31 results on '"Stochmal E"'
Search Results
2. Persistent trigeminal artery as a rare cause of ischaemic lesion and migraine-like headache
- Author
-
Uhlig, S., primary, Kurzepa, J., additional, Czekajska-Chehab, E., additional, Staśkiewicz, G., additional, Polar, M. K., additional, Nastaj, M., additional, Stochmal, E., additional, and Drop, A., additional
- Published
- 2015
- Full Text
- View/download PDF
3. Validation of Prediction of the Score (Systematic Coronary Risk Evaluation) in Urban Population
- Author
-
Szurkowska, M, primary, Szafraniec, K, additional, Pach, D, additional, Januszewska, A Gilis, additional, Stochmal, E, additional, Szybinski, Z, additional, and Huszno, B, additional
- Published
- 2006
- Full Text
- View/download PDF
4. Doping of selected schiff polybases and polyaniline with heteropolyacids: catalytic properties of the products
- Author
-
Kulszewicz-Bajer, I., primary, Hasik, M., additional, Wielgus, I., additional, Stochmal, E., additional, Turek, W., additional, Lapkowski, M., additional, and Profon, A., additional
- Published
- 1994
- Full Text
- View/download PDF
5. EFFECT OF SODIUM NITROPRUSSIDE ON MOUSE SPERM MIGRATION IN VITRO.
- Author
-
Sliwa, L. and Stochmal, E.
- Subjects
- *
SODIUM nitroferricyanide , *SPERMATOZOA , *ANIMAL behavior - Abstract
In the present study the effect of sodium nitroprusside, a nitric oxide releaser, on mouse sperm motion behavior was examined. The number of sperm migrating in experimental plate to medium containing sodium nitroprusside in concentration 50 nM was significantly higher than the number migrating to control. This effect was observed after 3 and 5 h of incubation, and it was not time dependent. The presence of sodium nitroprusside in higher concentrations did not cause any visible changes or decrease the migration of sperm. These effects were interpreted as chemokinesis but not chemotaxis of sperm induced by influence of sodium nitroprusside on sperm metabolism and motility. [ABSTRACT FROM AUTHOR]
- Published
- 2000
- Full Text
- View/download PDF
6. Conjugated Polymer-Supported Catalysts - Polyaniline Protonated with 12-Tungstophosphoric Acid
- Author
-
Hasik, M., Turek, W., Stochmal, E., Lapkowski, M., and Pron, A.
- Abstract
New types of conjugated polymer supported catalysts were prepared from polyaniline and 12-tungstophosphoric acid. Two preparation methods were used: (i) chemical polymerization of aniline in the presence of H3PW12O40 and (ii) protonation of polyemeraldine base with H3PW12O40. UV-VIS, FTIR, and X-ray studies unequivocally prove the protonation of polyaniline with simultaneous incorporation of heteropolyacid (HPA) in the polymer. Molecular dispersion of HPA in polyaniline matrix via a protonation reaction results in effective blocking of acid-base centers since protonation results in the abstraction of the most acidic proton from the molecules of the acid. As a result, in the test reaction of isopropyl alcohol conversion the obtained catalyst exhibits very low acid-base activity and high selectivity (>90% in all cases) towards acetone. Redox activity depends on the preparation method and is higher for the samples prepared through protonation of polyemeraldine base because in this case heteropolyanions are bound only to the surface of the polymer. On the contrary, HPA introduced into the polymer matrix in situ during polymerization is evenly distributed on the surface and in the bulk, and the access of alcohol molecules to those HPA which are located in the bulk is more difficult. Redox activity of the catalyst with HPA distribution limited to the surface of the polymer is comparable to that observed in unsupported H3PW12O40 for the highest obtainable protonation levels and decreases with the decrease of HPA surface concentration. On the other hand, activation energy derived from the Arrhenius plot for the dehydrogenation reaction drops with the decrease of the HPA surface concentration and is ca. 40 kJ/mole in these catalysts as compared to ca. 70 kJ/mole calculated for unsupported H3PW12O40.Copyright 1994, 1999 Academic Press, Inc.
- Published
- 1994
- Full Text
- View/download PDF
7. Bimodal influence of plasma estradiol on relation between insulin-like growth factor-I (IGF-I) and estradiol in women
- Author
-
Milewicz, T., Krzysiek, J., Rogatko, I., Sztefko, K., Stochmal, E., Jach, R., Galicka-Latała, D., Radowicki, S., Hubert Huras, and Radoń-Pokracka, M.
