4,712 results on '"Stone, James A."'
Search Results
2. The three-dimensional structure of black hole accretion flows within the plunging region
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Mummery, Andrew and Stone, James M.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We analyse, using new analytical models and numerical general relativistic magnetohydrodynamic simulations, the three-dimensional properties of accretion flows inside the plunging region of black hole spacetimes (i.e., at radii smaller than the innermost stable circular orbit). These simulations are of thick discs, with aspect ratios of order unity $h/r \sim 1$, and with a magnetic field geometry given by the standard low-magnetization "SANE" configuration. This work represents the first step in a wider analysis of this highly relativistic region. We show that analytical expressions derived in the "thin disc" limit describe the numerical results remarkably well, despite the large aspect ratio of the flow. We further demonstrate that accretion within this region is typically mediated via spiral arms, and that the geometric properties of these spiral structures can be understood with a simple analytical model. These results highlight how accretion within the plunging region is fundamentally two dimensional in character, which may have a number of observational implications. We derive a modified theoretical description of the pressure within the plunging region which accounts for turbulent heating and may be of use to black hole image modelling., Comment: 21 pages, 16 figures. Accepted for publication in MNRAS
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- 2024
3. Magnetized Accretion onto and Feedback from Supermassive Black Holes in Elliptical Galaxies
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Guo, Minghao, Stone, James M., Quataert, Eliot, and Kim, Chang-Goo
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
We present three-dimensional magnetohydrodynamic (MHD) simulations of the fueling of supermassive black holes in elliptical galaxies from a turbulent cooling medium on galactic scales, taking M87* as a typical case. We find that the mass accretion rate is increased by a factor of $\sim 10$ compared with analogous hydrodynamic simulations. The scaling of $\dot{M} \sim r^{1/2}$ roughly holds from $\sim 10\,\mathrm{pc}$ to $\sim 10^{-3}\,\mathrm{pc}$ ($\sim 10\, r_\mathrm{g}$) with the accretion rate through the event horizon being $\sim 10^{-2}\, M_\odot\,\mathrm{yr^{-1}}$. The accretion flow on scales $\sim 0.03-3\,\mathrm{kpc}$ takes the form of magnetized filaments. Within $\sim 30\,\mathrm{pc}$, the cold gas circularizes, forming a highly magnetized ($\beta\sim 10^{-3}$) thick disk supported by a primarily toroidal magnetic field. The cold disk is truncated and transitions to a turbulent hot accretion flow at $\sim0.3\,\mathrm{pc}$ ($10^3\,r_\mathrm{g}$). There are strong outflows towards the poles driven by the magnetic field. The outflow energy flux increases with smaller accretor size, reaching $\sim 3\times10^{43}\,\mathrm{erg\,s^{-1}}$ for $r_\mathrm{in}=8\,r_\mathrm{g}$; this corresponds to a nearly constant energy feedback efficiency of $\eta\sim0.05-0.1$ independent of accretor size. The feedback energy is enough to balance the total cooling of the M87/Virgo hot halo out to $\sim 50$ kpc. The accreted magnetic flux at small radii is similar to that in magnetically arrested disk models, consistent with the formation of a powerful jet on horizon scales in M87. Our results motivate a subgrid model for accretion in lower-resolution simulations in which the hot gas accretion rate is suppressed relative to the Bondi rate by $\sim (10r_\mathrm{g}/r_\mathrm{B})^{1/2}$., Comment: 23 pages, 14 figures, submitted to ApJ
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- 2024
4. Seeds of Stereotypes: A Large-Scale Textual Analysis of Race and Gender Associations with Diseases in Online Sources
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Hansen, Lasse Hyldig, Andersen, Nikolaj, Gallifant, Jack, McCoy, Liam G., Stone, James K, Izath, Nura, Aguirre-Jerez, Marcela, Bitterman, Danielle S, Gichoya, Judy, and Celi, Leo Anthony
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Computer Science - Computation and Language - Abstract
Background Advancements in Large Language Models (LLMs) hold transformative potential in healthcare, however, recent work has raised concern about the tendency of these models to produce outputs that display racial or gender biases. Although training data is a likely source of such biases, exploration of disease and demographic associations in text data at scale has been limited. Methods We conducted a large-scale textual analysis using a dataset comprising diverse web sources, including Arxiv, Wikipedia, and Common Crawl. The study analyzed the context in which various diseases are discussed alongside markers of race and gender. Given that LLMs are pre-trained on similar datasets, this approach allowed us to examine the potential biases that LLMs may learn and internalize. We compared these findings with actual demographic disease prevalence as well as GPT-4 outputs in order to evaluate the extent of bias representation. Results Our findings indicate that demographic terms are disproportionately associated with specific disease concepts in online texts. gender terms are prominently associated with disease concepts, while racial terms are much less frequently associated. We find widespread disparities in the associations of specific racial and gender terms with the 18 diseases analyzed. Most prominently, we see an overall significant overrepresentation of Black race mentions in comparison to population proportions. Conclusions Our results highlight the need for critical examination and transparent reporting of biases in LLM pretraining datasets. Our study suggests the need to develop mitigation strategies to counteract the influence of biased training data in LLMs, particularly in sensitive domains such as healthcare.
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- 2024
5. Nonthermal Signatures of Radiative Supernova Remnants
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Diesing, Rebecca, Guo, Minghao, Kim, Chang-Goo, Stone, James, and Caprioli, Damiano
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The end of supernova remnant (SNR) evolution is characterized by a so-called "radiative" stage, in which efficient cooling of the hot bubble inside the forward shock slows expansion, leading to eventual shock breakup. Understanding SNR evolution at this stage is vital for predicting feedback in galaxies, since SNRs are expected to deposit their energy and momentum into the interstellar medium at the ends of their lives. A key prediction of SNR evolutionary models is the formation at the onset of the radiative stage of a cold, dense shell behind the forward shock. However, searches for these shells via their neutral hydrogen emission have had limited success. We instead introduce an independent observational signal of shell formation arising from the interaction between nonthermal particles accelerated by the SNR forward shock (cosmic rays) and the dense shell. Using a semi-analytic model of particle acceleration based on state-of-the-art simulations coupled with a high-resolution hydrodynamic model of SNR evolution, we predict the nonthermal emission that arises from this interaction. We demonstrate that the onset of the radiative stage leads to nonthermal signatures from radio to $\gamma$-rays, including radio and $\gamma$-ray brightening by nearly two orders of magnitude. Such a signature may be detectable with current instruments, and will be resolvable with the next generation of gamma-ray telescopes (namely, the Cherenkov Telescope Array)., Comment: 13 pages, 6 figures, accepted to ApJ
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- 2024
6. Dissipation of AGN jets in a clumpy interstellar medium
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Dutta, Riju, Sharma, Prateek, Sarkar, Kartick C., and Stone, James M.
