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546 results on '"Stolarz‐Skrzypek, Katarzyna"'

1. An outcome-driven threshold for pulse pressure amplification

Author

Huang, Qi-Fang, An, De-Wei, Aparicio, Lucas S., Cheng, Yi-Bang, Wei, Fang-Fei, Yu, Yu-Ling, Sheng, Chang-Sheng, Yang, Wen-Yi, Niiranen, Teemu J., Boggia, José, Stolarz-Skrzypek, Katarzyna, Tikhonoff, Valérie, Gilis-Malinowska, Natasza, Wojciechowska, Wiktoria, Casiglia, Edoardo, Narkiewicz, Krzysztof, Filipovský, Jan, Kawecka-Jaszcz, Kalina, Nawrot, Tim S., Wang, Ji-Guang, Li, Yan, and Staessen, Jan A.

Published
2024
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2. Genetic insights into resting heart rate and its role in cardiovascular disease.

Author

van de Vegte, Yordi, Eppinga, Ruben, van der Ende, M, Hagemeijer, Yanick, Mahendran, Yuvaraj, Salfati, Elias, Smith, Albert, Tan, Vanessa, Arking, Dan, Ntalla, Ioanna, Appel, Emil, Schurmann, Claudia, Brody, Jennifer, Rueedi, Rico, Polasek, Ozren, Sveinbjornsson, Gardar, Lecoeur, Cecile, Ladenvall, Claes, Zhao, Jing, Isaacs, Aaron, Wang, Lihua, Luan, Jianan, Hwang, Shih-Jen, Mononen, Nina, Auro, Kirsi, Jackson, Anne, Bielak, Lawrence, Zeng, Linyao, Shah, Nabi, Nethander, Maria, Campbell, Archie, Rankinen, Tuomo, Pechlivanis, Sonali, Qi, Lu, Zhao, Wei, Rizzi, Federica, Tanaka, Toshiko, Robino, Antonietta, Cocca, Massimiliano, Lange, Leslie, Müller-Nurasyid, Martina, Roselli, Carolina, Zhang, Weihua, Kleber, Marcus, Guo, Xiuqing, Lin, Henry, Pavani, Francesca, Galesloot, Tessel, Noordam, Raymond, Milaneschi, Yuri, Schraut, Katharina, den Hoed, Marcel, Degenhardt, Frauke, Trompet, Stella, van den Berg, Marten, Pistis, Giorgio, Tham, Yih-Chung, Weiss, Stefan, Sim, Xueling, Li, Hengtong, van der Most, Peter, Nolte, Ilja, Lyytikäinen, Leo-Pekka, Said, M, Witte, Daniel, Iribarren, Carlos, Launer, Lenore, Ring, Susan, de Vries, Paul, Sever, Peter, Linneberg, Allan, Bottinger, Erwin, Padmanabhan, Sandosh, Psaty, Bruce, Sotoodehnia, Nona, Kolcic, Ivana, Arnar, David, Gudbjartsson, Daniel, Holm, Hilma, Balkau, Beverley, Silva, Claudia, Newton-Cheh, Christopher, Nikus, Kjell, Salo, Perttu, Mohlke, Karen, Peyser, Patricia, Schunkert, Heribert, Lorentzon, Mattias, Lahti, Jari, Rao, Dabeeru, Cornelis, Marilyn, Faul, Jessica, Smith, Jennifer, Stolarz-Skrzypek, Katarzyna, Bandinelli, Stefania, Concas, Maria, Sinagra, Gianfranco, Meitinger, Thomas, Waldenberger, Melanie, and Sinner, Moritz

Subjects
Humans, Cardiovascular Diseases, Risk Factors, Heart Rate, Genetic Predisposition to Disease, Atrial Fibrillation, Mendelian Randomization Analysis, Genome-Wide Association Study, Polymorphism, Single Nucleotide
Abstract

Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals 493 independent genetic variants in 352 loci, including 68 genetic variants outside previously identified resting heart rate associated loci. We prioritize 670 genes and in silico annotations point to their enrichment in cardiomyocytes and provide insights in their ECG signature. Two-sample Mendelian randomization analyses indicate that higher genetically predicted resting heart rate increases risk of dilated cardiomyopathy, but decreases risk of developing atrial fibrillation, ischemic stroke, and cardio-embolic stroke. We do not find evidence for a linear or non-linear genetic association between resting heart rate and all-cause mortality in contrast to our previous Mendelian randomization study. Systematic alteration of key differences between the current and previous Mendelian randomization study indicates that the most likely cause of the discrepancy between these studies arises from false positive findings in previous one-sample MR analyses caused by weak-instrument bias at lower P-value thresholds. The results extend our understanding of resting heart rate biology and give additional insights in its role in cardiovascular disease development.

Published
2023

5. Association of Air Pollution with a Urinary Biomarker of Biological Aging and Effect Modification by Vitamin K in the FLEMENGHO Prospective Population Study

Author

Martens, Dries S., An, De-Wei, Yu, Yu-Ling, Chori, Babangida S., Wang, Congrong, Silva, Ana Ines, Wei, Fang-Fei, Liu, Chen, Stolarz-Skrzypek, Katarzyna, Rajzer, Marek, Latosinska, Agnieszka, Mischak, Harald, Staessen, Jan A., and Nawrot, Tim S.