- Subjects
hormones ,estradiol ,insulin-like growth factor-I ,plasma
8. Correction to: Breastfeeding history and the risk of overweight and obesity in middle-aged women.
- Author
-
Cieśla E, Stochmal E, Głuszek S, and Suliga E
- Published
- 2021
- Full Text
- View/download PDF
9. Breastfeeding history and the risk of overweight and obesity in middle-aged women.
- Author
-
Cieśla E, Stochmal E, Głuszek S, and Suliga E
- Subjects
- Body Mass Index, Child, Female, Humans, Lactation, Middle Aged, Obesity epidemiology, Pregnancy, Risk Factors, Breast Feeding, Overweight epidemiology
- Abstract
Background: The increased metabolic activity required to sustain breastfeeding and its associated milk production helps to reduce maternal fat stores accumulated during pregnancy. This study aims to assess the association between breastfeeding duration and fatness indices in middle-aged women., Methods: The analysis was carried out in a group of 7500 parous 55.5 ± 5.3 year old women included body mass index, body fat percentage, and waist-to-height ratio. The likelihood of excessive weight or obesity in relation to total breastfeeding time using multivariate logistic regression analyses., Results: An analysis of adjusted odds ratios did not show significant associations between breastfeeding duration and the risk of excessive weight and obesity in premenopausal women. After menopause, women who gave birth to 2 children and breastfed 1-6 and > 12 months had a lower risk of abdominal obesity (OR 0.70; 95% CI 0.50-0.99; p = 0.042; and OR 0.68; 95% CI 0.47-0.98; p = 0.039). Women who gave birth to 3 or more children and breastfed for 1-6 months, also showed a lower risk of overweight (OR 0.52; 95% CI 0.27-0.99; p = 0.047), compared to those ones that have never breastfed. There was no relationship found between the duration of lactation and the risk of excessive body fat., Conclusion: Breastfeeding may have some beneficial, long-term effect on the risk of excessive weight and abdominal obesity in women.
- Published
- 2021
- Full Text
- View/download PDF
10. Splanchnic Vein Thrombosis in Acute Pancreatitis and Its Consequences.
- Author
-
Nawacki Ł, Matykiewicz J, Stochmal E, and Głuszek S
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Retrospective Studies, Venous Thrombosis pathology, Young Adult, Pancreatitis complications, Splanchnic Circulation physiology, Venous Thrombosis etiology
- Abstract
Splanchnic vein thrombosis (SVT) is a serious vascular complication that can occur in patients with acute pancreatitis. We assessed the incidence of SVT and its relationship with acute pancreatitis (AP) and associated complications. We carried out a retrospective analysis of medical histories from patients hospitalized with AP in a single surgical center. Histories were acquired from patients with abdominal and pelvic computed tomography scans performed between the 2nd and 3rd day of hospitalization. We assessed the impact and extent of thrombosis over the disease course. We found a strong positive correlation (Cramer's V coefficient = 0.34) between SVT and disease severity. Mortality in the study group was 7.2% (8 patients) of which 5 patients (62.5%) were diagnosed with SVT. We observed an increased incidence of death among patients with thrombosis, with results approaching significance ( P = 0.056). In our study, we found that SVT has a negative effect on the course of AP and is associated with more severe disease and increased mortality.
- Published
- 2021
- Full Text
- View/download PDF
11. Plasma sICAM levels during standard exercise test are higher in postmenopausal women with mixed hyperlipemia. sICAM level in postmenopausal women.
