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8. Oncologic Safety of Close Margins in Patients With Low- to Intermediate-Grade Major Salivary Gland Carcinoma

Author

Sajisevi, Mirabelle, Nguyen, Kenny, Callas, Peter, Holcomb, Andrew J., Vural, Emre, Davis, Kyle P., Thomas, Carissa M., Plonowska-Hirschfeld, Karolina A., Stein, John S., Eskander, Antoine, Kakarala, Kiran, Enepekides, Danny J., Hier, Michael P., Ryan, William R., Asarkar, Ameya A., Aulet, Ricardo, Bell, Rebecca K., Blasco, Michael A., Bowmaster, Vanessa B., Burruss, Clayton P., Chung, Jeffson, Chan, Kimberly, Chang, Brent A., Coffey, Charles S., Cognetti, David M., Cooper, Dylan J., Cordero, Joehassin, Donovan, John, Du, Yue (Jennifer), Dundar, Yusuf, Dedivitis, Rogerio A., Edwards, Heather A., Erovic, Boban M., Feinberg, Philip A., Garvey, Emily A., Goldstein, David P., Goodman, Joseph F., Goulart, Rafael N., Goyal, Neerav, Grasl, Stefan, Giurintano, Jonathan P., Gupta, Nikita, Habib, Andy M., Hackman, Trevor G., Hara, Jared H., Henson, Christina, Hinni, Michael L., Hua, Nadia, Johnson-Obaseki, Stephanie, Juloori, Aditya, Kalman, Noah S., Kejner, Alexandra E., Khaja, Sobia F., Ku, Jamie A., Lambert, Arnaud, Luu, Bao K., Magliocca, Kelly R., dos Santos, Luiz R. Medina, Michael, Cara, Miles, Brett A., de Melo, Giulianno Molina, Moore, Michael G., Morand, Gregoire B., Moura, Kauê, Mukdad, Laith, Noroozi, Hesameddin, Patel, Rusha, Paydarfar, Joseph A., Sadeghi, Nader, Savaria, Fabrice N., Schmitt, Nicole C., Shapiro, Justin, Shaver, Timothy B., Stoeckli, Sandro J., St. John, Maie, Stokes, William Alvo, Sulibhavi, Anita, Tasoulas, Jason, Vendra, Varun, Vinh, Daniel B., Virgen, Celina G., Wooten, Christian, Woody, Neil M., and Young, Geoffrey D.

Abstract

IMPORTANCE: Postoperative radiation therapy for close surgical margins in low- to intermediate-grade salivary carcinomas lacks multi-institutional supportive evidence. OBJECTIVE: To evaluate the oncologic outcomes for low- and intermediate-grade salivary carcinomas with close and positive margins. DESIGN, SETTING, AND PARTICIPANTS: The American Head and Neck Society Salivary Gland Section conducted a retrospective cohort study from 2010 to 2019 at 41 centers. Margins were classified as R0 (negative), R1 (microscopically positive), or R2 (macroscopically positive). R0 margins were subclassified into clear (>1 mm) or close (≤1 mm). Data analysis was performed from June to October 2023. MAIN OUTCOMES AND MEASURES: Main outcomes were risk factors for local recurrence. RESULTS: A total of 865 patients (median [IQR] age at surgery, 56 [43-66] years; 553 female individuals [64%] and 312 male individuals [36%]) were included. Of these, 801 (93%) had parotid carcinoma and 64 (7%) had submandibular gland carcinoma, and 748 (86%) had low-grade tumors and 117 (14%) had intermediate-grade tumors, with the following surgical margins: R0 in 673 (78%), R1 in 168 (19%), and R2 in 24 (3%). Close margins were found in 395 of 499 patients with R0 margins (79%), for whom margin distances were measured. A total of 305 patients (35%) underwent postoperative radiation therapy. Of all 865 patients, 35 (4%) had local recurrence with a median (IQR) follow-up of 35.3 (13.9-59.1) months. In patients with close margins as the sole risk factor for recurrence, the local recurrence rates were similar between those who underwent postoperative radiation therapy (0 of 46) or observation (4 of 165 [2%]). Patients with clear margins (n = 104) had no recurrences. The local recurrence rate in patients with R1 or R2 margins was better in those irradiated (2 of 128 [2%]) compared to observed (13 of 64 [20%]) (hazard ratio [HR], 0.05; 95% CI, 0.01-0.24). Multivariable analysis for local recurrence found the following independent factors: age at diagnosis (HR for a 10-year increase in age, 1.33; 95% CI, 1.06-1.67), R1 vs R0 (HR, 5.21; 95% CI, 2.58-10.54), lymphovascular invasion (HR, 4.47; 95% CI, 1.43-13.99), and postoperative radiation therapy (HR, 0.10; 95% CI, 0.04-0.29). The 3-year local recurrence-free survivals for the study population were 96% vs 97% in the close margin group. CONCLUSIONS AND RELEVANCE: In this cohort study of patients with low- and intermediate-grade major salivary gland carcinoma, postoperative radiation therapy for positive margins was associated with decreased risk of local recurrence. In isolation from other risk factors for local recurrence, select patients with close surgical margins (≤1 mm) may safely be considered for observation.