Subjects
Urine -- Analysis, Medical research, Medicine, Experimental, Aging -- Health aspects, Environmentally induced diseases -- Risk factors -- Statistics, Vitamin K -- Health aspects, Air pollution -- Health aspects -- Statistics, Biological markers -- Research, Particles -- Health aspects -- Statistics, Environmental issues, Health
Abstract

BACKGROUND: A recently developed urinary peptidomics biological aging clock can be used to study accelerated human aging. From 1990 to 2019, exposure to airborne particulate matter (PM) became the leading environmental risk factor worldwide. OBJECTIVES: This study investigated whether air pollution exposure is associated with accelerated urinary peptidomic aging, independent of calendar age, and whether this association is modified by other risk factors. METHODS: In a Flemish population, the urinary peptidomic profile (UPP) age (UPP-age) was derived from the urinary peptidomic profile measured by capillary electrophoresis coupled with mass spectrometry. UPP-age-R was calculated as the residual of the regression of UPP-age on chronological age, which reflects accelerated aging predicted by UPP-age, independent of chronological age. A high-resolution spatial-temporal interpolation method was used to assess each individual's exposure to P[M.sub.10], P[M.sub.2.5], black carbon (BC), and nitrogen dioxide (N[O.sub.2]). Associations of UPP-age-R with these pollutants were investigated by mixed models, accounting for clustering by residential address and confounders. Effect modifiers of the associations between UPP-age-R and air pollutants that included 18 factors reflecting vascular function, renal function, insulin resistance, lipid metabolism, or inflammation were evaluated. Direct and indirect (via UPP-age-R) effects of air pollution on mortality were evaluated by multivariable-adjusted Cox models. RESULTS: Among 660 participants (50.2% women; mean age: 50.7 y), higher exposure to P[M.sub.10], P[M.sub.2.5], BC, and N[O.sub.2] was associated with a higher UPP-age-R. Studying effect modifiers showed that higher plasma levels of desphospho-uncarboxylated matrix Gla protein (dpucMGP), signifying poorer vitamin K status, steepened the slopes of UPP-age-R on the air pollutants. In further analyses among participants with dpucMGP [greater than or equal to] 4.26 [micro]g/L (median), an interquartile range (IQR) higher level in P[M.sub.10], P[M.sub.2.5], BC, and N[O.sub.2] was associated with a higher UPP-age-R of 2.03 [95% confidence interval (CI): 0.60, 3.46], 2.22 (95% CI: 0.71, 3.74), 2.00 (95% CI: 0.56, 3.43), and 2.09 (95% CI: 0.77, 3.41) y, respectively. UPP-age-R was an indirect mediator of the associations of mortality with the air pollutants [multivariable-adjusted hazard ratios from 1.094 (95% CI: 1.000, 1.196) to 1.110 (95% CI: 1.007, 1.224)] in participants with a high dpucMGP, whereas no direct associations were observed. DISCUSSION: Ambient air pollution was associated with accelerated urinary peptidomics aging, and high vitamin K status showed a potential protective effect in this population. Current guidelines are insufficient to decrease the adverse health effects of airborne pollutants, including healthy aging trajectories. https://doi.org/10.1289/EHP13414, Introduction Over the past 20 y, global life expectancy at birth increased from 67.2 to 73.5 y. (1) In line with this remarkable increase in longevity, global exposure to harmful [...]

Published
2023
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6. SELECTED ECHOCARDIOGRAPHIC AND BLOOD PRESSURE PARAMETERS INCLUDING VENTRICULAR-ARTERIAL COUPLING IN PREDICTING ATRIAL FIBRILLATION RECURRENCE AFTER PULMONARY VEIN ISOLATION

Author

Gaczol, Mateusz, primary, Olszanecka, Agnieszka, additional, Bednarek, Agnieszka, additional, Kusiak, Aleksander, additional, Kielbasa, Grzegorz, additional, Moskal, Pawel, additional, Jastrzebski, Marek, additional, Sondej, Tomasz, additional, Stolarz-skrzypek, Katarzyna, additional, Rajzer, Marek, additional, and Wojciechowska, Wiktoria, additional

Published
2024
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7. ANGIOGENIC MARKERS AS PROGNOSTIC TOOLS IN PATIENTS WITH COVID-19: CRACOV-HHS STUDY

Author

Stolarz-skrzypek, Katarzyna, primary, Olszanecka, Agnieszka, additional, Wojciechowsa, Wiktoria, additional, Kusak, Piotr, additional, Bednarek, Agnieszka, additional, Rusinek, Jakub, additional, Kusnierz-cabala, Beata, additional, Wizner, Barbara, additional, Surdacki, Andrzej, additional, Sanak, Marek, additional, Grodzicki, Tomasz, additional, and Rajzer, Marek, additional

Published
2024
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8. LEAD-ASSOCIATED MORTALITY IN THE US 1999-2020: A TIME-STRATIFIED ANALYSIS OF A NATIONAL COHORT

Author

An, Dewei, primary, Yu, Yuling, additional, Hara, Azusa, additional, Martens, Dries, additional, Yang, Wen -Yi, additional, Cheng, Yi -Bang, additional, Huang, Qi -Fang, additional, Asayama, Kei, additional, Stolarz-skrzypek, Katarzyna, additional, Rajzer, Marek, additional, Verhamme, Peter, additional, Nawrot, Tim, additional, Li, Yan, additional, and Staessen, Jan, additional

Published
2024
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10. Management of hypertensive disorders in pregnancy: a Position Statement of the European Society of Hypertension Working Group 'Hypertension in Women'.