- Author
-
Ociepka A, Milewicz T, Krzyczkowska-Sendra-Kowska M, Stochmal E, and Fedak D
- Subjects
- Endothelin-1 blood, Exercise Test, Female, Humans, Hyperlipoproteinemia Type V psychology, Middle Aged, Tumor Necrosis Factor-alpha blood, Vascular Cell Adhesion Molecule-1 blood, White People, Hyperlipoproteinemia Type V blood, Intercellular Adhesion Molecule-1 blood, Postmenopause
- Abstract
Aim: Plasma sICAM, sVCAM, endothelin- 1 (ET-1), TNF-a, its soluble receptor levels and nitric oxide production evaluation during standard exercise test in postmenopausal women with mixed hyperlipidemia., Material and Methods: 35 white, normotensive, non-smoking, postmenopusal women. Group A consisted of 24 women normal plasma cholesterol and triglicerides. Group B- 11 women hypercholesterolemic and hypertrigliceridemic. Basic fasting plasma FSH, 17b- -estradiol, total cholesterol, LDL-cholesterol, triglicerides, HDL-cholesterol were measured. Standard exercise test was carried out according to Bruce protocol. During the test blood samples were taken trice (prior to, at peak exercise, at15th minute of recovery). The sICAM, sVCAM, ET-1, TNF-a, its soluble receptor and secretion of nitric oxide were measured. Statistical analysis: Fisher test and t-Welch test were used., Results: There were no differences between groups A and B in mean plasma concentrations of FSH, estradiol and HDL-cholesterol. Mean plasma total cholesterol, triglicerides and LDL-cholesterol levels were higher in group B compared to group A. Plasma levels of sICAM prior to standard exercise test, at peak exercise and at the 15th minute of recovery were significantly lower in group A compared to group B. Mean plasma sVCAM levels did no differ between groups. NO3 plasma levels was significantly higher at peak exercise in group B compared to group A. There were no significant differences between groups in regard to mean plasma NO2, endothelin-1, TNF-a, and TNF-a receptor levels., Conclusion: Plasma soluble intracellular adhesion molecules levels are higher at rest and during exercise in postmenopausal women with atherosclerosis risk factors.
- Published
- 2016
12. [Cyclic Cushing's Syndrome - rare or rarely recognized].
- Author
-
Kiałka M, Doroszewska K, Mrozińska S, Milewicz T, and Stochmal E
- Subjects
- Cushing Syndrome epidemiology, Cushing Syndrome therapy, Humans, Periodicity, Cushing Syndrome blood, Cushing Syndrome diagnosis, Hydrocortisone blood
- Abstract
Cyclic Cushing's syndrome is a type of Cushing's disease which is characterized by alternating periods of increasing and decreasing levels of cortisol in the blood. The diagnostic criteria for cyclic Cushing's syndrome are at least three periods of hypercortisolism alternating with at least two episodes of normal levels of serum cortisol concentration. The epidemiology, signs, symptoms, pathogenesis and treatment of cyclic Cushing's syndrome have been discussed.
- Published
- 2015
13. Evening not morning plasma cortisol level is higher in women with polycystic ovary syndrome.
- Author
-
Kiałka M, Ociepka A, Milewicz T, Krzyczkowska-Sendrakowska M, Gosztyła K, Stochmal E, Lurzyńska M, and Bałajewicz-Nowak M
- Subjects
- Adult, Body Mass Index, Circadian Rhythm physiology, Female, Humans, Young Adult, Estradiol blood, Follicle Stimulating Hormone blood, Hydrocortisone blood, Luteinizing Hormone blood, Polycystic Ovary Syndrome blood, Prolactin blood, Testosterone blood, Thyrotropin blood
- Abstract
Introduction: The aim of our study was to assess the morning and evening cortisol plasma levels in women with polycystic ovary syndrome (PCOS)., Material and Method: 95 patients gave their informed consent to participate in the study and were divided into 2 groups. Group A consisted of 40 PCOS patients and group B consisted of 55 women without features of PCOS. Between day 5 and 8 of the menstrual cycle, morning (7 am), fasting blood samples were taken for the assessment of luteinizng hormone (LH), follicle stimulating hormone (FSH), estradiol, cortisol, prolactin, thyreotropin (TSH), testosterone and dehydroepeiandrosterone (DHEAS). Evening (5 pm) blood samples were also taken for the evaluation of plasma cortisol level, Results: There were no differences in mean age, body mass index (BMI), FSH, SHBG, PRL, estradiol and TSH levels between group A and group B. Mean plasma LH level was higher in group A compared to group B (10.7 ± 6.8 IU/l vs 6.6 ± 4.5 LU/l, p < 0.02). Mean plasma testosterone and DHEAS levels were also higher in PCOS patients (3.8 ± 0.6 nmol/l vs 1.63 ± 0.6 nmol/l; 427.7 ± 162.9 vs 236.6 ± 97.8 respectively, p < 0.001). Mean evening plasma cortisol level was higher in PCOS patients (11.8 ± 4.1 ug/dl vs 4.7 ± 1.3 ug/dl, p < 0.02). Mean morning plasma cortisol levels did not differ between groups., Conclusion: PCOS women showed the increased evening plasma cortisol level with impacted diurnal secretion rate.
- Published
- 2015
14. [The disturbances of the thyroid hormone homeostasis caused by chemical substances occurring in natural environment].
