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2. Martian fluvial conglomerates at gale crater

Author

Williams, R. M. E., Grotzinger, J. P., Dietrich, W. E., Gupta, S., Sumner, D. Y., Wiens, R. C., Mangold, N., Malin, M. C., Edgett, K. S., Maurice, S., Forni, O., Gasnault, O., Ollila, A., Newsom, H. E., Dromart, G., Palucis, M. C., Yingst, R. A., Anderson, R. B., Herkenhoff, K. E., Le Mouelic, S., Goetz, W., Madsen, M. B., Koefoed, A., Jensen, J. K., Bridges, J. C., Schwenzer, S. P., Lewis, K. W., Stack, K. M., Rubin, D., Kah, L. C., Bell, J. F., Farmer, J. D., Sullivan, R., Van Beek, T., Blaney, D. L., Pariser, O., Deen, R. G., Kemppinen, O., Bridges, N., Johnson, J. R., Minitti, M., Cremers, D., Edgar, L., Godber, A., Wadhwa, M., Wellington, D., McEwan, I., Newman, C., Richardson, M., Charpentier, A., Peret, L., King, P., Blank, J., Weigle, G., Schmidt, M., Li, S., Milliken, R., Robertson, K., Sun, V., Baker, M., Edwards, C., Ehlmann, B., Farley, K., Griffes, J., Miller, H., Newcombe, M., Pilorget, C., Rice, M., Siebach, K., Stolper, E., Brunet, C., Hipkin, V., Leveille, R., Marchand, G., Sobron Sanchez, P., Favot, L., Cody, G., Steele, A., Fluckiger, L., Lees, D., Nefian, A., Martin, M., Gailhanou, M., Westall, F., Israel, G., Agard, C., Baroukh, J., Donny, C., Gaboriaud, A., Guillemot, P., Lafaille, V., Lorigny, E., Paillet, A., Perez, R., Saccoccio, M., Yana, C., Aparicio, C. A., Caride Rodriguez, J., Carrasco Blazquez, I., Gomez Gomez, F., Elvira, J. G., Hettrich, S., Lepinette Malvitte, A., Marin Jimenez, M., Frias, J. M., Soler, J. M., Torres, F. J. M., Molina Jurado, A., Sotomayor, L. M., Munoz Caro, G., Navarro Lopez, S., Gonzalez, V. P., Garcia, J. P., Rodriguez Manfredi, J. A., Planello, J. J. R., Alejandra Sans Fuentes, S., Sebastian Martinez, E., Torres Redondo, J., O'Callaghan, R. U., Zorzano Mier, M.-P., Chipera, S., Lacour, J.-L., Mauchien, P., Sirven, J.-B., Manning, H., Fairen, A., Hayes, A., Joseph, J., Squyres, S., Thomas, P., Dupont, A., Lundberg, A., Melikechi, N., Mezzacappa, A., DeMarines, J., Grinspoon, D., Reitz, G., Prats, B., Atlaskin, E., Genzer, M., Harri, A.-M., Haukka, H., Kahanpaa, H., Kauhanen, J., Paton, M., Polkko, J., Schmidt, W., Siili, T., Fabre, C., Wray, J., Wilhelm, M. B., Poitrasson, F., Patel, K., Gorevan, S., Indyk, S., Paulsen, G., Bish, D., Schieber, J., Gondet, B., Langevin, Y., Geffroy, C., Baratoux, D., Berger, G., Cros, A., Uston, C. d., Lasue, J., Lee, Q.-M., Meslin, P.-Y., Pallier, E., Parot, Y., Pinet, P., Schroder, S., Toplis, M., Lewin, E., Brunner, W., Heydari, E., Achilles, C., Oehler, D., Sutter, B., Cabane, M., Coscia, D., Szopa, C., Robert, F., Sautter, V., Nachon, M., Buch, A., Stalport, F., Coll, P., Francois, P., Raulin, F., Teinturier, S., Cameron, J., Clegg, S., Cousin, A., DeLapp, D., Dingler, R., Jackson, R. S., Johnstone, S., Lanza, N., Little, C., Nelson, T., Williams, R. B., Jones, A., Kirkland, L., Treiman, A., Baker, B., Cantor, B., Caplinger, M., Davis, S., Duston, B., Fay, D., Hardgrove, C., Harker, D., Herrera, P., Jensen, E., Kennedy, M. R., Krezoski, G., Krysak, D., Lipkaman, L., McCartney, E., McNair, S., Nixon, B., Posiolova, L., Ravine, M., Salamon, A., Saper, L., Stoiber, K., Supulver, K., Van Beek, J., Zimdar, R., French, K. L., Iagnemma, K., Miller, K., Summons, R., Goesmann, F., Hviid, S., Johnson, M., Lefavor, M., Lyness, E., Breves, E., Dyar, M. D., Fassett, C., Blake, D. F., Bristow, T., DesMarais, D., Edwards, L., Haberle, R., Hoehler, T., Hollingsworth, J., Kahre, M., Keely, L., McKay, C., Bleacher, L., Brinckerhoff, W., Choi, D., Conrad, P., Dworkin, J. P., Eigenbrode, J., Floyd, M., Freissinet, C., Garvin, J., Glavin, D., Harpold, D., Mahaffy, P., Martin, D. K., McAdam, A., Pavlov, A., Raaen, E., Smith, M. D., Stern, J., Tan, F., Trainer, M., Meyer, M., Posner, A., Voytek, M., Anderson, R. C., Aubrey, A., Beegle, L. W., Behar, A., Brinza, D., Calef, F., Christensen, L., Crisp, J. A., DeFlores, L., Feldman, J., Feldman, S., Flesch, G., Hurowitz, J., Jun, I., Keymeulen, D., Maki, J., Mischna, M., Morookian, J. M., Parker, T., Pavri, B., Schoppers, M., Sengstacken, A., Simmonds, J. J., Spanovich, N., de la Torre Juarez, M., Vasavada, A. R., Webster, C. R., Yen, A., Archer, P. D., Cucinotta, F., Jones, J. H., Ming, D., Morris, R. V., Niles, P., Rampe, E., Nolan, T., Fisk, M., Radziemski, L., Barraclough, B., Bender, S., Berman, D., Dobrea, E. N., Tokar, R., Vaniman, D., Leshin, L., Cleghorn, T., Huntress, W., Manhes, G., Hudgins, J., Olson, T., Stewart, N., Sarrazin, P., Grant, J., Vicenzi, E., Wilson, S. A., Bullock, M., Ehresmann, B., Hamilton, V., Hassler, D., Peterson, J., Rafkin, S., Zeitlin, C., Fedosov, F., Golovin, D., Karpushkina, N., Kozyrev, A., Litvak, M., Malakhov, A., Mitrofanov, I., Mokrousov, M., Nikiforov, S., Prokhorov, V., Sanin, A., Tretyakov, V., Varenikov, A., Vostrukhin, A., Kuzmin, R., Clark, B., Wolff, M., McLennan, S., Botta, O., Drake, D., Bean, K., Lemmon, M., Lee, E. M., Sucharski, R., Hernandez, M. A. d. P., Blanco Avalos, J. J., Ramos, M., Kim, M.-H., Malespin, C., Plante, I., Muller, J.-P., Gonzalez, R. N., Ewing, R., Boynton, W., Downs, R., Fitzgibbon, M., Harshman, K., Morrison, S., Kortmann, O., Williams, A., Lugmair, G., Wilson, M. A., Jakosky, B., Zunic, T. B., Frydenvang, J., Kinch, K., Stipp, S. L. S., Boyd, N., Campbell, J. L., Gellert, R., Perrett, G., Pradler, I., VanBommel, S., Jacob, S., Owen, T., Rowland, S., Savijarvi, H., Boehm, E., Bottcher, S., Burmeister, S., Guo, J., Kohler, J., Garcia, C. M., Mellin, R. M., Schweingruber, R. W., McConnochie, T., Benna, M., Franz, H., Bower, H., Brunner, A., Blau, H., Boucher, T., Carmosino, M., Atreya, S., Elliott, H., Halleaux, D., Renno, N., Wong, M., Pepin, R., Elliott, B., Spray, J., Thompson, L., Gordon, S., Williams, J., Vasconcelos, P., Bentz, J., Nealson, K., Popa, R., Moersch, J., Tate, C., Day, M., Kocurek, G., Hallet, B., Sletten, R., Francis, R., McCullough, E., Cloutis, E., ten Kate, I. L., Arvidson, R., Fraeman, A., Scholes, D., Slavney, S., Stein, T., Ward, J., Berger, J., Moores, J. E., NWO-NSO: The role of perchlorates in the preservation of organic compounds on Mars, Petrology, GeoRessources, and Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre de recherches sur la géologie des matières premières minérales et énergétiques (CREGU)-Institut national des sciences de l'Univers (INSU - CNRS)

Subjects
MSL Mars Gale Crater Fluvial Activity, Martian, Multidisciplinary, 010504 meteorology & atmospheric sciences, Outcrop, Curiosity rover, Geochemistry, Mars, Sediment, Fluvial, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Mars Exploration Program, 01 natural sciences, Abrasion (geology), martian fluvial conglomerates, 13. Climate action, Rocknest, 0103 physical sciences, MSL, Sedimentary rock, 010303 astronomy & astrophysics, Geology, 0105 earth and related environmental sciences
Abstract

Going to Mars The Mars Science Laboratory spacecraft containing the Curiosity rover, was launched from Earth in November 2011 and arrived at Gale crater on Mars in August 2012. Zeitlin et al. (p. 1080 ) report measurements of the energetic particle radiation environment inside the spacecraft during its cruise to Mars, confirming the hazard likely to be posed by this radiation to astronauts on a future potential trip to Mars. Williams et al. (p. 1068 , see the Perspective by Jerolmack ) report the detection of sedimentary conglomerates (pebbles mixed with sand and turned to rock) at Gale crater. The rounding of the rocks suggests abrasion of the pebbles as they were transported by flowing water several kilometers or more from their source.