Author

Thomopoulos, Costas, Hitij, Jana Brguljan, De Backer, Tine, Gkaliagkousi, Eugenia, Kreutz, Reinhold, Lopez-Sublet, Marilucy, Marketou, Maria, Mihailidou, Anastasia S., Olszanecka, Agnieszka, Pechère-Bertschi, Antoinette, Paula Pérez, Mariana, Persu, Alexandre, Piani, Federica, Socrates, Thenral, Stolarz-Skrzypek, Katarzyna, and Cífková, Renata

Published
2024
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12. Angiotensin-converting enzyme inhibitors and angiotensin-II-receptor antagonists modulate sodium handling assessed by endogenous lithium clearance

Author

Cwynar, Marcin, primary, Stolarz-Skrzypek, Katarzyna, additional, Gąsowski, Jerzy, additional, Wizner, Barbara, additional, Wojciechowska, Wiktoria, additional, Olszanecka, Agnieszka, additional, Gryglewska, Barbara, additional, Dzieża-Grudnik, Anna, additional, Bednarski, Adam, additional, Krośniak, Mirosław, additional, Bartoń, Henryk, additional, Kawecka-Jaszcz, Kalina, additional, Rajzer, Marek, additional, and Grodzicki, Tomasz, additional

Published
2024
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13. Mortality and Cardiovascular End Points In Relation to the Aortic Pulse Wave Components: An Individual-Participant Meta-Analysis.

Author

Norton, Gavin R., An, De-Wei, Aparicio, Lucas S., Yu, Yu-Ling, Wei, Fang-Fei, Niiranen, Teemu J., Liu, Chen, Stolarz-Skrzypek, Katarzyna, Wojciechowska, Wiktoria, Jula, Antti M., Rajzer, Marek, Martens, Dries S., Verhamme, Peter, Li, Yan, Kawecka-Jaszcz, Kalina, Nawrot, Tim S., Staessen, Jan A., and Woodiwiss, Angela J.

Abstract

BACKGROUND: Wave separation analysis enables individualized evaluation of the aortic pulse wave components. Previous studies focused on the pressure height with overall positive but differing results. In the present analysis, we assessed the associations of the pressure of forward and backward (Pfor and Pref) pulse waves with prospective cardiovascular end points, with extended analysis for time to pressure peak (Tfor and Tref). METHODS: Participants in 3 IDCARS (International Database of Central Arterial Properties for Risk Stratification) cohorts (Argentina, Belgium, and Finland) aged ≥20 years with valid pulse wave analysis and follow-up data were included. Pulse wave analysis was done using the SphygmoCor device, and pulse wave separation was done using the triangular method. The primary end points consisted of cardiovascular mortality and nonfatal cardiovascular and cerebrovascular events. Multivariable-adjusted Cox regression was used to calculate hazard ratios. RESULTS: A total of 2206 participants (mean age, 57.0 years; 55.0% women) were analyzed. Mean±SDs for Pfor, Pref, Tfor, and Tfor/Tref were 31.0±9.1 mm Hg, 20.8±8.4 mm Hg, 130.8±35.5, and 0.51±0.11, respectively. Over a median follow-up of 4.4 years, 146 (6.6%) participants experienced a primary end point. Every 1 SD increment in Pfor, Tfor, and Tfor/Tref was associated with 27% (95% CI, 1.07–1.49), 25% (95% CI, 1.07–1.45), and 32% (95% CI, 1.12–1.56) higher risk, respectively. Adding Tfor and Tfor/Tref to existing risk models improved model prediction (∆Uno's C, 0.020; P <0.01). CONCLUSIONS: Pulse wave components were predictive of composite cardiovascular end points, with Tfor/Tref showing significant improvement in risk prediction. Pending further confirmation, the ratio of time to forward and backward pressure peak may be useful to evaluate increased afterload and signify increased cardiovascular risk. [ABSTRACT FROM AUTHOR]

Published
2024
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14. The sodium–chloride difference: A marker of prognosis in patients with acute myocardial infarction.

Author

Terlecki, Michał, Kocowska‐Trytko, Maryla, Kurzyca, Aleksandra, Pavlinec, Christopher, Zając, Maciej, Rusinek, Jakub, Lis, Paweł, Bednarski, Adam, Wojciechowska, Wiktoria, Stolarz‐Skrzypek, Katarzyna, and Rajzer, Marek

Subjects
MYOCARDIAL infarction, CHLORIDE ions, SODIUM ions
Abstract

Background: The difference between serum sodium and chloride ion concentrations (SCD) may be considered as a surrogate of a strong ion difference and may help to identify patients with a worse prognosis. We aimed to assess SCD as an early prognostic marker among patients with myocardial infarction. Methods: Data of 594 consecutive patients with acute myocardial infarction treated with PCI (44.9% STEMI patients; 70.7% males) was analysed for SCD in relation to their 30‐day mortality. A restricted cubic spline regression model was used to study the relationship between mortality and SCD. Cox regression models were used to assess the association between SCD and the mortality risk. Results: Patients with Killip class ≥3 had lower SCD values in comparison to patients with Killip class ≤2: (32.0 [30.0–34.0] vs. 33.0 [31.0–36.0], p =.006). The overall 30‐day mortality was 7.7% (n = 46). There was a significant difference in SCD values between survivors and non‐survivors groups of patients (median (IQR): (33.0 [31.0–36.0] vs. 31.5 [28.0–34.0] (mmol/L), p =.002). The restricted cubic splines model confirmed a non‐linear association between SCD and mortality. Patients with SCD <30 mmol/L (in comparison to SCD ≥30 mmol/L) had an increased mortality risk (unadjusted HR 2.92, 95% CI 1.59–5.36, p =.001; and an adjusted HR 2.30, 95% CI 1.02–5.19, p =.04). Conclusions: Low SCD on admission is associated with an increased risk of 30‐day mortality in patients with acute myocardial infarction treated with PCI and may serve as a useful prognostic marker for these patients. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Isolated Diastolic Hypertension in the IDACO Study: An Age-Stratified Analysis Using 24-Hour Ambulatory Blood Pressure Measurements

