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3. Cortisol awakening response and developmental outcomes at 6–7 years in children born extremely preterm

Author

Jobe, Alan H, Caplan, Michael S, Polin, Richard A, Laptook, Abbot R, Hensman, Angelita M, Vieira, Elisa, Little, Emilee, Johnson, Katharine, Alksninis, Barbara, Keszler, Mary Lenore, Knoll, Andrea M, Leach, Theresa M, McGowan, Elisabeth C, Watson, Victoria E, Walsh, Michele C, Fanaroff, Avroy A, Payne, Allison, Wilson-Costello, Deanne E, Newman, Nancy S, Siner, Bonnie S, Zadell, Arlene, DiFiore, Julie, Bhola, Monika, Friedman, Harriet G, Yalcinkaya, Gulgun, Goldberg, Ronald N, Cotten, C Michael, Gustafson, Kathryn E, Goldstein, Ricki F, Ashley, Patricia, Auten, Kathy J, Fisher, Kimberley A, Foy, Katherine A, Freedman, Sharon F, Lohmeyer, Melody B, Malcolm, William F, Wallace, David K, Carlton, David P, Stoll, Barbara J, Adams-Chapman, Ira, Buchter, Susie, Piazza, Anthony J, Carter, Sheena, Fritz, Sobha, Hale, Ellen C, Hutchinson, Amy K, LaRossa, Maureen Mulligan, Loggins, Yvonne, Bottcher, Diane, Higgins, Rosemary D, Archer, Stephanie Wilson, Poindexter, Brenda B, Sokol, Gregory M, Harmon, Heidi M, Papile, Lu-Ann, Hines, Abbey C, Wilson, Leslie D, Herron, Dianne E, Smiley, Lucy, Granger, Douglas A, Kennedy, Kathleen A, Tyson, Jon E, Duncan, Andrea F, Dempsey, Allison G, John, Janice, Jones, Patrick M, Lillie, M Layne, Siddiki, Saba, Sperry, Daniel K, Blaisdell, Carol J, Das, Abhik, Wallace, Dennis, Gantz, Marie G, O’Donnell Auman, Jeanette, Hammond, Jane A, Newman, Jamie E, Poole, W Kenneth, Van Meurs, Krisa P, Stevenson, David K, Ball, M Bethany, DeAnda, Maria Elena, Goodlin, Gabrielle T, Frantz, Ivan D, Fiascone, John M, Kurfiss, Anne, MacKinnon, Brenda L, Nylen, Ellen, Brussa, Ana, Sibley, Cecelia, Carlo, Waldemar A, Ambalavanan, Namasivayam, Collins, Monica V, Cosby, Shirley S, Phillips, Vivien A, Domanovich, Kristy, Whitley, Sally, Smith, Leigh Ann, Kiser, Carin R, and Finer, Neil N

Subjects
Paediatrics, Biomedical and Clinical Sciences, Basic Behavioral and Social Science, Behavioral and Social Science, Mind and Body, Mental Health, Neurosciences, Clinical Research, Pediatric, 2.3 Psychological, social and economic factors, Aetiology, Mental health, Child, Female, Humans, Infant, Newborn, Executive Function, Hydrocortisone, Hypothalamo-Hypophyseal System, Infant, Extremely Premature, Pituitary-Adrenal System, SUPPORT NEURO School-Age Study Subcommittee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Paediatrics and Reproductive Medicine, Public Health and Health Services, Pediatrics
Abstract

BackgroundExtremely preterm (EPT) birth has been related to dysregulation of stress responses and behavioral/learning problems at school age. Early adverse experiences can blunt HPA axis reactivity. We hypothesized that an attenuated cortisol awakening response would be associated with developmental and behavioral problems at school age in EPT children.MethodsThis secondary analysis of a sub-cohort of the SUPPORT study included children born between 24 and 27 weeks, evaluated at 6-7 years with a neurodevelopmental battery and cortisol measures. Differences were tested between EPT and a term-born group. Relationships of cortisol awakening response to test scores were analyzed.ResultsCortisol was measured in 110 EPT and 29 term-born 6-7 year olds. Unadjusted WISC-IV and NEPSY-II scores were significantly worse among EPT children only. Conners Parent Rating Scale behavior scores were significantly worse among EPT children. After adjusting for covariates, blunted cortisol awakening responses were found to be associated with poorer scores on memory tests and greater problems with inattention for the EPT group (p

Published
2023

4. Probiotics and Human Milk Differentially Influence the Gut Microbiome and NEC Incidence in Preterm Pigs

Author

Hebib, Valeria Melendez, Taft, Diana H, Stoll, Barbara, Liu, Jinxin, Call, Lee, Guthrie, Gregory, Jensen, Nick, Hair, Amy B, Mills, David A, and Burrin, Douglas G

Subjects
Paediatrics, Biomedical and Clinical Sciences, Complementary and Integrative Health, Infant Mortality, Pediatric, Prevention, Rare Diseases, Preterm, Low Birth Weight and Health of the Newborn, Nutrition, Digestive Diseases, Perinatal Period - Conditions Originating in Perinatal Period, Biotechnology, Prevention of disease and conditions, and promotion of well-being, 3.3 Nutrition and chemoprevention, Oral and gastrointestinal, Animals, Humans, Bifidobacterium longum subspecies infantis, Enterocolitis, Necrotizing, Gastrointestinal Microbiome, Incidence, Milk, Human, Probiotics, Swine, microbiome, necrotizing enterocolitis, premature infant, human milk, Clostridium sensu stricto 1, Clostridium perfringens, human milk oligosaccharide, Bifidobacterium longum subsp, infantis, Bifidobacterium longum subsp. infantis, Food Sciences, Nutrition and Dietetics, Clinical sciences, Nutrition and dietetics, Public health
Abstract

Necrotizing enterocolitis (NEC) is the leading cause of death caused by gastrointestinal disease in preterm infants. Major risk factors include prematurity, formula feeding, and gut microbial colonization. Microbes have been linked to NEC, yet there is no evidence of causal species, and select probiotics have been shown to reduce NEC incidence in infants. In this study, we evaluated the effect of the probiotic Bifidobacterium longum subsp. infantis (BL. infantis), alone and in combination with a human milk oligosaccharide (HMO)-sialylactose (3'SL)-on the microbiome, and the incidence of NEC in preterm piglets fed an infant formula diet. We studied 50 preterm piglets randomized between 5 treatments: (1) Preterm infant formula, (2) Donor human milk (DHM), (3) Infant formula + 3'SL, (4) Infant formula + BL. infantis, and (5) Infant formula and BL. infantis + 3'SL. NEC incidence and severity were assessed through the evaluation of tissue from all the segments of the GI tract. The gut microbiota composition was assessed both daily and terminally through 16S and whole-genome sequencing (WGS) of rectal stool samples and intestinal contents. Dietary BL. infantis and 3'SL supplementation had no effect, yet DHM significantly reduced the incidence of NEC. The abundance of BL. infantis in the gut contents negatively correlated with disease severity. Clostridium sensu stricto 1 and Clostridium perfringens were significantly more abundant in NEC and positively correlated with disease severity. Our results suggest that pre- and probiotics are not sufficient for protection from NEC in an exclusively formula-based diet. The results highlight the differences in microbial species positively associated with both diet and NEC incidence.

Published
2023

5. Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study

Author

Green, Charles E., Tyson, Jon E., Heyne, Roy J., Hintz, Susan R., Vohr, Betty R., Bann, Carla M., Das, Abhik, Bell, Edward F., Debsareea, Sana Boral, Stephens, Emily, Gantz, Marie G., Petrie Huitema, Carolyn M., Johnson, Karen J., Watterberg, Kristi L., Mosquera, Ricardo, Peralta-Carcelen, Myriam, Wilson-Costello, Deanne E., Colaizy, Tarah T., Maitre, Nathalie L., Merhar, Stephanie L., Adams-Chapman, Ira, Fuller, Janell, Hartley-McAndrew, Michelle E., Malcolm, William F., Winter, Sarah, Duncan, Andrea F., Myer, Gary J., Kicklighter, Stephen D., Wyckoff, Myra H., DeMauro, Sara B., Hibbs, Anna Maria, Stoll, Barbara J., Carlo, Waldemar A., Van Meurs, Krisa P., Rysavy, Matthew A., Patel, Ravi M., Sánchez, Pablo J., Laptook, Abbot R., Cotten, C. Michael, D’Angio, Carl T., and Walsh, Michele C.

Published
2023
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9. Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial.

Author

Blakely, Martin L, Tyson, Jon E, Lally, Kevin P, Hintz, Susan R, Eggleston, Barry, Stevenson, David K, Besner, Gail E, Das, Abhik, Ohls, Robin K, Truog, William E, Nelin, Leif D, Poindexter, Brenda B, Pedroza, Claudia, Walsh, Michele C, Stoll, Barbara J, Geller, Rachel, Kennedy, Kathleen A, Dimmitt, Reed A, Carlo, Waldemar A, Cotten, C Michael, Laptook, Abbot R, Van Meurs, Krisa P, Calkins, Kara L, Sokol, Gregory M, Sanchez, Pablo J, Wyckoff, Myra H, Patel, Ravi M, Frantz, Ivan D, Shankaran, Seetha, D'Angio, Carl T, Yoder, Bradley A, Bell, Edward F, Watterberg, Kristi L, Martin, Colin A, Harmon, Carroll M, Rice, Henry, Kurkchubasche, Arlet G, Sylvester, Karl, Dunn, James CY, Markel, Troy A, Diesen, Diana L, Bhatia, Amina M, Flake, Alan, Chwals, Walter J, Brown, Rebeccah, Bass, Kathryn D, St Peter, Shawn D, Shanti, Christina M, Pegoli, Walter, Skarda, David, Shilyansky, Joel, Lemon, David G, Mosquera, Ricardo A, Peralta-Carcelen, Myriam, Goldstein, Ricki F, Vohr, Betty R, Purdy, Isabell B, Hines, Abbey C, Maitre, Nathalie L, Heyne, Roy J, DeMauro, Sara B, McGowan, Elisabeth C, Yolton, Kimberly, Kilbride, Howard W, Natarajan, Girija, Yost, Kelley, Winter, Sarah, Colaizy, Tarah T, Laughon, Matthew M, Lakshminrusimha, Satyanarayana, and Higgins, Rosemary D

Subjects
Perinatal Period - Conditions Originating in Perinatal Period, Clinical Research, Infant Mortality, Rare Diseases, Digestive Diseases, Preterm, Low Birth Weight and Health of the Newborn, Pediatric, Clinical Trials and Supportive Activities, Good Health and Well Being, Drainage, Enterocolitis, Necrotizing, Feasibility Studies, Female, Humans, Infant, Extremely Low Birth Weight, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Intestinal Perforation, Laparotomy, Male, Neurodevelopmental Disorders, Survival Rate, Treatment Outcome, isolated intestinal perforation, neonatal surgery, premature infant, randomized clinical trial, surgical necrotizing enterocolitis, Eunice Kennedy Shriver National Institute of Child Health, Human Development Neonatal Research Network, Medical and Health Sciences, Surgery
Abstract

ObjectiveThe aim of this study was to determine which initial surgical treatment results in the lowest rate of death or neurodevelopmental impairment (NDI) in premature infants with necrotizing enterocolitis (NEC) or isolated intestinal perforation (IP).Summary background dataThe impact of initial laparotomy versus peritoneal drainage for NEC or IP on the rate of death or NDI in extremely low birth weight infants is unknown.MethodsWe conducted the largest feasible randomized trial in 20 US centers, comparing initial laparotomy versus peritoneal drainage. The primary outcome was a composite of death or NDI at 18 to 22 months corrected age, analyzed using prespecified frequentist and Bayesian approaches.ResultsOf 992 eligible infants, 310 were randomized and 96% had primary outcome assessed. Death or NDI occurred in 69% of infants in the laparotomy group versus 70% with drainage [adjusted relative risk (aRR) 1.0; 95% confidence interval (CI): 0.87-1.14]. A preplanned analysis identified an interaction between preoperative diagnosis and treatment group (P = 0.03). With a preoperative diagnosis of NEC, death or NDI occurred in 69% after laparotomy versus 85% with drainage (aRR 0.81; 95% CI: 0.64-1.04). The Bayesian posterior probability that laparotomy was beneficial (risk difference

