. However, the potential impact on unintended pregnancy has garnered little attention. We discuss the potentia concerns and opportunities for PrEP to positively or negatively impact the sexual and reproductive health and rights (SRHR) of FSWs. Discussion: FSWs have high unmet need for effective contraception and unintended pregnancy is common in low- and middle-income countries. Unintended pregnancy can have enduring health and social effects for FSWs, including consequences of unsafe abortion and financial impacts affecting subsequent risk-taking. It is possible that PrEP could negatively impact condom and other contraceptive use among FSWs due to condom substitution, normalization, external pressures or PrEP provision by single-focus services. There are limited empirical data available to assess the impact of PrEP on pregnancy rates in real-life settings. However, pregnancy rates are relatively high in PrEP trials and modelling suggests a potential two-fold increase in condomless sex among FSWs on PrEP, which, given low use of non-barrier contraceptive methods, would increase rates of unintended pregnancy. Opportunities for integrating family planning with PrEP and HIV services may circumvent these concerns and support improved SRHR. Synergies between PrEP and family planning could promote uptake and maintenance for both interventions. Integrating family planning into FSW-focused community-based HIV services is likely to be the most effective model for improving access to non-barrier contraception among FSWs. However, barriers to integration, such as provider skills and training and funding mechanisms, need to be addressed. Conclusions: As PrEP is scaled up among FSWs, there is growing impetus to consider integrating family planning services with PrEP delivery in order to better meet the diverse SRHR needs of FSWs and to prevent unintended consequences. Programme monitoring combined with research can close data gaps and mobilize adequate resources to deliver comprehensive SRHR services respectful of all women's rights. Keywords: sex workers; Pre-Exposure Prophylaxis (PrEP); contraception; unplanned pregnancy; HIV infections, (1) | INTRODUCTION Female sex workers (FSWs) in low- and middle-income countries experience overlapping burdens of high HIV prevalence alongside high rates of sexually transmitted infections (STIs) and unintended pregnancy [...]

Published
2020
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41. A mobile phone application for malaria case-based reporting to advance malaria surveillance in Myanmar: a mixed methods evaluation

Author

Win Han Oo, Win Htike, Cutts, Julia C., Kyawt Mon Win, Kaung Myat Thu, May Chan Oo, Galau Naw Hkawng, Agius, Paul A., Pyae Phyo Htoon, Scott, Nick, Kearney, Ellen, Moreira, Clarissa, Pedrana, Alisa, Stoove, Mark, Aung Thi, Ye Win Aung, Min Min Thein, Rosecrans, Kathryn, Kyi Tun Lwin, Aung Kyi Min, and Fowkes, Freya J. I.

Published
2021
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42. Assessing the feasibility, acceptability and impacts of an education program on hepatitis B testing uptake among ethnic Chinese in Australia: results of a randomised controlled pilot study

Author

Xiao, Yinzong, Wallace, Jack, Ahad, Marvad, van Gemert, Caroline, Thompson, Alexander J., Doyle, Joseph, Lam, Ho Yin, Chan, Kico, Bennett, Gabrielle, Adamson, Emily, Yussf, Nafisa, Tang, Aurora, Pedrana, Alisa, Stoove, Mark, Hellard, Margaret, and Howell, Jessica

Published
2021
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47. Chlamydia retesting remains low among young women in Australia: an observational study using sentinel surveillance data, 2018–2022

Author

Munari, Stephanie C., primary, Wilkinson, Anna L., additional, Asselin, Jason, additional, Owen, Louise, additional, Read, Phillip, additional, Finlayson, Robert, additional, Martin, Sarah, additional, Bell, Charlotte, additional, O’Connor, Catherine C., additional, Carter, Allison, additional, Guy, Rebecca, additional, McNulty, Anna, additional, Varma, Rick, additional, Chow, Eric P. F., additional, Fairley, Christopher K., additional, Donovan, Basil, additional, Stoove, Mark, additional, Goller, Jane L., additional, Hocking, Jane, additional, and Hellard, Margaret E., additional

Published
2024
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48. Changes in incidence of hepatitis C virus reinfection and access to direct-acting antiviral therapies in people with HIV from six countries, 2010–19: an analysis of data from a consortium of prospective cohort studies

Author

Sacks-Davis, Rachel, primary, van Santen, Daniela K, additional, Boyd, Anders, additional, Young, Jim, additional, Stewart, Ashleigh, additional, Doyle, Joseph S, additional, Rauch, Andri, additional, Mugglin, Catrina, additional, Klein, Marina, additional, van der Valk, Marc, additional, Smit, Colette, additional, Jarrin, Inmaculada, additional, Berenguer, Juan, additional, Lacombe, Karine, additional, Requena, Maria-Bernarda, additional, Wittkop, Linda, additional, Leleux, Olivier, additional, Bonnet, Fabrice, additional, Salmon, Dominique, additional, Matthews, Gail V, additional, Guy, Rebecca, additional, Martin, Natasha K, additional, Spelman, Tim, additional, Prins, Maria, additional, Stoove, Mark, additional, Hellard, Margaret, additional, Hellard, Margaret E, additional, Sacks-Davis, Rachel, additional, Ke, Tianhui, additional, Zhang, Yanqin, additional, Pedrana, Alisa, additional, Asselin, Jason, additional, Dawe, Joshua, additional, Wilkinson, Anna, additional, Schinkel, Janke, additional, Sogni, Philippe, additional, Esterle, Laure, additional, Gilbert, Camille, additional, Merchadou, Laurence, additional, Gillet, Stephanie, additional, Khan, Coralie, additional, Le Marec, Fabien, additional, Perrier, Adelaide, additional, Matthews, Gail, additional, Shaw, Ineke, additional, Martinello, Marianne, additional, Applegate, Tanya, additional, Carson, Joanne, additional, Harney, Brendan, additional, Bryant, Melissa, additional, Jarrin Vera, Inmaculada, additional, Alejos, Belen, additional, Lazarus, Jeffrey V, additional, Moreno, Cristina, additional, Izquierdo, Rebecca, additional, Rava, Marta, additional, Wang, Shouao, additional, Lumia, Jessica, additional, Pexos, Costa, additional, Peiris, Hansi, additional, Saeed, Sahar, additional, Moodie, Erica, additional, Pick, Neora, additional, Conway, Brian, additional, Hull, Mark, additional, Wong, Alex, additional, Gill, John, additional, Barrett, Lisa, additional, Cohen, Jeff, additional, Cox, Joseph, additional, Cote, Pierre, additional, Haider, Shariq, additional, Rouleau, Danielle, additional, Vachon, Marie-Louise, additional, Rachlis, Anita, additional, Sandre, Roger, additional, Walmsley, Sharon, additional, Sadr, Aida, additional, Cooper, Curtis, additional, Sanche, Steve, additional, Salazar-Viscaya, Luisa, additional, Kusejko, Katharina, additional, Hage, Kris, additional, Requena, Maria-Bernada, additional, Girard, Pierre-Marie, additional, Brucker, Matthieu, additional, and Vincensini, Jean-Paul, additional

Published
2024
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