Published
2024
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9. Conserved stromal-immune cell circuits secure B cell homeostasis and function

Author

Lütge, Mechthild; https://orcid.org/0000-0001-9011-5319, De Martin, Angelina; https://orcid.org/0000-0002-9056-8075, Gil-Cruz, Cristina; https://orcid.org/0000-0001-5285-6503, Perez-Shibayama, Christian; https://orcid.org/0000-0001-9335-4120, Stanossek, Yves, Onder, Lucas; https://orcid.org/0000-0003-1471-412X, Cheng, Hung-Wei; https://orcid.org/0000-0003-1740-0337, Kurz, Lisa, Cadosch, Nadine, Soneson, Charlotte; https://orcid.org/0000-0003-3833-2169, Robinson, Mark D; https://orcid.org/0000-0002-3048-5518, Stoeckli, Sandro J, Ludewig, Burkhard; https://orcid.org/0000-0002-7685-573X, Pikor, Natalia B; https://orcid.org/0000-0002-6564-4232, Lütge, Mechthild; https://orcid.org/0000-0001-9011-5319, De Martin, Angelina; https://orcid.org/0000-0002-9056-8075, Gil-Cruz, Cristina; https://orcid.org/0000-0001-5285-6503, Perez-Shibayama, Christian; https://orcid.org/0000-0001-9335-4120, Stanossek, Yves, Onder, Lucas; https://orcid.org/0000-0003-1471-412X, Cheng, Hung-Wei; https://orcid.org/0000-0003-1740-0337, Kurz, Lisa, Cadosch, Nadine, Soneson, Charlotte; https://orcid.org/0000-0003-3833-2169, Robinson, Mark D; https://orcid.org/0000-0002-3048-5518, Stoeckli, Sandro J, Ludewig, Burkhard; https://orcid.org/0000-0002-7685-573X, and Pikor, Natalia B; https://orcid.org/0000-0002-6564-4232

Abstract

B cell zone reticular cells (BRCs) form stable microenvironments that direct efficient humoral immunity with B cell priming and memory maintenance being orchestrated across lymphoid organs. However, a comprehensive understanding of systemic humoral immunity is hampered by the lack of knowledge of global BRC sustenance, function and major pathways controlling BRC-immune cell interactions. Here we dissected the BRC landscape and immune cell interactome in human and murine lymphoid organs. In addition to the major BRC subsets underpinning the follicle, including follicular dendritic cells, PI16$^{+}$ RCs were present across organs and species. As well as BRC-produced niche factors, immune cell-driven BRC differentiation and activation programs governed the convergence of shared BRC subsets, overwriting tissue-specific gene signatures. Our data reveal that a canonical set of immune cell-provided cues enforce bidirectional signaling programs that sustain functional BRC niches across lymphoid organs and species, thereby securing efficient humoral immunity.