Published
2021

12. Early-Life Outcomes in Relation to Social Determinants of Health for Children Born Extremely Preterm

Author

Jobe, Alan H., Caplan, Michael S., Polin, Richard A., Laptook, Abbot R., Keszler, Martin, Hensman, Angelita M., Alksninis, Barbara, Bishop, Carmena, Burke, Robert T., Caskey, Melinda, Hoffman, Laurie, Johnson, Katharine, Keszler, Mary Lenore, Knoll, Andrea M., Lamberson, Vita, Leach, Teresa M., Little, Emilee, McGowan, Elisabeth C., Stephens, Bonnie E., Vieira, Elisa, St. Pierre, Lucille, Ventura, Suzy, Watson, Victoria E., Hibbs, Anna Maria, Walsh, Michele C., Wilson-Costello, Deanne E., Newman, Nancy S., Bhola, Monika, Payne, Allison H., Siner, Bonnie S., Yalcinkaya, Gulgun, Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Scott, Allison, Parimi, Prabhu S., Gaetano, Lisa, Poindexter, Brenda B., Schibler, Kurt, Kallapur, Suhas G., Donovan, Edward F., Merhar, Stephanie, Grisby, Cathy, Yolton, Kimberly, Alexander, Barbara, Beiersdorfer, Traci, Bridges, Kate, Cahill, Tanya E., Dudley, Juanita, Fischer, Estelle E., Gratton, Teresa L., Hayes, Devan, Hessling, Jody, Jackson, Lenora D., Kirker, Kristin, Mincey, Holly L., Muthig, Greg, Stacey, Sara, Steichen, Jean J., Tepe, Stacey, Thompson, Julia, Wuertz, Sandra, Cotten, C. Michael, Goldberg, Ronald N., Goldstein, Ricki F., Malcolm, William F., Mago-Shah, Deesha, Ashley, Patricia L., Finkle, Joanne, Auten, Kathy J., Fisher, Kimberley A., Grimes, Sandra, Gustafson, Kathryn E., Lohmeyer, Melody B., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Clark, Cindy, Talbert, Jennifer, Warner, Diane, Trembath, Andrea, O'Shea, T. Michael, Wereszczak, Janice, Kicklighter, Stephen D., Rhodes-Ryan, Ginger, White, Donna, Patel, Ravi M., Carlton, David P., Stoll, Barbara J., Hale, Ellen C., Loggins, Yvonne C., Adams-Chapman, Ira, Blackwelder, Ann, Bottcher, Diane I., Carter, Sheena L., Kendrick-Allwood, Salathiel, Laursen, Judith, LaRossa, Maureen Mulligan, Mackie, Colleen, Sanders, Amy, Seabrook, Irma, Smikle, Gloria, Wineski, Lynn C., Higgins, Rosemary D., Bremer, Andrew A., Archer, Stephanie Wilson, Sokol, Gregory M., Dusick, Anna M., Papile, Lu Ann, Gunn, Susan, Hamer, Faithe, Harmon, Heidi M., Herron, Dianne E., Hines, Abbey C., Lytle, Carolyn, Miller, Lucy C., Minnich, Heike M., Richard, Leslie, Smiley, Lucy, Wilson, Leslie Dawn, Tyson, Jon E., Kennedy, Kathleen A., Khan, Amir M., Duncan, Andrea, Mosquera, Ricardo, Stephens, Emily K., McDavid, Georgia E., Alaniz, Nora I., Allain, Elizabeth, Arldt-McAlister, Julie, Burson, Katrina, Dempsey, Allison G., Eason, Elizabeth, Evans, Patricia W., Garcia, Carmen, Green, Charles, Hall, Donna, Harris, Beverly Foley, Jiminez, Margarita, John, Janice, Jones, Patrick M., Lillie, M. Layne, Lis, Anna E., Martin, Karen, Martin, Sara C., Mason, Carrie M., McKee, Shannon, Morris, Brenda H., Rennie, Kimberly, Rodgers, Shawna, Siddiki, Saba Khan, Simmons, Maegan C., Sperry, Daniel, Pierce Tate, Patti L., Wright, Sharon L., Sánchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Slaughter, Jonathan L., Yeates, Keith O., Keim, Sarah, Maitre, Nathalie L., Timan, Christopher J., Luzader, Patricia, Clark, Erna, Fortney, Christine A., Gutentag, Julie, Park, Courtney, Shadd, Julie, Sullivan, Margaret, Stein, Melanie, Nelin, Mary Ann, Newton, Julia, Small, Kristi, Burkhardt, Stephanie, Purnell, Jessica, Pietruszewski, Lindsay, Levengood, Katelyn, Batterson, Nancy, Morehead, Pamela, Carey, Helen, Yoseff-Salameh, Lina, Sullivan, Rox Ann, Hague, Cole, Grothause, Jennifer, Fearns, Erin, Fowler, Aubrey, Notestine, Jennifer, Tonneman, Jill, Hay, Krystal, Chao, Michelle, Warnimont, Kyrstin, Marzec, Laura, Miller, Bethany, Beckford, Demi R., Baugher, Hallie, DeSantis, Brittany, Hanlon, Cory, McCool, Jacqueline, Das, Abhik, Gantz, Marie G., Bann, Carla M., Wallace, Dennis, Crawford, Margaret M., Gabrio, Jenna, Leblond, David, Newman, Jamie E., Petrie Huitema, Carolyn M., O'Donnell Auman, Jeanette, Poole, W. Kenneth, Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Chock, Valerie Y., Stevenson, David K., Adams, Marian M., Ball, M. Bethany, Bentley, Barbara, Bruno, Elizabeth, Davis, Alexis S., Elena DeAnda, Maria, DeBattista, Anne M., Huffman, Lynne C., Ismael, Magdy, Kohn, Jean G., Krueger, Casey, Lowe, Janice, Lucash, Ryan E., Palmquist, Andrew W., Patel, Jessica, Proud, Melinda S., Reichert, Elizabeth N., John, Nicholas H. St., Sivakumar, Dharshi, Taylor, Heather L., Wager, Natalie, Williams, R. Jordan, Weiss, Hali, Frantz, Ivan D., III, Fiascone, John M., MacKinnon, Brenda L., Furey, Anne, Nylen, Ellen, Church, Paige T., Sibley, Cecelia E., Brussa, Ana K., Carlo, Waldemar A., Ambalavanan, Namasivayam, Peralta-Carcelen, Myriam, Nelson, Kathleen G., Bailey, Kirstin J., Biasini, Fred J., Chopko, Stephanie A., Collins, Monica V., Cosby, Shirley S., Johnston, Kristen C., Moses, Mary Beth, Patterson, Cryshelle S., Phillips, Vivien A., Preskitt, Julie, Rector, Richard V., Whitley, Sally, Devaskar, Uday, Garg, Meena, Purdy, Isabell B., Chanlaw, Teresa, Geller, Rachel, Finer, Neil N., Vaucher, Yvonne E., Kaegi, David, Rasmussen, Maynard R., Arnell, Kathy, Demetrio, Clarence, Fuller, Martha G., Rich, Wade, Bell, Edward F., Colaizy, Tarah T., Widness, John A., Brumbaugh, Jane E., Acarregui, Michael J., Johnson, Karen J., Eastman, Diane L., Goeke, Claire A., Schmelzel, Mendi L., Walker, Jacky R., Baack, Michelle L., Hogden, Laurie A., Broadbent, Megan, Elenkiwich, Chelsey, Henning, Megan M., Van Muyden, Sarah, Ellsbury, Dan L., Campbell, Donia B., Tud, Tracy L., Duara, Shahnaz, Bauer, Charles R., Everett-Thomas, Ruth, Fajardo-Hiriart, Sylvia, Rigaud, Arielle, Calejo, Maria, Frade Eguaras, Silvia M., Berkowits, Michelle Harwood, Garcia, Andrea, Pierre, Helina, Stoerger, Alexandra, Watterberg, Kristi L., Fuller, Janell, Ohls, Robin K., Beauman, Sandra Sundquist, Lacy, Conra Backstrom, Duncan, Andrea F., Hanson, Mary, Hartenberger, Carol, Kuan, Elizabeth, Lowe, Jean R., Thomson, Rebecca A., DeMauro, Sara B., Eichenwald, Eric C., Schmidt, Barbara, Kirpalani, Haresh, Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Catts, Christine, Cook, Noah, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Ghavam, Sarvin, Hurt, Hallam, Snyder, Jonathan, Vangala, Saritha, Ziolkowski, Kristina, D'Angio, Carl T., Phelps, Dale L., Guillet, Ronnie, Myers, Gary J., Andrews-Hartley, Michelle, Johnson, Julie Babish, Binion, Kyle, Bowman, Melissa, Boylin, Elizabeth, Burnell, Erica, Coleman, Kelly R., Fallone, Cait, Farooq, Osman, Hunn, Julianne, Hust, Diane, Jensen, Rosemary L., Jones, Rachel, Kachelmeyer, Jennifer, Kushner, Emily, Maffett, Deanna, McKee, Kimberly G., Merzbach, Joan, Orme, Constance, Prinzing, Diane, Reubens, Linda J., Rochez, Daisy, Rowan, Mary, Sabaratnam, Premini, Scorsone, Ann Marie, Wadkins, Holly I.M., Yost, Kelley, Zwetsch, Lauren, Lakshminrusimha, Satyan, Reynolds, Anne Marie, Sacilowski, Michael G., Guilford, Stephanie, Li, Emily, Williams, Ashley, Zorn, William A., Wyckoff, Myra H., Brion, Luc P., Salhab, Walid A., Rosenfeld, Charles R., Heyne, Roy J., Vasil, Diana M., Adams, Sally S., Chen, Lijun, De Leon, Maria M., Eubanks, Francis, Guzman, Alicia, Hensley, Gaynelle, Heyne, Elizabeth T., Lee, Lizette E., Leps, Melissa H., Madden, Linda A., McDougald, E. Rebecca, Miller, Nancy A., Morgan, Janet S., Pavageau, Lara, Sepulveda, Pollieanna, Tolentino-Plata, Kristine, Boatman, Cathy Twell, Vera, Azucena, Waterbury, Jillian, Yoder, Bradley A., Baserga, Mariana, Faix, Roger G., Winter, Sarah, Minton, Stephen D., Sheffield, Mark J., Rau, Carrie A., Baker, Shawna, Bird, Karie, Burnett, Jill, Christensen, Susan, Cole-Bledsoe, Laura, Davis, Brandy, Elmont, Jennifer O., Jensen, Jennifer J., Loertscher, Manndi C., Jordan, Jamie, Marchant, Trisha, Maxson, Earl, McGrath, Kandace M., Osborne, Karen A., Parry, D. Melody, Reich, Brixen A., Schaefer, Susan T., Spencer, Cynthia, Steffen, Michael, Tice, Katherine, Weaver-Lewis, Kimberlee, Woodbury, Kathryn D., Zanetti, Karen, Dillard, Robert G., Washburn, Lisa K., Jackson, Barbara G., Peters, Nancy, Chiu, Korinne, Allred, Deborah Evans, Goldstein, Donald J., Halfond, Raquel, Peterson, Carroll, Waldrep, Ellen L., Welch, Cherrie D., Morris, Melissa Whalen, Hounshell, Gail Wiley, Shankaran, Seetha, Sood, Beena G., Natarajan, Girija, Pappas, Athina, Abramczyk, Katherine, Agarwal, Prashant, Bajaj, Monika, Bara, Rebecca, Billian, Elizabeth, Chawla, Sanjay, Childs, Kirsten, De Jesus, Lilia C., Driscoll, Debra, February, Melissa, Goldston, Laura A., Johnson, Mary E., Muran, Geraldine, Panaitescu, Bogdan, Prentiss, Jeannette E., White, Diane, Woldt, Eunice, Barks, John, Wiggins, Stephanie A., Christensen, Mary K., Carlson, Martha D., Ehrenkranz, Richard A., Jacobs, Harris, Butler, Christine G., Cervone, Patricia, Greisman, Sheila, Konstantino, Monica, Poulsen, JoAnn, Taft, Janet, Williams, Joanne, Romano, Elaine, Vohr, Betty R., Travers, Colm P., and Hintz, Susan R.

Published
2023
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15. Inadequate oral feeding as a barrier to discharge in moderately preterm infants

Author

Edwards, Laura, Cotten, C Michael, Smith, P Brian, Goldberg, Ronald, Saha, Shampa, Das, Abhik, Laptook, Abbot R, Stoll, Barbara J, Bell, Edward F, Carlo, Waldemar A, D’Angio, Carl T, DeMauro, Sara B, Sanchez, Pablo J, Shankaran, Seetha, Van Meurs, Krisa P, Vohr, Betty R, Walsh, Michele C, and Malcolm, William F

Subjects
Paediatrics, Biomedical and Clinical Sciences, Clinical Research, Preterm, Low Birth Weight and Health of the Newborn, Lung, Infant Mortality, Neonatal Respiratory Distress, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Reproductive health and childbirth, Bottle Feeding, Breast Feeding, Energy Intake, Feeding Behavior, Feeding Methods, Female, Humans, Infant, Infant, Newborn, Infant, Premature, Logistic Models, Male, Patient Discharge, Prospective Studies, Respiratory Distress Syndrome, Newborn, Sepsis, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Clinical Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectivesThe objectives describe the frequency that inadequate oral feeding (IOF) is the reason why moderately preterm (MPT) infants remain hospitalized and its association with neonatal morbidities.Study designProspective study using the NICHD Neonatal Research Network MPT Registry. Multivariable logistic regression was used to describe associations between IOF and continued hospitalization at 36 weeks postmenstrual age (PMA).ResultA total of 6017 MPT infants from 18 centers were included. Three-thousand three-seventy-six (56%) remained hospitalized at 36 weeks PMA, of whom 1262 (37%) remained hospitalized due to IOF. IOF was associated with RDS (OR 2.02, 1.66-2.46), PDA (OR 1.86, 1.37-2.52), sepsis (OR 2.36, 95% 1.48-3.78), NEC (OR 16.14, 7.27-35.90), and BPD (OR 3.65, 2.56-5.21) compared to infants discharged and was associated with medical NEC (OR 2.06, 1.19-3.56) and BPD (OR 0.46, 0.34-0.61) compared to infants remaining hospitalized for an alternative reason.ConclusionIOF is the most common barrier to discharge in MPT infants, especially among those with neonatal morbidities.

