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487 results on '"Stoffel-Wagner B"'

11. Parenteral trace element provision: recent clinical research and practical conclusions

Author

Stehle, P., Stoffel-Wagner, B., and Kuhn, K.S.

Subjects
Methods, Clinical trials -- Methods, Trace analysis -- Methods
Abstract

INTRODUCTION In human physiology, inorganic elements that are found in low concentrations in body tissues and fluids are generally termed as trace elements. (1) For nine trace elements, at least [...], The aim of this systematic review (PubMed, www.ncbi.nlm.nih.gov/pubmed and Cochrane, www.cochrane.org; last entry 31 December 2014) was to present data from recent clinical studies investigating parenteral trace element provision in adult patients and to draw conclusions for clinical practice. Important physiological functions in human metabolism are known for nine trace elements: selenium, zinc, copper, manganese, chromium, iron, molybdenum, iodine and fluoride. Lack of, or an insufficient supply of, these trace elements in nutrition therapy over a prolonged period is associated with trace element deprivation, which may lead to a deterioration of existing clinical symptoms and/or the development of characteristic malnutrition syndromes. Therefore, all parenteral nutrition prescriptions should include a daily dose of trace elements. To avoid trace element deprivation or imbalances, physiological doses are recommended. European Journal of Clinical Nutrition (2016) 70, 886-893; doi:10.1038/ejcn.2016.53; published online 6 April 2016

Published
2016
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20. Carboplatin Dosing in Children Using Estimated Glomerular Filtration Rate: Equation Matters.

Author

Velde, Mirjam E. van de, Bakker, E. de, Blufpand, H.N., Kaspers, G.L., Abbink, F.C.H., Kors, A.W.A., Wilhelm, A.J., Honeywell, R.J., Peters, G.J., Stoffel-Wagner, B., Buffart, L.M., Bökenkamp, A., Velde, Mirjam E. van de, Bakker, E. de, Blufpand, H.N., Kaspers, G.L., Abbink, F.C.H., Kors, A.W.A., Wilhelm, A.J., Honeywell, R.J., Peters, G.J., Stoffel-Wagner, B., Buffart, L.M., and Bökenkamp, A.

Abstract

Contains fulltext : 244770.pdf (Publisher’s version ) (Open Access), Renal function-based carboplatin dosing using measured glomerular filtration rate (GFR) results in more consistent drug exposure than anthropometric dosing. We aimed to validate the Newell dosing equation using estimated GFR (eGFR) and study which equation most accurately predicts carboplatin clearance in children with retinoblastoma. In 13 children with retinoblastoma 38 carboplatin clearance values were obtained from individual fits using MWPharm++. Carboplatin exposure (AUC) was calculated from administered dose and observed carboplatin clearance and compared to predicted AUC calculated with a carboplatin dosing equation (Newell) using different GFR estimates. Different dosing regimens were compared in terms of accuracy, bias and precision. All patients had normal eGFR. Carboplatin exposure using cystatin C-based eGFR equations tended to be more accurate compared to creatinine-based eGFR (30% accuracy 76.3-89.5% versus 76.3-78.9%, respectively), which led to significant overexposure, especially in younger (aged ≤ 2 years) children. Of all equations, the Schwartz cystatin C-based equation had the highest accuracy and lowest bias. Although anthropometric dosing performed comparably to many of the eGFR equations overall, we observed a weight-dependent change in bias leading to underdosing in the smallest patients. Using cystatin C-based eGFR equations for carboplatin dosing in children leads to more accurate carboplatin-exposure in patients with normal renal function compared to anthropometric dosing. In children with impaired kidney function, this trend might be more pronounced. Anthropometric dosing is hampered by a weight-dependent bias.

Published
2021

44. Systemic HMGB1, a novel predictive biomarker for cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage

Author

Muhammad, S, Rasul Chaudhry, S, Güresir, A, Stoffel Wagner, B, Vatter, H, and Güresir, E

Subjects
ddc: 610, chemical and pharmacologic phenomena, 610 Medical sciences, Medicine
Abstract

Objective: HMGB1 is a non-histone DNA binding nuclear protein expressed in almost all eukaryotic cells. Translocation of HMGB1 out of the nucleus up-regulates inflammatory response in different diseases including subarachnoid hemorrhage. Pro-inflammatory molecules have been suggested to play an important[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Published
2017
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48. Early diagnosis of DCI: Is there relevance for inflammatory biomarkers in routine clinical practice?

Author

Chamling, B, Stoffel-Wagner, B, Schubert, GA, Clusmann, H, Coburn, M, and Höllig, A

Subjects
ddc: 610, subarachnoid hemorrhage, inflammation, delayed cerebral ischemia, cardiovascular diseases, 610 Medical sciences, Medicine
Abstract

Objective: By clinical as well experimental studies multiple biomarkers have been proposed to predict delayed cerebral ischemia (DCI) after aneurysmal SAH at an early stage. So far, none of these biomarkers are used in everyday practice. Here, we review a panel of biomarkers for their value predicting[for full text, please go to the a.m. URL], 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Published
2016
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49. The effect of short post-apnea time on plasma triglycerides, lipoprotein and cholesterol derived oxysterols levels

Author

Dolscheid-Pommerich Ramona C., Stoffel-Wagner Birgit, Reinicke Madlen, Stellaard Frans, Lütjohann Dieter, and Eichhorn Lars

Subjects
apnea diving, cardiovascular disease, cholesterol, gas chromatography, hypoxia, lipids, mass spectrometry, Medical technology, R855-855.5
Abstract

Apnea diving is characterized by extreme hypoxia and hypercapnia. Possible pathophysiological processes concerning the cardiovascular system are not yet fully understood. Hypoxia has effects on triglyceride metabolism and circulating blood lipids. To date, in voluntary apnea divers, no short-time hypoxia expositions focusing on plasma triglycerides, lipoprotein and cholesterol derived oxysterols levels have been performed. We hypothesize that short time hypoxemia leads to altered triglyceride, cholesterol, and oxysterol plasma levels in voluntary apnea divers.

Published
2022
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