Published
2023

10. Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer

Author

Schilling, Clare, Stoeckli, Sandro J., Haerle, Stephan K., Broglie, Martina A., Huber, Gerhard F., Sorensen, Jens Ahm, Bakholdt, Vivi, Krogdahl, Annelise, von Buchwald, Christian, Bilde, Anders, Sebbesen, Lars R., Odell, Edward, Gurney, Benjamin, O'Doherty, Michael, de Bree, Remco, Bloemena, Elisabeth, Flach, Geke B., Villarreal, Pedro M., Fresno Forcelledo, Manuel Florentino, Junquera Gutiérrez, Luis Manuel, Amézaga, Julio Alvarez, Barbier, Luis, Santamaría-Zuazua, Joseba, Moreira, Augusto, Jacome, Manuel, Vigili, Maurizio Giovanni, Rahimi, Siavash, Tartaglione, Girolamo, Lawson, Georges, Nollevaux, Marie-Cecile, Grandi, Cesare, Donner, Davide, Bragantini, Emma, Dequanter, Didier, Lothaire, Philippe, Poli, Tito, Silini, Enrico M., Sesenna, Erinco, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, and McGurk, Mark

Published
2015
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13. Prediction of extranodal extension in oropharyngeal cancer patients and carcinoma of unknown primary: value of metabolic tumor imaging with hybrid PET compared with MRI and CT

Author

Nemmour, Amina, primary, Stadler, Thomas M., additional, Maurer, Alexander, additional, Kovacs, Zsofia, additional, Serrallach, Bettina, additional, Born, Diana, additional, Nemes, Constanze M., additional, Broglie, Martina A., additional, Pazahr, Shila, additional, Rupp, Niels J., additional, Hüllner, Martin W., additional, Stoeckli, Sandro J., additional, and Morand, Grégoire B., additional

Published
2022
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17. Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery

Author

Broglie, Martina A., Stoeckli, Sandro J., Sauter, Rafael, Pasche, Philippe, Reinhard, Antoine, de Leval, Laurence, Huber, Gerhard F., Pezier, Thomas F., Soltermann, Alex, Giger, Roland, Arnold, Andreas, Dettmer, Matthias, Arnoux, Andre, Müller, Martin, Spreitzer, Stefan, Lang, Florian, Lutchmaya, Mathieu, Stauffer, Edouard, Espeli, Vittoria, Martucci, Francesco, Bongiovanni, Massimo, Foerbs, Diana, and Jochum, Wolfram

Published
2017
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20. Prevalence of Transcriptionally Active HPV Infection in Tumor-Free Oropharyngeal Tissue of OPSCC-Patients

Author

Guarda, Vittoria, Schroeder, Lea, Pawlita, Michael, Ikenberg, Kristian, Rupp, Niels J, Jochum, Wolfram, Stoeckli, Sandro J, Holzinger, Dana, Broglie, Martina A, and University of Zurich

Subjects
Cancer Research, Oncology, 10049 Institute of Pathology and Molecular Pathology, 610 Medicine & health, 10045 Clinic for Otorhinolaryngology, female genital diseases and pregnancy complications
Abstract