- Author
-
Kiałka M, Doroszewska K, Mrozińska S, Milewicz T, Stochmal E, and Krzysiek J
- Subjects
- Homeostasis drug effects, Humans, Environmental Pollutants toxicity, Polychlorinated Biphenyls toxicity, Thyroid Gland drug effects, Thyroid Gland metabolism, Thyroid Hormones metabolism
- Abstract
The thyroid is an endocrine gland synthesizing, storaging and secreting thyroxine (T4) and triiodothyronine (T3). Currently, there are more and more reports and evidences that various chemical contaminants present in the environment, mainly polychlorinated biphenyls, interfere with stages of regulation, synthesis, secretion, transport of thyroid hormones. That can have a significant negative impact on the human body's endocrine homeostasis.
- Published
- 2014
15. The somatotropic axis in postmenopausal women during six month of transdermal continuous 17beta-estradiol administration combined with oral medroxyprogesterone.
- Author
-
Milewicz T, Krzysiek J, Rogatko I, Sztefko K, Stochmal E, Hubalewska-Dydejczyk A, Jach R, and Radowicki S
- Subjects
- Administration, Cutaneous, Administration, Oral, Dose-Response Relationship, Drug, Drug Therapy, Combination, Female, Growth Hormone blood, Humans, Middle Aged, Poland, Postmenopause blood, Women's Health, Estradiol administration & dosage, Estrogen Replacement Therapy, Growth Hormone drug effects, Medroxyprogesterone administration & dosage, Postmenopause drug effects
- Abstract
Aim: The evaluation of the influence of continuous transdermal estradiol supplementation combined with oral medroxyprogesterone on the somatotropic axis in postmenopausal women., Material and Methods: 25 women completed the study Group A--13 women received transdermal 17beta-estradiol (Oesclim 50 - Fournier-Solvay) combined with oral 5 mg daily medroxyprogesterone (Gestomikron - Adamed). Group B--12 women without treatment. Basic plasma FSH, estradiol, glucose, insulin, SHBG, hGH, total and free IGF-I, IGFBP-1 as well as IGFBP-3 were measured initially and at the 12th and 24th week of the study., Results: The mean plasma FSH level was reduced and mean plasma estradiol level was increased in group A during estradiol supplementation. Mean plasma level of free IGF-I and free to total IGF-I ratio were increased in group A during 24 weeks of hormone therapy. In the control group (group B) there was the significant increase in mean plasma IGFBP-3 level. Other parameters showed no significant changes in the control group., Conclusion: The administration of transdermal 17beta-estradiol combined with oral medroxyprogesterone increases the IGF-I bioavailability. However this influence do not exceed the physiologial level of IGF-I bioavailability.
- Published
- 2011
16. [Influence of estradiol administration mode on plasma insulin-like growth factor-I (IGF-I) and its binding proteins 1 and 3 concentration in postmenopausal women treated with norethisterone acetate].
- Author
-
Milewicz T, Krzysiek J, Rogatko I, Sztefko K, Stochmal E, Hubalewska-Dydejczyk A, Jach R, and Radowicki S
- Subjects
- Administration, Cutaneous, Administration, Oral, Adult, Drug Therapy, Combination, Estrogen Replacement Therapy, Female, Humans, Middle Aged, Treatment Outcome, Women's Health, Estradiol administration & dosage, Insulin-Like Growth Factor Binding Protein 1 blood, Insulin-Like Growth Factor Binding Protein 3 blood, Insulin-Like Growth Factor I analysis, Norethindrone administration & dosage, Postmenopause blood
- Abstract
Aim: The aim of the present work was to assess the influence of estradiol administration mode on the plasma IGF-I, IGFBP-1, IGFBP-3 levels in postmenopausal women treated with norethisterone acetate., Material and Methods: 39 women were enrolled into the study Group A--14 women received transdermal 17beta-estradiol (Oesclim 50--Fournier-Solvay) combined with oral norethisterone 2.5 mg daily (Primolut-Nor--Schering), Group B--10 women on oral 2 mg 17beta-estradiol combined with oral 1 mg daily norethisterone (Kliogest--Novo-Nordisk). Control group (group C) consisted of 15 postmenopausal women who received no treatment. Basic plasma FSH, estradiol and total IGF-I, IGFBP-1 as well as IGFBP-3 levels were measured initially and at the 52nd week of the study., Results: The mean plasma FSH level was reduced and mean plasma estradiol level was increased in groups A and B during hormone therapy. Mean plasma levels of total IGF-I, IGFBP-1, IGFBP-3 as well as IGFBP-3/IGF-I ratio did not changed significantly during 52 weeks of observation in groups A, B and C. The comparison of plasma IGF-I, IGFBP-1, IGFBP-3 between groups at the initial visit and after 52 weeks showed the lowest concentration f IGBP-3 in group B. Other parameters showed no differences among the three groups., Conclusion: Mode of administration of estradiol did not influenced the plasma levels of IGF-I, IGFBP-1, IGFBP-3 in postmenopausal women treated with norethisterone acetate.
