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3. P01.01.A Lesion-Function Analysis from Multimodal Imaging and Normative Brain Atlases for Prediction of Cognitive Deficits in Glioma Patients

Author

Kocher, M, primary, Jockwitz, C, additional, Lohmann, P, additional, Stoffels, G, additional, Filss, C, additional, Motthagy, F M, additional, Ruge, M I, additional, Weiss Lucas, C, additional, Goldbrunner, R, additional, Shah, N J, additional, Fink, G R, additional, Galldiks, N, additional, Langen, K, additional, and Caspers, S, additional

Published
2022
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4. P01.02.B Case Report: Disruption of Resting-State Networks and Cognitive Deficits After Whole Brain Irradiation for Singular Brain Metastasis

Author

Kocher, M, primary, Jockwitz, C, additional, Lerche, C, additional, Sabel, M, additional, Lohmann, P, additional, Stoffels, G, additional, Filss, C, additional, Motthagy, F M, additional, Ruge, M I, additional, Fink, G R, additional, Shah, N J, additional, Galldiks, N, additional, Caspers, S, additional, and Langen, K, additional

Published
2022
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5. KS05.5.A Alterations in white matter fiber density associated with structural MRI and metabolic PET lesions following multimodal therapy in glioma patients

Author

Friedrich, M, primary, Farrher, E, additional, Caspers, S, additional, Lohmann, P, additional, Stoffels, G, additional, Filss, C, additional, Weiss Lucas, C, additional, Ruge, M I, additional, Langen, K J, additional, Shah, N J, additional, Fink, G R, additional, Galldiks, N, additional, and Kocher, M, additional

Published
2022
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6. LESION-FUNCTION ANALYSIS FROM MULTIMODAL IMAGING AND NORMATIVE BRAIN ATLASES FOR PREDICTION OF COGNITIVE DEFICITS IN GLIOMA PATIENTS

Author

Kocher, M., Jockwitz, C., Lohmann, P., Stoffels, G., Filss, C., Motthagy, F. M., Ruge, M., I, Weiss Lucas, C., Goldbrunner, R., Shah, N. J., Fink, G. R., Galldiks, N., Langen, K., Caspers, S., Kocher, M., Jockwitz, C., Lohmann, P., Stoffels, G., Filss, C., Motthagy, F. M., Ruge, M., I, Weiss Lucas, C., Goldbrunner, R., Shah, N. J., Fink, G. R., Galldiks, N., Langen, K., and Caspers, S.

Published
2022

7. CASE REPORT: DISRUPTION OF RESTING-STATE NETWORKS AND COGNITIVE DEFICITS AFTER WHOLE BRAIN IRRADIATION FOR SINGULAR BRAIN METASTASIS

Author

Kocher, M., Jockwitz, C., Lerche, C., Sabel, M., Lohmann, P., Stoffels, G., Filss, C., Motthagy, F. M., Ruge, M., I, Fink, G. R., Shah, N. J., Galldiks, N., Caspers, S., Langen, K., Kocher, M., Jockwitz, C., Lerche, C., Sabel, M., Lohmann, P., Stoffels, G., Filss, C., Motthagy, F. M., Ruge, M., I, Fink, G. R., Shah, N. J., Galldiks, N., Caspers, S., and Langen, K.

Published
2022

8. ALTERATIONS IN WHITE MATTER FIBER DENSITY ASSOCIATED WITH STRUCTURAL MRI AND METABOLIC PET LESIONS FOLLOWING MULTIMODAL THERAPY IN GLIOMA PATIENTS

Author

Friedrich, M., Farrher, E., Caspers, S., Lohmann, P., Stoffels, G., Filss, C., Lucas, C. Weiss, Ruge, M., I, Langen, K. J., Shah, N. J., Fink, G. R., Galldiks, N., Kocher, M., Friedrich, M., Farrher, E., Caspers, S., Lohmann, P., Stoffels, G., Filss, C., Lucas, C. Weiss, Ruge, M., I, Langen, K. J., Shah, N. J., Fink, G. R., Galldiks, N., and Kocher, M.