Published
2013
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3. Abundance and isotopic composition of gases in the martian atmosphere from the Curiosity rover

Author

Mahaffy, P. R., Webster, C. R., Atreya, S. K., Franz, H., Wong, M., Conrad, P. G., Harpold, D., Jones, J. J., Leshin, L. A., Manning, H., Owen, T., Pepin, R. O., Squyres, S., Trainer, M., Kemppinen, O., Bridges, N., Johnson, J. R., Minitti, M., Cremers, D., Bell, J. F., Edgar, L., Farmer, J., Godber, A., Wadhwa, M., Wellington, D., McEwan, I., Newman, C., Richardson, M., Charpentier, A., Peret, L., King, P., Blank, J., Weigle, G., Schmidt, M., Li, S., Milliken, R., Robertson, K., Sun, V., Baker, M., Edwards, C., Ehlmann, B., Farley, K., Griffes, J., Grotzinger, J., Miller, H., Newcombe, M., Pilorget, C., Rice, M., Siebach, K., Stack, K., Stolper, E., Brunet, C., Hipkin, V., Leveille, R., Marchand, G., Sanchez, P. S., Favot, L., Cody, G., Steele, A., Fluckiger, L., Lees, D., Nefian, A., Martin, M., Gailhanou, M., Westall, F., Israel, G., Agard, C., Baroukh, J., Donny, C., Gaboriaud, A., Guillemot, P., Lafaille, V., Lorigny, E., Paillet, A., Perez, R., Saccoccio, M., Yana, C., Armiens-Aparicio, C., Rodriguez, J. C., Blazquez, I. C., Gomez, F. G., Gomez-Elvira, J., Hettrich, S., Malvitte, A. L., Jimenez, M. M., Martinez-Frias, J., Martin-Soler, J., Martin-Torres, F. J., Jurado, A. M., Mora-Sotomayor, L., Caro, G. M., Lopez, S. N., Peinado-Gonzalez, V., Pla-Garcia, J., Manfredi, J. A. R., Romeral-Planello, J. J., Fuentes, S. A. S., Martinez, E. S., Redondo, J. T., Urqui-O'Callaghan, R., Mier, M.-P. Z., Chipera, S., Lacour, J.-L., Mauchien, P., Sirven, J.-B., Fairen, A., Hayes, A., Joseph, J., Sullivan, R., Thomas, P., Dupont, A., Lundberg, A., Melikechi, N., Mezzacappa, A., DeMarines, J., Grinspoon, D., Reitz, G., Prats, B., Atlaskin, E., Genzer, M., Harri, A.-M., Haukka, H., Kahanpaa, H., Kauhanen, J., Paton, M., Polkko, J., Schmidt, W., Siili, T., Fabre, C., Wray, J., Wilhelm, M. B., Poitrasson, F., Patel, K., Gorevan, S., Indyk, S., Paulsen, G., Gupta, S., Bish, D., Schieber, J., Gondet, B., Langevin, Y., Geffroy, C., Baratoux, D., Berger, G., Cros, A., d'Uston, C., Forni, O., Gasnault, O., Lasue, J., Lee, Q.-M., Maurice, S., Meslin, P.-Y., Pallier, E., Parot, Y., Pinet, P., Schroder, S., Toplis, M., Lewin, E., Brunner, W., Heydari, E., Achilles, C., Oehler, D., Sutter, B., Cabane, M., Coscia, D., Szopa, C., Dromart, G., Robert, F., Sautter, V., Le Mouelic, S., Mangold, N., Nachon, M., Buch, A., Stalport, F., Coll, P., Francois, P., Raulin, F., Teinturier, S., Cameron, J., Clegg, S., Cousin, A., DeLapp, D., Dingler, R., Jackson, R. S., Johnstone, S., Lanza, N., Little, C., Nelson, T., Wiens, R. C., Williams, R. B., Jones, A., Kirkland, L., Treiman, A., Baker, B., Cantor, B., Caplinger, M., Davis, S., Duston, B., Edgett, K., Fay, D., Hardgrove, C., Harker, D., Herrera, P., Jensen, E., Kennedy, M. R., Krezoski, G., Krysak, D., Lipkaman, L., Malin, M., McCartney, E., McNair, S., Nixon, B., Posiolova, L., Ravine, M., Salamon, A., Saper, L., Stoiber, K., Supulver, K., Van Beek, J., Van Beek, T., Zimdar, R., French, K. L., Iagnemma, K., Miller, K., Summons, R., Goesmann, F., Goetz, W., Hviid, S., Johnson, M., Lefavor, M., Lyness, E., Breves, E., Dyar, M. D., Fassett, C., Blake, D. F., Bristow, T., DesMarais, D., Edwards, L., Haberle, R., Hoehler, T., Hollingsworth, J., Kahre, M., Keely, L., McKay, C., Bleacher, L., Brinckerhoff, W., Choi, D., Dworkin, J. P., Eigenbrode, J., Floyd, M., Freissinet, C., Garvin, J., Glavin, D., Martin, D. K., McAdam, A., Pavlov, A., Raaen, E., Smith, M. D., Stern, J., Tan, F., Meyer, M., Posner, A., Voytek, M., Anderson, R. C., Aubrey, A., Beegle, L. W., Behar, A., Blaney, D., Brinza, D., Calef, F., Christensen, L., Crisp, J. A., DeFlores, L., Feldman, J., Feldman, S., Flesch, G., Hurowitz, J., Jun, I., Keymeulen, D., Maki, J., Mischna, M., Morookian, J. M., Parker, T., Pavri, B., Schoppers, M., Sengstacken, A., Simmonds, J. J., Spanovich, N., Juarez, M. d. l. T., Vasavada, A. R., Yen, A., Archer, P. D., Cucinotta, F., Ming, D., Morris, R. V., Niles, P., Rampe, E., Nolan, T., Fisk, M., Radziemski, L., Barraclough, B., Bender, S., Berman, D., Dobrea, E. N., Tokar, R., Vaniman, D., Williams, R. M. E., Yingst, A., Lewis, K., Cleghorn, T., Huntress, W., Manhes, G., Hudgins, J., Olson, T., Stewart, N., Sarrazin, P., Grant, J., Vicenzi, E., Wilson, S. A., Bullock, M., Ehresmann, B., Hamilton, V., Hassler, D., Peterson, J., Rafkin, S., Zeitlin, C., Fedosov, F., Golovin, D., Karpushkina, N., Kozyrev, A., Litvak, M., Malakhov, A., Mitrofanov, I., Mokrousov, M., Nikiforov, S., Prokhorov, V., Sanin, A., Tretyakov, V., Varenikov, A., Vostrukhin, A., Kuzmin, R., Clark, B., Wolff, M., McLennan, S., Botta, O., Drake, D., Bean, K., Lemmon, M., Schwenzer, S. P., Anderson, R. B., Herkenhoff, K., Lee, E. M., Sucharski, R., Hernandez, M. A. d. P., Avalos, J. J. B., Ramos, M., Kim, M.-H., Malespin, C., Plante, I., Muller, J.-P., Navarro-Gonzalez, R., Ewing, R., Boynton, W., Downs, R., Fitzgibbon, M., Harshman, K., Morrison, S., Dietrich, W., Kortmann, O., Palucis, M., Sumner, D. Y., Williams, A., Lugmair, G., Wilson, M. A., Rubin, D., Jakosky, B., Balic-Zunic, T., Frydenvang, J., Jensen, J. K., Kinch, K., Koefoed, A., Madsen, M. B., Stipp, S. L. S., Boyd, N., Campbell, J. L., Gellert, R., Perrett, G., Pradler, I., VanBommel, S., Jacob, S., Rowland, S., Savijarvi, H., Boehm, E., Bottcher, S., Burmeister, S., Guo, J., Kohler, J., Garcia, C. M., Mueller-Mellin, R., Wimmer-Schweingruber, R., Bridges, J. C., McConnochie, T., Benna, M., Bower, H., Brunner, A., Blau, H., Boucher, T., Carmosino, M., Elliott, H., Halleaux, D., Renno, N., Elliott, B., Spray, J., Thompson, L., Gordon, S., Newsom, H., Ollila, A., Williams, J., Vasconcelos, P., Bentz, J., Nealson, K., Popa, R., Kah, L. C., Moersch, J., Tate, C., Day, M., Kocurek, G., Hallet, B., Sletten, R., Francis, R., McCullough, E., Cloutis, E., ten Kate, I. L., Arvidson, R., Fraeman, A., Scholes, D., Slavney, S., Stein, T., Ward, J., Berger, J., Moores, J. E., GeoRessources, Institut national des sciences de l'Univers (INSU - CNRS)-Centre de recherches sur la géologie des matières premières minérales et énergétiques (CREGU)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), MSL Science Team, NWO-NSO: The role of perchlorates in the preservation of organic compounds on Mars, and Petrology

Subjects
010504 meteorology & atmospheric sciences, Curiosity rover, chemistry.chemical_element, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Mars, MSL Mars Atmosphere Isotopis Composition, martian atmosphere, 01 natural sciences, Astrobiology, Isotopic signature, chemistry.chemical_compound, 0103 physical sciences, MSL, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Martian, Multidisciplinary, δ13C, Atmosphere of Mars, Nitrogen, chemistry, 13. Climate action, Sample Analysis at Mars, Carbon dioxide, Environmental science, Carbon monoxide
Abstract

Mars' Atmosphere from Curiosity The Sample Analysis at Mars (SAM) instrument on the Curiosity rover that landed on Mars in August last year is designed to study the chemical and isotopic composition of the martian atmosphere. Mahaffy et al. (p. 263 ) present volume-mixing ratios of Mars' five major atmospheric constituents (CO 2 , Ar, N 2 , O 2 , and CO) and isotope measurements of 40 Ar/ 36 Ar and C and O in CO 2 , based on data from one of SAM's instruments, obtained between 31 August and 21 November 2012. Webster et al. (p. 260 ) used data from another of SAM's instruments obtained around the same period to determine isotope ratios of H, C, and O in atmospheric CO 2 and H 2 O. Agreement between the isotopic ratios measured by SAM with those of martian meteorites, measured in laboratories on Earth, confirms the origin of these meteorites and implies that the current atmospheric reservoirs of CO 2 and H 2 O were largely established after the period of early atmospheric loss some 4 billion years ago.