- Published
- 2011
17. [The role of thyroid antibodies in the pathogenesis of the infertility and miscarriage].
- Author
-
Milewicz T, Spałkowska M, Wasyl B, Pełka A, Stochmal E, Pach D, Galicka-Latała D, and Krzysiek J
- Subjects
- Adult, Female, Humans, Pregnancy, Young Adult, Abortion, Spontaneous immunology, Hypothyroidism complications, Immunoglobulins, Thyroid-Stimulating immunology, Infertility, Female immunology
- Abstract
There are discordant opinions about the influence of subclinical hypothyroidism to the fertility of the women. No unequivocal opinion has been presented concerning the purposefulness of the diagnostics process and treatment of the pregnant women with subclinical hypothyroidism. Few clinical studies suggest that there is a connection between thyroid antibodies and infertility, spontaneous miscarriages, implantation failures and fetal malformations.
- Published
- 2011
18. Bimodal influence of plasma estradiol on relation between insulin-like growth factor-I (IGF-I) and estradiol in women.
- Author
-
Milewicz T, Krzysiek J, Rogatko I, Sztefko K, Stochmal E, Jach R, Galicka-Latała D, Radowicki S, Huras H, and Radoń-Pokracka M
- Subjects
- Adult, Body Mass Index, Female, Human Growth Hormone blood, Humans, Insulin-Like Growth Factor Binding Protein 3 blood, Young Adult, Estradiol blood, Insulin-Like Growth Factor I metabolism
- Abstract
Objective: To compare the influence of low and normal endogenous estradiol concentration on circulating hGH, IGF-I and IGFBP-3 levels as well as on mutual correlations of these parameters., Patients: 45 women (age 30.7 ± 9.0 years, BMI 25.7 ± 8.0) divided into group A - 15 hypoestrogenic women and group B - 30 normoestrogenic controls. Neither of the women was menopausal nor hyperprolactinemic., Methods: Blood sample was taken at the standard conditions prior to the initiation of hormonal supplementation therapy in group A and at the day 3-5 of menstrual cycle in group B. Serum hGH, IGF-I, IGFBP-3, insulin, testosterone, sex hormone binding globulin (SHBG) dihydroepiandrosterone sulphate (DHEAS) and LH as well as prolactin (PRL), FSH and estradiol levels were measured by standard RIA kits., Results: Mean IGF-1, LH, FSH, testosterone and estradiol and PRL plasma levels were lower in group A compared to group B. There were no significant differences in mean SHBG, insulin and DHEAS levels. There were also no differences in mean: age, body mass, BMI as well as percentage of each BMI range between groups. Regardless the estradiol level the IGF-I/age link was found in both groups. A IGF-I/IGFBP-3 relation was found in both groups. IGF-I/estradiol link was seen only in group A. In group B hGH/SHBG link was found, in group A this relation was indirect. A link between hGH and testosterone levels was found only in group B. SHBG was related in group B to IGFBP-3, testosterone and to DHEAS. Insulin/IGFBP-3 link was seen in group B. The stepwise multiple regression revealed DHEAS and LH as predictors of IGF-I level in group A, while in group B none of the parameters predicted IGF-I level. The results of the same analysis in case of hGH are as follows: in group A hGH level was predicted by estradiol and SHBG. In group B none of factors predicted hGH levels., Conclusion: Estradiol plasma level is correlated to circulating IGF-I, albeit the relation seems to be biphasic.
- Published
- 2011
19. [Placenta endocrine function influence on fetal hypothalamo-hypophyseo-thyroid axis].
- Author
-
Milewicz T, Pulka M, Stochmal E, Pach D, Galicka-Latała D, Juszczyk L, and Krzysiek J
- Subjects
- Chorionic Gonadotropin metabolism, Estrogens metabolism, Female, Humans, Prealbumin metabolism, Pregnancy, Hypothalamo-Hypophyseal System embryology, Placenta metabolism, Thyroid Hormones metabolism
- Abstract
The conteporary views on the influence of placenta on the fetal hypothalamo-hypophyseo-thyroid axis has been given. The role of hCG, estrogens, deiodineses, transfereses and arylosulphateses has been presented. Transthyretin role has been mentioned.