Published
2019

16. Association between Policy Changes for Oxygen Saturation Alarm Settings and Neonatal Morbidity and Mortality in Infants Born Very Preterm

Author

Foglia, Elizabeth E, Carper, Benjamin, Gantz, Marie, DeMauro, Sara B, Lakshminrusimha, Satyan, Walsh, Michele, Schmidt, Barbara, Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research, Caplan, Michael S, Laptook, Abbott R, Keszler, Martin, Hensman, Angelita M, Knoll, Andrea M, Little, Emilee, Vieira, Elisa, Basso, Kristin M, Keller, Jennifer A, Hibbs, Anna Maria, Fanaroff, Avroy A, Newman, Nancy S, Payne, Allison H, Schibler, Kurt, Donovan, Edward F, Grisby, Cathy, Bridges, Kate, Alexander, Barbara, Fischer, Estelle E, Mincey, Holly L, Hessling, Jody, Jackson, Lenora, Kirker, Kristin, Muthig, Greg, Tepe, Stacey, Cotten, C Michael, Goldberg, Ronald N, Auten, Kathy J, Fisher, Kimberley A, Finkle, Joanne, Carlton, David P, Stoll, Barbara J, Hale, Ellen C, Loggins, Yvonne, Bottcher, Diane I, Mackie, Colleen, Higgins, Rosemary D, Archer, Stephanie Wilson, Poindexter, Brenda B, Sokol, Gregory M, Herron, Dianne E, Miller, Lucy, Wilson, Leslie Dawn, Kennedy, Kathleen A, Tyson, Jon E, McDavid, Georgia E, Arldt-McAlister, Julie, Burson, Katrina, Garcia, Carmen, Harris, Beverly Foley, Lis, Anna E, Martin, Karen, Martin, Sara C, Rodgers, Shawna, Simmons, Maegan C, Tate, Patti L Pierce, Das, Abhik, Wallace, Dennis, Poole, W Kenneth, Auman, Jeanette O'Donnell, Crawford, Margaret M, Huitema, Carolyn M Petrie, Zaterka-Baxter, Kristin M, Van Meurs, Krisa P, Stevenson, David K, Adams, Marian M, Ball, M Bethany, Ismail, Magdy, Palmquist, Andrew W, Proud, Melinda S, Carlo, Waldemar A, Ambalavanan, Namasivayam, Collins, Monica V, Cosby, Shirley S, Bell, Edward F, Colaizy, Tarah T, Widness, John A, Johnson, Karen J, Walker, Jacky R, Watterberg, Kristi L, Ohls, Robin K, Lacy, Conra Backstrom, Hartenberger, Carol H, Beauman, Sandra Sundquist, Hanson, Mary Ruffaner, Wyckoff, Myra H, Brion, Luc P, Salhab, Walid A, Rosenfeld, Charles R, Vasil, Diana M, Chen, Lijun, and Guzman, Alicia

Subjects
Paediatrics, Biomedical and Clinical Sciences, Lung, Clinical Research, Neonatal Respiratory Distress, Infant Mortality, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Rare Diseases, Preterm, Low Birth Weight and Health of the Newborn, 2.4 Surveillance and distribution, Aetiology, Reproductive health and childbirth, Good Health and Well Being, Bronchopulmonary Dysplasia, Cohort Studies, Enterocolitis, Necrotizing, Female, Health Policy, Humans, Infant, Infant, Extremely Premature, Infant, Newborn, Intensive Care Units, Neonatal, Male, Morbidity, Oximetry, Oxygen Consumption, Policy Making, Retinopathy of Prematurity, Retrospective Studies, Surveys and Questionnaires, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, mortality, oxygen saturation, preterm, retinopathy of prematurity, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveTo determine the impact of policy changes for pulse oximetry oxygen saturation (SpO2) alarm limits on neonatal mortality and morbidity among infants born very preterm.Study designThis was a retrospective cohort study of infants born very preterm in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Infants were classified based on treatment at a hospital with an SpO2 alarm policy change and study epoch (before vs after policy change). We used a generalized linear mixed model to determine the effect of hospital group and epoch on the primary outcomes of mortality and severe retinopathy of prematurity (ROP) and secondary outcomes of necrotizing enterocolitis, bronchopulmonary dysplasia, and any ROP.ResultsThere were 3809 infants in 10 hospitals with an SpO2 alarm policy change and 3685 infants in 9 hospitals without a policy change. The nature of most policy changes was to narrow the SpO2 alarm settings. Mortality was lower in hospitals without a policy change (aOR 0.63; 95% CI 0.50-0.80) but did not differ between epochs in policy change hospitals. The odds of bronchopulmonary dysplasia were greater for hospitals with a policy change (aOR 1.65; 95% CI 1.36-2.00) but did not differ for hospitals without a policy change. Severe ROP and necrotizing enterocolitis did not differ between epochs for either group. The adjusted odds of any ROP were lower in recent years in both hospital groups.ConclusionsChanging SpO2 alarm policies was not associated with reduced mortality or increased severe ROP among infants born very preterm.

Published
2019

17. Prolonged duration of early antibiotic therapy in extremely premature infants

Author

Greenberg, Rachel G, Chowdhury, Dhuly, Hansen, Nellie I, Smith, P Brian, Stoll, Barbara J, Sánchez, Pablo J, Das, Abhik, Puopolo, Karen M, Mukhopadhyay, Sagori, Higgins, Rosemary D, and Cotten, C Michael

Subjects
Paediatrics, Biomedical and Clinical Sciences, Perinatal Period - Conditions Originating in Perinatal Period, Preterm, Low Birth Weight and Health of the Newborn, Pediatric, Infant Mortality, Infectious Diseases, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Reproductive health and childbirth, Good Health and Well Being, Anti-Bacterial Agents, Female, Humans, Infant, Extremely Premature, Infant, Newborn, Male, Retrospective Studies, United States, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Paediatrics and Reproductive Medicine, Public Health and Health Services, Pediatrics
Abstract

BackgroundProlonged early antibiotics in extremely premature infants may have negative effects. We aimed to assess prevalence and outcomes of provision of prolonged early antibiotics to extremely premature infants in the absence of culture-confirmed infection or NEC.MethodsCohort study of infants from 13 centers born without a major birth defect from 2008-2014 who were 401-1000 grams birth weight, 22-28 weeks gestation, and survived ≥5 days without culture-confirmed infection, NEC, or spontaneous intestinal perforation. We determined the proportion of infants who received prolonged early antibiotics, defined as ≥5 days of antibiotic therapy started at ≤72 h of age, by center and over time. Associations between prolonged early antibiotics and adverse outcomes were assessed using multivariable logistic regression.ResultsA total of 5730 infants were included. The proportion of infants receiving prolonged early antibiotics varied from 30-69% among centers and declined from 49% in 2008 to 35% in 2014. Prolonged early antibiotics was not significantly associated with death (adjusted odds ratio 1.17 [95% CI: 0.99-1.40], p = 0.07) and was not associated with NEC.ConclusionsThe proportion of extremely premature infants receiving prolonged early antibiotics decreased, but significant center variation persists. Prolonged early antibiotics were not significantly associated with increased odds of death or NEC.

Published
2019

18. Discordance in Antenatal Corticosteroid Use and Resuscitation Following Extremely Preterm Birth

Author

Rysavy, Matthew A, Bell, Edward F, Iams, Jay D, Carlo, Waldemar A, Li, Lei, Mercer, Brian M, Hintz, Susan R, Stoll, Barbara J, Vohr, Betty R, Shankaran, Seetha, Walsh, Michele C, Brumbaugh, Jane E, Colaizy, Tarah T, Das, Abhik, Higgins, Rosemary D, and Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research

Subjects
Paediatrics, Biomedical and Clinical Sciences, Perinatal Period - Conditions Originating in Perinatal Period, Preterm, Low Birth Weight and Health of the Newborn, Clinical Trials and Supportive Activities, Lung, Infant Mortality, Neonatal Respiratory Distress, Pediatric, Prevention, Neurosciences, Clinical Research, Reproductive health and childbirth, Good Health and Well Being, Adrenal Cortex Hormones, Female, Follow-Up Studies, Gestational Age, Humans, Infant, Infant, Extremely Premature, Infant, Newborn, Infant, Premature, Diseases, Male, Multivariate Analysis, Premature Birth, Prospective Studies, Resuscitation, Treatment Outcome, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveTo describe discordance in antenatal corticosteroid use and resuscitation following extremely preterm birth and its relationship with infant survival and neurodevelopment.Study designA multicenter cohort study of 4858 infants 22-26 weeks of gestation born 2006-2011 at 24 US hospitals participating in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, with follow-up through 2013. Survival and neurodevelopmental outcomes were available at 18-22 months of corrected age for 4576 (94.2%) infants. We described antenatal interventions, resuscitation, and infant outcomes. We modeled the effect on infant outcomes of each hospital increasing antenatal corticosteroid exposure for resuscitated infants born at 22-24 weeks of gestation to rates observed at 25-26 weeks of gestation.ResultsDiscordant antenatal corticosteroid use and resuscitation, where one and not the other occurred, were more frequent for births at 22 and 23 but not 24 weeks (rate ratio [95% CI] at 22 weeks: 1.7 [1.3-2.2]; 23 weeks: 2.6 [2.2-3.2]; 24 weeks: 1.0 [0.8-1.2]) when compared with 25-26 weeks. Among infants resuscitated at 23 weeks, adjusting each hospital's rate of antenatal corticosteroid use to the average at 25-26 weeks (89.2%) was projected to increase infant survival by 7.1% (95% CI 5.4-8.8%) and survival without severe impairment by 6.4% (95% CI 4.7-8.1%). No significant change in outcomes was projected for infants resuscitated at 22 weeks, where few (n = 22) resuscitated infants received antenatal corticosteroids.ConclusionsInfants born at 23 weeks were more frequently resuscitated without antenatal corticosteroids than other extremely preterm infants. When resuscitation is intended, consistent provision of antenatal corticosteroids may increase infant survival and survival without impairment.Trial registrationClinicalTrials.govNCT00063063 (Generic Database) and NCT00009633 (Follow-Up Study).

Published
2019

19. Weaning of Moderately Preterm Infants from the Incubator to the Crib: A Randomized Clinical Trial.

Author

Shankaran, Seetha, Bell, Edward F, Laptook, Abbot R, Saha, Shampa, Newman, Nancy S, Kazzi, S Nadya J, Barks, John, Stoll, Barbara J, Bara, Rebecca, Gabrio, Jenna, Childs, Kirsten, Das, Abhik, Higgins, Rosemary D, Carlo, Waldemar A, Sánchez, Pablo J, Carlton, David P, Pavageau, Lara, Malcolm, William F, D'Angio, Carl T, Ohls, Robin K, Poindexter, Brenda B, Sokol, Gregory M, Van Meurs, Krisa P, Colaizy, Tarah T, Khmour, Ayman, Puopolo, Karen M, Garg, Meena, Walsh, Michele C, and Eunice Kennedy Shriver National Institute of Child Health, and Human Development Neonatal Research Network

Subjects
Eunice Kennedy Shriver National Institute of Child Health, and Human Development Neonatal Research Network, Humans, Body Weight, Length of Stay, Patient Discharge, Incubators, Infant, Infant Equipment, Infant, Newborn, Infant, Premature, Intensive Care Units, Neonatal, Female, Male, incubator, moderately preterm infants, randomized controlled trial, temperature, weaning, Infant Mortality, Perinatal Period - Conditions Originating in Perinatal Period, Patient Safety, Clinical Research, Pediatric, Clinical Trials and Supportive Activities, Preterm, Low Birth Weight and Health of the Newborn, Reproductive health and childbirth, Good Health and Well Being, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveTo assess whether length of hospital stay is decreased among moderately preterm infants weaned from incubator to crib at a lower vs higher weight.Study designThis trial was conducted in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Infants with gestational ages 29-33 weeks, birthweight

Published
2019

20. Pediatric Swine Model of Methicillin-Resistant Staphylococcus aureus Sepsis-Induced Coagulopathy, Disseminated Microvascular Thrombosis, and Organ Injuries

Author

Nguyen, Trung C., Marini, Juan C., Guillory, Bobby, Valladolid-Brown, Christian, Martinez-Vargas, Marina, Subramanyam, Deepika, Cohen, Daniel, Cirlos, Sonya C., Lam, Fong, Stoll, Barbara, Didelija, Inka C., Vonderohe, Caitlin, Orellana, Renan, Saini, Arun, Pradhan, Subhashree, Bashir, Dalia, Desai, Moreshwar S., Flores, Saul, Virk, Manpreet, Tcharmtchi, Hossein, Navaei, Amir, Kaplan, Sheldon, Lamberth, Linda, Hulten, Kristina G., Scull, Brooks P., Allen, Carl E., Akcan-Arikan, Ayse, Vijayan, K. Vinod, and Cruz, Miguel A.

Published
2023
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22. Surgical Necrotizing Enterocolitis and Spontaneous Intestinal Perforation Lead to Severe Growth Failure in Infants.

Author

Speer, Allison L., Lally, Kevin P., Pedroza, Claudia, Yuxin Zhang, Poindexter, Brenda B., Chwals, Walter J., Hintz, Susan R., Besner, Gail E., Stevenson, David K., Ohls, Robin K., Truog, William E., Stoll, Barbara J., Rysavy, Matthew A., Das, Abhik, Tyson, Jon E., and Blakely, Martin L.

Abstract

Objective: We aimed to determine the incidence of growth failure in infants with necrotizing enterocolitis (NEC) or spontaneous intestinal perforation (SIP) and whether initial laparotomy versus peritoneal drainage (PD) impacted the likelihood of growth failure. Summary Background Data: Infants with surgical NEC and SIP have high mortality, and most have neurodevelopmental impairment and poor growth. Existing literature on growth outcomes for these infants is limited. Methods: This is a preplanned secondary study of the Necrotizing Enterocolitis Surgery Trial dataset. The primary outcome was growth failure (Z-score for weight < -2.0) at 18 to 22 months. We used logistic regression, including diagnosis and treatment, as covariates. Secondary outcomes were analyzed using the Fisher exact or Pearson χ² test for categorical variables and the Wilcoxon rank sum test or one-way ANOVA for continuous variables. Results: Among 217 survivors, 207 infants (95%) had primary outcome data. Growth failure at 18 to 22 months occurred in 24/50 (48%) of NEC infants versus 65/157 (42%) SIP (P=0.4). The mean weight-for-age Z-score at 18 to 22 months in NEC infants was -2.05±0.99 versus -1.84±1.09 SIP (P= 0.2), and the predicted mean weight-for-age Z-score SIP (Beta -0.27; 95% CI: -0.53, -0.01; P=0.041). Median declines in weight-for-age Z-score between birth and 18 to 22 months were significant in all infants but most severe (>2) in NEC infants (P=0.2). Conclusions: This first ever prospective study of growth outcomes in infants with surgical NEC or SIP demonstrates that growth failure is very common, especially in infants with NEC, and persists at 18-22 months. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Increased Circulating Cortisol After Vaginal Birth Is Associated With Increased FGF19 Secretion in Neonatal Pigs.