Author

McEvoy, John W., Yang, Wen-Yi, Thijs, Lutgarde, Zhang, Zhen-Yu, Melgarejo, Jesus D., Boggia, José, Hansen, Tine W., Asayama, Kei, Ohkubo, Takayoshi, Dolan, Eamon, Stolarz-Skrzypek, Katarzyna, Malyutina, Sofia, Casiglia, Edoardo, Lind, Lars, Filipovský, Jan, Maestre, Gladys E., Li, Yan, Wang, Ji-Guang, Imai, Yutaka, Kawecka-Jaszcz, Kalina, Sandoya, Edgardo, Narkiewicz, Krzysztof, O’Brien, Eoin, Vanassche, Thomas, and Staessen, Jan A.

Published
2021
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22. Serial echocardiographic evaluation of COVID-19 patients without prior history of structural heart disease: a 1-year follow-up CRACoV-HHS study

Author

Olszanecka, Agnieszka, primary, Wojciechowska, Wiktoria, additional, Bednarek, Agnieszka, additional, Kusak, Piotr, additional, Wizner, Barbara, additional, Terlecki, Michał, additional, Stolarz-Skrzypek, Katarzyna, additional, Klocek, Marek, additional, Drożdż, Tomasz, additional, Sładek, Krzysztof, additional, Bociąga-Jasik, Monika, additional, Garlicki, Aleksander, additional, Rewiuk, Krzysztof, additional, Matyja, Andrzej, additional, Małecki, Maciej, additional, Sydor, Wojciech, additional, Krzanowski, Marcin, additional, Grodzicki, Tomasz, additional, and Rajzer, Marek, additional

Published
2023
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23. Blood pressure and cardiovascular risk in relation to birth weight and urinary sodium: an individual-participant meta-analysis of European family-based population studies

Author

Yu, Yu-Ling, Moliterno, Paula, An, De-Wei, Raaijmakers, Anke, Martens, Dries S, Stolarz-Skrzypek, Katarzyna, Tikhonoff, Valerie, Malyutina, Sofia, Casiglia, Edoardo, Chori, Babangida, Filipovsky, Jan, Rajzer, Marek, Allegaert, Karel, Kawecka-Jaszcz, Kalina, Verhamme, Peter, Nawrot, Tim S, Staessen, Jan A, Boggia, Jose, Yu, Yu-Ling, Moliterno, Paula, An, De-Wei, Raaijmakers, Anke, MARTENS, Dries, Stolarz-Skrzypek, Katarzyna, Tikhonoff, Valérie, Malyutina, Sofia, Casiglia, Edoardo, Filipovský, Jan, CHORI, Babangida, Rajzer, Marek, Allegaert, Karel, Kawecka-Jaszcz, Kalina, Verhamme, Peter, NAWROT, Tim, Staessen, Jan A., and Boggia, José

Subjects
hypertension, urinary sodium excretion, HDL, interquartile range, Physiology, FLEMENGHO, high-density lipoprotein, European Project on Genes in Hypertension, Genes and Health Outcomes, 24-h urinary sodium excretion, BP, urinary sodium-to-potassium ratio, eGFR, Internal Medicine, BW, total mortality, EPOGH, UVNA, cardiovascular risks, IQR, birth weight, blood pressure, 95%CI, UNAK, 95%confidence interval, Cardiology and Cardiovascular Medicine, estimated glomerular filtration rate derived from serum creatinine, Flemish Study on Environment
Abstract

BACKGROUND: Although the relation of salt intake with blood pressure (BP) is linear, it is U-shaped for mortality and cardiovascular disease (CVD). This individual-participant meta-analysis explored whether the relation of hypertension, death or CVD with 24-h urinary sodium excretion (UVNA) or sodium-to-potassium (UNAK) ratio was modified by birth weight. METHODS: Families were randomly enrolled in the Flemish Study on Genes, Environment and Health Outcomes (1985-2004) and the European Project on Genes in Hypertension (1999-2001). Categories of birth weight, UVNA and UNAK (≤2500, >2500-4000, >4000 g; 4.6 g; and 2, respectively) were coded using deviation-from-mean coding and analyzed by Kaplan-Meier survival functions and linear and Cox regression. RESULTS: The study population was subdivided into the Outcome ( n = 1945), Hypertension ( n = 1460) and Blood Pressure cohorts ( n = 1039) to analyze the incidence of mortality and cardiovascular endpoints, hypertension and BP changes as function of UVNA changes. The prevalence of low/medium/high birth weight in the Outcome cohort was 5.8/84.5/9.7%. Over 16.7 years (median), rates were 4.9, 8 and 27.1% for mortality, CVD and hypertension, respectively, but were not associated with birth weight. Multivariable-adjusted hazard ratios were not significant for any endpoint in any of the birth weight, UVNA and UNAK strata. Adult body weight tracked with birth weight ( P