- Published
- 2011
20. Overexpression of P53 protein and local hGH, IGF-I, IGFBP-3, IGFBP-2 and PRL secretion by human breast cancer explants.
- Author
-
Milewicz T, Ryś J, Wójtowicz A, Stochmal E, Jach R, Krzysiek J, Gregoraszczuk E, Huras H, and Dziadek O
- Subjects
- Female, Humans, Immunohistochemistry, Mastectomy, Radical, Mutation genetics, Mutation physiology, Organ Culture Techniques, Radioimmunoassay, Breast Neoplasms genetics, Breast Neoplasms metabolism, Genes, p53 genetics, Human Growth Hormone metabolism, Insulin-Like Growth Factor Binding Protein 2 metabolism, Insulin-Like Growth Factor Binding Protein 3 metabolism, Insulin-Like Growth Factor I metabolism, Prolactin metabolism, Tumor Suppressor Protein p53 biosynthesis
- Abstract
Background: Insulin-like growth factor-I (IGF-I) in concert with insulin-like binding protein 3 (IGFBP-3), insulin-like binding protein 2 (IGFBP-2), human growth hormone (GH) and P53 protein is involved in autocrine/paracrine growth signaling pathways as an adaptive response to environmental stimuli., Objective: The study evaluated the local secretion of PRL, hGH, IGF-I, IGFBP-2 and IGFBP-3 by breast cancer tissue explants in relation to the overexpression of P53 protein in breast cancer tissue., Materials and Methods: Breast cancer explants were obtained during radical mastectomies. The overexpression of P53 protein was assessed immunohistochemically using monoclonal antibody (DAKO, Anti-Human P53 protein, clone DO-7); the results of the reaction were stratified into 5 groups. The lack of P53 protein overexpression was defined as 0% of cells that overexpressed P53 protein. IGF-I, IGFBP-3, IGFBP-2, and hGH levels were measured with RIA kits, and prolactin was measured with the MEIA kit., Results: The local secretion of hGH by tumour explants - presenting a positive immunohistochemical reaction (IHCR) to the product of P53 gene - was twice as high as those with no IHCR to product of P53 gene; the opposite was noted in the case of IGF-I, IGFBP-2 and IGFBP-3 secretion. In both cases, the level of hGH, IGF-I and IGFBP-3 secretion did not correlate with the ratio of cells overexpressing P53 protein. There was a significant decrease in local, basic IGFBP-2 secretion along with an increased ratio of cells with positive IHCR to product of P53 gene. Furthermore, local PRL secretion was not correlated with the ratio of cells overexpressing P53 protein in breast cancer tissue. Prolactin also exerts no influence on IGF-I secretion., Conclusion: Our results may suggest the presence of local hGH/IGF-I feedback in breast tissue as well as the possibility of P53/hGH/IGF-I/IGFBP-3 but not P53/PRL/IGF-I axis.
- Published
- 2011
21. Age, place of living and education influences the pregnancy universal thyroid function screening program attendance - questionnaire study.
- Author
-
Milewicz T, Zuk M, Stochmal E, Hubalewska-Dydejczyk A, Galicka-Latała D, Juszczyk L, and Krzysiek J
- Subjects
- Adolescent, Adult, Age Factors, Female, Humans, Middle Aged, Poland, Pregnancy, Social Environment, Surveys and Questionnaires, Educational Status, Mass Screening statistics & numerical data, Pregnancy Complications diagnosis, Pregnant Women psychology, Residence Characteristics, Thyroid Diseases diagnosis, Thyroid Function Tests statistics & numerical data
- Abstract
Background: The aim of this study was to assess attendance at the universal screening programme for thyroid function in pregnancy and attempt to evaluate the influence of age, number of past pregnancies, level of education, and place of residence on the attendance. The study was performed by means of a questionnaire., Material and Methods: Our study was performed on the basis of an anonymous questionnaire handed out to 543 women aged 16-45 years, on the third day of their puerperal stay in one of five obstetric wards in southern Poland. The questionnaire contained questions about participation in plasma level measurements of TSH, fT4, total T4, thyroid antibodies or thyroid ultrasound scanning at least once in pregnancy., Results: The rate of attendance at any examination of thyroid function among pregnant women was 26.7%. The highest attendance rate (32.7%) was found among women living in provincial capitals or with higher education (41.3%), whereas the lowest was among women who had completed only primary school (11%) and those living in county towns (15%). The number of previous pregnancies did not influence the thyroid screening attendance. Women over 21 years of age participated in this screening programme more frequently (27.1-30%)., Conclusion: Less than one third of pregnant women participated in the thyroid function screening. Place of living, education level, and age were the main factors influencing the attendance rate.