Author

Vonderohe, Caitlin, Guthrie, Gregory, Stoll, Barbara, Hebib, Valeria Melendez, Dawson, Harry, and Burrin, Douglas

Subjects
FIBROBLAST growth factors, CESAREAN section, BLOOD collection, PERINATAL period, BILE acids
Abstract

The influence of birth modality (scheduled cesarean or spontaneous vaginal) on the development of the newborn has been a source of controversy in neonatology. The impact of cesarean vs vaginal birth on the development of bile acid and fibroblast growth factor 19 (FGF19) signaling is unknown. Our aim was to determine the effect of birth modality and gestational age (preterm vs term) on plasma hormone levels, bile acid pool distribution, expression of genes in the bile acid-FXR-FGF19 pathway, and plasma levels of FGF19 at birth and on day 3 of life in neonatal pigs. Four sows underwent cesarean delivery on gestation day 105 (n = 2) and 114 (n = 2; term = 115 days), and 2 additional sows were allowed to farrow at term (gestation days 112 and 118). Piglets were euthanized at birth (Term-Vaginal n = 6; Term-Cesarean n = 8; Preterm n = 10) for tissue and blood collection, and the remaining pigs received total parenteral nutrition then were fed enterally on day 3 (Term-Vaginal n = 8; Term-Cesarean n = 10; Preterm n = 8), before blood and tissue were collected. Piglets born vaginally had a markedly (30-fold) higher plasma FGF19 at birth than term pigs born via cesarean delivery, and 70-fold higher than preterm pigs (P < 0.001). However, distal ileum FGF19 gene expression was similar in all groups (P > 0.05). Plasma FGF19 positively correlated with plasma cortisol (r = 0.58; P < 0.05) and dexamethasone treatment increased ileal FGF19 expression in cultured pig tissue explants and human enteroids. Our findings suggest that exposure to maternal or endogenous glucocorticoids in the perinatal period may upregulate the development of the bile acid–FGF19 pathway. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Citrulline and ADI-PEG20 reduce inflammation in a juvenile porcine model of acute endotoxemia.

Author

Vonderohe, Caitlin, Stoll, Barbara, Didelija, Inka, Trung Nguyen, Mohammad, Mahmoud, Jones-Hall, Yava, Cruz, Miguel A., Marini, Juan, and Burrin, Douglas

Subjects
ESSENTIAL amino acids, ARGININE deiminase, SEPTIC shock, CITRULLINE, HYPOVOLEMIC anemia
Abstract

Background: Arginine is a conditionally essential amino acid that is depleted in critically ill or surgical patients. In pediatric and adult patients, sepsis results in an arginine-deficient state, and the depletion of plasma arginine is associated with greater mortality. However, direct supplementation of arginine can result in the excessive production of nitric oxide (NO), which can contribute to the hypotension and macrovascular hypo-reactivity observed in septic shock. Pegylated arginine deiminase (ADI-PEG20, pegargiminase) reduces plasma arginine and generates citrulline that can be transported intracellularly to generate local arginine and NO, without resulting in hypotension, while maintaining microvascular patency. The objective of this study was to assess the efficacy of ADI-PEG20 with and without supplemental intravenous citrulline in mitigating hypovolemic shock, maintaining tissue levels of arginine, and reducing systemic inflammation in an endotoxemic pediatric pig model. Methods: Twenty 3-week-old crossbred piglets were implanted with jugular and carotid catheters as well as telemetry devices in the femoral artery to measure blood pressure, body temperature, heart rate, and respiration rate. The piglets were assigned to one of three treatments before undergoing a 5 h lipopolysaccharide (LPS) infusion protocol. Twenty-four hours before LPS infusion, control pigs (LPS; n=6) received saline, ADI-PEG20 pigs (n=7) received an injection of ADI-PEG20, and seven pigs (ADI-PEG20 + CIT pigs [n=7]) received ADI-PEG20 and 250 mg/kg citrulline intravenously. Pigs were monitored throughout LPS infusion and tissue was harvested at the end of the protocol. Results: Plasma arginine levels decreased and remained low in ADI-PEG20 + CIT and ADI-PEG20 pigs compared with LPS pigs but tissue arginine levels in the liver and kidney were similar across all treatments. Mean arterial pressure in all groups decreased from 90 mmHg to 60 mmHg within 1 h of LPS infusion but there were no significant differences between treatment groups. ADI-PEG20 and ADIPEG20 + CIT pigs had less CD45+ infiltrate in the liver and lung and lower levels of pro-inflammatory cytokines in the plasma. Conclusion: ADI-PEG20 and citrulline supplementation failed to ameliorate the hypotension associated with acute endotoxic sepsis in pigs but reduced systemic and local inflammation in the lung and liver. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Antecedents and Outcomes of Abnormal Cranial Imaging in Moderately Preterm Infants.

Author

Natarajan, Girija, Shankaran, Seetha, Saha, Shampa, Laptook, Abbot, Das, Abhik, Higgins, Rosemary, Stoll, Barbara J, Bell, Edward F, Carlo, Waldemar A, D'Angio, Carl, DeMauro, Sara B, Sanchez, Pablo, Van Meurs, Krisa, Vohr, Betty, Newman, Nancy, Hale, Ellen, Walsh, Michele, and Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Subjects
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Brain, Humans, Intracranial Hemorrhages, Leukomalacia, Periventricular, Hydrocephalus, Chorioamnionitis, Neonatal Screening, Resuscitation, Cesarean Section, Registries, Logistic Models, Risk Factors, Prospective Studies, Gestational Age, Pregnancy, Adult, Infant, Infant, Newborn, Infant, Small for Gestational Age, Infant, Premature, Female, Young Adult, intracranial hemorrhage, moderate preterm, periventricular leukomalacia, ultrasound, Pediatric, Infant Mortality, Clinical Research, Perinatal Period - Conditions Originating in Perinatal Period, Preterm, Low Birth Weight and Health of the Newborn, Lung, Reproductive health and childbirth, Good Health and Well Being, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

OBJECTIVES:To describe the frequency and findings of cranial imaging in moderately preterm infants (born at 290/7-336/7 weeks of gestation) across centers, and to examine the association between abnormal imaging and clinical characteristics. STUDY DESIGN:We used data from the Neonatal Research Network Moderately Preterm Registry, including the most severe early (≤28 days) and late (>28 days) cranial imaging. Stepwise logistic regression and CART analysis were performed after adjustment for gestational age, antenatal steroid use, and center. RESULTS:Among 7021 infants, 4184 (60%) underwent cranial imaging. These infants had lower gestational ages and birth weights and higher rates of small for gestational age, outborn birth, cesarean delivery, neonatal resuscitation, and treatment with surfactant, compared with those without imaging (P

Published
2018

26. Delivery Room Resuscitation and Short-Term Outcomes in Moderately Preterm Infants

Author

Bajaj, Monika, Natarajan, Girija, Shankaran, Seetha, Wyckoff, Myra, Laptook, R, Bell, Edward F, Stoll, Barbara J, Carlo, Waldemar A, Vohr, Betty R, Saha, Shampa, Van Meurs, Krisa P, Sanchez, Pablo J, D'Angio, Carl T, Higgins, Rosemary D, Das, Abhik, Newman, Nancy, Walsh, Michele C, Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research, Polin, Richard A, Keszler, Martin, Hensman, Angelita M, Vieira, Elisa, Hibbs, Anna Marie, Siner, Bonnie S, Truog, William E, Pallotto, Eugenia K, Kilbride, Howard W, Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Poindexter, Brenda B, Schibler, Kurt, Kallapur, Suhas G, Grisby, Cathy, Alexander, Barbara, Fischer, Estelle E, Jackson, Lenora, Kirker, Kristin, Jennings, Jennifer, Wuertz, Sandra, Muthig, Greg, Cotten, C Michael, Goldberg, Ronald N, Finkle, Joanne, Fisher, Kimberley A, Laughon, Matthew M, Bose, Carl L, Bernhardt, Janice, Clark, Cindy, Carlton, David P, Hale, Ellen C, Loggins, Yvonne, Bottcher, Diane I, Archer, Stephanie Wilson, Sokol, Greg, Herron, Dianne E, Nelin, Leif D, Jadcherla, Sudarshan R, Luzader, Patricia, Parikh, Nehal A, Nist, Marliese Dion, Fuller, Jennifer, Gutentag, Julie, Jones, Marissa E, McGregor, Sarah, Rodgers, Elizabeth, Ulloa, Jodi A, Wolfe, Tara, Wallace, Dennis, Zaterka-Baxter, Kristin M, Crawford, Margaret, Gabrio, Jenna, Kandefer, Sarah, Auman, Jeanette O'Donnell, Stevenson, David K, Ball, M Bethany, Proud, Melinda S, Ambalavanan, Namasivayam, Collins, Monica V, Cosby, Shirley S, Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Colaizy, Tarah T, Ellsbury, Dan L, Brumbaugh, Jane E, Johnson, Karen J, Campbell, Donia B, Walker, Jacky R, Watterberg, Kristi L, Ohls, Robin K, Lacy, Conra Backstrom, Beauman, Sandy Sundquist, Hartenberger, Carol, Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B, Cook, Noah, and Chaudhary, Aasma S

Subjects
Paediatrics, Biomedical and Clinical Sciences, Preterm, Low Birth Weight and Health of the Newborn, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Infant Mortality, Lung, Clinical Research, Reproductive health and childbirth, Good Health and Well Being, Cardiopulmonary Resuscitation, Continuous Positive Airway Pressure, Delivery Rooms, Female, Humans, Infant, Newborn, Infant, Premature, Infant, Small for Gestational Age, Intubation, Intratracheal, Male, Outcome Assessment, Health Care, Oxygen Inhalation Therapy, Prospective Studies, Registries, Risk Factors, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, CPR, delivery room, endotracheal intubation, moderate Preterm, oxygen, resuscitation, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectivesTo describe the frequency and extent of delivery room resuscitation and evaluate the association of delivery room resuscitation with neonatal outcomes in moderately preterm (MPT) infants.Study designThis was an observational cohort study of MPT infants delivered at 290/7 to 336/7 weeks' gestational age (GA) enrolled in the Neonatal Research Network MPT registry. Infants were categorized into 5 groups based on the highest level of delivery room intervention: routine care, oxygen and/or continuous positive airway pressure, bag and mask ventilation, endotracheal intubation, and cardiopulmonary resuscitation including chest compressions and/or epinephrine use. The association of antepartum and intrapartum risk factors and discharge outcomes with the intensity of resuscitation was evaluated.ResultsOf 7014 included infants, 1684 (24.0%) received routine care and no additional resuscitation, 2279 (32.5%) received oxygen or continuous positive airway pressure, 1831 (26.1%) received bag and mask ventilation, 1034 (14.7%) underwent endotracheal intubation, and 186 (2.7%) received cardiopulmonary resuscitation. Among the antepartum and intrapartum factors, increasing GA, any exposure to antenatal steroids and prolonged rupture of membranes decreased the likelihood of receipt of all levels of resuscitation. Infants who were small for GA (SGA) had increased risk of delivery room resuscitation. Among the neonatal outcomes, respiratory support at 28 days, days to full oral feeds and length of stay were significantly associated with the intensity of delivery room resuscitation. Higher intensity of resuscitation was associated with increased risk of mortality.ConclusionsThe majority of MPT infants receive some level of delivery room resuscitation. Increased intensity of delivery room interventions was associated with prolonged respiratory and nutritional support, increased mortality, and a longer length of stay.

Published
2018

27. Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants

Author

Laptook, R, Bell, Edward F, Shankaran, Seetha, Boghossian, Nansi S, Wyckoff, Myra H, Kandefer, Sarah, Walsh, Michele, Saha, Shampa, Higgins, Rosemary, Network, Generic and Moderate Preterm Subcommittees of the NICHD Neonatal Research, Polin, Richard A, Keszler, Martin, Vohr, Betty R, Hensman, Angelita M, Vieira, Elisa, Little, Emilee, Fanaroff, Avroy A, Hibbs, Anna Marie, Newman, Nancy S, Siner, Bonnie S, Truog, William E, Pallotto, Eugenia K, Kilbride, Howard W, Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Schibler, Kurt, Kallapur, Suhas G, Grisby, Cathy, Alexander, Barbara, Fischer, Estelle E, Jackson, Lenora, Kirker, Kristin, Jennings, Jennifer, Wuertz, Sandra, Muthig, Greg, Donovan, Edward F, Hessling, Jody, Mersmann, Marcia Worley, Mincey, Holly L, Cotten, C Michael, Goldberg, Ronald N, Finkle, Joanne, Fisher, Kimberley A, Auten, Kathy J, Laughon, Matthew M, Bose, Carl L, Bernhardt, Janice, Clark, Cindy, Stoll, Barbara J, Carlton, David P, Hale, Ellen C, Loggins, Yvonne, Bottcher, Diane I, Archer, Stephanie Wilson, Wright, Linda L, McClure, Elizabeth M, Poindexter, Brenda B, Sokol, Gregory M, Herron, Dianne E, Lemons, James A, Appel, Diana D, Miller, Lucy C, Sanchez, Pablo J, Nelin, Leif D, Jadcherla, Sudarshan R, Luzader, Patricia, Parikh, Nehal A, Nist, Marliese Dion, Fuller, Jennifer, Gutentag, Julie, Jones, Marissa E, McGregor, Sarah, Rodgers, Elizabeth, Ulloa, Jodi A, Wolfe, Tara, Das, Abhik, Wallace, Dennis, Poole, W Kenneth, Zaterka-Baxter, Kristin M, Crawford, Margaret, Gabrio, Jenna, Auman, Jeanette O'Donnell, Huitema, Carolyn Petrie, Hastings, Betty K, Van Meurs, Krisa P, Stevenson, David K, Ball, M Bethany, Proud, Melinda S, Carlo, Waldemar A, Ambalavanan, Namasivayam, Collins, Monica V, Cosby, Shirley S, Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Colaizy, Tarah T, Ellsbury, Dan L, and Brumbaugh, Jane E

Subjects
Paediatrics, Biomedical and Clinical Sciences, Perinatal Period - Conditions Originating in Perinatal Period, Infant Mortality, Pediatric, Clinical Research, Preterm, Low Birth Weight and Health of the Newborn, Reproductive health and childbirth, Good Health and Well Being, Body Temperature, Female, Fever, Hospital Mortality, Humans, Hypothermia, Infant, Extremely Premature, Infant, Newborn, Infant, Premature, Diseases, Intensive Care Units, Neonatal, Logistic Models, Male, Patient Admission, Risk Factors, United States, Generic and Moderate Preterm Subcommittees of the NICHD Neonatal Research Network, hyperthermia, hypothermia, prematurity, survival, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveTo evaluate the temperature distribution among moderately preterm (MPT, 29-33 weeks) and extremely preterm (EPT, 37.5°C (4.2% vs 6.2%). For EPT infants in 2012-2013 compared with 2002-2003, the percentage of temperatures between 36.5°C and 37.5°C more than doubled and the percentage of temperatures >37.5°C more than tripled. Admission temperature was inversely associated with in-hospital mortality.ConclusionsLow and high admission temperatures are more frequent among EPT than MPT infants. Compared with a decade earlier, fewer EPT infants experience low admission temperatures but more have elevated temperatures. In spite of a change in distribution of NICU admission temperature, an inverse association between temperature and mortality risk persists.