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Astrophysics - Astrophysics of Galaxies ,Physics - Fluid Dynamics - Abstract
Accreting supermassive black holes (SMBHs) frequently power jets that interact with the interstellar/circumgalactic medium (ISM/CGM), regulating star-formation in the galaxy. Highly supersonic jets launched by active galactic nuclei (AGN) power a cocoon that confines them and shocks the ambient medium. We build upon the models of narrow conical jets interacting with a smooth ambient medium, to include the effect of dense clouds that are an essential ingredient of a multiphase ISM. The key physical ingredient of this model is that the clouds along the supersonic jet-beam strongly decelerate the jet-head, but the subsonic cocoon easily moves around the clouds without much resistance. We propose scalings for important physical quantities -- cocoon pressure, head & cocoon speed, and jet radius. We obtain, for the first time, the analytic condition on clumpiness of the ambient medium for the jet to dissipate within the cocoon and verify it with numerical simulations of conical jets interacting with a uniform ISM with embedded spherical clouds. A jet is defined to be dissipated when the cocoon speed exceeds the speed of the jet-head. We compare our models to more sophisticated numerical simulations, direct observations of jet-ISM interaction (e.g., quasar J1316+1753), and discuss implications for the Fermi/eROSITA bubbles. Our work also motivates effective subgrid models for AGN jet feedback in a clumpy ISM unresolved by the present generation of cosmological galaxy formation simulations., Comment: 23 pages, 12 figures, 3 tables; to be submitted; comments are welcome; accompanying video: http://youtu.be/DUpSwMMrGfk
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- 2023
7. Tearing-mediated reconnection in magnetohydrodynamic poorly ionized plasmas. I. Onset and linear evolution
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Tolman, Elizabeth A., Kunz, Matthew W., Stone, James M., and Arzamasskiy, Lev
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Astrophysics - Solar and Stellar Astrophysics ,Physics - Plasma Physics - Abstract
In high-Lundquist-number plasmas, reconnection proceeds via onset of tearing, followed by a nonlinear phase during which plasmoids continuously form, merge, and are ejected from the current sheet (CS). This process is understood in fully ionized, magnetohydrodynamic plasmas. However, many plasma environments, such as star-forming molecular clouds and the solar chromosphere, are poorly ionized. We use theory and computation to study tearing-mediated reconnection in such poorly ionized systems. In this paper, we focus on the onset and linear evolution of this process. In poorly ionized plasmas, magnetic nulls on scales below $v_{\rm A,n0}/\nu_{\rm ni0}$, with $v_{\rm A,n0}$ the neutral Alfv\'{e}n speed and $\nu_{\rm ni0}$ the neutral-ion collision frequency, will self-sharpen via ambipolar diffusion. This sharpening occurs at an increasing rate, inhibiting the onset of reconnection. Once the CS becomes thin enough, however, ions decouple from neutrals and thinning of the CS slows, allowing tearing to onset in a time of order $\nu_{\rm ni0}^{-1}$. We find that the wavelength and growth rate of the mode that first disrupts the forming sheet can be predicted from a poorly ionized tearing dispersion relation; as the plasma recombination rate increases and ionization fraction decreases, the growth rate becomes an increasing multiple of $\nu_{ni0}$ and the wavelength becomes a decreasing fraction of $v_{\rm A,n0}/\nu_{\rm ni0}$., Comment: 19 pages, 13 figures
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- 2023
8. Guidance of ultraviolet light down to 190 nm in a hollow-core optical fibre
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Mears, Robbie, Harrington, Kerrianne, Wadsworth, William J., Knight, Jonathan C., Stone, James M., and Birks, Tim A.
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Physics - Optics - Abstract
We report an anti-resonant hollow core fibre with ultraviolet transmission down to 190 nm, covering the entire UV-A, UV-B and much of the UV-C band. Guidance from 190 - 400 nm is achieved apart for a narrow high loss resonance band at 245 - 265 nm. The minimum attenuation is 0.13 dB/m at 235 nm and 0.16 dB/m at 325 nm. With an inscribed core diameter of ~ 12 $\mu$m, the fibre's bend loss at 325 nm was 0.22 dB per turn for a bend radius of 3 cm at 325 nm.
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- 2023
9. A Global 3-D Simulation of Magnetospheric Accretion: I. Magnetically Disrupted Disks and Surface Accretion
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Zhu, Zhaohuan, Stone, James M., and Calvet, Nuria
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
We present a 3-D ideal MHD simulation of magnetospheric accretion onto a non-rotating star. The accretion process unfolds with intricate 3-D structures driven by various mechanisms. First, the disc develops filaments at the magnetospheric truncation radius ($R_T$) due to magnetic interchange instability. These filaments penetrate deep into the magnetosphere, form multiple accretion columns, and eventually impact the star at $\sim$30$^o$ from the poles at nearly the free-fall speed. Over 50% (90%) of accretion occurs on just 5% (20%) of the stellar surface. Second, the disc region outside $R_T$ develops large-scale magnetically dominated bubbles, again due to magnetic interchange instability. These bubbles orbit at a sub-Keplerian speed, persisting for a few orbits while leading to asymmetric mass ejection. The disc outflow is overall weak because of mostly closed field lines. Third, magnetically-supported surface accretion regions appear above the disc, resembling a magnetized disc threaded by net vertical fields, a departure from traditional magnetospheric accretion models. Stellar fields are efficiently transported into the disc region due to above instabilities, contrasting with the ``X-wind'' model. The accretion rate onto the star remains relatively steady with a 23% standard deviation. The periodogram reveals variability occurring at around 0.2 times the Keplerian frequency at $R_T$, linked to the large-scale magnetic bubbles. The ratio of the spin-up torque to $\dot{M}(GM_*R_T)^{1/2}$ is around 0.8. Finally, after scaling the simulation, we investigate planet migration in the inner protoplanetary disc. The disc driven migration is slow in the MHD turbulent disc beyond $R_T$, while aerodynamic drag plays a significant role in migration within $R_T$., Comment: Accepted to MNRAS
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- 2023
10. The Foot and Ankle
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Stone, James, primary, John, Kennedy, additional, and Glazebrook, Mark, additional
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- 2024
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11. Debridement With Stimulation of the Subchondral Bone
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Stone, James W., primary
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- 2024
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12. Arthroscopic Anatomical Reconstruction of the Lateral Ankle Ligaments
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Guillo, Stephane, primary, Takao, Masato, additional, Stone, James W., additional, and Glazebrook, Mark, additional
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- 2024
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13. Damping of MHD Turbulence in A Partially Ionized Medium
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Hu, Yue, Xu, Siyao, Arzamasskiy, Lev, Stone, James M., and Lazarian, A.