Published
2022

10. POSTER ABSTRACTS

Author

Lambert, SJ, primary, Lunde, B, additional, Porsch, L, additional, Stoffels, G, additional, MacIsaac, L, additional, Dayananda, I, additional, and Dragoman, MV, additional

Published
2021
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13. Lesion-Function Analysis from Multimodal Imaging and Normative Brain Atlases for Prediction of Cognitive Deficits in Glioma Patients

Author

Kocher, M., Jockwitz, C., Lohmann, P., Stoffels, G., Filss, C., Mottaghy, F.M., Ruge, M.I., Lucas, C.W., Goldbrunner, R., Shah, N.J., Fink, G.R., Galldiks, N., Langen, K.J., Caspers, S., RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Beeldvorming, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, and RS: Carim - B06 Imaging

Subjects
positron emission tomography, SURGERY, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, TRAIL, PERFORMANCE, LOW-GRADE, brain networks, Article, TEST-B, glioma, cognitive testing, ddc:610, radiotherapy, RC254-282
Abstract

Cancers 13(10), 2373 (2021). doi:10.3390/cancers13102373 special issue: "Topical collection "Diagnostic and therapeutic challenges in patients with primary or secondary brain tumor" / editors: Giuseppe Lombardi, guest editor; Alberto Feletti, co-guest editor; Anna Luisa Di Stefano, co-guest editor", Published by MDPI, Basel

Published
2021

16. Diagnosis of pseudoprogression following lomustine-temozolomide chemoradiation in newly diagnosed glioblastoma patients using FET PET

Author

Werner, JM, additional, Weller, J, additional, Ceccon, G, additional, Schaub, C, additional, Tscherpel, C, additional, Lohmann, P, additional, Bauer, EK, additional, Schäfer, N, additional, Stoffels, G, additional, Baues, C, additional, Celik, E, additional, Marnitz, S, additional, Kabbasch, C, additional, Gielen, GH, additional, Fink, GR, additional, Langen, KJ, additional, Herrlinger, U, additional, and Galldiks, N, additional

Published
2021
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17. Role of the default mode resting-state network for cognitive functioning in malignant glioma patients following multimodal treatment

Author

Kocher, M., Jockwitz, C., Caspers, S., Schreiber, J., Farrher, E., Stoffels, G., Filss, C., Lohmann, P., Tscherpel, C., Ruge, M., Fink, G., Shah, N., Galldiks, N., Langen, K. -J, Kocher, M., Jockwitz, C., Caspers, S., Schreiber, J., Farrher, E., Stoffels, G., Filss, C., Lohmann, P., Tscherpel, C., Ruge, M., Fink, G., Shah, N., Galldiks, N., and Langen, K. -J

Published
2020

23. Prediction of survival in patients with IDH-wildtype astrocytic gliomas using dynamic O-(2-[ 18 F]-fluoroethyl)-L-tyrosine PET

Author

Bauer, E. K, additional, Stoffels, G, additional, Blau, T, additional, Reifenberger, G, additional, Felsberg, J, additional, Werner, JM, additional, Lohmann, P, additional, Rosen, J, additional, Ceccon, G, additional, Tscherpel, C, additional, Rapp, M, additional, Sabel, M, additional, Filss, CP, additional, Shah, NJ, additional, Neumaier, B, additional, Fink, GR, additional, Langen, KJ, additional, and Galldiks, N, additional

Published
2020
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28. Purification and characterization of a new bacteriocin isolated from Carnobacterium sp

Author

Stoffels, G., Nissen-Meyer, J., Gudmundsdottir, A., Sletten, K., Holo, H., and Nes, I.F.

Subjects
Lactic acid -- Research, Bacteriocins -- Analysis, Biological sciences
Abstract

A new bacteriocin was isolated and purified from Carnobacterium sp. isolated from fish. The bacteriocin was designated as carnocin UI49 and contained 35 to 37 amino acid residues, 55% to 60% of which are nonpolar. Strong evidence indicated the presence of lanthionine. Sequence analysis revealed seven N-terminal amino acids which were non-homologous to any other sequenced bacteriocins from lactic acid bacteria. Mass spectrometry revealed a molecular weight of 4,635 Da. The mode of action was found to be bactericidal, with optimum activity between pH 2.0 and 8.0. The results indicate that carnocin UI49 is a lantibiotic.