Published
2018

28. Limitations of Conventional Magnetic Resonance Imaging as a Predictor of Death or Disability Following Neonatal Hypoxic–Ischemic Encephalopathy in the Late Hypothermia Trial

Author

Caplan, Michael S., Polin, Richard A., Keszler, Martin, Oh, William, Vohr, Betty R., McGowan, Elizabeth C., Alksninis, Barbara, Basso, Kristin, Bliss, Joseph, Bishop, Carmena, Burke, Robert T., Cashore, William, Caskey, Melinda, Gingras, Dan, Guerina, Nicholas, Johnson, Katharine, Keszler, Mary Lenore, Knoll, Andrea M., Leach, Theresa M., Leonard, Martha R., Little, Emilee, Stephens, Bonnie E., Vieira, Elisa, Watson, Victoria E., Hibbs, Anna Maria, Wilson-Costello, Deanne E., Newman, Nancy S., Batton, Beau, Bhola, Monika, Di Fiore, Juliann M., Friedman, Harriet G., Siner, Bonnie S., Stork, Eileen K., Yalcinkaya, Gulgun, Zadell, Arlene, Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Knutson, Allison, Schibler, Kurt, Yolton, Kimberly, Grisby, Cathy, Gratton, Teresa L., Merhar, Stephanie, Wuertz, Sandra, Cotten, C. Michael, Fisher, Kimberley A., Grimes, Sandra, Finkle, Joanne, Goldstein, Ricki F., Gustafson, Kathryn E., Malcolm, William F., Ashley, Patricia L., Auten, Kathy J., Lohmeyer, Melody B., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Clark, Cindy, Warner, Diane D., Wereszcsak, Janice, Aliaga, Sofia, Carlton, David P., Stoll, Barbara J., Hale, Ellen C., Loggins, Yvonne, Bottcher, Diane I., Mackie, Colleen, LaRossa, Maureen Mulligan, Adams-Chapman, Ira, Wineski, Lynn C., Carter, Sheena L., Higgins, Rosemary D., Archer, Stephanie Wilson, Harmon, Heidi M., Papile, Lu-Ann, Dusick, Anna M., Gunn, Susan, Herron, Dianne E., Hines, Abbey C., Kardatzke, Darlene, Lytle, Carolyn, Minnich, Heike M., Richard, Leslie, Smiley, Lucy C., Wilson, Leslie Dawn, Kennedy, Kathleen A., Allain, Elizabeth, Mason, Carrie M., Arldt-McAlister, Julie, Burson, Katrina, Dempsey, Allison G., Duncan, Andrea F., Evans, Patricia W., Garcia, Carmen, Green, Charles E., Jimenez, Margarita, John, Janice, Jones, Patrick M., Lillie, M. Layne, Martin, Karen, Martin, Sara C., McDavid, Georgia E., McKee, Shannon, Pierce Tate, Patti L., Rodgers, Shawna, Siddiki, Saba Khan, Sperry, Daniel K., Wright, Sharon L., Sánchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Fortney, Christine A., Grothause, Jennifer L., Wallace, Dennis, Gantz, Marie G., Zaterka-Baxter, Kristin M., Crawford, Margaret M., McDonald, Scott A., Newman, Jamie E., O'Donnell Auman, Jeanette, Petrie Huitema, Carolyn M., Pickett, James W., II, Yost, Patricia, Van Meurs, Krisa P., Stevenson, David K., Ball, M. Bethany, Bentley, Barbara, Chock, Valerie Y., Bruno, Elizabeth F., Davis, Alexis S., DeAnda, Maria Elena, DeBattista, Anne M., Earhart, Beth, Huffman, Lynne C., Kohn, Jean G., Krueger, Casey E., Proud, Melinda S., Rhine, William D., St. John, Nicholas H., Taylor, Heather, Weiss, Hali E., Carlo, Waldemar A., Peralta-Carcelen, Myriam, Collins, Monica V., Cosby, Shirley S., Phillips, Vivien A., Rector, Richard V., Whitley, Sally, Colaizy, Tarah T., Brumbaugh, Jane E., Johnson, Karen J., Eastman, Diane L., Acarregui, Michael J., Walker, Jacky R., Goeke, Claire A., Klein, Jonathan M., Krutzfield, Nancy J., Segar, Jeffrey L., Dagle, John M., Lindower, Julie B., McElroy, Steven J., Rabe, Glenda K., Roghair, Robert D., Meyer, Lauritz R., Ellsbury, Dan L., Campbell, Donia B., Murphy, Cary R., Bhavsar, Vipinchandra, Ohls, Robin K., Lacy, Conra Backstrom, Beauman, Sandra Sundquist, Brown, Sandra, Fernandez, Erika, Duncan, Andrea Freeman, Fuller, Janell, Kuan, Elizabeth, Lowe, Jean R., Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B., Dysart, Kevin C., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Hurt, Hallam, D'Angio, Carl, Lakshminrusimha, Satyan, Laroia, Nirupama, Myers, Gary J., Yost, Kelley, Guilford, Stephanie, Jensen, Rosemary L., Wynn, Karen, Farooq, Osman, Reynolds, Anne Marie, Wadkins, Holly I.M., Williams, Ashley, Merzbach, Joan, Conway, Patrick, Bowman, Melissa, Hartley-McAndrew, Michele, Zorn, William, Fallone, Cait, Binion, Kyle, Orme, Constance, Scorsone, Ann Marie, Brion, Luc P., Chalak, Lina F., Heyne, Roy J., Chen, Lijun, Vasil, Diana M., Adams, Sally S., Boatman, Catherine Twell, Guzman, Alicia, Heyne, Elizabeth T., Lee, Lizette E., Leps, Melissa H., Madden, Linda A., Miller, Nancy A., Ramon, Emma, Yoder, Bradley A., Osborne, Karen A., Spencer, Cynthia, Steele, R. Edison, Steffen, Mike, Strong, Karena, Weaver-Lewis, Kimberlee, Baker, Shawna, Winter, Sarah, Bird, Karie, Burnett, Jill, Sood, Beena G., Bara, Rebecca, Childs, Kirsten, De Jesus, Lilia C., Panaitescu, Bogdan, Chawla, Sanjay M.D., Prentice, Jeannette E., Goldston, Laura A., Woldt, Eunice Hinz, Natarajan, Girija, Bajaj, Monika, Barks, John, Christensen, Mary, Wiggins, Stephanie A., Laptook, Abbot R., Shankaran, Seetha, Barnes, Patrick, Rollins, Nancy, Do, Barbara T., Parikh, Nehal A., Hamrick, Shannon, Hintz, Susan R., Tyson, Jon E., Bell, Edward F., Ambalavanan, Namasivayam, Goldberg, Ronald N., Pappas, Athina, Huitema, Carolyn, Pedroza, Claudia, Chaudhary, Aasma S., Hensman, Angelita M., Das, Abhik, Wyckoff, Myra, Khan, Amir, Walsh, Michelle C., Watterberg, Kristi L., Faix, Roger, Truog, William, Guillet, Ronnie, Sokol, Gregory M., and Poindexter, Brenda B.

Published
2021
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29. Mortality, In-Hospital Morbidity, Care Practices, and 2-Year Outcomes for Extremely Preterm Infants in the US, 2013–2018

Author

Bell, Edward F., Hintz, Susan R., Hansen, Nellie I., Bann, Carla M., Wyckoff, Myra H., DeMauro, Sara B., Walsh, Michele C., Vohr, Betty R., Stoll, Barbara J., Carlo, Waldemar A., Van Meurs, Krisa P., Rysavy, Matthew A., Patel, Ravi M., Merhar, Stephanie L., Sánchez, Pablo J., Laptook, Abbot R., Hibbs, Anna Maria, Cotten, C. Michael, DʼAngio, Carl T., Winter, Sarah, Fuller, Janell, and Das, Abhik

Published
2022
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30. Outcomes Following Post-Hemorrhagic Ventricular Dilatation among Infants of Extremely Low Gestational Age

Author

Shankaran, Seetha, Bajaj, Monika, Natarajan, Girija, Saha, Shampa, Pappas, Athina, Davis, Alexis S., Hintz, Susan R., Adams-Chapman, Ira, Das, Abhik, Bell, Edward F., Stoll, Barbara J., Walsh, Michele C., Laptook, Abbot R., Carlo, Waldemar A., Van Meurs, Krisa P., Sánchez, Pablo J., Ball, M. Bethany, Hale, Ellen C., Seabrook, Ruth, and Higgins, Rosemary D.

Published
2020
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31. DLK1: A Novel Biomarker of Placental Insufficiency in Stillbirth and Live Birth.

Author

Page, Jessica M., Allshouse, Amanda A., Gaffney, Jessica E., Roberts, Victoria H. J., Thorsten, Vanessa, Gibbins, Karen J., Dudley, Donald J., Saade, George, Goldenberg, Robert L., Stoll, Barbara J., Hogue, Carol J., Bukowski, Radek, Parker, Corette, Conway, Deborah, Reddy, Uma M., Varner, Michael W., Frias, Antonio E., and Silver, Robert M.

Subjects
FETAL malnutrition, CROSS-sectional method, PLACENTA, SMALL for gestational age, CALCIUM-binding proteins, FETAL growth retardation, LOGISTIC regression analysis, ENZYME-linked immunosorbent assay, PREGNANCY outcomes, PERINATAL death, DESCRIPTIVE statistics, ODDS ratio, GESTATIONAL age, RESEARCH, GROWTH factors, COMPARATIVE studies, BIOMARKERS, MEMBRANE proteins, REGRESSION analysis
Abstract

Objective Delta-like homolog 1 (DLK1) is a growth factor that is reduced in maternal sera in pregnancies with small for gestational age neonates. We sought to determine if DLK1 is associated with stillbirth (SB), with and without placental insufficiency. Study Design A nested case-control study was performed using maternal sera from a multicenter case-control study of SB and live birth (LB). SB and LB were stratified as placental insufficiency cases (small for gestational age <5% or circulatory lesions on placental histopathology) or normal placenta controls (appropriate for gestational age and no circulatory lesions). Enzyme-linked immunosorbent assay (ELISA) was used to measure DLK1. The mean difference in DLK1 was compared on the log scale in an adjusted linear regression model with pairwise differences, stratified by term/preterm deliveries among DLK1 results in the quantifiable range. In exploratory analysis, geometric means were compared among all data and the proportion of "low DLK1" (less than the median value for gestational age) was compared between groups and modeled using linear and logistic regression, respectively. Results Overall, 234 SB and 234 LB were analyzed; 246 DLK1 values were quantifiable within the standard curve. Pairwise comparisons of case and control DLK1 geometric means showed no significant differences between groups. In exploratory analysis of all data, adjusted analysis revealed a significant difference for the LB comparison only (SB: 71.9 vs. 99.1 pg/mL, p = 0.097; LB: 37.6 vs. 98.1 pg/mL, p = 0.005). In exploratory analysis of "low DLK1," there was a significant difference between the odds ratio of having "low DLK1" between preterm cases and controls for both SB and LB. There were no significant differences in geometric means nor "low DLK1" between SB and LB. Conclusion In exploratory analysis, more placental insufficiency cases in preterm SB and LB had "low DLK1." However, low DLK1 levels were not associated with SB. Key Points Maternally circulating DLK1 is correlated with placental insufficiency. Maternally circulating DLK1 is not correlated with SB. DLK1 is a promising marker for placental insufficiency. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Behavior Profiles at 2 Years for Children Born Extremely Preterm with Bronchopulmonary Dysplasia