Published
2013
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4. Curiosity at Gale Crater, Mars: Characterization and analysis of the rocknest sand shadow

Author

Blake, D. F., Morris, R. V., Kocurek, G., Morrison, S. M., Downs, R. T., Bish, D., Ming, D. W., Edgett, K. S., Rubin, D., Goetz, W., Madsen, M. B., Sullivan, R., Gellert, R., Campbell, I., Treiman, A. H., McLennan, S. M., Yen, A. S., Grotzinger, J., Vaniman, D. T., Chipera, S. J., Achilles, C. N., Rampe, E. B., Sumner, D., Meslin, P.- Y., Maurice, S., Forni, O., Gasnault, O., Fisk, M., Schmidt, M., Mahaffy, P., Leshin, L. A., Glavin, D., Steele, A., Freissinet, C., Navarro-Gonzalez, R., Yingst, R. A., Kah, L. C., Bridges, N., Lewis, K. W., Bristow, T. F., Farmer, J. D., Crisp, J. A., Stolper, E. M., Des Marais, D. J., Sarrazin, P., Agard, C., Alves Verdasca, J. A., Anderson, R., Archer, D., Armiens-Aparicio, C., Arvidson, R., Atlaskin, E., Atreya, S., Aubrey, A., Baker, B., Baker, M., Balic-Zunic, T., Baratoux, D., Baroukh, J., Barraclough, B., Bean, K., Beegle, L., Behar, A., Bell, J., Bender, S., Benna, M., Bentz, J., Berger, G., Berger, J., Berman, D., Blanco Avalos, J. J., Blaney, D., Blank, J., Blau, H., Bleacher, L., Boehm, E., Botta, O., Bottcher, S., Boucher, T., Bower, H., Boyd, N., Boynton, B., Breves, E., Bridges, J., Brinckerhoff, W., Brinza, D., Brunet, C., Brunner, A., Brunner, W., Buch, A., Bullock, M., Burmeister, S., Cabane, M., Calef, F., Cameron, J., Cantor, B., Caplinger, M., Rodriguez, J. C., Carmosino, M., Blazquez, I. C., Charpentier, A., Choi, D., Clark, B., Clegg, S., Cleghorn, T., Cloutis, E., Cody, G., Coll, P., Conrad, P., Coscia, D., Cousin, A., Cremers, D., Cros, A., Cucinotta, F., d'Uston, C., Davis, S., Day, M., Juarez, M. d. l. T., DeFlores, L., DeLapp, D., DeMarines, J., Dietrich, W., Dingler, R., Donny, C., Drake, D., Dromart, G., Dupont, A., Duston, B., Dworkin, J., Dyar, M. D., Edgar, L., Edwards, C., Edwards, L., Ehlmann, B., Ehresmann, B., Eigenbrode, J., Elliott, B., Elliott, H., Ewing, R., Fabre, C., Fairen, A., Farley, K., Fassett, C., Favot, L., Fay, D., Fedosov, F., Feldman, J., Feldman, S., Fitzgibbon, M., Flesch, G., Floyd, M., Fluckiger, L., Fraeman, A., Francis, R., Francois, P., Franz, H., French, K. L., Frydenvang, J., Gaboriaud, A., Gailhanou, M., Garvin, J., Geffroy, C., Genzer, M., Godber, A., Goesmann, F., Golovin, D., Gomez, F. G., Gomez-Elvira, J., Gondet, B., Gordon, S., Gorevan, S., Grant, J., Griffes, J., Grinspoon, D., Guillemot, P., Guo, J., Gupta, S., Guzewich, S., Haberle, R., Halleaux, D., Hallet, B., Hamilton, V., Hardgrove, C., Harker, D., Harpold, D., Harri, A.-M., Harshman, K., Hassler, D., Haukka, H., Hayes, A., Herkenhoff, K., Herrera, P., Hettrich, S., Heydari, E., Hipkin, V., Hoehler, T., Hollingsworth, J., Hudgins, J., Huntress, W., Hurowitz, J., Hviid, S., Iagnemma, K., Indyk, S., Israel, G., Jackson, R., Jacob, S., Jakosky, B., Jensen, E., Jensen, J. K., Johnson, J., Johnson, M., Johnstone, S., Jones, A., Jones, J., Joseph, J., Jun, I., Kahanpaa, H., Kahre, M., Karpushkina, N., Kasprzak, W., Kauhanen, J., Keely, L., Kemppinen, O., Keymeulen, D., Kim, M.-H., Kinch, K., King, P., Kirkland, L., Koefoed, A., Kohler, J., Kortmann, O., Kozyrev, A., Krezoski, J., Krysak, D., Kuzmin, R., Lacour, J. L., Lafaille, V., Langevin, Y., Lanza, N., Lasue, J., Le Mouelic, S., Lee, E. M., Lee, Q.-M., Lees, D., Lefavor, M., Lemmon, M., Lepinette Malvitte, A., Leveille, R., Lewin-Carpintier, E., Li, S., Lipkaman, L., Little, C., Litvak, M., Lorigny, E., Lugmair, G., Lundberg, A., Lyness, E., Maki, J., Malakhov, A., Malespin, C., Malin, M., Mangold, N., Manning, H., Marchand, G., Marin Jimenez, M., Martin Garcia, C., Martin, D., Martin, M., Martinez-Frias, J., Martin-Soler, J., Martin-Torres, F. J., Mauchien, P., McAdam, A., McCartney, E., McConnochie, T., McCullough, E., McEwan, I., McKay, C., McNair, S., Melikechi, N., Meyer, M., Mezzacappa, A., Miller, H., Miller, K., Milliken, R., Minitti, M., Mischna, M., Mitrofanov, I., Moersch, J., Mokrousov, M., Molina Jurado, A., Moores, J., Mora-Sotomayor, L., Morookian, J. M., Mueller-Mellin, R., Muller, J.-P., Munoz Caro, G., Nachon, M., Navarro Lopez, S., Nealson, K., Nefian, A., Nelson, T., Newcombe, M., Newman, C., Newsom, H., Nikiforov, S., Niles, P., Nixon, B., Dobrea, E. N., Nolan, T., Oehler, D., Ollila, A., Olson, T., Owen, T., Pablo, H., Paillet, A., Pallier, E., Palucis, M., Parker, T., Parot, Y., Patel, K., Paton, M., Paulsen, G., Pavlov, A., Pavri, B., Peinado-Gonzalez, V., Pepin, R., Peret, L., Perez, R., Perrett, G., Peterson, J., Pilorget, C., Pinet, P., Pla-Garcia, J., Plante, I., Poitrasson, F., Polkko, J., Popa, R., Posiolova, L., Pradler, I., Prats, B., Prokhorov, V., Purdy, S. W., Raaen, E., Radziemski, L., Rafkin, S., Ramos, M., Raulin, F., Ravine, M., Reitz, G., Renno, N., Rice, M., Richardson, M., Robert, F., Rodriguez Manfredi, J. A., Romeral-Planello, J. J., Rowland, S., Saccoccio, M., Salamon, A., Sandoval, J., Sanin, A., Sans Fuentes, S. A., Saper, L., Sautter, V., Savijarvi, H., Schieber, J., Schmidt, W., Scholes, D., Schoppers, M., Schroder, S., Sebastian Martinez, E., Sengstacken, A., Shterts, R., Siebach, K., Siili, T., Simmonds, J., Sirven, J.-B., Slavney, S., Sletten, R., Smith, M., Sobron Sanchez, P., Spanovich, N., Spray, J., Squyres, S., Stack, K., Stalport, F., Stein, T., Stern, J., Stewart, N., Stipp, S. L. S., Stoiber, K., Sucharski, B., Summons, R., Sun, V., Supulver, K., Sutter, B., Szopa, C., Tate, C., Teinturier, S., ten Kate, I. L., Thomas, P., Thompson, L., Tokar, R., Toplis, M., Torres Redondo, J., Trainer, M., Tretyakov, V., Urqui-O'Callaghan, R., Van Beek, J., Van Beek, T., VanBommel, S., Varenikov, A., Vasavada, A., Vasconcelos, P., Vicenzi, E., Vostrukhin, A., Voytek, M., Wadhwa, M., Ward, J., Webster, C., Weigle, E., Wellington, D., Westall, F., Wiens, R. C., Wilhelm, M. B., Williams, A., Williams, J., Williams, R., Williams, R. B., Wilson, M., Wimmer-Schweingruber, R., Wolff, M., Wong, M., Wray, J., Wu, M., Yana, C., Zeitlin, C., Zimdar, R., Zorzano Mier, M.-P., GeoRessources, Institut national des sciences de l'Univers (INSU - CNRS)-Centre de recherches sur la géologie des matières premières minérales et énergétiques (CREGU)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), NASA Ames Research Center (ARC), NASA Johnson Space Center (JSC), NASA, Department of Geological Sciences [Austin], Jackson School of Geosciences (JSG), University of Texas at Austin [Austin]-University of Texas at Austin [Austin], Department of Geology [Tucson], University of Arizona, Department of Geological Sciences [Bloomington], Indiana University [Bloomington], Indiana University System-Indiana University System, Malin Space Science Systems (MSSS), NASA Goddard Space Flight Center (GSFC), NWO-NSO: The role of perchlorates in the preservation of organic compounds on Mars, and Petrology

Subjects
Basalt, Meridiani Planum, Multidisciplinary, 010504 meteorology & atmospheric sciences, Curiosity rover, Geochemistry, Mars, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Mars Exploration Program, Exploration of Mars, 01 natural sciences, Astrobiology, Impact crater, 13. Climate action, MSL Mars Gale Crater Rocknest, Rocknest, 0103 physical sciences, Sample Analysis at Mars, Aeolian processes, MSL, Rocknest aeolian deposit, 010303 astronomy & astrophysics, Geology, 0105 earth and related environmental sciences
Abstract

The Rocknest aeolian deposit is similar to aeolian features analyzed by the Mars Exploration Rovers (MERs) Spirit and Opportunity. The fraction of sand

Published
2013
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5. The Petrochemistry of Jake_M: A Martian Mugearite