Published
2023

24. Association of Fatal and Nonfatal Cardiovascular Outcomes With 24-Hour Mean Arterial Pressure

Author

Melgarejo, Jesus D., Yang, Wen-Yi, Thijs, Lutgarde, Li, Yan, Asayama, Kei, Hansen, Tine W., Wei, Fang-Fei, Kikuya, Masahiro, Ohkubo, Takayoshi, Dolan, Eamon, Stolarz-Skrzypek, Katarzyna, Huang, Qi-Fang, Tikhonoff, Valérie, Malyutina, Sofia, Casiglia, Edoardo, Lind, Lars, Sandoya, Edgardo, Filipovský, Jan, Gilis-Malinowska, Natasza, Narkiewicz, Krzysztof, Kawecka-Jaszcz, Kalina, Boggia, José, Wang, Ji-Guang, Imai, Yutaka, Vanassche, Thomas, Verhamme, Peter, Janssens, Stefan, O’Brien, Eoin, Maestre, Gladys E., Staessen, Jan A., and Zhang, Zhen-Yu

Published
2021
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25. Urinary proteomics combined with home blood pressure telemonitoring for health care reform trial—First progress report

Author

Chori, Babangida S., An, De‐Wei, Martens, Dries S., Yu, Yu‐Ling, Gilis-Malinowska, Natasza, Abubakar, Sani M., Ibrahim, Etubi A., Ajanya, Ojonojima, Abiodun, Olugbenga O., Anya, Tina, Tobechukwu, Iyidobi, Isiguzo, Godsent, Cheng, Hao‐Min, Chen, Chen‐Huan, Liao, Chia‐Te, Mokwatsi, Gontse, Stolarz-Skrzypek, Katarzyna, Wojciechowska, Wiktoria, Narkiewicz, Krzysztof, Rajzer, Marek, Brguljan‐Hitij, Jana, Nawrot, Tim, Asayama, Kei, Reyskens, Peter, Mischak, Harald, Odili, Augustine N., Staessen, Jan A., CHORI, Babangida, An, De‐Wei, MARTENS, Dries, Yu, Yu‐Ling, Gilis‐Malinowska, Natasza, Abubakar, Sani M., Ibrahim, Etubi A., Ajanya, Ojonojima, Abiodun, Olugbenga O., Anya, Tina, Tobechukwu, Iyidobi, Isiguzo, Godsent, Cheng, Hao‐Min, Chen, Chen‐Huan, Liao, Chia‐Te, Mokwatsi, Gontse, Stolarz‐Skrzypek, Katarzyna, Wojciechowska, Wiktoria, Narkiewicz, Krzysztof, Rajzer, Marek, Brguljan‐Hitij, Jana, NAWROT, Tim, Asayama, Kei, Reyskens, Peter, Mischak, Harald, Odili, Augustine N., and Staessen, Jan A.

Subjects
left ventricular function, hypertension, Chronic kidney disease, diabetic nephropathy, home blood pressure telemonitoring, type-2 diabetes mellitus
Abstract

Background Hypertension and diabetes cause chronic kidney disease (CKD) and diastolic left ventricular dysfunction (DVD) as forerunners of disability and death. Home blood pressure telemonitoring (HTM) and urinary peptidomic profiling (UPP) are technologies enabling prevention. Methods UPRIGHT-HTM (Urinary Proteomics Combined with Home Blood Pressure Telemonitoring for Health Care Reform [NCT04299529]) is an investigator-initiated 5-year clinical trial with patient-centred design, which will randomise 1148 patients to be recruited in Europe, sub-Saharan Africa and South America. During the whole study, HTM data will be collected and freely accessible for patients and caregivers. The UPP, measured at enrolment only, will be communicated early during follow-up to 50% of patients and their caregivers (intervention), but only at trial closure in 50% (control). The hypothesis is that early knowledge of the UPP risk profile will lead to more rigorous risk factor management and result in benefit. Eligible patients, aged 55-75 years old, are asymptomatic, but have >= 5 CKD- or DVD-related risk factors, preferably including hypertension, type-2 diabetes, or both. The primary endpoint is a composite of new-onset intermediate and hard cardiovascular and renal outcomes. Demonstrating that combining UPP with HTM is feasible in a multicultural context and defining the molecular signatures of early CKD and DVD are secondary endpoints. Expected outcomes The expected outcome is that application of UPP on top of HTM will be superior to HTM alone in the prevention of CKD and DVD and associated complications and that UPP allows shifting emphasis from treating to preventing disease, thereby empowering patients. The authors gratefully acknowledge the enthusiasm of the patientsenrolled in UPRIGHT-HTM and the expert assistance of the consul-tants, residents and nursing staff supporting the trial at the clinicalsites. The Alliance for the Promotion of Preventive Medicine is anot-profitresearchinstitute(URL:www.appremed.org;Belgianregis-trationnumber,739849385),whichreceivedanon-bindinggrantfromOMRONHealthcareCo.Ltd.,Kyoto,Japan.UPRIGHT-HTMisaTopZprojectsupportedbyOMRONHealthcareCo.Ltd.,Kyoto,Japan

Published
2023

28. Cardiovascular End Points and Mortality Are Not Closer Associated With Central Than Peripheral Pulsatile Blood Pressure Components

Author

Huang, Qi-Fang, Aparicio, Lucas S., Thijs, Lutgarde, Wei, Fang-Fei, Melgarejo, Jesus D., Cheng, Yi-Bang, Sheng, Chang-Sheng, Yang, Wen-Yi, Gilis-Malinowska, Natasza, Boggia, José, Niiranen, Teemu J., Wojciechowska, Wiktoria, Stolarz-Skrzypek, Katarzyna, Barochiner, Jessica, Ackermann, Daniel, Tikhonoff, Valérie, Ponte, Belen, Pruijm, Menno, Casiglia, Edoardo, Narkiewicz, Krzysztof, Filipovský, Jan, Czarnecka, Danuta, Kawecka-Jaszcz, Kalina, Jula, Antti M., Bochud, Murielle, Vanassche, Thomas, Verhamme, Peter, Struijker-Boudier, Harry A.J., Wang, Ji-Guang, Zhang, Zhen-Yu, Li, Yan, and Staessen, Jan A.