ObjectivesThe natural history of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is still largely unknown. Since reports of second primary tumors (SPTs) in patients with HPV-related OPSCCs are increasing, a multifocal HPV infection, hinting a «virus-induced field effect», has been hypothesized. This study aimed to investigate the HPV-prevalence in normal appearing oropharyngeal tissue in patients with OPSCCs.Materials and Methods49 OPSCC patients undergoing panendoscopy were prospectively enrolled. Tumor specimens and biopsies of normal appearing oropharyngeal tissue adjacent to and distant from the index OPSCC underwent histopathological examination, p16INK4A immunohistochemical staining, HPV DNA and mRNA-detection. Patient characteristics and follow-up data on SPTs were obtained.Results26 of 49 (53%) OPSCC were positive for HPV DNA and p16INK4A. HPV mRNA was detected in 23 of 26 (88%) of these tumor samples. HPV DNA was detected in 36% adjacent mucosa and in 17% distant mucosa samples and only in patients with an HPV-related index OPSCC. HPV mRNA could not be detected in tumor-free distant and adjacent mucosa samples. No evidence of association between HPV detection in normal appearing mucosa and development of second primary tumors was found.ConclusionsHPV was detectable but not transcriptionally active in adjacent/distant tumor-free oropharyngeal tissue. This suggests that a multifocal HPV infection, hinting a «virus-induced fielcd cancerization», may not be pertaining to HPV-related OPSCC.

Published
2022
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21. Prevalence of Transcriptionally Active HPV Infection in Tumor-Free Oropharyngeal Tissue of OPSCC-Patients

Author

Guarda, Vittoria; https://orcid.org/0000-0002-3078-5908, Schroeder, Lea, Pawlita, Michael; https://orcid.org/0000-0002-4720-8306, Ikenberg, Kristian, Rupp, Niels J; https://orcid.org/0000-0002-7043-3456, Jochum, Wolfram; https://orcid.org/0000-0001-6170-2020, Stoeckli, Sandro J, Holzinger, Dana; https://orcid.org/0000-0002-5010-5236, Broglie, Martina A; https://orcid.org/0000-0002-5573-818X, Guarda, Vittoria; https://orcid.org/0000-0002-3078-5908, Schroeder, Lea, Pawlita, Michael; https://orcid.org/0000-0002-4720-8306, Ikenberg, Kristian, Rupp, Niels J; https://orcid.org/0000-0002-7043-3456, Jochum, Wolfram; https://orcid.org/0000-0001-6170-2020, Stoeckli, Sandro J, Holzinger, Dana; https://orcid.org/0000-0002-5010-5236, and Broglie, Martina A; https://orcid.org/0000-0002-5573-818X

Abstract

Objectives: The natural history of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is still largely unknown. Since reports of second primary tumors (SPTs) in patients with HPV-related OPSCCs are increasing, a multifocal HPV infection, hinting a «virus-induced field effect», has been hypothesized. This study aimed to investigate the HPV-prevalence in normal appearing oropharyngeal tissue in patients with OPSCCs. Materials and Methods: 49 OPSCC patients undergoing panendoscopy were prospectively enrolled. Tumor specimens and biopsies of normal appearing oropharyngeal tissue adjacent to and distant from the index OPSCC underwent histopathological examination, p16INK4A immunohistochemical staining, HPV DNA and mRNA-detection. Patient characteristics and follow-up data on SPTs were obtained. Results: 26 of 49 (53%) OPSCC were positive for HPV DNA and p16INK4A. HPV mRNA was detected in 23 of 26 (88%) of these tumor samples. HPV DNA was detected in 36% adjacent mucosa and in 17% distant mucosa samples and only in patients with an HPV-related index OPSCC. HPV mRNA could not be detected in tumor-free distant and adjacent mucosa samples. No evidence of association between HPV detection in normal appearing mucosa and development of second primary tumors was found. Conclusions: HPV was detectable but not transcriptionally active in adjacent/distant tumor-free oropharyngeal tissue. This suggests that a multifocal HPV infection, hinting a «virus-induced fielcd cancerization», may not be pertaining to HPV-related OPSCC.