Author

Stolper, E. M., Baker, M. B., Newcombe, M. E., Schmidt, M. E., Treiman, A. H., Cousin, A., Dyar, M. D., Fisk, M. R., Gellert, R., King, P. L., Leshin, L., Maurice, S., McLennan, S. M., Minitti, M. E., Perrett, G., Rowland, S., Sautter, V., Wiens, R. C., Kemppinen, O., Bridges, N., Johnson, J. R., Cremers, D., Bell, J. F., Edgar, L., Farmer, J., Godber, A., Wadhwa, M., Wellington, D., McEwan, I., Newman, C., Richardson, M., Charpentier, A., Peret, L., Blank, J., Weigle, G., Li, S., Milliken, R., Robertson, K., Sun, V., Edwards, C., Ehlmann, B., Farley, K., Griffes, J., Grotzinger, J., Miller, H., Pilorget, C., Rice, M., Siebach, K., Stack, K., Brunet, C., Hipkin, V., Leveille, R., Marchand, G., Sanchez, P. S., Favot, L., Cody, G., Steele, A., Fluckiger, L., Lees, D., Nefian, A., Martin, M., Gailhanou, M., Westall, F., Israel, G., Agard, C., Baroukh, J., Donny, C., Gaboriaud, A., Guillemot, P., Lafaille, V., Lorigny, E., Paillet, A., Perez, R., Saccoccio, M., Yana, C., Armiens-Aparicio, C., Rodriguez, J. C., Blazquez, I. C., Gomez, F. G., Gomez-Elvira, J., Hettrich, S., Malvitte, A. L., Jimenez, M. M., Martinez-Frias, J., Martin-Soler, J., Martin-Torres, F. J., Jurado, A. M., Mora-Sotomayor, L., Caro, G. M., Lopez, S. N., Peinado-Gonzalez, V., Pla-Garcia, J., Manfredi, J. A. R., Romeral-Planello, J. J., Fuentes, S. A. S., Martinez, E. S., Redondo, J. T., Urqui-O'Callaghan, R., Mier, M.-P. Z., Chipera, S., Lacour, J.-L., Mauchien, P., Sirven, J.-B., Manning, H., Fairen, A., Hayes, A., Joseph, J., Squyres, S., Sullivan, R., Thomas, P., Dupont, A., Lundberg, A., Melikechi, N., Mezzacappa, A., DeMarines, J., Grinspoon, D., Reitz, G., Prats, B., Atlaskin, E., Genzer, M., Harri, A.-M., Haukka, H., Kahanpaa, H., Kauhanen, J., Paton, M., Polkko, J., Schmidt, W., Siili, T., Fabre, C., Wray, J., Wilhelm, M. B., Poitrasson, F., Patel, K., Gorevan, S., Indyk, S., Paulsen, G., Gupta, S., Bish, D., Schieber, J., Gondet, B., Langevin, Y., Geffroy, C., Baratoux, D., Berger, G., Cros, A., d'Uston, C., Forni, O., Gasnault, O., Lasue, J., Lee, Q.-M., Meslin, P.-Y., Pallier, E., Parot, Y., Pinet, P., Schroder, S., Toplis, M., Lewin, E., Brunner, W., Heydari, E., Achilles, C., Oehler, D., Sutter, B., Cabane, M., Coscia, D., Szopa, C., Teinturier, S., Dromart, G., Robert, F., Le Mouelic, S., Mangold, N., Nachon, M., Buch, A., Stalport, F., Coll, P., Francois, P., Raulin, F., Cameron, J., Clegg, S., DeLapp, D., Dingler, R., Jackson, R. S., Johnstone, S., Lanza, N., Little, C., Nelson, T., Williams, R. B., Kirkland, L., Baker, B., Cantor, B., Caplinger, M., Davis, S., Duston, B., Edgett, K., Fay, D., Hardgrove, C., Harker, D., Herrera, P., Jensen, E., Kennedy, M. R., Krezoski, G., Krysak, D., Lipkaman, L., Malin, M., McCartney, E., McNair, S., Nixon, B., Posiolova, L., Ravine, M., Salamon, A., Saper, L., Stoiber, K., Supulver, K., Van Beek, J., Van Beek, T., Zimdar, R., French, K. L., Iagnemma, K., Miller, K., Summons, R., Goesmann, F., Goetz, W., Hviid, S., Johnson, M., Lefavor, M., Lyness, E., Breves, E., Fassett, C., Blake, D. F., Bristow, T., DesMarais, D., Edwards, L., Haberle, R., Hoehler, T., Hollingsworth, J., Kahre, M., Keely, L., McKay, C., Bleacher, L., Brinckerhoff, W., Choi, D., Conrad, P., Dworkin, J. P., Eigenbrode, J., Floyd, M., Freissinet, C., Garvin, J., Glavin, D., Harpold, D., Mahaffy, P., Martin, D. K., McAdam, A., Pavlov, A., Raaen, E., Smith, M. D., Stern, J., Tan, F., Trainer, M., Meyer, M., Posner, A., Voytek, M., Anderson, R. C., Aubrey, A., Beegle, L. W., Behar, A., Blaney, D., Brinza, D., Calef, F., Christensen, L., Crisp, J., DeFlores, L., Feldman, J., Feldman, S., Flesch, G., Hurowitz, J., Jun, I., Keymeulen, D., Maki, J., Mischna, M., Morookian, J. M., Parker, T., Pavri, B., Schoppers, M., Sengstacken, A., Simmonds, J. J., Spanovich, N., Juarez, M. d. l. T., Vasavada, A., Webster, C. R., Yen, A., Archer, P. D., Cucinotta, F., Jones, J. H., Ming, D., Morris, R. V., Niles, P., Rampe, E., Nolan, T., Radziemski, L., Barraclough, B., Bender, S., Berman, D., Dobrea, E. N., Tokar, R., Vaniman, D., Williams, R. M. E., Yingst, A., Lewis, K., Cleghorn, T., Huntress, W., Manhes, G., Hudgins, J., Olson, T., Stewart, N., Sarrazin, P., Grant, J., Vicenzi, E., Wilson, S. A., Bullock, M., Ehresmann, B., Hamilton, V., Hassler, D., Peterson, J., Rafkin, S., Zeitlin, C., Fedosov, F., Golovin, D., Karpushkina, N., Kozyrev, A., Litvak, M., Malakhov, A., Mitrofanov, I., Mokrousov, M., Nikiforov, S., Prokhorov, V., Sanin, A., Tretyakov, V., Varenikov, A., Vostrukhin, A., Kuzmin, R., Clark, B., Wolff, M., Botta, O., Drake, D., Bean, K., Lemmon, M., Schwenzer, S. P., Anderson, R. B., Herkenhoff, K., Lee, E. M., Sucharski, R., Hernandez, M. A. d. P., Avalos, J. J. B., Ramos, M., Jones, A., Kim, M.-H., Malespin, C., Plante, I., Muller, J.-P., Navarro-Gonzalez, R., Ewing, R., Boynton, W., Downs, R., Fitzgibbon, M., Harshman, K., Morrison, S., Dietrich, W., Kortmann, O., Palucis, M., Sumner, D. Y., Williams, A., Lugmair, G., Wilson, M. A., Rubin, D., Jakosky, B., Balic-Zunic, T., Frydenvang, J., Jensen, J. K., Kinch, K., Koefoed, A., Madsen, M. B., Stipp, S. L. S., Boyd, N., Campbell, J. L., Pradler, I., VanBommel, S., Jacob, S., Owen, T., Savijarvi, H., Boehm, E., Bottcher, S., Burmeister, S., Guo, J., Kohler, J., Garcia, C. M., Mueller-Mellin, R., Wimmer-Schweingruber, R., Bridges, J. C., McConnochie, T., Benna, M., Franz, H., Bower, H., Brunner, A., Blau, H., Boucher, T., Carmosino, M., Atreya, S., Elliott, H., Halleaux, D., Renno, N., Wong, M., Pepin, R., Elliott, B., Spray, J., Thompson, L., Gordon, S., Newsom, H., Ollila, A., Williams, J., Vasconcelos, P., Bentz, J., Nealson, K., Popa, R., Kah, L. C., Moersch, J., Tate, C., Day, M., Kocurek, G., Hallet, B., Sletten, R., Francis, R., McCullough, E., Cloutis, E., ten Kate, I. L., Arvidson, R., Fraeman, A., Scholes, D., Slavney, S., Stein, T., Ward, J., Berger, J., Moores, J. E., GeoRessources, Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre de recherches sur la géologie des matières premières minérales et énergétiques (CREGU)-Institut national des sciences de l'Univers (INSU - CNRS), California Institute of Technology (CALTECH), Department of Earth Sciences [St. Catharines], Brock University [Canada], Lunar and Planetary Institute [Houston] (LPI), Los Alamos National Laboratory (LANL), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Mount Holyoke College, Oregon State University (OSU), University of Guelph, Research School of Earth Sciences [Canberra] (RSES), Australian National University (ANU), Rensselaer Polytechnic Institute (RPI), State University of New York (SUNY), Johns Hopkins University Applied Physics Laboratory [Laurel, MD] (APL), University of Hawaii, Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de recherche pour le développement [IRD] : UR206-Centre National de la Recherche Scientifique (CNRS), MSL Science Team, Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), and Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)

Subjects
010504 meteorology & atmospheric sciences, Curiosity rover, Geochemistry, Mars, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, 010502 geochemistry & geophysics, 01 natural sciences, Jake_M: a martian mugearite, chemistry.chemical_compound, Nepheline, MSL, Chemical composition, 0105 earth and related environmental sciences, Martian, Phonolite, Multidisciplinary, Fractional crystallization (geology), petrochemistry, Igneous rock, Planetary science, MSL Mars Petrochemistry, chemistry, 13. Climate action, Petrochemistry, Geology, [SDU.STU.MI]Sciences of the Universe [physics]/Earth Sciences/Mineralogy
Abstract

International audience; "Jake_M," the first rock analyzed by the Alpha Particle X-ray Spectrometer instrument on the Curiosity rover, differs substantially in chemical composition from other known martian igneous rocks: It is alkaline (>15% normative nepheline) and relatively fractionated. Jake_M is compositionally similar to terrestrial mugearites, a rock type typically found at ocean islands and continental rifts. By analogy with these comparable terrestrial rocks, Jake_M could have been produced by extensive fractional crystallization of a primary alkaline or transitional magma at elevated pressure, with or without elevated water contents. The discovery of Jake_M suggests that alkaline magmas may be more abundant on Mars than on Earth and that Curiosity could encounter even more fractionated alkaline rocks (for example, phonolites and trachytes).

Published
2013
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6. Volatile, Isotope, and Organic Analysis of Martian Fines with the Mars Curiosity Rover