Published
2020
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30. Opposing Age-Related Trends in Absolute and Relative Risk of Adverse Health Outcomes Associated With Out-of-Office Blood Pressure

Author

Li, Yan, Thijs, Lutgarde, Zhang, Zhen-Yu, Asayama, Kei, Hansen, Tine W., Boggia, José, Björklund-Bodegård, Kristina, Yang, Wen-Yi, Niiranen, Teemu J., Ntineri, Angeliki, Wei, Fang-Fei, Kikuya, Masahiro, Ohkubo, Takayoshi, Dolan, Eamon, Hozawa, Atsushi, Tsuji, Ichiro, Stolarz-Skrzypek, Katarzyna, Huang, Qi-Fang, Melgarejo, Jesus D., Tikhonoff, Valérie, Malyutina, Sofia, Casiglia, Edoardo, Nikitin, Yuri, Lind, Lars, Sandoya, Edgardo, Aparicio, Lucas, Barochiner, Jessica, Gilis-Malinowska, Natasza, Narkiewicz, Krzysztof, Kawecka-Jaszcz, Kalina, Maestre, Gladys E., Jula, Antti M., Johansson, Jouni K., Kuznetsova, Tatiana, Filipovský, Jan, Stergiou, George, Wang, Ji-Guang, Imai, Yutaka, OʼBrien, Eoin, and Staessen, Jan A.

Published
2019
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31. Outcome-Driven Thresholds for Ambulatory Blood Pressure Based on the New American College of Cardiology/American Heart Association Classification of Hypertension

Author

Cheng, Yi-Bang, Thijs, Lutgarde, Zhang, Zhen-Yu, Kikuya, Masahiro, Yang, Wen-Yi, Melgarejo, Jesus D., Boggia, José, Wei, Fang-Fei, Hansen, Tine W., Yu, Cai-Guo, Asayama, Kei, Ohkubo, Takayoshi, Dolan, Eamon, Stolarz-Skrzypek, Katarzyna, Malyutina, Sofia, Casiglia, Edoardo, Lind, Lars, Filipovský, Jan, Maestre, Gladys E., Imai, Yutaka, Kawecka-Jaszcz, Kalina, Sandoya, Edgardo, Narkiewicz, Krzysztof, Li, Yan, O’Brien, Eoin, Wang, Ji-Guang, and Staessen, Jan A.

Published
2019
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32. Risk Stratification by Cross-Classification of Central and Brachial Systolic Blood Pressure

Author

Cheng, Yi-Bang, Thijs, Lutgarde, Aparicio, Lucas S., Huang, Qi-Fang, Wei, Fang-Fei, Yu, Yu-Ling, Barochiner, Jessica, Sheng, Chang-Sheng, Yang, Wen-Yi, Niiranen, Teemu J., Boggia, Jose, Zhang, Zhen-Yu, Stolarz-Skrzypek, Katarzyna, Gilis-Malinowska, Natasza, Tikhonoff, Valerie, Wojciechowska, Wiktoria, Casiglia, Edoardo, Narkiewicz, Krzysztof, Filipovsky, Jan, Kawecka-Jaszcz, Kalina, Wang, Ji-Guang, Li, Yan, and Staessen, Jan A.

Subjects
cardiovascular risk, Male, brachial blood pressure, hypertension, Brachial Artery, Physiology, central blood pressure, Blood Pressure, Blood Pressure Determination, Middle Aged, mortality, Risk Assessment, population science, Female, Humans, Hypertension, Internal Medicine, Cardiology and Cardiovascular Medicine
Abstract

Background: Whether cardiovascular risk is more tightly associated with central (cSBP) than brachial (bSBP) systolic pressure remains debated, because of their close correlation and uncertain thresholds to differentiate cSBP into normotension versus hypertension. Methods: In a person-level meta-analysis of the International Database of Central Arterial Properties for Risk Stratification (n=5576; 54.1% women; mean age 54.2 years), outcome-driven thresholds for cSBP were determined and whether the cross-classification of cSBP and bSBP improved risk stratification was explored. cSBP was tonometrically estimated from the radial pulse wave using SphygmoCor software. Results: Over 4.1 years (median), 255 composite cardiovascular end points occurred. In multivariable bootstrapped analyses, cSBP thresholds (in mm Hg) of 110.5 (95% CI, 109.1–111.8), 120.2 (119.4–121.0), 130.0 (129.6–130.3), and 149.5 (148.4–150.5) generated 5-year cardiovascular risks equivalent to the American College of Cardiology/American Heart Association bSBP thresholds of 120, 130, 140, and 160. Applying 120/130 mm Hg as cSBP/bSBP thresholds delineated concordant central and brachial normotension (43.1%) and hypertension (48.2%) versus isolated brachial hypertension (5.0%) and isolated central hypertension (3.7%). With concordant normotension as reference, the multivariable hazard ratios for the cardiovascular end point were 1.30 (95% CI, 0.58–2.94) for isolated brachial hypertension, 2.28 (1.21–4.30) for isolated central hypertension, and 2.02 (1.41–2.91) for concordant hypertension. The increased cardiovascular risk associated with isolated central and concordant hypertension was paralleled by cerebrovascular end points with hazard ratios of 3.71 (1.37–10.06) and 2.60 (1.35–5.00), respectively. Conclusions: Irrespective of the brachial blood pressure status, central hypertension increased cardiovascular and cerebrovascular risk indicating the importance of controlling central hypertension.