Author

Caplan, Michael S., Polin, Richard A., Laptook, Abbot R., Keszler, Martin, Hensman, Angelita M., Vieira, Elisa, Little, Emilee, Burke, Robert T., Stephens, Bonnie E., Alksninis, Barbara, Bishop, Carmena, Keszler, Mary L., Leach, Teresa M., Watson, Victoria E., Knoll, Andrea M., Walsh, Michele C., Fanaroff, Avroy A., Newman, Nancy S., Wilson-Costello, Deanne E., Payne, Allison, Bhola, Monika, Yalcinkaya, Gulgun, Siner, Bonnie S., Friedman, Harriet G., Roth, Elizabeth, Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Knutson, Allison, Schibler, Kurt, Poindexter, Brenda B., Merhar, Stephanie, Yolton, Kimberly, Gratton, Teresa L., Grisby, Cathy, Kirker, Kristin, Wuertz, Sandra, Carlton, David P., Adams-Chapman, Ira, Hale, Ellen C., Loggins, Yvonne C., Bottcher, Diane I., Mackie, Colleen, Carter, Sheena L., LaRossa, Maureen Mulligan, Wineski, Lynn C., Smikle, Gloria V., Leon-Hernandez, Angela, Kendrick-Allwood, Salathiel, Cotten, C. Michael, Goldberg, Ronald N., Goldstein, Ricki F., Malcolm, William F., Ashley, Patricia L., Finkle, Joanne, Fisher, Kimberley A., Grimes, Sandra, Gustafson, Kathryn E., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Warner, Diane, Wereszczak, Janice, Kicklighter, Stephen D., Rhodes-Ryan, Ginger, Higgins, Rosemary D., Wilson Archer, Stephanie, Sokol, Gregory M., Papile, Lu Ann, Hines, Abbey C., Herron, Dianne E., Gunn, Susan, Smiley, Lucy, Kennedy, Kathleen A., Tyson, Jon E., Arldt-McAlister, Julie, Burson, Katrina, Dempsey, Allison G., Evans, Patricia W., Garcia, Carmen, Jiminez, Margarita, John, Janice, Jones, Patrick M., Lillie, M. Layne, Martin, Karen, Martin, Sara C., McDavid, Georgia E., Rodgers, Shawna, Siddiki, Saba Khan, Sperry, Daniel, Pierce Tate, Patti L., Wright, Sharon L., Sánchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Fortney, Christine A., Besner, Gail E., Parikh, Nehal A., Wallace, Dennis, Gantz, Marie G., Newman, Jamie E., Auman, Jeanette O'Donnell, Crawford, Margaret, Gabrio, Jenna, Leblond, David, Petrie Huitema, Carolyn M., Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Chock, Valerie Y., Stevenson, David K., Adams, Marian M., Ball, M. Bethany, Bentley, Barbara, DeAnda, Maria Elena, Debattista, Anne M., Earhart, Beth, Huffman, Lynne C., Ismael, Magdy, Krueger, Casey E., Palmquist, Andrew W., Proud, Melinda S., Reichert, Elizabeth N., Sankar, Meera N., St. John, Nicholas H., Taylor, Heather L., Weiss, Hali E., Frantz, Ivan D., III, Fiascone, John M., MacKinnon, Brenda L., Nylen, Ellen, Furey, Anne, Sibley, Cecelia E., Brussa, Ana K., Carlo, Waldemar A., Ambalavanan, Namasivayam, Bailey, Kirstin J., Biasini, Fred J., Collins, Monica V., Cosby, Shirley S., Phillips, Vivien A., Rector, Richard V., Whitley, Sally, Devaskar, Uday, Garg, Meena, Purdy, Isabell B., Chanlaw, Teresa, Geller, Rachel, Finer, Neil N., Vaucher, Yvonne E., Kaegi, David, Rasmussen, Maynard R., Arnell, Kathy, Demetrio, Clarence, Fuller, Martha G., Rich, Wade, West, Radmila, Baack, Michelle L., Ellsbury, Dan L., Hogden, Laurie A., Klein, Jonathan M., Dagle, John M., Johnson, Karen J., Tud, Tracy L., Elenkiwich, Chelsey, Henning, Megan M., Broadbent, Megan, Schmelzel, Mendi L., Walker, Jacky R., Goeke, Claire A., Watterberg, Kristi L., Ohls, Robin K., Backstrom Lacy, Conra, Brown, Sandra, Fuller, Janell, Hartenberger, Carol, Lowe, Jean R., Sundquist Beauman, Sandra, Hanson, Mary Ruffner, Dupont, Tara, Kuan, Elizabeth, Schmidt, Barbara, Kirpalani, Haresh, Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Hurt, Hallam, D'Angio, Carl T., Guillet, Ronnie, Myers, Gary J., Lakshminrusimha, Satyan, Reynolds, Anne Marie, Hartley-McAndrew, Michelle E., Wadkins, Holly I.M., Sacilowski, Michael G., Reubens, Linda J., Jensen, Rosemary L., Merzbach, Joan, Zorn, William, Farooq, Osman, Maffett, Deanna, Williams, Ashley, Hunn, Julianne, Guilford, Stephanie, Yost, Kelley, Rowan, Mary, Prinzing, Diane M., Wynn, Karen, Fallone, Cait, Scorsone, Ann Marie, Wyckoff, Myra H., Brion, Luc P., Heyne, Roy J., Vasil, Diana M., Adams, Sally S., Chen, Lijun, De Leon, Maria M., Eubanks, Frances, Guzman, Alicia, Heyne, Elizabeth T., Madden, Linda A., Miller, Nancy A., Lee, Lizette E., Pavageau, Lara, Sepulveda, Pollieanna, Boatman, Cathy Twell, Faix, Roger G., Yoder, Bradley A., Baserga, Mariana, Osborne, Karen A., Baker, Shawna, Bird, Karie, Burnett, Jill, Christensen, Susan, Davis, Brandy, Elmont, Jennifer O., Jensen, Jennifer J., Loertscher, Manndi C., Marchant, Trisha, Maxson, Earl, Minton, Stephen D., Parry, D. Melody, Rau, Carrie A., Schaefer, Susan T., Sheffield, Mark J., Spencer, Cynthia, Steffen, Mike, Weaver-Lewis, Kimberlee, Winter, Sarah, Woodbury, Kathryn D., Zanetti, Karen, Shankaran, Seetha, Chawla, Sanjay, Sood, Beena G., Pappas, Athina, Natarajan, Girija, Bajaj, Monika, Bara, Rebecca, Johnson, Mary E., Goldston, Laura, Wiggins, Stephanie A., Christensen, Mary K., Carlson, Martha, Barks, John, White, Diane F., Ehrenkranz, Richard A., Jacobs, Harris, Butler, Christine G., Cervone, Patricia, Greisman, Sheila, Konstantino, Monica, Poulsen, JoAnn, Taft, Janet, Romano, Elaine, Brumbaugh, Jane E., Bell, Edward F., Grey, Scott F., DeMauro, Sara B., Vohr, Betty R., Harmon, Heidi M., Bann, Carla M., Rysavy, Matthew A., Logan, J. Wells, Colaizy, Tarah T., Peralta-Carcelen, Myriam A., McGowan, Elisabeth C., Duncan, Andrea F., Stoll, Barbara J., Das, Abhik, and Hintz, Susan R.

Published
2020
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34. New generation lipid emulsions increase brain DHA and improve body composition, but not short-term neurodevelopment in parenterally-fed preterm piglets

Author

Molina, Tiffany L., Stoll, Barbara, Mohammad, Mahmoud, Mohila, Carrie A., Call, Lee, Cui, Liwei, Guthrie, Gregory, Kunichoff, Dennis, Lin, Sen, Welch-Jernigan, Rebecca, Nielsen, Jon, Premkumar, Muralidhar, Robinson, Jason, Smith, Victoria, Teets, Haley, Obelitz-Ryom, Karina, Hagan, Joseph, Cruz, Stephanie, Lau, Patricio, Puyau, Maurice, Shypailo, Roman, Manjarin, Rodrigo, Butte, Nancy, Fang, Zhengfeng, Olutoye, Oluyinka, Thymann, Thomas, Sangild, Per, and Burrin, Douglas

Published
2020
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36. Impact of Optimized Breastfeeding on the Costs of Necrotizing Enterocolitis in Extremely Low Birthweight Infants

Author

Colaizy, Tarah T, Bartick, Melissa C, Jegier, Briana J, Green, Brittany D, Reinhold, Arnold G, Schaefer, Andrew J, Bogen, Debra L, Schwarz, Eleanor Bimla, Stuebe, Alison M, Jobe, Alan H, Oh, William, Vohr, Betty R, Walden, Rachel V, Alksninis, Barbara, Hensman, Angelita M, Leonard, Martha R, Noel, Lucy, Leach, Teresa M, Watson, Victoria E, Fanaroff, Avroy A, Walsh, Michele C, Wilson-Costello, Deanne E, Newman, Nancy S, Siner, Bonnie S, Friedman, Harriet G, Donovan, Edward F, Schibler, Kurt, Steichen, Jean J, Alexander, Barbara, Grisby, Cathy, Mersmann, Marcia Worley, Mincey, Holly L, Hessling, Jody, Gratton, Teresa L, Stoll, Barbara J, Adams-Chapman, Ira, Hale, Ellen C, LaRossa, Maureen Mulligan, Carter, Sheena, Higgins, Rosemary D, Wright, Linda L, McClure, Elizabeth M, Poindexter, Brenda B, Lemons, James A, Dusick, Anna M, Kardatzke, Darlene, Lytle, Carolyn, Appel, Diana D, Bohnke, Lon G, Eaken, Greg, Herron, Dianne E, Miller, Lucy C, Richard, Leslie, Wilson, Leslie Dawn, Das, Abhik, Poole, W Kenneth, Wrage, Lisa Ann, Hastings, Betty K, Auman, Jeanette O'Donnell, Taylor, Sarah, Stevenson, David K, Hintz, Susan R, Ball, M Bethany, Kohn, Jean G, Baran, Joan M, Lee-Ancajas, Julie C, St. John, Nicholas H, Carlo, Waldemar A, Ambalavanan, Namasivayam, Nelson, Kathleen G, Peralta-Carcelen, Myriam, Bailey, Kirstin J, Biasini, Fred J, Chopko, Stephanie A, Collins, Monica V, Cosby, Shirley S, Phillips, Vivien A, Rector, Richard V, Finer, Neil N, Vaucher, Yvonne E, Anderson, Jack M, Rasmussen, Maynard R, Arnell, Kathy, Demetrio, Clarence, Fuller, Martha G, Henderson, Christopher, Posin, Donna, Bell, Edward F, Bauer, Charles R, Duara, Shahnaz, Worth, Amy Mur, Everett-Thomas, Ruth, Diaz, Alexis N, Mathews, Elaine O, Hamlin-Smith, Kasey, Jean-Gilles, Lisa, Calejo, Maria, and Frade, Silvia M

Subjects
Paediatrics, Biomedical and Clinical Sciences, Perinatal Period - Conditions Originating in Perinatal Period, Nutrition, Infant Mortality, Digestive Diseases, Clinical Research, Pediatric, Preterm, Low Birth Weight and Health of the Newborn, Rare Diseases, Prevention, Prevention of disease and conditions, and promotion of well-being, 3.3 Nutrition and chemoprevention, Reproductive health and childbirth, Good Health and Well Being, Breast Feeding, Enterocolitis, Necrotizing, Health Care Costs, Humans, Infant Formula, Infant, Extremely Low Birth Weight, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Milk, Human, Models, Economic, Monte Carlo Method, United States, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, economic analysis, human milk, monte carlo modeling, necrotizing enterocolitis, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveTo estimate risk of necrotizing enterocolitis (NEC) for extremely low birth weight (ELBW) infants as a function of preterm formula (PF) and maternal milk intake and calculate the impact of suboptimal feeding on the incidence and costs of NEC.Study designWe used aORs derived from the Glutamine Trial to perform Monte Carlo simulation of a cohort of ELBW infants under current suboptimal feeding practices, compared with a theoretical cohort in which 90% of infants received at least 98% human milk.ResultsNEC incidence among infants receiving ≥98% human milk was 1.3%; 11.1% among infants fed only PF; and 8.2% among infants fed a mixed diet (P = .002). In adjusted models, compared with infants fed predominantly human milk, we found an increased risk of NEC associated with exclusive PF (aOR = 12.1, 95% CI 1.5, 94.2), or a mixed diet (aOR 8.7, 95% CI 1.2-65.2). In Monte Carlo simulation, current feeding of ELBW infants was associated with 928 excess NEC cases and 121 excess deaths annually, compared with a model in which 90% of infants received ≥98% human milk. These models estimated an annual cost of suboptimal feeding of ELBW infants of $27.1 million (CI $24 million, $30.4 million) in direct medical costs, $563 655 (CI $476 191, $599 069) in indirect nonmedical costs, and $1.5 billion (CI $1.3 billion, $1.6 billion) in cost attributable to premature death.ConclusionsAmong ELBW infants, not being fed predominantly human milk is associated with an increased risk of NEC. Efforts to support milk production by mothers of ELBW infants may prevent infant deaths and reduce costs.

Published
2016

37. Protocol for the development of a core outcome set for neonatal sepsis (NESCOS)

Author

Taneri, Petek Eylul, primary, Kirkham, Jamie J., additional, Molloy, Eleanor J., additional, Biesty, Linda, additional, Polin, Richard A., additional, Wynn, James L., additional, Stoll, Barbara J., additional, Kissoon, Niranjan, additional, Kawaza, Kondwani, additional, Daly, Mandy, additional, Branagan, Aoife, additional, Bonnard, Lívia Nagy, additional, Giannoni, Eric, additional, Strunk, Tobias, additional, Ohaja, Magdalena, additional, Mugabe, Kenneth, additional, Suguitani, Denise, additional, Quirke, Fiona, additional, and Devane, Declan, additional

Published
2023
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40. Developmental Outcomes of Extremely Preterm Infants with a Need for Child Protective Services Supervision