Author

Leshin, L. A., Mahaffy, P. R., Webster, C. R., Cabane, M., Coll, P., Conrad, P. G., Archer, P. D., Atreya, S. K., Brunner, A. E., Buch, A., Eigenbrode, J. L., Flesch, G. J., Franz, H. B., Freissinet, C., Glavin, D. P., McAdam, A. C., Miller, K. E., Ming, D. W., Morris, R. V., Navarro-Gonzalez, R., Niles, P. B., Owen, T., Pepin, R. O., Squyres, S., Steele, A., Stern, J. C., Summons, R. E., Sumner, D. Y., Sutter, B., Szopa, C., Teinturier, S., Trainer, M. G., Wray, J. J., Grotzinger, J. P., Kemppinen, O., Bridges, N., Johnson, J. R., Minitti, M., Cremers, D., Bell, J. F., Edgar, L., Farmer, J., Godber, A., Wadhwa, M., Wellington, D., McEwan, I., Newman, C., Richardson, M., Charpentier, A., Peret, L., King, P., Blank, J., Weigle, G., Schmidt, M., Li, S., Milliken, R., Robertson, K., Sun, V., Baker, M., Edwards, C., Ehlmann, B., Farley, K., Griffes, J., Miller, H., Newcombe, M., Pilorget, C., Rice, M., Siebach, K., Stack, K., Stolper, E., Brunet, C., Hipkin, V., Leveille, R., Marchand, G., Sanchez, P. S., Favot, L., Cody, G., Fluckiger, L., Lees, D., Nefian, A., Martin, M., Gailhanou, M., Westall, F., Israel, G., Agard, C., Baroukh, J., Donny, C., Gaboriaud, A., Guillemot, P., Lafaille, V., Lorigny, E., Paillet, A., Perez, R., Saccoccio, M., Yana, C., Armiens-Aparicio, C., Rodriguez, J. C., Blazquez, I. C., Gomez, F. G., Gomez-Elvira, J., Hettrich, S., Malvitte, A. L., Jimenez, M. M., Martinez-Frias, J., Martin-Soler, J., Martin-Torres, F. J., Jurado, A. M., Mora-Sotomayor, L., Caro, G. M., Lopez, S. N., Peinado-Gonzalez, V., Pla-Garcia, J., Manfredi, J. A. R., Romeral-Planello, J. J., Fuentes, S. A. S., Martinez, E. S., Redondo, J. T., Urqui-O'Callaghan, R., Mier, M.-P. Z., Chipera, S., Lacour, J.-L., Mauchien, P., Sirven, J.-B., Manning, H., Fairen, A., Hayes, A., Joseph, J., Sullivan, R., Thomas, P., Dupont, A., Lundberg, A., Melikechi, N., Mezzacappa, A., DeMarines, J., Grinspoon, D., Reitz, G., Prats, B., Atlaskin, E., Genzer, M., Harri, A.-M., Haukka, H., Kahanpaa, H., Kauhanen, J., Paton, M., Polkko, J., Schmidt, W., Siili, T., Fabre, C., Wilhelm, M. B., Poitrasson, F., Patel, K., Gorevan, S., Indyk, S., Paulsen, G., Gupta, S., Bish, D., Schieber, J., Gondet, B., Langevin, Y., Geffroy, C., Baratoux, D., Berger, G., Cros, A., d'Uston, C., Forni, O., Gasnault, O., Lasue, J., Lee, Q.-M., Maurice, S., Meslin, P.-Y., Pallier, E., Parot, Y., Pinet, P., Schroder, S., Toplis, M., Lewin, E., Brunner, W., Heydari, E., Achilles, C., Oehler, D., Coscia, D., Dromart, G., Robert, F., Sautter, V., Le Mouelic, S., Mangold, N., Nachon, M., Stalport, F., Francois, P., Raulin, F., Cameron, J., Clegg, S., Cousin, A., DeLapp, D., Dingler, R., Jackson, R. S., Johnstone, S., Lanza, N., Little, C., Nelson, T., Wiens, R. C., Williams, R. B., Jones, A., Kirkland, L., Treiman, A., Baker, B., Cantor, B., Caplinger, M., Davis, S., Duston, B., Edgett, K., Fay, D., Hardgrove, C., Harker, D., Herrera, P., Jensen, E., Kennedy, M. R., Krezoski, G., Krysak, D., Lipkaman, L., Malin, M., McCartney, E., McNair, S., Nixon, B., Posiolova, L., Ravine, M., Salamon, A., Saper, L., Stoiber, K., Supulver, K., Van Beek, J., Van Beek, T., Zimdar, R., French, K. L., Iagnemma, K., Goesmann, F., Goetz, W., Hviid, S., Johnson, M., Lefavor, M., Lyness, E., Breves, E., Dyar, M. D., Fassett, C., Blake, D. F., Bristow, T., DesMarais, D., Edwards, L., Haberle, R., Hoehler, T., Hollingsworth, J., Kahre, M., Keely, L., McKay, C., Bleacher, L., Brinckerhoff, W., Choi, D., Dworkin, J. P., Floyd, M., Garvin, J., Harpold, D., Martin, D. K., Pavlov, A., Raaen, E., Smith, M. D., Tan, F., Meyer, M., Posner, A., Voytek, M., Anderson, R. C., Aubrey, A., Beegle, L. W., Behar, A., Blaney, D., Brinza, D., Calef, F., Christensen, L., Crisp, J. A., DeFlores, L., Feldman, J., Feldman, S., Hurowitz, J., Jun, I., Keymeulen, D., Maki, J., Mischna, M., Morookian, J. M., Parker, T., Pavri, B., Schoppers, M., Sengstacken, A., Simmonds, J. J., Spanovich, N., Juarez, M. d. l. T., Vasavada, A. R., Yen, A., Cucinotta, F., Jones, J. H., Rampe, E., Nolan, T., Fisk, M., Radziemski, L., Barraclough, B., Bender, S., Berman, D., Dobrea, E. N., Tokar, R., Vaniman, D., Williams, R. M. E., Yingst, A., Lewis, K., Cleghorn, T., Huntress, W., Manhes, G., Hudgins, J., Olson, T., Stewart, N., Sarrazin, P., Grant, J., Vicenzi, E., Wilson, S. A., Bullock, M., Ehresmann, B., Hamilton, V., Hassler, D., Peterson, J., Rafkin, S., Zeitlin, C., Fedosov, F., Golovin, D., Karpushkina, N., Kozyrev, A., Litvak, M., Malakhov, A., Mitrofanov, I., Mokrousov, M., Nikiforov, S., Prokhorov, V., Sanin, A., Tretyakov, V., Varenikov, A., Vostrukhin, A., Kuzmin, R., Clark, B., Wolff, M., McLennan, S., Botta, O., Drake, D., Bean, K., Lemmon, M., Schwenzer, S. P., Anderson, R. B., Herkenhoff, K., Lee, E. M., Sucharski, R., Hernandez, M. A. d. P., Avalos, J. J. B., Ramos, M., Kim, M.-H., Malespin, C., Plante, I., Muller, J.-P., Ewing, R., Boynton, W., Downs, R., Fitzgibbon, M., Harshman, K., Morrison, S., Dietrich, W., Kortmann, O., Palucis, M., Williams, A., Lugmair, G., Wilson, M. A., Rubin, D., Jakosky, B., Balic-Zunic, T., Frydenvang, J., Jensen, J. K., Kinch, K., Koefoed, A., Madsen, M. B., Stipp, S. L. S., Boyd, N., Campbell, J. L., Gellert, R., Perrett, G., Pradler, I., VanBommel, S., Jacob, S., Rowland, S., Savijarvi, H., Boehm, E., Bottcher, S., Burmeister, S., Guo, J., Kohler, J., Garcia, C. M., Mueller-Mellin, R., Wimmer-Schweingruber, R., Bridges, J. C., McConnochie, T., Benna, M., Bower, H., Blau, H., Boucher, T., Carmosino, M., Elliott, H., Halleaux, D., Renno, N., Wong, M., Elliott, B., Spray, J., Thompson, L., Gordon, S., Newsom, H., Ollila, A., Williams, J., Vasconcelos, P., Bentz, J., Nealson, K., Popa, R., Kah, L. C., Moersch, J., Tate, C., Day, M., Kocurek, G., Hallet, B., Sletten, R., Francis, R., McCullough, E., Cloutis, E., ten Kate, I. L., Arvidson, R., Fraeman, A., Scholes, D., Slavney, S., Stein, T., Ward, J., Berger, J., Moores, J. E., Department of Earth and Environmental Sciences [Troy, NY], Rensselaer Polytechnic Institute (RPI), NASA Goddard Space Flight Center (GSFC), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interuniversitaire des Systèmes Atmosphériques (LISA (UMR_7583)), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Astromaterials Research and Exploration Science (ARES), NASA Johnson Space Center (JSC), NASA-NASA, Department of Atmospheric, Oceanic, and Space Sciences [Ann Arbor] (AOSS), University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Department of Astronomy [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, Laboratoire de Génie des Procédés et Matériaux - EA 4038 (LGPM), CentraleSupélec, Center for Research and Exploration in Space Science and Technology [GSFC] (CRESST), Department of Earth, Atmospheric and Planetary Sciences [MIT, Cambridge] (EAPS), Massachusetts Institute of Technology (MIT), Laboratorio de Química de Plasmas y Estudios Planetarios [Mexico], Instituto de Ciencias Nucleares [Mexico], Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM)-Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Institute for Astronomy [Honolulu], University of Hawai‘i [Mānoa] (UHM), School of Physics and Astronomy [Minneapolis], University of Minnesota [Twin Cities] (UMN), University of Minnesota System-University of Minnesota System, Cornell University [New York], Geophysical Laboratory [Carnegie Institution], Carnegie Institution for Science, University of California [Davis] (UC Davis), University of California (UC), Jacobs Technology ESCG, Institut Pierre-Simon-Laplace (IPSL), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), School of Earth and Atmospheric Sciences [Atlanta], Georgia Institute of Technology [Atlanta], Division of Geological and Planetary Sciences [Pasadena], California Institute of Technology (CALTECH), NWO-NSO: The role of perchlorates in the preservation of organic compounds on Mars, Petrology, California Institute of Technology (CALTECH)-NASA, Universidad Nacional Autónoma de México (UNAM)-Universidad Nacional Autónoma de México (UNAM), Carnegie Institution for Science [Washington], University of California, École normale supérieure - Paris (ENS Paris), IMPEC - LATMOS, Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), University of Minnesota [Twin Cities], Cornell University, and École normale supérieure - Paris (ENS Paris)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National d'Études Spatiales [Toulouse] (CNES)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)

Subjects
Martian, Multidisciplinary, 010504 meteorology & atmospheric sciences, [PHYS.ASTR.EP]Physics [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Thermal decomposition, Curiosity rover, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], chemistry.chemical_element, Mars, organic analysis, Mars Exploration Program, 01 natural sciences, Astrobiology, chemistry.chemical_compound, chemistry, 13. Climate action, Isotopes of carbon, Rocknest, 0103 physical sciences, Sample Analysis at Mars, Carbonate, MSL Mars Volatiles Isotopes Organics Soil Gale Crater, 010303 astronomy & astrophysics, Carbon, 0105 earth and related environmental sciences
Abstract

Samples from the Rocknest aeolian deposit were heated to ~835°C under helium flow and evolved gases analyzed by Curiosity’s Sample Analysis at Mars instrument suite. H 2 O, SO 2 , CO 2 , and O 2 were the major gases released. Water abundance (1.5 to 3 weight percent) and release temperature suggest that H 2 O is bound within an amorphous component of the sample. Decomposition of fine-grained Fe or Mg carbonate is the likely source of much of the evolved CO 2 . Evolved O 2 is coincident with the release of Cl, suggesting that oxygen is produced from thermal decomposition of an oxychloride compound. Elevated δD values are consistent with recent atmospheric exchange. Carbon isotopes indicate multiple carbon sources in the fines. Several simple organic compounds were detected, but they are not definitively martian in origin.