Published
2022

34. Lead-Associated Mortality&nbsp;In the US&nbsp;1999-2020: Aggregate and Time-Stratified Analyses of a National Cohort

Author

An, De-Wei, primary, Yu, Yu-Ling, additional, Hara, Azusa, additional, Martens, Dries S., additional, Yang, Wen-Yi, additional, Cheng, Yi-Bang, additional, Huang, Qi-Fang, additional, Asayama, Kei, additional, Stolarz-Skrzypek, Katarzyna, additional, Rajzer, Marek W., additional, Verhamme, Peter, additional, Nawrot, Tim S., additional, Li, Yan, additional, and Staessen, Jan, additional

Published
2023
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38. Derivation of an Outcome-Driven Threshold for Aortic Pulse Wave Velocity: An Individual-Participant Meta-Analysis.

Author

De-Wei An, Hansen, Tine W., Aparicio, Lucas S., Chori, Babangida, Qi-Fang Huang, Fang-Fei Wei, Yi-Bang Cheng, Yu-Ling Yu, Chang-Sheng Sheng, Gilis-Malinowska, Natasza, Boggia, José, Wojciechowska, Wiktoria, Niiranen, Teemu J., Tikhonoff, Valérie, Casiglia, Edoardo, Narkiewicz, Krzysztof, Stolarz-Skrzypek, Katarzyna, Kawecka-Jaszcz, Kalina, Jula, Antti M., and Wen-Yi Yang

Abstract

BACKGROUND: Aortic pulse wave velocity (PWV) predicts cardiovascular events (CVEs) and total mortality (TM), but previous studies proposing actionable PWV thresholds have limited generalizability. This individual-participant meta-analysis is aimed at defining, testing calibration, and validating an outcome-driven threshold for PWV, using 2 populations studies, respectively, for derivation IDCARS (International Database of Central Arterial Properties for Risk Stratification) and replication MONICA (Monitoring of Trends and Determinants in Cardiovascular Disease Health Survey - Copenhagen). METHODS: A risk-carrying PWV threshold for CVE and TM was defined by multivariable Cox regression, using stepwise increasing PWV thresholds and by determining the threshold yielding a 5-year risk equivalent with systolic blood pressure of 140 mm Hg. The predictive performance of the PWV threshold was assessed by computing the integrated discrimination improvement and the net reclassification improvement. RESULTS: In well-calibrated models in IDCARS, the risk-carrying PWV thresholds converged at 9 m/s (10 m/s considering the anatomic pulse wave travel distance). With full adjustments applied, the threshold predicted CVE (hazard ratio [CI]: 1.68 [1.15-2.45]) and TM (1.61 [1.01-2.55]) in IDCARS and in MONICA (1.40 [1.09-1.79] and 1.55 [1.23-1.95]). In IDCARS and MONICA, the predictive accuracy of the threshold for both end points was ≈-0.75. Integrated discrimination improvement was significant for TM in IDCARS and for both TM and CVE in MONICA, whereas net reclassification improvement was not for any outcome. CONCLUSIONS: PWV integrates multiple risk factors into a single variable and might replace a large panel of traditional risk factors. Exceeding the outcome-driven PWV threshold should motivate clinicians to stringent management of risk factors, in particular hypertension, which over a person's lifetime causes stiffening of the elastic arteries as waypoint to CVE and death. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Predictive power of 24-h ambulatory pulse pressure and its components for mortality and cardiovascular outcomes in 11 848 participants recruited from 13 populations

Author

Gavish, Benjamin, primary, Bursztyn, Michael, additional, Thijs, Lutgarde, additional, Wei, Dong-Mei, additional, Melgarejo, Jesus D., additional, Zhang, Zhen-Yu, additional, Boggia, José, additional, Hansen, Tine W., additional, Asayama, Kei, additional, Ohkubo, Takayoshi, additional, Kikuya, Masahiro, additional, Yang, Wen-Yi, additional, Stolarz-Skrzypek, Katarzyna, additional, Malyutina, Sofia, additional, Casiglia, Edoardo, additional, Lind, Lars, additional, Li, Yan, additional, Kawecka-Jaszcz, Kalina, additional, Filipovský, Jan, additional, Tikhonoff, Valérie, additional, Gilis-Malinowska, Natasza, additional, Dolan, Eamon, additional, Sandoya, Edgardo, additional, Narkiewicz, Krzysztof, additional, Wang, Ji-Guang, additional, Imai, Yutaka, additional, Maestre, Gladys E., additional, O’Brien, Eoin, additional, and Staessen, Jan A., additional

Published
2022
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45. Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Author