- Published
- 2011
22. Intake of iodine-containing multivitamin preparations by pregnant women from the Krakow region of Poland.
- Author
-
Milewicz T, Czyżewicz M, Stochmal E, Galicka-Latała D, Hubalewska-Dydejczyk A, and Krzysiek J
- Subjects
- Adult, Female, Humans, Iodine deficiency, Poland, Pregnancy, Rural Health, Socioeconomic Factors, Surveys and Questionnaires, Urban Health, Young Adult, Dietary Supplements, Iodine administration & dosage, Pregnancy Complications prevention & control, Prenatal Care standards, Thyroid Diseases prevention & control, Vitamins administration & dosage
- Abstract
Background: The aim of this study was to evaluate the number of women who take multivitamin formulations containing iodine., Material and Methods: A 34-question questionnaire was given to 500 women during their puerperal stay in two obstetrics/gynaecology wards in Krakow., Results: 295 pregnant women (59%) took iodine-containing formulations. 205 pregnant women (41%) took multivitamin preparations without iodine. 49.7% of the women (91 out of 183) who inhabited rural areas and small towns were not supplemented with iodine during pregnancy. Women in Krakow took iodine-containing multivitamin formulations in 61.2% of cases. Women with primary and secondary education did not use iodine supplementation in 48.3% and 50.3% of cases respectively. Women with a university education did not use supplementation in 38.6% of cases. The prevalence of women using iodine-containing multivitamin preparation was similar in each age group., Conclusions: The promotion of iodine supplementation to pregnant women should be augmented at each level of contact with medical staff. Medical staff should be reminded about such promotion at each level of medical care and training (general practitioner, obstetrics/gynaecology specialist, endocrinologist, postgraduate training).
- Published
- 2011
23. [The impact of polychlorinated biphenyls on placental and ovarian steroidogenesis].
- Author
-
Gosztyła K, Pulka M, Milewicz T, Lurzyńska M, Opiła J, Stochmal E, Hubalewska-Dydejczyk A, Galicka-Latała D, and Krzysiek J
- Subjects
- Animals, Estrogens metabolism, Female, Humans, Male, Ovary metabolism, Polychlorinated Biphenyls chemistry, Polychlorinated Biphenyls pharmacokinetics, Pregnancy, Environmental Pollutants toxicity, Hormones metabolism, Ovary drug effects, Placenta drug effects, Polychlorinated Biphenyls toxicity, Reproduction drug effects
- Abstract
The structure and turnover of polichlorinated biphenyls (PCB) in environment was presented. The PCB absorption and metabolism in organisms as well as the PCB induced disruption of placental and ovarian steroidogenesis were discussed.
- Published
- 2011
24. [The incidence of neoplasm in women using contraceptives].
- Author
-
Krzysiek J, Wiatr J, Milewicz T, Wyroba J, Krzyczkowska-Sendrakowska M, Galicka-Latała D, Rajtar-Ciosek A, Kacalska-Janssen O, Zmaczyński A, Stochmal E, Hubalewska-Dydejczyk A, Kabzińska-Turek M, Bereza T, and Jedrzejczyk A
- Subjects
- Adult, Causality, Comorbidity, Contraceptive Agents, Contraindications, Female, Humans, Incidence, Risk Assessment, Smoking epidemiology, Contraception methods, Contraception statistics & numerical data, Neoplasms classification, Neoplasms epidemiology
- Abstract
Contraceptive is an important issue of women's life. In the present times there are many methods to prevent unwanted pregnancy. Each of them has its advantages and disadvantages and an appropriate choice of the method determines its promotion high efficiency and comfort its application. Today there is no method of contraception, which would not be charged some risk for the application. Following the review will allow literature to analyze impact of the various methods for the development of cancer control means diseases which may constitute a serious threat to health and life women.
- Published
- 2010
25. [Retrospective hormonal analysis of incidentally discovered and operated adrenal tumors for subclinical Cushing's syndrome].