Published
2013
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7. X-ray diffraction results from mars science laboratory: Mineralogy of rocknest at Gale crater

Author

Bish, D. L., Blake, D. F., Vaniman, D. T., Chipera, S. J., Morris, R. V., Ming, D. W., Treiman, A. H., Sarrazin, P., Morrison, S. M., Downs, R. T., Achilles, C. N., Yen, A. S., Bristow, T. F., Crisp, J. A., Morookian, J. M., Farmer, J. D., Rampe, E. B., Stolper, E. M., Spanovich, N., Achilles, C., Agard, C., Verdasca, J. A. A., Anderson, R., Archer, D., Armiens-Aparicio, C., Arvidson, R., Atlaskin, E., Atreya, S., Aubrey, A., Baker, B., Baker, M., Balic-Zunic, T., Baratoux, D., Baroukh, J., Barraclough, B., Bean, K., Beegle, L., Behar, A., Bell, J., Bender, S., Benna, M., Bentz, J., Berger, G., Berger, J., Berman, D., Bish, D., Avalos, J. J. B., Blaney, D., Blank, J., Blau, H., Bleacher, L., Boehm, E., Botta, O., Bottcher, S., Boucher, T., Bower, H., Boyd, N., Boynton, B., Breves, E., Bridges, J., Bridges, N., Brinckerhoff, W., Brinza, D., Bristow, T., Brunet, C., Brunner, A., Brunner, W., Buch, A., Bullock, M., Burmeister, S., Cabane, M., Calef, F., Cameron, J., Campbell, J. I., Cantor, B., Caplinger, M., Rodriguez, J. C., Carmosino, M., Blazquez, I. C., Charpentier, A., Chipera, S., Choi, D., Clark, B., Clegg, S., Cleghorn, T., Cloutis, E., Cody, G., Coll, P., Conrad, P., Coscia, D., Cousin, A., Cremers, D., Crisp, J., Cros, A., Cucinotta, F., d'Uston, C., Davis, S., Day, M. K., Juarez, M. d. l. T., DeFlores, L., DeLapp, D., DeMarines, J., DesMarais, D., Dietrich, W., Dingler, R., Donny, C., Downs, B., Drake, D., Dromart, G., Dupont, A., Duston, B., Dworkin, J., Dyar, M. D., Edgar, L., Edgett, K., Edwards, C., Edwards, L., Ehlmann, B., Ehresmann, B., Eigenbrode, J., Elliott, B., Elliott, H., Ewing, R., Fabre, C., Fairen, A., Farley, K., Farmer, J., Fassett, C., Favot, L., Fay, D., Fedosov, F., Feldman, J., Feldman, S., Fisk, M., Fitzgibbon, M., Flesch, G., Floyd, M., Fluckiger, L., Forni, O., Fraeman, A., Francis, R., Francois, P., Franz, H., Freissinet, C., French, K. L., Frydenvang, J., Gaboriaud, A., Gailhanou, M., Garvin, J., Gasnault, O., Geffroy, C., Gellert, R., Genzer, M., Glavin, D., Godber, A., Goesmann, F., Goetz, W., Golovin, D., Gomez, F. G., Gomez-Elvira, J., Gondet, B., Gordon, S., Gorevan, S., Grant, J., Griffes, J., Grinspoon, D., Grotzinger, J., Guillemot, P., Guo, J., Gupta, S., Guzewich, S., Haberle, R., Halleaux, D., Hallet, B., Hamilton, V., Hardgrove, C., Harker, D., Harpold, D., Harri, A.-M., Harshman, K., Hassler, D., Haukka, H., Hayes, A., Herkenhoff, K., Herrera, P., Hettrich, S., Heydari, E., Hipkin, V., Hoehler, T., Hollingsworth, J., Hudgins, J., Huntress, W., Hurowitz, J., Hviid, S., Iagnemma, K., Indyk, S., Israel, G., Jackson, R., Jacob, S., Jakosky, B., Jensen, E., Jensen, J. K., Johnson, J., Johnson, M., Johnstone, S., Jones, A., Jones, J., Joseph, J., Jun, I., Kah, L., Kahanpaa, H., Kahre, M., Karpushkina, N., Kasprzak, W., Kauhanen, J., Keely, L., Kemppinen, O., Keymeulen, D., Kim, M.-H., Kinch, K., King, P., Kirkland, L., Kocurek, G., Koefoed, A., Kohler, J., Kortmann, O., Kozyrev, A., Krezoski, J., Krysak, D., Kuzmin, R., Lacour, J. L., Lafaille, V., Langevin, Y., Lanza, N., Lasue, J., Le Mouelic, S., Lee, E. M., Lee, Q.-M., Lees, D., Lefavor, M., Lemmon, M., Malvitte, A. L., Leshin, L., Leveille, R., Lewin-Carpintier, E., Lewis, K., Li, S., Lipkaman, L., Little, C., Litvak, M., Lorigny, E., Lugmair, G., Lundberg, A., Lyness, E., Madsen, M., Mahaffy, P., Maki, J., Malakhov, A., Malespin, C., Malin, M., Mangold, N., Manhes, G., Manning, H., Marchand, G., Jimenez, M. M., Garcia, C. M., Martin, D., Martin, M., Martinez-Frias, J., Martin-Soler, J., Martin-Torres, F. J., Mauchien, P., Maurice, S., McAdam, A., McCartney, E., McConnochie, T., McCullough, E., McEwan, I., McKay, C., McLennan, S., McNair, S., Melikechi, N., Meslin, P.-Y., Meyer, M., Mezzacappa, A., Miller, H., Miller, K., Milliken, R., Ming, D., Minitti, M., Mischna, M., Mitrofanov, I., Moersch, J., Mokrousov, M., Jurado, A. M., Moores, J., Mora-Sotomayor, L., Morris, R., Morrison, S., Mueller-Mellin, R., Muller, J.-P., Caro, G. M., Nachon, M., Lopez, S. N., Navarro-Gonzalez, R., Nealson, K., Nefian, A., Nelson, T., Newcombe, M., Newman, C., Newsom, H., Nikiforov, S., Niles, P., Nixon, B., Dobrea, E. N., Nolan, T., Oehler, D., Ollila, A., Olson, T., Owen, T., Hernandez, M. A. d. P., Paillet, A., Pallier, E., Palucis, M., Parker, T., Parot, Y., Patel, K., Paton, M., Paulsen, G., Pavlov, A., Pavri, B., Peinado-Gonzalez, V., Pepin, R., Peret, L., Perez, R., Perrett, G., Peterson, J., Pilorget, C., Pinet, P., Pla-Garcia, J., Plante, I., Poitrasson, F., Polkko, J., Popa, R., Posiolova, L., Posner, A., Pradler, I., Prats, B., Prokhorov, V., Purdy, S. W., Raaen, E., Radziemski, L., Rafkin, S., Ramos, M., Rampe, E., Raulin, F., Ravine, M., Reitz, G., Renno, N., Rice, M., Richardson, M., Robert, F., Robertson, K., Manfredi, J. A. R., Romeral-Planello, J. J., Rowland, S., Rubin, D., Saccoccio, M., Salamon, A., Sandoval, J., Sanin, A., Fuentes, S. A. S., Saper, L., Sautter, V., Savijarvi, H., Schieber, J., Schmidt, M., Schmidt, W., Scholes, D. D., Schoppers, M., Schroder, S., Schwenzer, S., Martinez, E. S., Sengstacken, A., Shterts, R., Siebach, K., Siili, T., Simmonds, J., Sirven, J.-B., Slavney, S., Sletten, R., Smith, M., Sanchez, P. S., Spray, J., Squyres, S., Stack, K., Stalport, F., Steele, A., Stein, T., Stern, J., Stewart, N., Stipp, S. L. S., Stoiber, K., Stolper, E., Sucharski, B., Sullivan, R., Summons, R., Sumner, D., Sun, V., Supulver, K., Sutter, B., Szopa, C., Tan, F., Tate, C., Teinturier, S., ten Kate, I., Thomas, P., Thompson, L., Tokar, R., Toplis, M., Redondo, J. T., Trainer, M., Treiman, A., Tretyakov, V., Urqui-O'Callaghan, R., Van Beek, J., Van Beek, T., VanBommel, S., Vaniman, D., Varenikov, A., Vasavada, A., Vasconcelos, P., Vicenzi, E., Vostrukhin, A., Voytek, M., Wadhwa, M., Ward, J., Webster, C., Weigle, E., Wellington, D., Westall, F., Wiens, R. C., Wilhelm, M. B., Williams, A., Williams, J., Williams, R., Williams, R. B. M., Wilson, M., Wimmer-Schweingruber, R., Wolff, M., Wong, M., Wray, J., Wu, M., Yana, C., Yen, A., Yingst, A., Zeitlin, C., Zimdar, R., Mier, M.-P. Z., GeoRessources, Institut national des sciences de l'Univers (INSU - CNRS)-Centre de recherches sur la géologie des matières premières minérales et énergétiques (CREGU)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), NWO-NSO: The role of perchlorates in the preservation of organic compounds on Mars, and Petrology

Subjects
Multidisciplinary, 010504 meteorology & atmospheric sciences, Water on Mars, Curiosity rover, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Mineralogy, Mars, Mars Exploration Program, Martian soil, engineering.material, 01 natural sciences, MSL Mars X-ray Diffraction Mineralogy Rocknest Gale Crater, Meteorite, Impact crater, 13. Climate action, Rocknest, 0103 physical sciences, Pigeonite, engineering, Composition of Mars, MSL, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, mineralogy of Rocknest at Gale crater
Abstract

The Mars Science Laboratory rover Curiosity scooped samples of soil from the Rocknest aeolian bedform in Gale crater. Analysis of the soil with the Chemistry and Mineralogy (CheMin) x-ray diffraction (XRD) instrument revealed plagioclase (~An57), forsteritic olivine (~Fo62), augite, and pigeonite, with minor K-feldspar, magnetite, quartz, anhydrite, hematite, and ilmenite. The minor phases are present at, or near, detection limits. The soil also contains 27 ± 14 weight percent x-ray amorphous material, likely containing multiple Fe 3+ - and volatile-bearing phases, including possibly a substance resembling hisingerite. The crystalline component is similar to the normative mineralogy of certain basaltic rocks from Gusev crater on Mars and of martian basaltic meteorites. The amorphous component is similar to that found on Earth in places such as soils on the Mauna Kea volcano, Hawaii.