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Astrophysics - Astrophysics of Galaxies - Abstract
The coupling state between ions and neutrals in the interstellar medium plays a key role in the dynamics of magnetohydrodynamic (MHD) turbulence, but is challenging to study numerically. In this work, we investigate the damping of MHD turbulence in a partially ionized medium using 3D two-fluid (ions+neutrals) simulations generated with the AthenaK code. Specifically, we examine the velocity, density, and magnetic field statistics of the two-fluid MHD turbulence in different regimes of neutral-ion coupling. Our results demonstrate that when ions and neutrals are strongly coupled, the velocity statistics resemble those of single-fluid MHD turbulence. Both the velocity structures and kinetic energy spectra of ions and neutrals are similar, while their density structures can be significantly different. With an excess of small-scale sharp density fluctuations in ions, the density spectrum in ions is shallower than that of neutrals. When ions and neutrals are weakly coupled, the turbulence in ions is more severely damped due to the ion-neutral collisional friction than that in neutrals, resulting in a steep kinetic energy spectrum and density spectrum in ions compared to the Kolmogorov spectrum. We also find that the magnetic energy spectrum basically follows the shape of the kinetic energy spectrum of ions, irrespective of the coupling regime. In addition, we find large density fluctuations in ions and neutrals and thus spatially inhomogeneous ionization fractions. As a result, the neutral-ion decoupling and damping of MHD turbulence take place over a range of length scales., Comment: 17 pages, 14 figures, accepted for publication in MNRAS
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- 2023
14. Implementation of chemistry in the Athena++ code
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Gong, Munan, Ho, Ka-Wai, Stone, James M., Ostriker, Eve C., Caselli, Paola, Grassi, Tommaso, Kim, Chang-Goo, Kim, Jeong-Gyu, and Halevi, Goni
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Chemistry plays a key role in many aspects of astrophysical fluids. Atoms and molecules are agents for heating and cooling, determine the ionization fraction, serve as observational tracers, and build the molecular foundation of life. We present the implementation of a chemistry module in the publicly available magneto-hydrodynamic code Athena++. We implement several chemical networks and heating and cooling processes suitable for simulating the interstellar medium (ISM). A general chemical network framework in the KIDA format is also included, allowing the user to easily implement their own chemistry. Radiation transfer and cosmic-ray ionization are coupled with chemistry and solved with the simple six-ray approximation. The chemical and thermal processes are evolved as a system of coupled ODEs with an implicit solver from the CVODE library. We perform and present a series of tests to ensure the numerical accuracy and convergence of the code. Many tests combine chemistry with gas dynamics, including comparisons with analytic solutions, 1D problems of the photo-dissociation regions and shocks, and realistic 3D simulations of the turbulent ISM. We release the code with the new public version of Athena++, aiming to provide a robust and flexible code for the astrochemical simulation community.
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- 2023
15. Mahakala: a Python-based Modular Ray-tracing and Radiative Transfer Algorithm for Curved Space-times
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Sharma, Aniket, Medeiros, Lia, Chan, Chi-kwan, Halevi, Goni, Mullen, Patrick D., Stone, James M., and Wong, George N.
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Astrophysics - High Energy Astrophysical Phenomena ,General Relativity and Quantum Cosmology - Abstract
We introduce Mahakala, a Python-based, modular, radiative ray-tracing code for curved space-times. We employ Google's JAX framework for accelerated automatic differentiation, which can efficiently compute Christoffel symbols directly from the metric, allowing the user to easily and quickly simulate photon trajectories through non-Kerr metrics. JAX also enables Mahakala to run in parallel on both CPUs and GPUs and achieve speeds comparable to C-based codes. Mahakala natively uses the Cartesian Kerr-Schild coordinate system, which avoids numerical issues caused by the "pole" of spherical coordinates. We demonstrate Mahakala's capabilities by simulating the 1.3 mm wavelength images (the wavelength of Event Horizon Telescope observations) of general relativistic magnetohydrodynamic simulations of low-accretion rate supermassive black holes. The modular nature of Mahakala allows us to easily quantify the relative contribution of different regions of the flow to image features. We show that most of the emission seen in 1.3 mm images originates close to the black hole. We also quantify the relative contribution of the disk, forward jet, and counter jet to 1.3 mm images., Comment: 15 pages, 11 figures
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- 2023
16. Mesenteric Ischemia
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Grewal, Shivraj, Kansagra, Kartik, Stone, James R., Vatakencherry, Geogy, Keefe, Nicole A., editor, Haskal, Ziv J.J, editor, Park, Auh Whan, editor, and Angle, John F., editor
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- 2024
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17. ANTsX neuroimaging-derived structural phenotypes of UK Biobank
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Tustison, Nicholas J., Yassa, Michael A., Rizvi, Batool, Cook, Philip A., Holbrook, Andrew J., Sathishkumar, Mithra T., Tustison, Mia G., Gee, James C., Stone, James R., and Avants, Brian B.
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- 2024
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18. LAMS use in malignant stricture of duodenal apex with synchronous malignant biliary obstruction: a potentially effective and simpler endoscopic approach
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Mai, Hugh D., Panicker, Linoj, Stone, James J., and Brahmbhatt, Mihir N.
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- 2024
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19. Effects of gamma frequency binaural beats on attention and anxiety
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Leistiko, Natalya Marie, Madanat, Louay, Yeung, Wing Kwan Antonia, and Stone, James M.