Published
2022

24. PI16+reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches

Author

De Martin, Angelina, Stanossek, Yves, Lütge, Mechthild, Cadosch, Nadine, Onder, Lucas, Cheng, Hung-Wei, Brandstadter, Joshua D., Maillard, Ivan, Stoeckli, Sandro J., Pikor, Natalia B., and Ludewig, Burkhard

Abstract

Fibroblastic reticular cells (FRCs) direct the interaction and activation of immune cells in discrete microenvironments of lymphoid organs. Despite their important role in steering innate and adaptive immunity, the age- and inflammation-associated changes in the molecular identity and functional properties of human FRCs have remained largely unknown. Here, we show that human tonsillar FRCs undergo dynamic reprogramming during life and respond vigorously to inflammatory perturbation in comparison to other stromal cell types. The peptidase inhibitor 16 (PI16)-expressing reticular cell (PI16+RC) subset of adult tonsils exhibited the strongest inflammation-associated structural remodeling. Interactome analysis combined with ex vivo and in vitro validation revealed that T cell activity within subepithelial niches is controlled by distinct molecular pathways during PI16+RC–lymphocyte interaction. In sum, the topological and molecular definition of the human tonsillar stromal cell landscape reveals PI16+RCs as a specialized FRC niche at the core of mucosal immune responses in the oropharynx.

Published
2023
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25. Advances in diagnostic modalities to detect occult lymph node metastases in head and neck squamous cell carcinoma

Author

de Bree, Remco, Takes, Robert P., Castelijns, Jonas A., Medina, Jesus E., Stoeckli, Sandro J., Mancuso, Anthony A., Hunt, Jennifer L., Rodrigo, Juan P., Triantafyllou, Asterios, Teymoortash, Afshin, Civantos, Francisco J., Rinaldo, Alessandra, Pitman, Karen T., Hamoir, Marc, Robbins, Thomas K., Silver, Carl E., Hoekstra, Otto S., and Ferlito, Alfio

Published
2015
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36. Management of von Hippel-Lindau Disease: An Interdisciplinary Review

Author

Schmid, Sabine, Gillessen, Silke, Binet, Isabelle, Brändle, Michael, Engeler, Daniel, Greiner, Jeannette, Hader, Claudia, Heinimann, Karl, Kloos, Patrik, Krek, Willy, Krull, Ina, Stoeckli, Sandro J., Sulz, Michael C., van Leyen, Karin, Weber, Johannes, Rothermundt, Christian, and Hundsberger, Thomas

Published
2014
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37. Joint practice guidelines for radionuclide lymphoscintigraphy for sentinel node localization in oral/oropharyngeal squamous cell carcinoma

Author

Alkureishi, Lee W. T., Burak, Zeynep, Alvarez, Julio A., Ballinger, James, Bilde, Anders, Britten, Alan J., Calabrese, Luca, Chiesa, Carlo, Chiti, Arturo, de Bree, Remco, Gray, Harry W., Hunter, Keith, Kovacs, Adorjan F., Lassmann, Michael, Leemans, C. Rene, Mamelle, Gerard, McGurk, Mark, Mortensen, Jann, Poli, Tito, Shoaib, Taimur, Sloan, Philip, Sorensen, Jens A., Stoeckli, Sandro J., Thomsen, Jorn B., Trifiro, Giusepe, Werner, Jochen, Ross, Gary L., and The European Association of Nuclear Medicine (EANM) Oncology Committee and European Sentinel Node Biopsy Trial (SENT) Committee

Published
2009
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40. Distinct microbial communities colonize tonsillar squamous cell carcinoma

Author

De Martin, Angelina, Lütge, Mechthild, Stanossek, Yves, Engetschwiler, Céline, Cupovic, Jovana, Brown, Kirsty, Demmer, Izadora, Broglie, Martina A, Geuking, Markus B, Jochum, Wolfram, McCoy, Kathy D, Stoeckli, Sandro J, Ludewig, Burkhard, University of Zurich, and Ludewig, Burkhard

Subjects
tonsillar squamous cell carcinoma, Tonsillar Neoplasms, Immunology, microbiome, 610 Medicine & health, 10045 Clinic for Otorhinolaryngology, tonsil cancer, stomatognathic system, RNA, Ribosomal, 16S, otorhinolaryngologic diseases, high risk-human papilloma virus (hr-hpv), Humans, Immunology and Allergy, 16s rrna gene amplicon sequencing, Phylogeny, RC254-282, Original Research, Clostridiales, 2403 Immunology, Microbiota, tonsillar microbiome, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, respiratory system, RC581-607, stomatognathic diseases, Oncology, Carcinoma, Squamous Cell, 2723 Immunology and Allergy, 2730 Oncology, Immunologic diseases. Allergy, Research Article
Abstract