Published
2013
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17. Pulmonale Puls Transit Zeit (pPTT): ein neuer echocardiographischer Indikator für vaskuläre Veränderungen bei pulmonaler Hypertonie (PH) und Lungenfibrose (PF)

Author

Wibmer, T, primary, Rüdiger, S, additional, Spiess, J, additional, Scharnbeck, D, additional, Radermacher, M, additional, Markovic, S, additional, Stoiber, K, additional, Slatosch, H, additional, Blanta, I, additional, Kropf-Sanchen, C, additional, Rottbauer, W, additional, and Schumann, C, additional

Published
2013
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18. Histologie als potenzieller klinischer Prediktor in der Behandlung des fortgeschrittenen nichtkleinzelligen Bronchialkarzinoms (NSCLC) mit Vinorelbin und Mitomycin (VM)

Author

Wibmer, T, primary, Berghmans, T, additional, Kropf-Sanchen, C, additional, Lafitte, JJ, additional, Stoiber, K, additional, Paesmans, M, additional, Rüdiger, S, additional, Scherpereel, A, additional, Blanta, I, additional, Rottbauer, W, additional, Sculier, JP, additional, and Schumann, C, additional

Published
2013
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39. Navigate Flying Molecular Elephants Safely to the Ground: Mass-Selective Soft Landing up to the Mega-Dalton Range by Electrospray Controlled Ion-Beam Deposition.

Author

Walz A, Stoiber K, Huettig A, Schlichting H, and Barth JV

Subjects
Mass Spectrometry, Organic Chemicals, Proteins, Ions chemistry
Abstract

The prototype of a highly versatile and efficient preparative mass spectrometry system used for the deposition of molecules in ultrahigh vacuum (UHV) is presented, along with encouraging performance data obtained using four model species that are thermolabile or not sublimable. The test panel comprises two small organic compounds, a small and very large protein, and a large DNA species covering a 4-log mass range up to 1.7 MDa as part of a broad spectrum of analyte species evaluated to date. Three designs of innovative ion guides, a novel digital mass-selective quadrupole (dQMF), and a standard electrospray ionization (ESI) source are combined to an integrated device, abbreviated electrospray controlled ion-beam deposition (ES-CIBD). Full control is achieved by (i) the square-wave-driven radiofrequency (RF) ion guides with steadily tunable frequencies, including a dQMF allowing for investigation, purification, and deposition of a virtually unlimited m / z range, (ii) the adjustable landing energy of ions down to ∼2 eV/z enabling integrity-preserving soft landing, (iii) the deposition in UHV with high ion beam intensity (up to 3 nA) limiting contaminations and deposition time, and (iv) direct coverage control via the deposited charge. The maximum resolution of R = 650 and overall efficiency up to T total = 4.4% calculated from the solution to UHV deposition are advantageous, whereby the latter can be further enhanced by optimizing ionization performance. In the setup presented, a scanning tunneling microscope (STM) is attached for in situ UHV investigations of deposited species, demonstrating a selective, structure-preserving process and atomically clean layers.

Published
2022
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40. Depositing Molecular Graphene Nanoribbons on Ag(111) by Electrospray Controlled Ion Beam Deposition: Self-Assembly and On-Surface Transformations.

Author

Ran W, Walz A, Stoiber K, Knecht P, Xu H, Papageorgiou AC, Huettig A, Cortizo-Lacalle D, Mora-Fuentes JP, Mateo-Alonso A, Schlichting H, Reichert J, and Barth JV

Abstract

The chemical processing of low-dimensional carbon nanostructures is crucial for their integration in future devices. Here we apply a new methodology in atomically precise engineering by combining multistep solution synthesis of N-doped molecular graphene nanoribbons (GNRs) with mass-selected ultra-high vacuum electrospray controlled ion beam deposition on surfaces and real-space visualisation by scanning tunnelling microscopy. We demonstrate how this method yields solely a controllable amount of single, otherwise unsublimable, GNRs of 2.9 nm length on a planar Ag(111) surface. This methodology allows for further processing by employing on-surface synthesis protocols and exploiting the reactivity of the substrate. Following multiple chemical transformations, the GNRs provide reactive building blocks to form extended, metal-organic coordination polymers., (© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)

Published
2022
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41. Veno-venous extracorporeal membrane oxygenation (vv-ECMO) for severe respiratory failure in adult cancer patients: a retrospective multicenter analysis.

Author

Kochanek M, Kochanek J, Böll B, Eichenauer DA, Beutel G, Bracht H, Braune S, Eisner F, Friesecke S, Günther U, Heinz G, Hallek M, Karagiannidis C, Kluge S, Kogelmann K, Lebiedz P, Lepper PM, Liebregts T, Lueck C, Muellenbach RM, Hansen M, Putensen C, Schellongowski P, Schewe JC, Schumann-Stoiber K, Seiler F, Spieth P, Weber-Carstens S, Brodie D, Azoulay E, and Shimabukuro-Vornhagen A

Subjects
Adult, Aged, Humans, Male, Middle Aged, Retrospective Studies, Extracorporeal Membrane Oxygenation adverse effects, Neoplasms complications, Neoplasms therapy, Respiratory Distress Syndrome, Respiratory Insufficiency etiology, Respiratory Insufficiency therapy
Abstract

Purpose: The question of whether cancer patients with severe respiratory failure benefit from veno-venous extracorporeal membrane oxygenation (vv-ECMO) remains unanswered. We, therefore, analyzed clinical characteristics and outcomes of a large cohort of cancer patients treated with vv-ECMO with the aim to identify prognostic factors., Methods: 297 cancer patients from 19 German and Austrian hospitals who underwent vv-ECMO between 2009 and 2019 were retrospectively analyzed. A multivariable cox proportional hazards analysis for overall survival was performed. In addition, a propensity score-matched analysis and a latent class analysis were conducted., Results: Patients had a median age of 56 (IQR 44-65) years and 214 (72%) were males. 159 (54%) had a solid tumor and 138 (47%) a hematologic malignancy. The 60-day overall survival rate was 26.8% (95% CI 22.1-32.4%). Low platelet count (HR 0.997, 95% CI 0.996-0.999; p = 0.0001 per 1000 platelets/µl), elevated lactate levels (HR 1.048, 95% CI 1.012-1.084; p = 0.0077), and disease status (progressive disease [HR 1.871, 95% CI 1.081-3.238; p = 0.0253], newly diagnosed [HR 1.571, 95% CI 1.044-2.364; p = 0.0304]) were independent adverse prognostic factors for overall survival. A propensity score-matched analysis with patients who did not receive ECMO treatment showed no significant survival advantage for treatment with ECMO., Conclusion: The overall survival of cancer patients who require vv-ECMO is poor. This study shows that the value of vv-ECMO in cancer patients with respiratory failure is still unclear and further research is needed. The risk factors identified in the present analysis may help to better select patients who may benefit from vv-ECMO., (© 2022. The Author(s).)

Published
2022
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42. Targeting de novo lipogenesis as a novel approach in anti-cancer therapy.

Author

Stoiber K, Nagło O, Pernpeintner C, Zhang S, Koeberle A, Ulrich M, Werz O, Müller R, Zahler S, Lohmüller T, Feldmann J, and Braig S

Subjects
Acetyl-CoA Carboxylase antagonists & inhibitors, Cell Line, Tumor, Cell Membrane drug effects, Cell Movement drug effects, Cell Proliferation, Cerulenin administration & dosage, Cerulenin pharmacology, Enzyme Inhibitors pharmacology, Fatty Acid Synthase, Type I antagonists & inhibitors, Gene Knockdown Techniques, Humans, Macrolides administration & dosage, Macrolides pharmacology, Membrane Fluidity drug effects, Molecular Targeted Therapy, Neoplasm Invasiveness, Neoplasms metabolism, Phospholipids analysis, Photobleaching, Xenograft Model Antitumor Assays, Acetyl-CoA Carboxylase genetics, Enzyme Inhibitors administration & dosage, Fatty Acid Synthase, Type I genetics, Lipogenesis drug effects, Neoplasms drug therapy
Abstract

Background: Although altered membrane physiology has been discussed within the context of cancer, targeting membrane characteristics by drugs being an attractive therapeutic strategy has received little attention so far., Methods: Various acetyl-CoA carboxylase 1 (ACC1), and fatty acid synthase (FASN) inhibitors (like Soraphen A and Cerulenin) as well as genetic knockdown approaches were employed to study the effects of disturbed phospholipid composition on membrane properties and its functional impact on cancer progression. By using state-of-the-art methodologies such as LC-MS/MS, optical tweezers measurements of giant plasma membrane vesicles and fluorescence recovery after photobleaching analysis, membrane characteristics were examined. Confocal laser scanning microscopy, proximity ligation assays, immunoblotting as well as migration, invasion and proliferation experiments unravelled the functional relevance of membrane properties in vitro and in vivo., Results: By disturbing the deformability and lateral fluidity of cellular membranes, the dimerisation, localisation and recycling of cancer-relevant transmembrane receptors is compromised. Consequently, impaired activation of growth factor receptor signalling cascades results in abrogated tumour growth and metastasis in different in vitro and in vivo models., Conclusions: This study highlights the field of membrane properties as a promising druggable cellular target representing an innovative strategy for development of anti-cancer agents.

Published
2018
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43. Validating Metal-Organic Framework Nanoparticles for Their Nanosafety in Diverse Biomedical Applications.

Author

Wuttke S, Zimpel A, Bein T, Braig S, Stoiber K, Vollmar A, Müller D, Haastert-Talini K, Schaeske J, Stiesch M, Zahn G, Mohmeyer A, Behrens P, Eickelberg O, Bölükbas DA, and Meiners S

Subjects
Animals, Drug Carriers adverse effects, Endothelial Cells cytology, Fibroblasts cytology, Gingiva cytology, Humans, Mice, Nanoparticles adverse effects, Drug Carriers chemistry, Endothelial Cells metabolism, Fibroblasts metabolism, Gingiva metabolism, Nanoparticles chemistry
Abstract

Metal-organic frameworks (MOFs) are promising platforms for the synthesis of nanoparticles for diverse medical applications. Their fundamental design principles allow for significant control of the framework architecture and pore chemistry, enabling directed functionalization for nanomedical applications. However, before applying novel nanomaterials to patients, it is imperative to understand their potential health risks. In this study, the nanosafety of different MOF nanoparticles is analyzed comprehensively for diverse medical applications. The authors first evaluate the effects of MOFs on human endothelial and mouse lung cells, which constitute a first line of defense upon systemic blood-mediated and local lung-specific applications of nanoparticles. Second, we validated these MOFs for multifunctional surface coatings of dental implants using human gingiva fibroblasts. Moreover, biocompatibility of MOFs is assessed for surface coating of nerve guidance tubes using human Schwann cells and rat dorsal root ganglion cultures. The main finding of this study is that the nanosafety and principal suitability of our MOF nanoparticles as novel agents for drug delivery and implant coatings strongly varies with the effector cell type. We conclude that it is therefore necessary to carefully evaluate the nanosafety of MOF nanomaterials with respect to their particular medical application and their interacting primary cell types, respectively., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2017
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44. Isotope ratios of H, C, and O in CO2 and H2O of the martian atmosphere.