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- 2024
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20. The Athena++ Adaptive Mesh Refinement Framework: Multigrid Solvers for Self-Gravity
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Tomida, Kengo and Stone, James M.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We describe the implementation of multigrid solvers in the Athena++ adaptive mesh refinement (AMR) framework and their application to the solution of the Poisson equation for self-gravity. The new solvers are built on top of the AMR hierarchy and TaskList framework of Athena++ for efficient parallelization. We adopt a conservative formulation for the Laplacian operator that avoids artificial accelerations at level boundaries. Periodic, fixed, and zero-gradient boundary conditions are implemented, as well as open boundary conditions based on a multipole expansion. Hybrid parallelization using both MPI and OpenMP is adopted, and we present results of tests demonstrating the accuracy and scaling of the methods. On a uniform grid we show multigrid significantly outperforms methods based on FFTs, and requires only a small fraction of the compute time required by the (highly optimized) magnetohydrodynamic solver in Athena++. As a demonstration of the capabilities of the methods, we present the results of a test calculation of magnetized protostellar collapse on an adaptive mesh., Comment: 28 pages, 13 figures, submitted to AAS Journals
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- 2023
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21. An Extension of the Athena++ Code Framework for Radiation-Magnetohydrodynamics in General Relativity Using a Finite-Solid-Angle Discretization
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White, Christopher J., Mullen, Patrick D., Jiang, Yan-Fei, Davis, Shane W., Stone, James M., Morozova, Viktoriya, and Zhang, Lizhong
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics ,General Relativity and Quantum Cosmology - Abstract
We extend the general-relativistic magnetohydrodynamics (GRMHD) capabilities of Athena++ to incorporate radiation. The intensity field in each finite-volume cell is discretized in angle, with explicit transport in both space and angle properly accounting for the effects of gravity on null geodesics, and with matter and radiation coupled in a locally implicit fashion. Here we describe the numerical procedure in detail, verifying its correctness with a suite of tests. Motivated in particular by black hole accretion in the high-accretion-rate, thin-disk regime, we demonstrate the application of the method to this problem. With excellent scaling on flagship computing clusters, the port of the algorithm to the GPU-enabled AthenaK code now allows the simulation of many previously intractable radiation-GRMHD systems., Comment: To be published in ApJS
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- 2023
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22. Global Three-Dimensional Radiation Magnetohydrodynamic Simulations of Accretion onto a Stellar Mass Black Hole at Sub- and Near-critical Accretion Rates
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Huang, Jiahui, Jiang, Yan-Fei, Feng, Hua, Davis, Shane W., Stone, James M., and Middleton, Matthew J.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present global 3D radiation magnetohydrodynamical simulations of accretion onto a 6.62 solar mass black hole with quasi-steady state accretion rates reaching 0.016 to 0.9 times the critical accretion rate, which is defined as the accretion rate to power the Eddington luminosity assuming a 10% radiative efficiency, in different runs. The simulations show no sign of thermal instability over hundreds of thermal timescales at 10 $r_{\rm g}$. The energy dissipation happens close to the mid-plane in the near-critical runs and near the disk surface in the low accretion rate run. The total radiative luminosity inside $\sim$20 $r_{\rm g}$ is about 1% to 30% the Eddington limit, with a radiative efficiency of about 6% and 3%, respectively, in the sub- and near-critical accretion regimes. In both cases, self-consistent turbulence generated by the magnetorotational instability (MRI) leads to angular momentum transfer, and the disk is supported by magnetic pressure. Outflows from the central low-density funnel with a terminal velocity of $\sim$0.1$c$ are seen only in the near-critical runs. We conclude that these magnetic pressure dominated disks are thermally stable and thicker than the $\alpha$ disk, and the effective temperature profiles are much flatter than that in the $\alpha$ disks. The magnetic pressure of these disks are comparable within an order of magnitude with the previous analytical magnetic pressure dominated disk model., Comment: 17 pages, 13 figures, 3 tables, accepted for publication in ApJ
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- 2023
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23. The Inner 2 pc of Sagittarius A*: Simulations of the Circumnuclear Disk and Multiphase Gas Accretion in the Galactic Center
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Solanki, Siddhant, Ressler, Sean M., Murchikova, Lena, Stone, James M., and Morris, Mark R.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present hydrodynamic simulations of the inner few parsecs of the Milky Way's Galactic Center that, for the first time, combine a realistic treatment of stellar winds and the circumnuclear disk as they interact with the gravitational potential of the nuclear star cluster and Sagittarius~A*. We observe a complex interaction of the stellar winds with the inner edge of the circumnuclear disk, which leads to the growth of instabilities, induced accretion of cool gas from the inner edge of the disk, and the eventual formation of a small accretion disk of $\sim 10^4-10^5$ K within $r \sim 0.1$ pc., Comment: 26 pages, 16 figures, (Submitted to ApJ)
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- 2023
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24. The Genetic Determinants of Aortic Distention.
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Pirruccello, James, Rämö, Joel, Choi, Seung, Chaffin, Mark, Kany, Shinwan, Nekoui, Mahan, Chou, Elizabeth, Jurgens, Sean, Friedman, Samuel, Juric, Dejan, Stone, James, Batra, Puneet, Ng, Kenney, Philippakis, Anthony, Lindsay, Mark, and Ellinor, Patrick
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aorta ,cardiovascular disease ,deep learning ,distensibility ,genetics ,strain ,Humans ,Aorta ,Thoracic ,Aorta ,Aortic Diseases ,Magnetic Resonance Imaging ,Stroke - Abstract
BACKGROUND: As the largest conduit vessel, the aorta is responsible for the conversion of phasic systolic inflow from ventricular ejection into more continuous peripheral blood delivery. Systolic distention and diastolic recoil conserve energy and are enabled by the specialized composition of the aortic extracellular matrix. Aortic distensibility decreases with age and vascular disease. OBJECTIVES: In this study, we sought to discover epidemiologic correlates and genetic determinants of aortic distensibility and strain. METHODS: We trained a deep learning model to quantify thoracic aortic area throughout the cardiac cycle from cardiac magnetic resonance images and calculated aortic distensibility and strain in 42,342 UK Biobank participants. RESULTS: Descending aortic distensibility was inversely associated with future incidence of cardiovascular diseases, such as stroke (HR: 0.59 per SD; P = 0.00031). The heritabilities of aortic distensibility and strain were 22% to 25% and 30% to 33%, respectively. Common variant analyses identified 12 and 26 loci for ascending and 11 and 21 loci for descending aortic distensibility and strain, respectively. Of the newly identified loci, 22 were not significantly associated with thoracic aortic diameter. Nearby genes were involved in elastogenesis and atherosclerosis. Aortic strain and distensibility polygenic scores had modest effect sizes for predicting cardiovascular outcomes (delaying or accelerating disease onset by 2%-18% per SD change in scores) and remained statistically significant predictors after accounting for aortic diameter polygenic scores. CONCLUSIONS: Genetic determinants of aortic function influence risk for stroke and coronary artery disease and may lead to novel targets for medical intervention.