Published
1992

29. Use of FET PET in glioblastoma patients undergoing neurooncological treatment including tumor-treating fields: Initial experiences

Author

Ceccon, G, Lazaridis, L, Stoffels, G, Rapp, M, Lohmann, P, Kebir, S, Fink, GR, Langen, KJ, Glas, M, and Galldiks, N

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: The aim of this retrospective study was to present our first clinical experiences with O-(2-18F-fluoroethyl)-L-tyrosine (FET) PET in patients with high-grade glioma treated with various neurooncological therapies including tumor-treating fields (TTF) for the differentiation of tumor progression[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Published
2018
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43. Navigated transcranial magnetic stimulation in perirolandic cerebral metastases as compared to matched high-grade gliomas: Functional outcome and impact upon the extent of resection

Author

Faymonville, A, Schröter, C, Stoffels, G, Grefkes, C, Goldbrunner, R, and Weiß Lucas, C

Subjects
nTMS, ddc: 610, rolandic metastases, 610 Medical sciences, Medicine, Outcome
Abstract

Objective: In contrast to high-grade gliomas (HGG) with their infiltrative growth pattern, brain metastases (MET) are usually regarded as well delineated tumours. Surgical resection may thus be supported more often for MET in eloquent localizations than for HGG. The objective of this study was to compare[for full text, please go to the a.m. URL], 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Published
2016
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50. Multimodal Imaging in Malignant Brain Tumors: Enhancing the Preoperative Risk Evaluation for Motor Deficits with a Combined Hybrid MRI-PET and Navigated Transcranial Magnetic Stimulation Approach

Author

Neuschmelting, V., Lucas, C. Weiss, Stoffels, G., Oros-Peusquens, A. -M., Lockau, H., Shah, N. J., Langen, K. -J., Goldbrunner, R., Grefkes, C., Neuschmelting, V., Lucas, C. Weiss, Stoffels, G., Oros-Peusquens, A. -M., Lockau, H., Shah, N. J., Langen, K. -J., Goldbrunner, R., and Grefkes, C.

Abstract

Patients with malignant brain tumors involving the central region underwent a hybrid O-(2-[F-18]fluoroethyl)-L-tyrosine-PET-MR imaging and motor mapping by neuronavigated transcranial magnetic stimulation. The spatial relationship between functional tissue and lesion volumes as depicted by structural and metabolic imaging was analyzed. Tumor infiltration of the M1 region or the corticospinal tract as depicted by FET-PET is highly indicative of motor impairment, better than contrast-enhanced T1WI alone, and is of predictive value for operative-risk evaluation. BACKGROUND AND PURPOSE: Motor deficits in patients with brain tumors are caused mainly by irreversible infiltration of the motor network or by indirect mass effects; these deficits are potentially reversible on tumor removal. Here we used a novel multimodal imaging approach consisting of structural, functional, and metabolic neuroimaging to better distinguish these underlying causes in a preoperative setting and determine the predictive value of this approach. MATERIALS AND METHODS: Thirty patients with malignant brain tumors involving the central region underwent a hybrid O-(2-[F-18]fluoroethyl)-L-tyrosine-PET-MR imaging and motor mapping by neuronavigated transcranial magnetic stimulation. The functional maps served as localizers for DTI tractography of the corticospinal tract. The spatial relationship between functional tissue (motor cortex and corticospinal tract) and lesion volumes as depicted by structural and metabolic imaging was analyzed. RESULTS: Motor impairment was found in nearly all patients in whom the contrast-enhanced T1WI or PET lesion overlapped functional tissue. All patients who functionally deteriorated after the operation showed such overlap on presurgical maps, while the absence of overlap predicted a favorable motor outcome. PET was superior to contrast-enhanced T1WI for revealing a motor deficit before the operation. However, the best correlation with clinical impairment was found for

Published
2016

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