Author

Webster CR, Mahaffy PR, Flesch GJ, Niles PB, Jones JH, Leshin LA, Atreya SK, Stern JC, Christensen LE, Owen T, Franz H, Pepin RO, Steele A, Achilles C, Agard C, Alves Verdasca JA, Anderson R, Anderson R, Archer D, Armiens-Aparicio C, Arvidson R, Atlaskin E, Aubrey A, Baker B, Baker M, Balic-Zunic T, Baratoux D, Baroukh J, Barraclough B, Bean K, Beegle L, Behar A, Bell J, Bender S, Benna M, Bentz J, Berger G, Berger J, Berman D, Bish D, Blake DF, Blanco Avalos JJ, Blaney D, Blank J, Blau H, Bleacher L, Boehm E, Botta O, Böttcher S, Boucher T, Bower H, Boyd N, Boynton B, Breves E, Bridges J, Bridges N, Brinckerhoff W, Brinza D, Bristow T, Brunet C, Brunner A, Brunner W, Buch A, Bullock M, Burmeister S, Cabane M, Calef F, Cameron J, Campbell J, Cantor B, Caplinger M, Caride Rodríguez J, Carmosino M, Carrasco Blázquez I, Charpentier A, Chipera S, Choi D, Clark B, Clegg S, Cleghorn T, Cloutis E, Cody G, Coll P, Conrad P, Coscia D, Cousin A, Cremers D, Crisp J, Cros A, Cucinotta F, d'Uston C, Davis S, Day M, de la Torre Juarez M, DeFlores L, DeLapp D, DeMarines J, DesMarais D, Dietrich W, Dingler R, Donny C, Downs B, Drake D, Dromart G, Dupont A, Duston B, Dworkin J, Dyar MD, Edgar L, Edgett K, Edwards C, Edwards L, Ehlmann B, Ehresmann B, Eigenbrode J, Elliott B, Elliott H, Ewing R, Fabre C, Fairén A, Farley K, Farmer J, Fassett C, Favot L, Fay D, Fedosov F, Feldman J, Feldman S, Fisk M, Fitzgibbon M, Floyd M, Flückiger L, Forni O, Fraeman A, Francis R, François P, Freissinet C, French KL, Frydenvang J, Gaboriaud A, Gailhanou M, Garvin J, Gasnault O, Geffroy C, Gellert R, Genzer M, Glavin D, Godber A, Goesmann F, Goetz W, Golovin D, Gómez Gómez F, Gómez-Elvira J, Gondet B, Gordon S, Gorevan S, Grant J, Griffes J, Grinspoon D, Grotzinger J, Guillemot P, Guo J, Gupta S, Guzewich S, Haberle R, Halleaux D, Hallet B, Hamilton V, Hardgrove C, Harker D, Harpold D, Harri AM, Harshman K, Hassler D, Haukka H, Hayes A, Herkenhoff K, Herrera P, Hettrich S, Heydari E, Hipkin V, Hoehler T, Hollingsworth J, Hudgins J, Huntress W, Hurowitz J, Hviid S, Iagnemma K, Indyk S, Israël G, Jackson R, Jacob S, Jakosky B, Jensen E, Jensen JK, Johnson J, Johnson M, Johnstone S, Jones A, Joseph J, Jun I, Kah L, Kahanpää H, Kahre M, Karpushkina N, Kasprzak W, Kauhanen J, Keely L, Kemppinen O, Keymeulen D, Kim MH, Kinch K, King P, Kirkland L, Kocurek G, Koefoed A, Köhler J, Kortmann O, Kozyrev A, Krezoski J, Krysak D, Kuzmin R, Lacour JL, Lafaille V, Langevin Y, Lanza N, Lasue J, Le Mouélic S, Lee EM, Lee QM, Lees D, Lefavor M, Lemmon M, Lepinette Malvitte A, Léveillé R, Lewin-Carpintier É, Lewis K, Li S, Lipkaman L, Little C, Litvak M, Lorigny E, Lugmair G, Lundberg A, Lyness E, Madsen M, Maki J, Malakhov A, Malespin C, Malin M, Mangold N, Manhes G, Manning H, Marchand G, Marín Jiménez M, Martín García C, Martin D, Martin M, Martínez-Frías J, Martín-Soler J, Martín-Torres FJ, Mauchien P, Maurice S, McAdam A, McCartney E, McConnochie T, McCullough E, McEwan I, McKay C, McLennan S, McNair S, Melikechi N, Meslin PY, Meyer M, Mezzacappa A, Miller H, Miller K, Milliken R, Ming D, Minitti M, Mischna M, Mitrofanov I, Moersch J, Mokrousov M, Molina Jurado A, Moores J, Mora-Sotomayor L, Morookian JM, Morris R, Morrison S, Mueller-Mellin R, Muller JP, Muñoz Caro G, Nachon M, Navarro López S, Navarro-González R, Nealson K, Nefian A, Nelson T, Newcombe M, Newman C, Newsom H, Nikiforov S, Nixon B, Noe Dobrea E, Nolan T, Oehler D, Ollila A, Olson T, de Pablo Hernández MÁ, Paillet A, Pallier E, Palucis M, Parker T, Parot Y, Patel K, Paton M, Paulsen G, Pavlov A, Pavri B, Peinado-González V, Peret L, Perez R, Perrett G, Peterson J, Pilorget C, Pinet P, Pla-García J, Plante I, Poitrasson F, Polkko J, Popa R, Posiolova L, Posner A, Pradler I, Prats B, Prokhorov V, Purdy SW, Raaen E, Radziemski L, Rafkin S, Ramos M, Rampe E, Raulin F, Ravine M, Reitz G, Rennó N, Rice M, Richardson M, Robert F, Robertson K, Rodriguez Manfredi JA, Romeral-Planelló JJ, Rowland S, Rubin D, Saccoccio M, Salamon A, Sandoval J, Sanin A, Sans Fuentes SA, Saper L, Sarrazin P, Sautter V, Savijärvi H, Schieber J, Schmidt M, Schmidt W, Scholes D, Schoppers M, Schröder S, Schwenzer S, Sebastian Martinez E, Sengstacken A, Shterts R, Siebach K, Siili T, Simmonds J, Sirven JB, Slavney S, Sletten R, Smith M, Sobrón Sánchez P, Spanovich N, Spray J, Squyres S, Stack K, Stalport F, Stein T, Stewart N, Stipp SL, Stoiber K, Stolper E, Sucharski B, Sullivan R, Summons R, Sumner D, Sun V, Supulver K, Sutter B, Szopa C, Tan F, Tate C, Teinturier S, ten Kate I, Thomas P, Thompson L, Tokar R, Toplis M, Torres Redondo J, Trainer M, Treiman A, Tretyakov V, Urqui-O'Callaghan R, Van Beek J, Van Beek T, VanBommel S, Vaniman D, Varenikov A, Vasavada A, Vasconcelos P, Vicenzi E, Vostrukhin A, Voytek M, Wadhwa M, Ward J, Weigle E, Wellington D, Westall F, Wiens RC, Wilhelm MB, Williams A, Williams J, Williams R, Williams RB, Wilson M, Wimmer-Schweingruber R, Wolff M, Wong M, Wray J, Wu M, Yana C, Yen A, Yingst A, Zeitlin C, Zimdar R, and Zorzano Mier MP

Abstract

Stable isotope ratios of H, C, and O are powerful indicators of a wide variety of planetary geophysical processes, and for Mars they reveal the record of loss of its atmosphere and subsequent interactions with its surface such as carbonate formation. We report in situ measurements of the isotopic ratios of D/H and (18)O/(16)O in water and (13)C/(12)C, (18)O/(16)O, (17)O/(16)O, and (13)C(18)O/(12)C(16)O in carbon dioxide, made in the martian atmosphere at Gale Crater from the Curiosity rover using the Sample Analysis at Mars (SAM)'s tunable laser spectrometer (TLS). Comparison between our measurements in the modern atmosphere and those of martian meteorites such as ALH 84001 implies that the martian reservoirs of CO2 and H2O were largely established ~4 billion years ago, but that atmospheric loss or surface interaction may be still ongoing.

Published
2013
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45. Effectiveness of omalizumab in patients 50 years and older with severe persistent allergic asthma.

Author

Korn S, Schumann C, Kropf C, Stoiber K, Thielen A, Taube C, and Buhl R

Subjects
Adolescent, Adult, Aged, Anti-Asthmatic Agents adverse effects, Antibodies, Anti-Idiotypic, Antibodies, Monoclonal adverse effects, Antibodies, Monoclonal, Humanized, Asthma blood, Asthma immunology, Asthma physiopathology, Child, Disease Progression, Female, Follow-Up Studies, Germany, Humans, Immunoglobulin E blood, Male, Middle Aged, Omalizumab, Product Surveillance, Postmarketing, Respiratory Function Tests, Age Factors, Anti-Asthmatic Agents administration & dosage, Antibodies, Monoclonal administration & dosage, Asthma drug therapy, Asthma epidemiology
Abstract

Background: Omalizumab is approved for the treatment of severe allergic asthma., Objectives: To compare the efficacy of omalizumab therapy in patients 50 years or older with patients younger than 50 years., Methods: Between November 2005 and November 2007 a total of 174 asthma patients 50 years or older (40.7% male, 51.1% taking oral corticosteroids, and mean [SD] serum IgE level of 315 [353] U/L) and 297 asthma patients younger than 50 years (40.0% male, 50.5% taking oral corticosteroids, and mean [SD] serum IgE level of 363 [431] U/L) who met the European Union criteria for add-on therapy with anti-IgE were treated prospectively with omalizumab for 4 months as part of 2 postmarketing surveillance trials., Results: Compared with the pretrial period omalizumab treatment reduced the rate of severe exacerbations in patients 50 years or older by 68.9% (P < .001) and in patients younger than 50 years by 75.4% (P < .001). After 4 months there was a marked reduction of daily asthma symptoms and nocturnal awakenings by 67.8% and 72.6% in the older and by 79.3% and 82.5% in the younger patients, respectively (P < .001, all 4 comparisons). In 60% of patients 50 years or older lung function improved compared with 69% of patients younger than 50 years. Efficacy of omalizumab was rated as excellent or good by most physicians in patients 50 years or older (68.4%) and younger than 50 years (76.8%, P = .05 elderly vs younger). Adverse events were reported in 35.5% of patients 50 years or older and 32.1% of patients younger than 50 years. There was a higher rate of discontinuation of omalizumab therapy in older patients (20.9% vs 11.1%, P = .006)., Conclusions: The present study confirms the clinical efficacy of omalizumab in patients with severe allergic asthma irrespective of age in a real-life setting outside the omalizumab trial program., (Copyright © 2010 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)

Published
2010
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