Author

Polin, Richard A., Laptook, Abbott R., Keszler, Martin, Hensman, Angelita M., Alksninis, Barbara, Basso, Kristin M., Burke, Robert, Caskey, Melinda, Johnson, Katharine, Keszler, Mary Lenore, Knoll, Andrea M., Leach, Theresa M., Little, Emilee, McGowan, Elisabeth C., Vieira, Elisa, Watson, Victoria E., Ventura, Suzy, Walsh, Michele C., Fanaroff, Avroy A., Hibbs, Anna Marie, Wilson-Costello, Deanne E., Newman, Nancy S., Payne, Allison H., Siner, Bonnie S., Bhola, Monika, Yalcinkaya, Gulgun, Friedman, Harriet G., Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Knutson, Allison, Schibler, Kurt, Donovan, Edward F., Grisby, Cathy, Bridges, Kate, Alexander, Barbara, Fischer, Estelle E., Mincey, Holly L., Hessling, Jody, Gratton, Teresa L., Jackson, Lenora, Kirker, Kristin, Muthig, Greg, Steichen, Jean J., Tepe, Stacey, Yolton, Kimberly, Goldberg, Ronald N., Cotten, C. Michael, Goldstein, Ricki F., Ashley, Patricia L., Malcolm, William F., Auten, Kathy J., Fisher, Kimberley A., Grimes, Sandra, Gustafson, Kathryn E., Lohmeyer, Melody B., Finkle, Joanne, Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Clark, Cindy, Manor, Linda, Warner, Diane, Wereszczak, Janice, Carlton, David P., Stoll, Barbara J., Adams-Chapman, Ira, Hale, Ellen C., Loggins, Yvonne, Archer, Stephanie Wilson, Sokol, Gregory M., Poindexter, Brenda B., Dusick, Anna M., Papile, Lu-Ann, Gunn, Susan, Hamer, Faithe, Herron, Dianne E., Hines, Abbey C., Lytle, Carolyn, Minnich, Heike M., Smiley, Lucy, Wilson, Leslie Dawn, Sanchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Fortney, Christine A., Besner, Gail E., Parikh, Nehal A., Das, Abhik, Wallace, Dennis, Gantz, Marie G., Poole, W. Kenneth, Newman, Jamie E., O'Donnell Auman, Jeanette, Crawford, Margaret M., Petrie Huitema, Carolyn M., Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Stevenson, David K., Hintz, Susan R., Ball, M. Bethany, Davis, Alexis S., Palmquist, Andrew W., Proud, Melinda S., Bentley, Barbara, Bruno, Elizabeth, DeAnda, Maria Elena, DeBattista, Anne M., Earhart, Beth, Huffman, Lynne C., Kohn, Jean G., Krueger, Casey, Weiss, Hali E., Frantz, Ivan D., III, Fiascone, John M., MacKinnon, Brenda L., Furey, Anne, Nylen, Ellen, Carlo, Waldemar A., Ambalavanan, Namasivayam, Peralta-Carcelen, Myriam, Collins, Monica V., Cosby, Shirley S., Biasini, Fred J., Johnston, Kristen C., Nelson, Kathleen G., Patterson, Cryshelle S., Phillips, Vivien A., Whitley, Sally, Devaskar, Uday, Garg, Meena, Purdy, Isabell B., Chanlaw, Teresa, Geller, Rachel, Finer, Neil N., Vaucher, Yvonne E., Kaegi, David, Rasmussen, Maynard R., Arnell, Kathy, Demetrio, Clarence, Fuller, Martha G., Rich, Wade, Bell, Edward F., Colaizy, Tarah T., Acarregui, Michael J., Ellsbury, Dan L., Widness, John A., Johnson, Karen J., Campbell, Donia B., Eastman, Diane L., Walker, Jacky R., Brumbaugh, Jane E., Duara, Shahnaz, Bauer, Charles R., Everett-Thomas, Ruth, Fajardo-Hiriart, Sylvia, Rigaud, Arielle, Calejo, Maria, Frade Eguaras, Silvia M., Berkowits, Michelle Harwood, Garcia, Andrea, Pierre, Helina, Stoerger, Alexandra, Watterberg, Kristi L., Lowe, Jean R., Fuller, Janell F., Ohls, Robin K., Lacy, Conra Backstrom, Duncan, Andrea F., Montman, Rebecca, Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B., Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Hurt, Hallam, D'Angio, Carl T., Phelps, Dale L., Guillet, Ronnie, Lakshminrusimha, Satyan, Johnson, Julie Babish, Reubens, Linda J., Horihan, Cassandra A., Hust, Diane, Jensen, Rosemary L., Kushner, Emily, Merzbach, Joan, Myers, Gary J., Rowan, Mary, Wadkins, Holly I.M., Bowman, Melissa, Hunn, Julianne, Guilford, Stephanie, Maffett, Deanna, Osman, Farooq, Prinzing, Diane, Reynolds, Anne Marie, Sacilowski, Michael G., Williams, Ashley, Wynn, Karen, Yost, Kelley, Zorn, William, Zwetsch, Lauren, Kennedy, Kathleen A., Tyson, Jon E., McDavid, Georgia E., Alaniz, Nora I., Arldt-McAlister, Julie, Burson, Katrina, Evans, Patricia W., Garcia, Carmen, Green, Charles, Harris, Beverly Foley, Jiminez, Margarita, John, Janice, Jones, Patrick M., Lillie, Layne M., Lis, Anna E., Martin, Karen, Martin, Sara C., Morris, Brenda H., Poundstone, M. Layne, Robichaux, Peggy, Rodgers, Shawna, Siddiki, Saba, Simmons, Maegan C., Sperry, Daniel, Pierce Tate, Patti L., Wright, Sharon L., Wyckoff, Myra H., Brion, Luc P., Heyne, Roy J., Salhab, Walid A., Rosenfeld, Charles R., Vasil, Diana M., Chen, Lijun, Guzman, Alicia, Hensley, Gaynelle, Leps, Melissa H., Miller, Nancy A., Morgan, Janet S., Adams, Sally S., Boatman, Catherine Twell, Heyne, Elizabeth T., Madden, Linda A., Torres, Lizette E., Faix, Roger G., Yoder, Bradley A., Osborne, Karen A., Spencer, Cynthia, Weaver-Lewis, Kimberlee, Baker, Shawna, Bird, Karie, Burnett, Jill, Steffen, Michael, Jensen, Jennifer J., Winter, Sarah, Zanetti, Karen, O'Shea, T. Michael, Dillard, Robert G., Washburn, Lisa K., Jackson, Barbara G., Peters, Nancy, Chiu, Korinne, Allred, Deborah Evans, Goldstein, Donald J., Halfond, Raquel, Peterson, Carroll, Waldrep, Ellen L., Welch, Cherrie D., Morris, Melissa Whalen, Hounshell, Gail Wiley, Shankaran, Seetha, Pappas, Athina, Barks, John, Bara, Rebecca, Goldston, Laura A., Natarajan, Girija, Christensen, Mary, Wiggins, Stephanie A., White, Diane, Ehrenkranz, Richard A., Jacobs, Harris, Butler, Christine G., Cervone, Patricia, Greisman, Sheila, Konstantino, Monica, Poulsen, JoAnn, Taft, Janet, Williams, Joanne, Romano, Elaine, Laptook, Abbot. R., Lowe, Jean, Chowdhury, Dhuly, Higgins, Rosemary D., and Vohr, Betty R.

Published
2019
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42. Diversity and Inclusion Training in Pediatric Departments

Author

Mendoza, Fernando S, Walker, Leslie R, Stoll, Barbara J, Fuentes-Afflick, Elena, St Geme, Joseph W, Cheng, Tina L, del Rey, Javier A Gonzalez, Harris, Christopher E, Rimsza, Mary E, Li, Jie, and Sectish, Theodore C

Subjects
Biomedical and Clinical Sciences, Health Sciences, Psychology, Pediatric, Clinical Research, Quality Education, Child, Cultural Competency, Cultural Diversity, Curriculum, Data Collection, Female, Hospital Departments, Humans, Inservice Training, Male, Pediatrics, Psychological Distance, United States, Asian American, LGBT, academic leadership, cultural competency, diversity, gender, minority, pediatric workforce, Medical and Health Sciences, Psychology and Cognitive Sciences, Biomedical and clinical sciences, Health sciences
Abstract

Background and objectiveThe diversifying US population of children necessitates assessing the diversity of the pediatric academic workforce and its level of cultural competency training. Such data are essential for workforce and educational policies.MethodsAn 8-question survey was sent to 131 US pediatric chairs to assess plans for diversity, targeted groups, departmental diversity, diversity measures, perceived success in diversity, and presence and type of cultural competency training.ResultsIn all, 49.6% of chairs responded, and three-quarters of them reported having a plan for diversity, which targeted racial; ethnic; gender; lesbian, gay, bisexual, and transgender; disabled; and social class groups. Of the residents, 75% were women, as compared with 54% of faculty and 26% of chairs. Racial and ethnic diversity was limited among trainees, faculty, and leaders;

Published
2015

43. Causes and Timing of Death in Extremely Premature Infants from 2000 through 2011

Author

Patel, Ravi M, Kandefer, Sarah, Walsh, Michele C, Bell, Edward F, Carlo, Waldemar A, Laptook, Abbot R, Sánchez, Pablo J, Shankaran, Seetha, Van Meurs, Krisa P, Ball, M Bethany, Hale, Ellen C, Newman, Nancy S, Das, Abhik, Higgins, Rosemary D, and Stoll, Barbara J

Subjects
Rare Diseases, Pediatric, Infant Mortality, Neurosciences, Preterm, Low Birth Weight and Health of the Newborn, Perinatal Period - Conditions Originating in Perinatal Period, Clinical Research, Reproductive health and childbirth, Good Health and Well Being, Cause of Death, Congenital Abnormalities, Enterocolitis, Necrotizing, Gestational Age, Humans, Infant, Infant, Extremely Premature, Infant, Newborn, Infant, Premature, Diseases, Infant, Very Low Birth Weight, Risk Factors, United States, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundUnderstanding the causes and timing of death in extremely premature infants may guide research efforts and inform the counseling of families.MethodsWe analyzed prospectively collected data on 6075 deaths among 22,248 live births, with gestational ages of 22 0/7 to 28 6/7 weeks, among infants born in study hospitals within the National Institute of Child Health and Human Development Neonatal Research Network. We compared overall and cause-specific in-hospital mortality across three periods from 2000 through 2011, with adjustment for baseline differences.ResultsThe number of deaths per 1000 live births was 275 (95% confidence interval [CI], 264 to 285) from 2000 through 2003 and 285 (95% CI, 275 to 295) from 2004 through 2007; the number decreased to 258 (95% CI, 248 to 268) in the 2008-2011 period (P=0.003 for the comparison across three periods). There were fewer pulmonary-related deaths attributed to the respiratory distress syndrome and bronchopulmonary dysplasia in 2008-2011 than in 2000-2003 and 2004-2007 (68 [95% CI, 63 to 74] vs. 83 [95% CI, 77 to 90] and 84 [95% CI, 78 to 90] per 1000 live births, respectively; P=0.002). Similarly, in 2008-2011, as compared with 2000-2003, there were decreases in deaths attributed to immaturity (P=0.05) and deaths complicated by infection (P=0.04) or central nervous system injury (P

Published
2015

44. Antenatal magnesium sulfate exposure and acute cardiorespiratory events in preterm infants.

Author

De Jesus, Lilia C, Sood, Beena G, Shankaran, Seetha, Kendrick, Douglas, Das, Abhik, Bell, Edward F, Stoll, Barbara J, Laptook, Abbot R, Walsh, Michele C, Carlo, Waldemar A, Sanchez, Pablo J, Van Meurs, Krisa P, Bara, Rebecca, Hale, Ellen C, Newman, Nancy S, Ball, M Bethany, Higgins, Rosemary D, and Eunice Kennedy Shriver National Institute of Health and Human Development Neonatal Research Network

Subjects
Eunice Kennedy Shriver National Institute of Health and Human Development Neonatal Research Network, Humans, Respiration Disorders, Prenatal Exposure Delayed Effects, Heart Diseases, Infant, Premature, Diseases, Acute Disease, Magnesium Sulfate, Retrospective Studies, Pregnancy, Adult, Infant, Newborn, Infant, Premature, Female, Young Adult, antenatal magnesium, nasal continuous positive airway pressure, neonatal resuscitation, preterm infants, Perinatal Period - Conditions Originating in Perinatal Period, Cardiovascular, Clinical Research, Preterm, Low Birth Weight and Health of the Newborn, Pediatric, Lung, Clinical Trials and Supportive Activities, Neonatal Respiratory Distress, Infant Mortality, Prevention, Reproductive health and childbirth, Good Health and Well Being, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine
Abstract

ObjectiveAntenatal magnesium (anteMg) is used for various obstetric indications including fetal neuroprotection. Infants exposed to anteMg may be at risk for respiratory depression and delivery room (DR) resuscitation. The study objective was to compare the risk of acute cardiorespiratory events among preterm infants who were and were not exposed to anteMg.Study designThis was a retrospective analysis of prospective data collected in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network's Generic Database from April 1, 2011, through March 31, 2012. The primary outcome was DR intubation or respiratory support at birth or on day 1 of life. Secondary outcomes were invasive mechanical ventilation, hypotension treatment, neonatal morbidities, and mortality. Logistic regression analysis evaluated the risk of primary outcome after adjustment for covariates.ResultsWe evaluated 1544 infants

Published
2015

46. Association between Policy Changes for Oxygen Saturation Alarm Settings and Neonatal Morbidity and Mortality in Infants Born Very Preterm

Author

Caplan, Michael S., Laptook, Abbott R., Keszler, Martin, Hensman, Angelita M., Knoll, Andrea M., Little, Emilee, Vieira, Elisa, Basso, Kristin M., Keller, Jennifer A., Hibbs, Anna Maria, Fanaroff, Avroy A., Newman, Nancy S., Payne, Allison H., Schibler, Kurt, Donovan, Edward F., Grisby, Cathy, Bridges, Kate, Alexander, Barbara, Fischer, Estelle E., Mincey, Holly L., Hessling, Jody, Jackson, Lenora, Kirker, Kristin, Muthig, Greg, Tepe, Stacey, Cotten, C. Michael, Goldberg, Ronald N., Auten, Kathy J., Fisher, Kimberley A., Finkle, Joanne, Carlton, David P., Stoll, Barbara J., Hale, Ellen C., Loggins, Yvonne, Bottcher, Diane I., Mackie, Colleen, Higgins, Rosemary D., Archer, Stephanie Wilson, Poindexter, Brenda B., Sokol, Gregory M., Herron, Dianne E., Miller, Lucy, Wilson, Leslie Dawn, Kennedy, Kathleen A., Tyson, Jon E., McDavid, Georgia E., Arldt-McAlister, Julie, Burson, Katrina, Garcia, Carmen, Harris, Beverly Foley, Lis, Anna E., Martin, Karen, Martin, Sara C., Rodgers, Shawna, Simmons, Maegan C., Pierce Tate, Patti L., Das, Abhik, Wallace, Dennis, Poole, W. Kenneth, O'Donnell Auman, Jeanette, Crawford, Margaret M., Petrie Huitema, Carolyn M., Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Stevenson, David K., Adams, Marian M., Ball, M. Bethany, Ismail, Magdy, Palmquist, Andrew W., Proud, Melinda S., Carlo, Waldemar A., Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Bell, Edward F., Colaizy, Tarah T., Widness, John A., Johnson, Karen J., Walker, Jacky R., Watterberg, Kristi L., Ohls, Robin K., Lacy, Conra Backstrom, Hartenberger, Carol H., Beauman, Sandra Sundquist, Hanson, Mary Ruffaner, Wyckoff, Myra H., Brion, Luc P., Salhab, Walid A., Rosenfeld, Charles R., Vasil, Diana M., Chen, Lijun, Guzman, Alicia, Hensley, Gaynelle, Lee, Lizette E., Leps, Melissa H., Miller, Nancy A., Morgan, Janet S., Pavageau, Lara, Shankaran, Seetha, Pappas, Athina, Bara, Rebecca, Natarajan, Girija, Foglia, Elizabeth E., Carper, Benjamin, Gantz, Marie, DeMauro, Sara B., Lakshminrusimha, Satyan, Walsh, Michele, and Schmidt, Barbara

Published
2019
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48. Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm

Author

Jobe, Alan H., Caplan, Michael S., Laptook, Abbot R., Vohr, Betty R., Oh, William, Hensman, Angelita M., Alksninis, Barbara, Andrews, Dawn, Angela, Kristen, Barnett, Susan, Cashore, Bill, Caskey, Melinda, Francis, Kim, Gingras, Dan, Johnson, Katharine, Leach, Theresa M., Stephens, Bonnie E., Watson, Victoria E., Walsh, Michele C., Fanaroff, Avroy A., Newman, Nancy S., Wilson-Costello, Deanne E., Siner, Bonnie S., Zadell, Arlene, DiFiore, Julie, Bhola, Monika, Friedman, Harriet G., Yalcinkaya, Gulgun, Bulas, Dorothy, Goldberg, Ronald N., Cotten, C. Michael, Goldstein, Ricki F., Ashley, Patricia, Auten, Kathy J., Fisher, Kimberley A., Foy, Katherine A., Freedman, Sharon F., Gustafson, Kathryn E., Lohmeyer, Melody B., Malcolm, William F., Wallace, David K., Carlton, David P., Stoll, Barbara J., Adams-Chapman, Ira, Buchter, Susie, Piazza, Anthony J., Carter, Sheena, Fritz, Sobha, Hale, Ellen C., Hutchinson, Amy K., LaRossa, Maureen Mulligan, Higgins, Rosemary D., Archer, Stephanie Wilson, Sokol, Gregory M., Poindexter, Brenda B., Dusick, Anna M., Lemons, James A., Wilson, Leslie D., Hamer, Faithe, Cook, Ann B., Herron, Dianne E., Lytle, Carolyn, Minnich, Heike M., Berberich, Mary Anne, Blaisdell, Carol J., Gail, Dorothy B., Kiley, James P., Das, Abhik, Gantz, Marie G., Newman, Jamie E., Cheng, Helen, Hastings, Betty K., McClure, Elizabeth M., Auman, Jeanette O'Donnell, Huitema, Carolyn Petrie, Poole, W. Kenneth, Pickett, James W., II, Wallace, Dennis, Wrage, Lisa A., Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Stevenson, David K., Ball, M. Bethany, Barnes, Patrick D., Bentley, Barbara, Bruno, Elizabeth F., DeAnda, Maria Elena, DeBattista, Anne M., Kohn, Jean G., Proud, Melinda S., Pyle, Renee P., Weiss, Hali E., Frantz, Ivan D., III, Fiascone, John M., McGowan, Elisabeth C., Furey, Anne, MacKinnon, Brenda L., Nylen, Ellen, Brussa, Ana, Sibley, Cecelia, Carlo, Waldemar A., Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Phillips, Vivien A., Bailey, Kirstin J., Biasini, Fred J., Hopkins, Maria, Johnston, Kristen C., Nelson, Kathleen G., Patterson, Cryshelle S., Rector, Richard V., Rodriguez, Leslie, Soong, Amanda, Whitley, Sally, York, Sheree, Finer, Neil N., Rasmussen, Maynard R., Wozniak, Paul R., Vaucher, Yvonne E., Rich, Wade, Arnell, Kathy, Barbieri-Welge, Rene, Ben-Tall, Ayala, Bridge, Renee, Demetrio, Clarence, Fuller, Martha G., Ito, Elaine, Lukasik, Meghan, Pontillo, Deborah, Posin, Donna, Runyan, Cheryl, Wilkes, James, Zlotnik, Paul, Bell, Edward F., Widness, John A., Acarregui, Michael J., Klein, Jonathan M., Colaizy, Tarah T., Johnson, Karen J., Eastman, Diane L., Duara, Shahnaz, Bauer, Charles R., Everett-Thomas, Ruth, Calejo, Maria, Diaz, Alexis N., Frade Eguaras, Silvia M., Garcia, Andrea, Hamlin-Smith, Kasey, Berkowits, Michelle Harwood, Hiriart-Fajardo, Sylvia, Mathews, Elaine O., Pierre, Helina, Riguard, Arielle, Stroerger, Alexandra, Watterberg, Kristi L., Ohls, Robin K., Fuller, Janell, Rohr, Julie, Lacy, Conra Backstrom, Lowe, Jean, Montman, Rebecca, Brown, Sandra, Laroia, Nirupama, Phelps, Dale L., Myers, Gary J., Markowitz, Gary D., Reubens, Linda J., Hust, Diane, Augostino, Lisa, Johnson, Julie Babish, Burnell, Erica, Gelbard, Harris, Jensen, Rosemary L., Kushner, Emily, Merzbach, Joan, Mink, Jonathan, Torres, Carlos, Wang, David, Yost, Kelley, Sánchez, Pablo J., Rosenfeld, Charles R., Salhab, Walid A., Heyne, Roy J., Adams, Sally S., Allen, James, Grau, Laura, Guzman, Alicia, Hensley, Gaynelle, Heyne, Elizabeth T., Hickman, Jackie F., Leps, Melissa H., Madden, Linda A., Martin, Melissa, Miller, Nancy A., Morgan, Janet S., Solis, Araceli, Torres, Lizette E., Boatman, Catherine Twell, Vasil, Diana M., Kennedy, Kathleen A., Tyson, Jon E., Evans, Patricia W., Akpa, Esther G., Alaniz, Nora I., Harris, Beverly Foley, Green, Charles, Jiminez, Margarita, Lis, Anna E., Martin, Sarah, McDavid, Georgia E., Morris, Brenda H., Poundstone, Margaret L., Reddoch, Stacy, Siddiki, Saba, Pierce Tate, Patti L., Wright, Sharon L., Yoder, Bradley A., Faix, Roger G., Baker, Shawna, Bird, Karie, Bullwinkle, Anna E., Burnett, Jill, Cole, Laura, Osborne, Karen A., Spencer, Cynthia, Steele, R. Edison, Steffen, Michael, Weaver-Lewis, Kimberlee, O'Shea, T. Michael, Dillard, Robert G., Washburn, Lisa K., Peters, Nancy J., Jackson, Barbara G., Chiu, Korinne, Allred, Deborah Evans, Goldstein, Donald J., Halfond, Raquel, Peterson, Carroll, Waldrep, Ellen L., Welch, Cherrie D., Morris, Melissa Whalen, Hounshell, Gail Wiley, Shankaran, Seetha, Sood, Beena G., Slovis, Thomas L., Pappas, Athina, Bara, Rebecca, Billian, Elizabeth, Goldston, Laura A., Johnson, Mary, Duncan, Andrea F., Bann, Carla M., Dempsey, Allison, Peralta-Carcelen, Myriam, and Hintz, Susan

Published
2019
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49. Weaning of Moderately Preterm Infants from the Incubator to the Crib: A Randomized Clinical Trial

Author

Polin, Richard A., Keszler, Martin, Hensman, Angelita M., Vieira, Elisa, Hibbs, Anna Marie, Siner, Bonnie S., Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Schibler, Kurt, Kallapur, Suhas G., Grisby, Cathy, Alexander, Barbara, Fischer, Estelle E., Jackson, Lenora, Kirker, Kristin, Jennings, Jennifer, Wuertz, Sandra, Muthig, Greg, Cotten, C. Michael, Goldberg, Ronald N., Roach, Theresa, Finkle, Joanne, Fisher, Kimberley A., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Clark, Cindy, Kicklighter, Stephen D., Rhodes-Ryan, Ginger, Hale, Ellen C., Loggins, Yvonne, Bottcher, Diane I., Archer, Stephanie Wilson, Harmon, Heidi, Herron, Dianne E., Wright-Coltart, Shirley I., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Gutentag, Julie, Park, Courtney, Shadd, Julie C., Sullivan, Margaret, Grothause, Jennifer L., Stein, Melanie, Clark, Erna, Sullivan, Rox Ann, Wallace, Dennis, Zaterka-Baxter, Kristin M., Crawford, Margaret, Auman, Jeanette O'Donnell, Stevenson, David K., Herfert, Lou Ann, Ball, M. Bethany, Goodlin, Gabrielle T., Proud, Melinda S., Williams, R. Jordan, Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Chanlaw, Teresa, Geller, Rachel, Ellsbury, Dan L., Brumbaugh, Jane E., Johnson, Karen J., Campbell, Donia B., Walker, Jacky R., Watterberg, Kristi, Lacy, Conra Backstrom, Beauman, Sandy Sundquist, Hartenberger, Carol, Kirpalani, Haresh, Eichenwald, Eric C., DeMauro, Sara B., Cook, Noah, Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara, Lakshminrusimha, Satyan, Guillet, Ronnie, Scorsone, Ann Marie, Hunn, Julianne, Jensen, Rosemary, Wadkins, Holly I.M., Guilford, Stephanie, Williams, Ashley, Wyckoff, Myra, Brion, Luc P., Vasil, Diana M., Chen, Lijun, Torres, Lizette E., Pappas, Athina, Panaitescu, Bogdan, Handel, Shelley, White, Diane F., Christensen, Mary, Wiggins, Stephanie A., Shankaran, Seetha, Bell, Edward F., Laptook, Abbot R., Saha, Shampa, Newman, Nancy S., Kazzi, S. Nadya J., Barks, John, Stoll, Barbara J., Bara, Rebecca, Gabrio, Jenna, Childs, Kirsten, Das, Abhik, Higgins, Rosemary D., Carlo, Waldemar A., Sánchez, Pablo J., Carlton, David P., Pavageau, Lara, Malcolm, William F., D'Angio, Carl T., Ohls, Robin K., Poindexter, Brenda B., Sokol, Gregory M., Van Meurs, Krisa P., Colaizy, Tarah T., Khmour, Ayman, Puopolo, Karen M., Garg, Meena, and Walsh, Michele C.

Published
2019
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50. Neurodevelopmental Outcomes of Extremely Preterm Infants Fed Donor Milk or Preterm Infant Formula: A Randomized Clinical Trial.

Author

Colaizy, Tarah T., Poindexter, Brenda B., McDonald, Scott A., Bell, Edward F., Carlo, Waldemar A., Carlson, Susan J., DeMauro, Sara B., Kennedy, Kathleen A., Nelin, Leif D., Sánchez, Pablo J., Vohr, Betty R., Johnson, Karen J., Herron, Dianne E., Das, Abhik, Crawford, Margaret M., Walsh, Michele C., Higgins, Rosemary D., Stoll, Barbara J., Ambalavanan, Namisavayam, and Wyckoff, Myra H.

Subjects
PREMATURE infants, BABY foods, INFANT formulas, CLINICAL trials, BREAST milk, NEURAL development, DELAY of gratification, CRYING
Abstract

Key Points: Question: Among extremely preterm infants fed minimal maternal milk, does feeding of donor human milk compared with preterm formula during the birth hospitalization result in improved neurodevelopmental outcomes? Findings: In this randomized clinical trial, the Bayley Scales of Infant and Toddler Development adjusted mean cognitive score was 80.7 (measured at 22-26 months' corrected age) for infants fed donor human milk vs 81.1 for infants fed preterm formula (adjusted between-group mean difference, −0.77 [95% CI, −3.93 to 2.39]), which was not a significant difference. The adjusted mean language and motor scores also did not differ. Meaning: Among extremely preterm infants, donor milk feeding did not result in different 2-year neurodevelopmental outcomes compared with preterm formula feeding. Importance: Maternal milk feeding of extremely preterm infants during the birth hospitalization has been associated with better neurodevelopmental outcomes compared with preterm formula. For infants receiving no or minimal maternal milk, it is unknown whether donor human milk conveys similar neurodevelopmental advantages vs preterm formula. Objective: To determine if nutrient-fortified, pasteurized donor human milk improves neurodevelopmental outcomes at 22 to 26 months' corrected age compared with preterm infant formula among extremely preterm infants who received minimal maternal milk. Design, Setting, and Participants: Double-blind, randomized clinical trial conducted at 15 US academic medical centers within the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Infants younger than 29 weeks 0 days' gestation or with a birth weight of less than 1000 g were enrolled between September 2012 and March 2019. Intervention: Preterm formula or donor human milk feeding from randomization to 120 days of age, death, or hospital discharge. Main Outcomes and Measures: The primary outcome was the Bayley Scales of Infant and Toddler Development (BSID) cognitive score measured at 22 to 26 months' corrected age; a score of 54 (score range, 54-155; a score of ≥85 indicates no neurodevelopmental delay) was assigned to infants who died between randomization and 22 to 26 months' corrected age. The 24 secondary outcomes included BSID language and motor scores, in-hospital growth, necrotizing enterocolitis, and death. Results: Of 1965 eligible infants, 483 were randomized (239 in the donor milk group and 244 in the preterm formula group); the median gestational age was 26 weeks (IQR, 25-27 weeks), the median birth weight was 840 g (IQR, 676-986 g), and 52% were female. The birthing parent's race was self-reported as Black for 52% (247/478), White for 43% (206/478), and other for 5% (25/478). There were 54 infants who died prior to follow-up; 88% (376/429) of survivors were assessed at 22 to 26 months' corrected age. The adjusted mean BSID cognitive score was 80.7 (SD, 17.4) for the donor milk group vs 81.1 (SD, 16.7) for the preterm formula group (adjusted mean difference, −0.77 [95% CI, −3.93 to 2.39], which was not significant); the adjusted mean BSID language and motor scores also did not differ. Mortality (death prior to follow-up) was 13% (29/231) in the donor milk group vs 11% (25/233) in the preterm formula group (adjusted risk difference, −1% [95% CI, −4% to 2%]). Necrotizing enterocolitis occurred in 4.2% of infants (10/239) in the donor milk group vs 9.0% of infants (22/244) in the preterm formula group (adjusted risk difference, −5% [95% CI, −9% to −2%]). Weight gain was slower in the donor milk group (22.3 g/kg/d [95% CI, 21.3 to 23.3 g/kg/d]) compared with the preterm formula group (24.6 g/kg/d [95% CI, 23.6 to 25.6 g/kg/d]). Conclusions and Relevance: Among extremely preterm neonates fed minimal maternal milk, neurodevelopmental outcomes at 22 to 26 months' corrected age did not differ between infants fed donor milk or preterm formula. Trial Registration: ClinicalTrials.gov Identifier: NCT01534481 This randomized clinical trial compares the effect of donor human milk on neurodevelopmental outcomes at 22 to 26 months' corrected age compared with preterm infant formula among extremely preterm infants who received minimal maternal milk. [ABSTRACT FROM AUTHOR]

Published
2024
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