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- 2023
25. Methods for Estimating Neural Information
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Stone, James V
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Quantitative Biology - Neurons and Cognition ,Computer Science - Information Theory - Abstract
Estimating the Shannon information associated with individual neurons is a non-trivial problem. Three key methods used to estimate the mutual information between neuron inputs and outputs are described, and a list of further readings is provided., Comment: 7 pages, 2 figures
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- 2022
26. Toward Horizon-scale Accretion Onto Supermassive Black Holes in Elliptical Galaxies
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Guo, Minghao, Stone, James M., Kim, Chang-Goo, and Quataert, Eliot
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
We present high-resolution, three-dimensional hydrodynamic simulations of the fueling of supermassive black holes in elliptical galaxies from a turbulent medium on galactic scales, taking M87* as a typical case. The simulations use a new GPU-accelerated version of the Athena++ AMR code, and span more than 6 orders of magnitude in radius, reaching scales similar to the black hole horizon. The key physical ingredients are radiative cooling and a phenomenological heating model. We find that the accretion flow takes the form of multiphase gas at radii less than about a kpc. The cold gas accretion includes two dynamically distinct stages: the typical disk stage in which the cold gas resides in a rotationally supported disk and relatively rare chaotic stages ($\lesssim 10\%$ of the time) in which the cold gas inflows via chaotic streams. Though cold gas accretion dominates the time-averaged accretion rate at intermediate radii, accretion at the smallest radii is dominated by hot virialized gas at most times. The accretion rate scales with radius as $\dot{M}\propto r^{1/2}$ when hot gas dominates and we obtain $\dot{M}\simeq10^\mathrm{-4}-10^\mathrm{-3}\,M_\odot\,\mathrm{yr^{-1}}$ near the event horizon, similar to what is inferred from EHT observations. The orientation of the cold gas disk can differ significantly on different spatial scales. We propose a subgrid model for accretion in lower-resolution simulations in which the hot gas accretion rate is suppressed relative to the Bondi rate by $\sim (r_\mathrm{g}/r_{\rm Bondi})^{1/2}$. Our results can also provide more realistic initial conditions for simulations of black hole accretion at the event horizon scale., Comment: 28 pages, 25 figures, 2 tables, accepted for publication in ApJ
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- 2022
27. Prograde and Retrograde Gas Flow around Disk-embedded Companions: Dependence on Eccentricity, Mass and Disk Properties
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Chen, Yi-Xian, Bailey, Avery, Stone, James M., and Zhu, Zhaohuan
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We apply 3D hydrodynamical simulations to study the rotational aspect of gas flow patterns around eccentric companions embedded in an accretion disk around its primary host. We sample a wide range of companion mass ratio q and disk aspect ratio h, and confirm a generic transition from prograde (steady tidal interaction dominated) to retrograde (background Keplerian shear dominated) circum-companion flow when orbital eccentricity exceeds a critical value et. We find et \sim h for sub-thermal companions while et \sim (q/h)^1/3 for super-thermal companions, and propose an empirical formula to unify the two scenarios. Our results also suggest that et is insensitive to modest levels of turbulence, modeled in the form of a kinematic viscosity term. In the context of stellar-mass Black Holes (sBHs) embedded in AGN accretion disks, the bifurcation of their circum-stellar disk (CSD) rotation suggest the formation of a population of nearly anti-aligned sBHs, whose relevance to low spin gravitational waves (GW) events can be probed in more details with future population models of sBH evolution in AGN disks, making use of our quantitative scaling for et; In the context of circum-planetary disks (CPDs), our results suggest the possibility of forming retrograde satellites in-situ in retrograde CPDs around eccentric planets., Comment: Accepted to ApJL, 10 pages, 5 figures
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- 2022
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28. Turbulent Magnetic Field Amplification by the Interaction of Shock Wave and Inhomogeneous Medium
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Hu, Yue, Xu, Siyao, Stone, James M., and Lazarian, Alex
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Astrophysics - Astrophysics of Galaxies - Abstract
Magnetic fields on the order of 100 $\mu$G observed in young supernova remnants cannot be amplified by shock compression alone. To investigate the amplification caused by turbulent dynamo, we perform three-dimensional MHD simulations of the interaction between shock wave and inhomogeneous density distribution with a shallow spectrum in the preshock medium. The postshock turbulence is mainly driven by the strongest preshock density contrast and follows the Kolmogorov scaling. The resulting turbulence amplifies the postshock magnetic field. The time evolution of the magnetic fields agrees with the prediction of the nonlinear turbulent dynamo theory in Xu & Lazarian (2016). When the initial weak magnetic field is perpendicular to the shock normal, the maximum amplification of the field's strength achieves a factor of $\approx200$, which is twice larger than that for a parallel shock. We find that the perpendicular shock exhibits a smaller turbulent Alfv\'en Mach number in the vicinity of the shock front than the parallel shock. However, the strongest magnetic field has a low volume filling factor and is limited by the turbulent energy due to the reconnection diffusion taking place in a turbulent and magnetized fluid. The magnetic field strength averaged along the $z$-axis is reduced by a factor $\gtrsim10$. We decompose the turbulent velocity and magnetic field into solenoidal and compressive modes. The solenoidal mode is dominant and evolves to follow the Kolmogorov scaling, even though the preshock density distribution has a shallow spectrum. When the preshock density distribution has a Kolmogorov spectrum, the turbulent velocity's compressive component increases., Comment: 19 pages, 15 figures, accepted for publication in ApJ
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- 2022
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29. Virus-Induced Acute Respiratory Distress Syndrome Causes Cardiomyopathy Through Eliciting Inflammatory Responses in the Heart
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Grune, Jana, Bajpai, Geetika, Ocak, Pervin Tülin, Kaufmann, Eva, Mentkowski, Kyle, Pabel, Steffen, Kumowski, Nina, Pulous, Fadi E., Tran, Kim A., Rohde, David, Zhang, Shuang, Iwamoto, Yoshiko, Wojtkiewicz, Gregory R., Vinegoni, Claudio, Green, Ursula, Swirski, Filip K., Stone, James R., Lennerz, Jochen K., Divangahi, Maziar, Hulsmans, Maarten, and Nahrendorf, Matthias
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- 2024
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30. Parthenon -- a performance portable block-structured adaptive mesh refinement framework
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Grete, Philipp, Dolence, Joshua C., Miller, Jonah M., Brown, Joshua, Ryan, Ben, Gaspar, Andrew, Glines, Forrest, Swaminarayan, Sriram, Lippuner, Jonas, Solomon, Clell J., Shipman, Galen, Junghans, Christoph, Holladay, Daniel, Stone, James M., and Roberts, Luke F.
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Computer Science - Distributed, Parallel, and Cluster Computing ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
On the path to exascale the landscape of computer device architectures and corresponding programming models has become much more diverse. While various low-level performance portable programming models are available, support at the application level lacks behind. To address this issue, we present the performance portable block-structured adaptive mesh refinement (AMR) framework Parthenon, derived from the well-tested and widely used Athena++ astrophysical magnetohydrodynamics code, but generalized to serve as the foundation for a variety of downstream multi-physics codes. Parthenon adopts the Kokkos programming model, and provides various levels of abstractions from multi-dimensional variables, to packages defining and separating components, to launching of parallel compute kernels. Parthenon allocates all data in device memory to reduce data movement, supports the logical packing of variables and mesh blocks to reduce kernel launch overhead, and employs one-sided, asynchronous MPI calls to reduce communication overhead in multi-node simulations. Using a hydrodynamics miniapp, we demonstrate weak and strong scaling on various architectures including AMD and NVIDIA GPUs, Intel and AMD x86 CPUs, IBM Power9 CPUs, as well as Fujitsu A64FX CPUs. At the largest scale on Frontier (the first TOP500 exascale machine), the miniapp reaches a total of $1.7\times10^{13}$ zone-cycles/s on 9,216 nodes (73,728 logical GPUs) at ~92% weak scaling parallel efficiency (starting from a single node). In combination with being an open, collaborative project, this makes Parthenon an ideal framework to target exascale simulations in which the downstream developers can focus on their specific application rather than on the complexity of handling massively-parallel, device-accelerated AMR., Comment: 17 pages, 11 figures, accepted for publication in IJHPCA, Codes available at https://github.com/parthenon-hpc-lab