Background: Squamous cell carcinoma of the tonsil is one of the most frequent cancers of the oropharynx. The escalating rate of tonsil cancer during the last decades is associated with the increase of high risk-human papilloma virus (HR-HPV) infections. While the microbiome in oropharyngeal malignant diseases has been characterized to some extent, the microbial colonization of HR-HPV-associated tonsil cancer remains largely unknown.Results: Using 16S rRNA gene amplicon amplicon sequencing, we have characterized the microbiome of human palatine tonsil crypts in patients suffering from HR-HPV-associated tonsil cancer in comparison to an age-matched control cohort of sleep apnea patients. We found an increased abundance of the phyla Firmicutes and Actinobacteria in tumor patients, whereas the abundance of Spirochaetes and Synergistetes was significantly higher in the control cohort. Furthermore, the accumulation of several genera such as Veillonella, Streptococcus and Prevotella_7 in tonsillar crypts was associated with tonsil cancer. In contrast, Fusobacterium, Prevotella and Treponema_2 were enriched in sleep apnea patients. Machine learning-based bacterial species analysis indicated that a particular bacterial composition in tonsillar crypts is tumor-predictive. Species-specific PCR-based validation in extended patient cohorts confirmed that differential abundance of Filifactor alocis and Prevotella melaninogenica is a distinct trait of tonsil cancer.Conclusion: This study shows that tonsil cancer patients harbor a characteristic microbiome in the crypt environment that differs from the microbiome of sleep apnea patients on all phylogenetic levels. Moreover, our analysis indicates that profiling of microbial communities in distinct tonsillar niches provides microbiome-based avenues for the diagnosis of tonsil cancer.

Published
2021

42. Distinct microbial communities colonize tonsillar squamous cell carcinoma

Author

De Martin, Angelina; https://orcid.org/0000-0002-9056-8075, Lütge, Mechthild; https://orcid.org/0000-0001-9011-5319, Stanossek, Yves, Engetschwiler, Céline, Cupovic, Jovana, Brown, Kirsty, Demmer, Izadora, Broglie, Martina A, Geuking, Markus B, Jochum, Wolfram, McCoy, Kathy D; https://orcid.org/0000-0002-3900-9227, Stoeckli, Sandro J, Ludewig, Burkhard; https://orcid.org/0000-0002-7685-573X, De Martin, Angelina; https://orcid.org/0000-0002-9056-8075, Lütge, Mechthild; https://orcid.org/0000-0001-9011-5319, Stanossek, Yves, Engetschwiler, Céline, Cupovic, Jovana, Brown, Kirsty, Demmer, Izadora, Broglie, Martina A, Geuking, Markus B, Jochum, Wolfram, McCoy, Kathy D; https://orcid.org/0000-0002-3900-9227, Stoeckli, Sandro J, and Ludewig, Burkhard; https://orcid.org/0000-0002-7685-573X