Nolte, Ilja M., Munoz, M. Loretto, Tragante, Vinicius, Amare, Azmeraw T., Jansen, Rick, Vaez, Ahmad, von der Heyde, Benedikt, Avery, Christy L., Bis, Joshua C., Dierckx, Bram, van Dongen, Jenny, Gogarten, Stephanie M., Goyette, Philippe, Hernesniemi, Jussi, Huikari, Ville, Hwang, Shih-Jen, Jaju, Deepali, Kerr, Kathleen F., Kluttig, Alexander, Krijthe, Bouwe P., Kumar, Jitender, van der Laan, Sander W., Lyytikäinen, Leo-Pekka, Maihofer, Adam X., Minassian, Arpi, van der Most, Peter J., Müller-Nurasyid, Martina, Nivard, Michel, Salvi, Erika, Stewart, James D., Thayer, Julian F., Verweij, Niek, Wong, Andrew, Zabaneh, Delilah, Zafarmand, Mohammad H., Abdellaoui, Abdel, Albarwani, Sulayma, Albert, Christine, Alonso, Alvaro, Ashar, Foram, Auvinen, Juha, Axelsson, Tomas, Baker, Dewleen G., de Bakker, Paul I. W., Barcella, Matteo, Bayoumi, Riad, Bieringa, Rob J., Boomsma, Dorret, Boucher, Gabrielle, Britton, Annie R., Christophersen, Ingrid, Dietrich, Andrea, Ehret, George B., Ellinor, Patrick T., Eskola, Markku, Felix, Janine F., Floras, John S., Franco, Oscar H., Friberg, Peter, Gademan, Maaike G. J., Geyer, Mark A., Giedraitis, Vilmantas, Hartman, Catharina A., Hemerich, Daiane, Hofman, Albert, Hottenga, Jouke-Jan, Huikuri, Heikki, Hutri-Kähönen, Nina, Jouven, Xavier, Junttila, Juhani, Juonala, Markus, Kiviniemi, Antti M., Kors, Jan A., Kumari, Meena, Kuznetsova, Tatiana, Laurie, Cathy C., Lefrandt, Joop D., Li, Yong, Li, Yun, Liao, Duanping, Limacher, Marian C., Lin, Henry J., Lindgren, Cecilia M., Lubitz, Steven A., Mahajan, Anubha, McKnight, Barbara, zu Schwabedissen, Henriette Meyer, Milaneschi, Yuri, Mononen, Nina, Morris, Andrew P., Nalls, Mike A., Navis, Gerjan, Neijts, Melanie, Nikus, Kjell, North, Kari E., O'Connor, Daniel T., Ormel, Johan, Perz, Siegfried, Peters, Annette, Psaty, Bruce M., Raitakari, Olli T., Risbrough, Victoria B., Sinner, Moritz F., Siscovick, David, Smit, Johannes H., Smith, Nicholas L., Soliman, Elsayed Z., Sotoodehnia, Nona, Staessen, Jan A., Stein, Phyllis K., Stilp, Adrienne M., Stolarz-Skrzypek, Katarzyna, Strauch, Konstantin, Sundström, Johan, Swenne, Cees A., Syvänen, Ann-Christine, Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thornton, Timothy A., Tinker, Lesley E., Uitterlinden, André G., van Setten, Jessica, Voss, Andreas, Waldenberger, Melanie, Wilhelmsen, Kirk C., Willemsen, Gonneke, Wong, Quenna, Zhang, Zhu-Ming, Zonderman, Alan B, Cusi, Daniele, Evans, Michele K., Greiser, Halina K., van der Harst, Pim, Hassan, Mohammad, Ingelsson, Erik, Järvelin, Marjo-Riitta, Kääb, Stefan, Kähönen, Mika, Kivimaki, Mika, Kooperberg, Charles, Kuh, Diana, Lehtimäki, Terho, Lind, Lars, Nievergelt, Caroline M., O'Donnell, Chris J., Oldehinkel, Albertine J., Penninx, Brenda, Reiner, Alexander P., Riese, Harriëtte, van Roon, Arie M., Rioux, John D., Rotter, Jerome I., Sofer, Tamar, Stricker, Bruno H., Tiemeier, Henning, Vrijkotte, Tanja G. M., Asselbergs, Folkert W., Brundel, Bianca J. J.M, Heckbert, Susan R., Whitsel, Eric A., den Hoed, Marcel, Snieder, Harold, and de Geus, Eco J. C.

Published
2017
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47. OUTCOME-BASED THRESHOLD FOR CAROTID-FEMORAL PULSE WAVE VELOCITY: THE IDCARS STUDY

Author

An, Dewei, primary, Cheng, Yi-Bang, additional, Aparicio, Lucas S., additional, Thijs, Lutgarde, additional, Huang, Qi-Fang, additional, Wei, Fang-Fei, additional, Barochiner, Jessica, additional, Sheng, Chang-Sheng, additional, Yang, Wen-Yi, additional, Niiranen, Teemu J., additional, Boggia, José, additional, Stolarz-Skrzypek, Katarzyna, additional, Gilis-Malinowska, Natasza, additional, Tikhonoff, Valérie, additional, Wojciechowska, Wiktoria, additional, Casiglia, Edoardo, additional, Narkiewicz, Krzysztof, additional, Filipovský, Jan, additional, Kawecka-Jaszcz, Kalina, additional, Wang, Ji-Guang, additional, Li, Yan, additional, and Staessen, Jan A., additional

Published
2022
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48. RISK STRATIFICATION BY CROSS-CLASSIFICATION OF CENTRAL AND BRACHIAL SYSTOLIC BLOOD PRESSURE

Author

Cheng, Yi-Bang, primary, Thijs, Lutgarde, additional, Aparicio, Lucas S., additional, Huang, Qi-Fang, additional, Wei, Fang-Fei, additional, Yu, Yu-Ling, additional, Barochiner, Jessica, additional, Sheng, Chang-Sheng, additional, Yang, Wen-Yi, additional, Niiranen, Teemu J., additional, Boggia, José, additional, Zhang, Zhen-Yu, additional, Stolarz-Skrzypek, Katarzyna, additional, Gilis-Malinowska, Natasza, additional, Tikhonoff, Valérie, additional, Wojciechowska, Wiktoria, additional, Casiglia, Edoardo, additional, Narkiewicz, Krzysztof, additional, Filipovský, Jan, additional, Kawecka-Jaszcz, Kalina, additional, Wang, Ji-Guang, additional, Li, Yan, additional, and Staessen, Jan A., additional

Published
2022
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