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- 2022
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31. A machine learning algorithm improves the diagnostic accuracy of the histologic component of antibody mediated rejection (AMR-H) in cardiac transplant endomyocardial biopsies
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Glass, Matthew, Ji, Zhicheng, Davis, Richard, Pavlisko, Elizabeth N., DiBernardo, Louis, Carney, John, Fishbein, Gregory, Luthringer, Daniel, Miller, Dylan, Mitchell, Richard, Larsen, Brandon, Butt, Yasmeen, Bois, Melanie, Maleszewski, Joseph, Halushka, Marc, Seidman, Michael, Lin, Chieh-Yu, Buja, Maximilian, Stone, James, Dov, David, Carin, Lawrence, and Glass, Carolyn
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- 2024
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32. A Patch Wearable Cardioverter-Defibrillator for Patients at Risk of Sudden Cardiac Arrest
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Hargrove, Joe L., Surber, Joseph, Goldner, Bruce, Tomassoni, Gery, Stone, James, Wahid, Faisal, El-Chami, Mikhael, Zweibel, Steve, Nair, Devi, Atwater, Brett, Krishnasamy, Kavita, Eldadah, Zayd, Patel, Dilesh, Cavalcanti, Rafael, Singh, Sandeep, Sinha, Sunil, Houmsse, Mahmoud, Long, Robert, Pickett, Robert, Rangaswamy, Chandhiran, Patil, Kaustubha, Bailin, Steven, Joyner, Charles, Mela, Theofanie, Shirazi, Jonathan, Turitto, Gioia, Romero, Jorge, Gordon, Robert, Di Biase, Luigi, Levine, Yehoshua, Hummel, John, Hargrove, Joe, Mathews, Kiran, Thakkar, Anjali B., Ullery, Steven, Eapen, Zubin J., Kumar, Uday N., Mehran, Roxana, and Butler, Javed
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- 2024
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33. EGFR Inhibition Potentiates FGFR Inhibitor Therapy and Overcomes Resistance in FGFR2 Fusion–Positive Cholangiocarcinoma
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Wu, Qibiao, Zhen, Yuanli, Shi, Lei, Vu, Phuong, Greninger, Patricia, Adil, Ramzi, Merritt, Joshua, Egan, Regina, Wu, Meng-Ju, Yin, Xunqin, Ferrone, Cristina R, Deshpande, Vikram, Baiev, Islam, Pinto, Christopher J, McLoughlin, Daniel E, Walmsley, Charlotte S, Stone, James R, Gordan, John D, Zhu, Andrew X, Juric, Dejan, Goyal, Lipika, Benes, Cyril H, and Bardeesy, Nabeel
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Digestive Diseases - (Gallbladder) ,Digestive Diseases ,6.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,Evaluation of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,Bile Duct Neoplasms ,Bile Ducts ,Intrahepatic ,Cholangiocarcinoma ,ErbB Receptors ,Humans ,Protein Kinase Inhibitors ,Pyrimidines ,Receptor ,Fibroblast Growth Factor ,Type 2 ,Oncology and Carcinogenesis - Abstract
FGFR inhibitors are approved for the treatment of advanced cholangiocarcinoma harboring FGFR2 fusions. However, the response rate is moderate, and resistance emerges rapidly due to acquired secondary FGFR2 mutations or due to other less-defined mechanisms. Here, we conducted high-throughput combination drug screens, biochemical analysis, and therapeutic studies using patient-derived models of FGFR2 fusion-positive cholangiocarcinoma to gain insight into these clinical profiles and uncover improved treatment strategies. We found that feedback activation of EGFR signaling limits FGFR inhibitor efficacy, restricting cell death induction in sensitive models and causing resistance in insensitive models lacking secondary FGFR2 mutations. Inhibition of wild-type EGFR potentiated responses to FGFR inhibitors in both contexts, durably suppressing MEK/ERK and mTOR signaling, increasing apoptosis, and causing marked tumor regressions in vivo. Our findings reveal EGFR-dependent adaptive signaling as an important mechanism limiting FGFR inhibitor efficacy and driving resistance and support clinical testing of FGFR/EGFR inhibitor therapy for FGFR2 fusion-positive cholangiocarcinoma.SignificanceWe demonstrate that feedback activation of EGFR signaling limits the effectiveness of FGFR inhibitor therapy and drives adaptive resistance in patient-derived models of FGFR2 fusion-positive cholangiocarcinoma. These studies support the potential of combination treatment with FGFR and EGFR inhibitors as an improved treatment for patients with FGFR2-driven cholangiocarcinoma. This article is highlighted in the In This Issue feature, p. 1171.
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- 2022
34. Who's the Daddy? Infidelity Favours Father-Son Facial Dissimilarity
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Stone, James V
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Quantitative Biology - Populations and Evolution - Abstract
Evolutionary theory predicts that children fare better if they resemble their father. However, if a man is promiscuous then his children tend to be (unwittingly) raised within other families; such children should fare better if they do not resemble their father. This suggests that father-son facial similarity should decrease as a function of male promiscuity. To test this hypothesis, the degree of similarity between each of 37 pairs of father-son photographs was rated by 83 participants. The promiscuity score of a father was defined as the number of sexual relationships he had been involved in. A linear regression of father-son similarity ratings against fathers' promiscuity scores indicated that the slope of the fitted line was significantly less than zero (slope=-0.176, p < 0.001), and that fathers' promiscuity scores account for 75% of the variance father-son facial similarity ratings. Additionally, a significant negative non-parametric correlation (Spearman's rho rho=-0.886, p=0.019) between father-son similarity ratings and fathers' promiscuity scores was found.
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- 2021
35. Using Information Theory to Measure Psychophysical Performance
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Stone, James V
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Quantitative Biology - Neurons and Cognition ,Computer Science - Information Theory - Abstract
Most psychophysical experiments discard half the data collected. Specifically, experiments discard reaction time data, and use binary responses (e.g. yes/no) to measure performance. Here, Shannon's information theory is used to define Shannon competence $s'$, which depends on the mutual information between stimulus strength (e.g. luminance) and a combination of reaction times and binary responses. Mutual information is the entropy of the joint distribution of responses minus the residual entropy after a model has been fitted to these responses. Here, this model is instantiated as a proportional rate diffusion model, with the additional innovation that the full covariance structure of responses is taken into account. Results suggest information associated with reaction times is independent of (i.e. additional to) information associated with binary responses, and that reaction time and binary responses together provide substantially more than the sum of their individual contributions (i.e. they act synergistically). Consequently, the additional information supplied by reaction times suggests that using combined reaction time and binary responses requires fewer stimulus presentations, without loss of precision in psychophysical parameters. Finally, because s' takes account of both reaction time and binary responses, (and in contrast to d') $s'$ is immune to speed-accuracy trade-offs, which vary between observers and experimental designs.
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- 2021
36. Large vessel giant cell arteritis
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van der Geest, Kornelis S M, Sandovici, Maria, Bley, Thorsten A, Stone, James R, Slart, Riemer H J A, and Brouwer, Elisabeth
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- 2024
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37. Duration of SARS-CoV-2 mRNA vaccine persistence and factors associated with cardiac involvement in recently vaccinated patients
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Krauson, Aram J., Casimero, Faye Victoria C., Siddiquee, Zakir, and Stone, James R.