Abstract

Squamous cell carcinoma of the tonsil is one of the most frequent cancers of the oropharynx. The escalating rate of tonsil cancer during the last decades is associated with the increase of high risk-human papilloma virus (HR-HPV) infections. While the microbiome in oropharyngeal malignant diseases has been characterized to some extent, the microbial colonization of HR-HPV-associated tonsil cancer remains largely unknown. Using 16S rRNA gene amplicon sequencing, we have characterized the microbiome of human palatine tonsil crypts in patients suffering from HR-HPV-associated tonsil cancer in comparison to a control cohort of adult sleep apnea patients. We found an increased abundance of the phyla Firmicutes and Actinobacteria in tumor patients, whereas the abundance of Spirochetes and Synergistetes was significantly higher in the control cohort. Furthermore, the accumulation of several genera such as Veillonella, Streptococcus and Prevotella_7 in tonsillar crypts was associated with tonsil cancer. In contrast, Fusobacterium, Prevotella and Treponema_2 were enriched in sleep apnea patients. Machine learning-based bacterial species analysis indicated that a particular bacterial composition in tonsillar crypts is tumor-predictive. Species-specific PCR-based validation in extended patient cohorts confirmed that differential abundance of Filifactor alocis and Prevotella melaninogenica is a distinct trait of tonsil cancer. This study shows that tonsil cancer patients harbor a characteristic microbiome in the crypt environment that differs from the microbiome of sleep apnea patients on all phylogenetic levels. Moreover, our analysis indicates that profiling of microbial communities in distinct tonsillar niches provides microbiome-based avenues for the diagnosis of tonsil cancer.

Published
2021

43. Impact of the new TNM Staging System (8th edition) on oral tongue cancers

Author

Ammann, Yanic, Beutner, Ulrich, Vital, Domenic Gian, Morand, Grgoire, Broglie Daeppen, Martina A; https://orcid.org/0000-0002-5573-818X, Born, Diana, Stoeckli, Sandro J, Huber, Gerhard F, Ammann, Yanic, Beutner, Ulrich, Vital, Domenic Gian, Morand, Grgoire, Broglie Daeppen, Martina A; https://orcid.org/0000-0002-5573-818X, Born, Diana, Stoeckli, Sandro J, and Huber, Gerhard F

Abstract

AIM OF THE STUDY For tumours of the oral tongue, the most recent 8th edition of the AJCC/UICC staging system has introduced depth of infiltration (DOI) as a novel parameter. With this study we wanted to investigate its impact regarding this risk stratification compared with the preceding 7th edition. METHODS Between 2008 and 2017, 161 patients of two tertiary referral centres in Switzerland (Kantonsspital St. Gallen and University Hospital Zurich) with T1 N0 or T2 N0 tongue cancers were enrolled in this study. The primary tumours were restaged according to the 8th edition of the TNM classification. Kaplan-Meier curves for overall and disease-specific survival were calculated. RESULTS According to the 7th edition, of the 161 patients, 102 were staged after surgery as pT1 (stage I) and 59 as pT2 (stage II). According to the 8th edition, 36 patients (22.4%) were re-staged to a higher stage. Of these 36 patients, 8 (22.2%) experienced a recurrence, and 9 (25%) died. In the remaining, not re-staged group, 20 patients (16.0%) experienced a recurrence (p = 0.55) and 14 (11.2%) died (p = 0.025*). The 7th edition showed a statistically significant difference between pT1 and pT2 tumours for overall survival (p = 0.025), but not for disease-specific survival (p = 0.091), whereas the 8th edition was able to well discriminate between pT1, pT2 and pT3 for both overall (pT1 vs pT2, p = 0.016*; pT2 vs pT3, p = 0.031*) and disease-specific survival (pT1 vs pT2, p = 0.037*; pT2 vs pT3, p = 0.023*). CONCLUSION The recent TNM 8th edition provides a more accurate prediction of overall and disease-specific survival for this subgroup of patients. Hence, a more aggressive treatment should be considered for patients re-staged to pT3 due to depth of infiltration.

Published
2021

47. Distinct Microbial Communities Colonize Tonsillar Squamous Cell Carcinoma

Author

Ludewig, Burkhard, primary, Martin, Angelina De, additional, Lütge, Mechthild, additional, Stanossek, Yves, additional, Engetschwiler, Céline, additional, Cupovic, Jovana, additional, Brown, Kirsty, additional, Demmer, Izadora, additional, Broglie, Martina A., additional, McCoy, Kathy, additional, Geuking, Markus, additional, Jochum, Wolfram, additional, and Stoeckli, Sandro J., additional

Published
2021
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