- Published
- 2023
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38. The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antipsychotic treatment
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Jauhar, Sameer, McCutcheon, Robert A., Veronese, Mattia, Borgan, Faith, Nour, Matthew, Rogdaki, Maria, Pepper, Fiona, Stone, James M., Egerton, Alice, Vamvakas, George, Turkheimer, Federico, McGuire, Philip K., and Howes, Oliver D.
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- 2023
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39. Molecular Pathology of the Heart and Cardiovascular System
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(Rex) Hung, Yin P., Stone, James R., Cheng, Liang, editor, Netto, George J., editor, and Eble, John N., editor
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- 2023
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40. Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis
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Merritt, Kate, McCutcheon, Robert A., Aleman, André, Ashley, Sarah, Beck, Katherine, Block, Wolfgang, Bloemen, Oswald J. N., Borgan, Faith, Boules, Christiana, Bustillo, Juan R., Capizzano, Aristides A., Coughlin, Jennifer M., David, Anthony, de la Fuente-Sandoval, Camilo, Demjaha, Arsime, Dempster, Kara, Do, Kim Q., Du, Fei, Falkai, Peter, Galińska-Skok, Beata, Gallinat, Jürgen, Gasparovic, Charles, Ginestet, Cedric E., Goto, Naoki, Graff-Guerrero, Ariel, Ho, Beng-Choon, Howes, Oliver, Jauhar, Sameer, Jeon, Peter, Kato, Tadafumi, Kaufmann, Charles A., Kegeles, Lawrence S., Keshavan, Matcheri S., Kim, Sang-Young, King, Bridget, Kunugi, Hiroshi, Lauriello, J., León-Ortiz, Pablo, Liemburg, Edith, Mcilwain, Meghan E., Modinos, Gemma, Mouchlianitis, Elias, Nakamura, Jun, Nenadic, Igor, Öngür, Dost, Ota, Miho, Palaniyappan, Lena, Pantelis, Christos, Patel, Tulsi, Plitman, Eric, Posporelis, Sotirios, Purdon, Scot E., Reichenbach, Jürgen R., Renshaw, Perry F., Reyes-Madrigal, Francisco, Russell, Bruce R., Sawa, Akira, Schaefer, Martin, Shungu, Dikoma C., Smesny, Stefan, Stanley, Jeffrey A., Stone, James, Szulc, Agata, Taylor, Reggie, Thakkar, Katharine N., Théberge, Jean, Tibbo, Philip G., van Amelsvoort, Thérèse, Walecki, Jerzy, Williamson, Peter C., Wood, Stephen J., Xin, Lijing, Yamasue, Hidenori, McGuire, Philip, and Egerton, Alice
- Published
- 2023
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41. Sub millimetre flexible fibre probe for background and fluorescence free Raman spectroscopy
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Yerolatsitis, Stephanos, Kufcsák, András, Ehrlich, Katjana, Wood, Harry A. C., Fernandes, Susan, Quinn, Tom, Young, Vikki, Young, Irene, Hamilton, Katie, Akram, Ahsan R., Thomson, Robert R., Finlayson, Keith, Dhaliwal, Kevin, and Stone, James M.
- Subjects
Physics - Biological Physics ,Physics - Optics - Abstract
Using the shifted-excitation Raman difference spectroscopy technique and an optical fibre featuring a negative curvature excitation core and a coaxial ring of high numerical aperture collection cores, we have developed a portable, background and fluorescence free, endoscopic Raman probe. The probe consists of a single fibre with a diameter of less than 0.25 mm packaged in a sub-millimetre tubing, making it compatible with standard bronchoscopes. The Raman excitation light in the fibre is guided in air and therefore interacts little with silica, enabling an almost background free transmission of the excitation light. In addition, we used the shifted-excitation Raman difference spectroscopy technique and a tunable 785 nm laser to separate the fluorescence and the Raman spectrum from highly fluorescent samples, demonstrating the suitability of the probe for biomedical applications. Using this probe we also acquired fluorescence free human lung tissue data.
- Published
- 2020
42. Transition region from turbulent to dead zone in protoplanetary disks: local shearing box simulations
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Pucci, Fulvia, Tomida, Kengo, Stone, James, Takasao, Shinsuke, Ji, Hantao, and Okamura, Shoichi
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
The dynamical evolution of protoplanetary disks is of key interest for building a comprehensive theory of planet formation and to explain the observational properties of these objects. Using the magnetohydrodynamics code Athena++, with an isothermal shearing box setup, we study the boundary between the active and dead zone, where the accretion rate changes and mass can accumulate. We quantify how the turbulence level is affected by the presence of a non uniform ohmic resistivity in the radial-x direction that leads to a region of inhibited turbulence (or dead zone). Comparing the turbulent activity to that of ideal simulations, the turbulence inhibited area shows density fluctuations and magnetic activity at its boundaries, driven by energy injection from the active (ideal) zone boundaries. We find magnetic dissipation to be significantly stronger in the ideal regions, and the turbulence penetration through the boundary of the dead zone is determined by the value of the resistivity itself, through the ohmic dissipation process, though the thickness of the transition does not play a significant role in changing the dissipation. We investigate the 1D spectra along the shearing direction: magnetic spectra appear flat at large scales both in ideal as well as resistive simulations, though a Kolmogorov scaling over more than one decade persists in the dead zone, suggesting the turbulent cascade is determined by the hydrodynamics of the system: MRI dynamo action is inhibited where sufficiently high resistivity is present., Comment: 11 pages 12 figures
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- 2020
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43. Stratified Global MHD Models of Accretion Disks in Semi-Detached Binaries
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Pjanka, Patryk and Stone, James M.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present results of the first global magnetohydrodynamic (MHD) simulations of accretion disks fed by Roche lobe overflow, including vertical stratification, in order to investigate the roles of spiral shocks, magnetorotational instability (MRI), and the accretion stream on disk structure and evolution. Our models include a simple treatment of gas thermodynamics, with orbital Mach numbers at the inner edge of the disk $M_{\rm in}$ of 5 and 10. We find mass accretion rates to vary considerably on all time scales, with only the Mach 5 model reaching a clear quasi-stationary state. For Mach 10, the model undergoes an outside-in magnetically-driven accretion event occurring on a time scale of $\sim10$ orbital periods of the binary. Both models exhibit spiral shocks inclined with respect to the binary plane, with their position and inclination changing rapidly. However, the time-averaged location of these shocks in the equatorial plane is well-fit by simple linear models. MRI turbulence in the disk generates toroidal magnetic field patterns (butterfly diagrams) that are in some cases irregular, perhaps due to interaction with spiral structure. While many of our results are in good agreement with local studies, we find some features (most notably those related to spiral shocks) can only be captured in global models such as studied here. Thus, while global studies remain computationally expensive -- even as idealized models -- they are essential (along with more sophisticated treatment of radiation transport and disk thermodynamics) for furthering our understanding of accretion in binary systems., Comment: 30 pages, 13 figures; Accepted for publication in ApJ
- Published
- 2020
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44. New Psychoanalytic Readings of Shakespeare
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Newlin, James, primary and Stone, James W., additional
- Published
- 2023
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45. “Is this a holiday?”
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Stone, James W., primary
- Published
- 2023
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46. Introduction
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Newlin, James, primary and Stone, James W., additional
- Published
- 2023
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47. Cosmological simulations of quasar fueling to sub-parsec scales using Lagrangian hyper-refinement
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Anglés-Alcázar, Daniel, Quataert, Eliot, Hopkins, Philip, Somerville, Rachel, Hayward, Christopher, Faucher-Giguère, Claude-André, Bryan, Greg, Kereš, Dušan, Hernquist, Lars, and Stone, James
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present cosmological hydrodynamic simulations of a quasar-mass halo ($M_{\rm halo} \approx 10^{12.5}\,{\rm M}_{\odot}$ at z=2) that for the first time resolve gas transport down to the inner 0.1 pc surrounding the central massive black hole. We model a multi-phase interstellar medium including stellar feedback by supernovae, stellar winds, and radiation, and a hyper-Lagrangian refinement technique increasing the resolution dynamically approaching the black hole. We do not include black hole feedback. We show that the sub-pc inflow rate (1) can reach ~6 M$_{\odot}$yr$^{-1}$ roughly in steady state during the epoch of peak nuclear gas density (z~2), sufficient to power a luminous quasar, (2) is highly time variable in the pre-quasar phase, spanning 0.001-10 M$_{\odot}$yr$^{-1}$ on Myr timescales, and (3) is limited to short (~2 Myr) active phases (0.01-0.1 M$_{\odot}$yr$^{-1}$) followed by longer periods of inactivity at lower nuclear gas density and late times (z~1), owing to the formation of a hot central cavity. Inflowing gas is primarily cool, rotational support dominates over turbulence and thermal pressure, and star formation can consume as much gas as provided by inflows across 1 pc - 10 kpc. Gravitational torques from multi-scale stellar non-axisymmetries dominate angular momentum transport over gas self-torquing and pressure gradients, with accretion weakly dependent on black hole mass. Sub-pc inflow rates correlate with nuclear (but decouple from global) star formation and can exceed the Eddington rate by x10. The black hole can move ~10 pc from the galaxy center on ~0.1 Myr. Accreting gas forms pc-scale, rotationally supported, obscuring structures often misaligned with the galaxy-scale disk. These simulations open a new avenue to investigate black hole-galaxy co-evolution., Comment: 34 pages, 23 figures, ApJ accepted
- Published
- 2020
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48. Turbulent dissipation, CH$^+$ abundance, H$_2$ line luminosities, and polarization in the cold neutral medium
- Author
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Moseley, Eric R., Draine, B. T., Tomida, Kengo, and Stone, James M.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
In the cold neutral medium, high out-of-equilibrium temperatures are created by intermittent dissipation processes, including shocks, viscous heating, and ambipolar diffusion. The high-temperature excursions are thought to explain the enhanced abundance of CH$^{+}$ observed along diffuse molecular sight-lines. Intermittent high temperatures should also have an impact on H$_2$ line luminosities. We carry out simulations of MHD turbulence in molecular clouds including heating and cooling, and post-process them to study H$_2$ line emission and hot-gas chemistry, particularly the formation of CH$^+$. We explore multiple magnetic field strengths and equations of state. We use a new H$_2$ cooling function for $n_{\rm H} \leq 10^5\,{\rm cm}^{-3}$, $T\leq 5000\,{\rm K}$, and variable H$_2$ fraction. We make two important simplifying assumptions: (i) the ${\rm H}_2/{\rm H}$ fraction is fixed everywhere, and (ii) we exclude from our analysis regions where the ion-neutral drift velocity is calculated to be greater than 5 km/s. Our models produce H$_2$ emission lines in accord with many observations, although extra excitation mechanisms are required in some clouds. For realistic r.m.s. magnetic field strengths ($\approx 10$ $\mu$G) and velocity dispersions, we reproduce observed CH$^+$ abundances. These findings contrast with those of Valdivia et al. (2017). Comparison of predicted dust polarization with observations by {\it Planck} suggests that the mean field $\gtrsim 5 \mu$G, so that the turbulence is sub-Alfv\'enic. We recommend future work treating ions and neutrals as separate fluids to more accurately capture the effects of ambipolar diffusion on CH$^+$ abundance., Comment: 20 pages, 18 figures, accepted for publication to MNRAS
- Published
- 2020
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49. Interpretable, similarity-driven multi-view embeddings from high-dimensional biomedical data
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Avants, Brian B., Tustison, Nicholas J., and Stone, James R.
- Subjects
Statistics - Machine Learning ,Computer Science - Machine Learning - Abstract
Similarity-driven multi-view linear reconstruction (SiMLR) is an algorithm that exploits inter-modality relationships to transform large scientific datasets into smaller, more well-powered and interpretable low-dimensional spaces. SiMLR contributes a novel objective function for identifying joint signal, regularization based on sparse matrices representing prior within-modality relationships and an implementation that permits application to joint reduction of large data matrices, each of which may have millions of entries. We demonstrate that SiMLR outperforms closely related methods on supervised learning problems in simulation data, a multi-omics cancer survival prediction dataset and multiple modality neuroimaging datasets. Taken together, this collection of results shows that SiMLR may be applied with default parameters to joint signal estimation from disparate modalities and may yield practically useful results in a variety of application domains., Comment: accepted to Nature Computational Science
- Published
- 2020
50. Ab Initio Horizon-Scale Simulations of Magnetically Arrested Accretion in Sagittarius A* Fed by Stellar Winds
- Author
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Ressler, Sean M., White, Christopher J., Quataert, Eliot, and Stone, James M.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present 3D general relativistic magnetohydrodynamic (GRMHD) simulations of the accretion flow surrounding Sagittarius A* that are initialized using larger-scale MHD simulations of the $\sim$ 30 Wolf--Rayet (WR) stellar winds in the Galactic center. The properties of the resulting accretion flow on horizon scales are set not by ad hoc initial conditions but by the observationally constrained properties of the WR winds with limited free parameters. For this initial study we assume a non-spinning black hole. Our simulations naturally produce a $\sim 10^{-8} M_\odot$ yr$^{-1}$ accretion rate, consistent with previous phenomenological estimates. We find that a magnetically arrested flow is formed by the continuous accretion of coherent magnetic field being fed from large radii. Near the event horizon, the magnetic field is so strong that it tilts the gas with respect to the initial angular momentum and concentrates the originally quasi-spherical flow to a narrow disk-like structure. We also present 230 GHz images calculated from our simulations where the inclination angle and physical accretion rate are not free parameters but are determined by the properties of the WR stellar winds. The image morphology is highly time variable. Linear polarization on horizon scales is coherent with weak internal Faraday rotation., Comment: Accepted by ApJL. 14 pages, 8 figures. Animations available at https://smressle.bitbucket.io/animations.html
- Published
- 2020
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