- Author
-
Przybylik-Mazurek E, Buziak-Bereza M, Fedorowicz A, Kuźniarz-Rymarz S, Stochmal E, and Hubalewska-Dydejczyk A
- Subjects
- Adrenal Gland Neoplasms complications, Adrenal Gland Neoplasms pathology, Circadian Rhythm, Cushing Syndrome blood, Cushing Syndrome etiology, Female, Humans, Incidental Findings, Male, Middle Aged, Retrospective Studies, Adrenal Gland Neoplasms blood, Adrenal Gland Neoplasms surgery, Hydrocortisone blood
- Abstract
In the last twenty years the introduction of new imaging techniques has caused increasing incidence of accidental detection of adrenal tumors, which are usually mild and in most cases are hormonally inactive adenomas. Among hormonal disorders in patients with adrenal incidentalomas the hypercortisolism is often described, which, if not treated properly, leads to multiple organ complications, and further to the patient's death. The aim of the study was the retrospective analysis of the group of patients with adrenal incidentaloma, verified by histopathology for assessment of subclinical Cushing's syndrome. Among the group of 225 patients: 62 men and 163 women with incidentally detected adrenal tumors in age from 19 to 81 years diagnosed and treated in the Department of Clinical Endocrinology, University Hospital in Krakow, 59 patients was sent to surgery: 15 men and 42 women. Two groups of patients were analysed, divided on the basis of histopathological examination result. Group A consisted of patients with adrenal cortical adenoma: 38 people (11 men and 27 women). In group B there were people with so-called other hormonal inactive adrenal tumors - 17 people (4 men and 13 women). The average age of the patients in group A was 52.05 +/- 11.52 years, in group B 51.44 +/- 14.14 years. In group A the mean morning level of cortisol was 18.23 +/- 6.42 ug/dl and did not differ statistically significantly from the results of group B (mean morning cortisol level of 15.86 +/- 4.6 ug/dl). However a significantly higher nocturnal cortisol levels in the blood serum of patients with group A versus group B was observed (6.78 +/- 5.65 ug/dl vs. 3.57 +/- 1.77 ug/dl). There was no cortisol diurnal rhythm disorders in group B, while in group A slightly disrupted cortisol diurnal rhythm was found in 17 people. Mean values of 24-hour urine 17-OHCS and free cortisol were statistically higher in group A than in group B, although mean values remained within normal limits. In 24 patients from group A where abnormalities in the screening test with 1 mg DXA were found, a test with 2 and 8 mg was performed, which showed incomplete suppression of the excretion of steroid metabolites in the urine after administration of 8 mg in 17 subjects, and 3 of the total absence of suppression. In group B in 4 people there was no suppression in 1 mg of DXA test, while the suppression test with 8 mg of DXA was normal. A detailed analysis of the clinical signs, meticulously carried out and repeated hormonal diagnosis with the use of functional tests should be focused on the detection of subclinical hormonal disorders, which is crucial in preventing organ damage and making a decision of the right treatment of the patient, which is surgical.
- Published
- 2010
26. [Diagnostic difficulties in recognizing of pheochromocytoma].
- Author
-
Przybylik-Mazurek E, Buziak-Bereza M, Stochmal E, Budzyński A, Białas M, Kostecka-Matyja M, and Hubalewska-Dydejczyk A
- Subjects
- Adolescent, Adrenal Gland Neoplasms blood, Adrenal Gland Neoplasms surgery, Adrenalectomy, Adult, Aged, Biomarkers, Tumor blood, Biomarkers, Tumor urine, Catecholamines blood, Catecholamines urine, Female, Humans, Male, Middle Aged, Pheochromocytoma blood, Pheochromocytoma surgery, Young Adult, Adrenal Gland Neoplasms diagnosis, Adrenal Gland Neoplasms urine, Normetanephrine urine, Pheochromocytoma diagnosis, Pheochromocytoma urine
- Abstract
Pheochromocytoma (PH) is a tumour of chromaffin cells of the sympathetic nervous system and its clinical symptoms are associated with excessive production and release of catecholamines. The main criterion for clinical diagnosis of PH is finding increased concentrations of catecholamines or their metabolites in serum and/or urine. The largest diagnostic and therapeutic problems are patients with slightly elevated levels of methoxycatecholamines in serum and/ or urine. Aim of this study was to determine the cut-off point for elevated methoxycatecholamine in the collection of daily urine, which would give the basis for determining the reasonable recommendations of the biochemical criteria for diagnosis of PH. Retrospectively we analysed the results of 45 patients sent to laparoscopic adrenalectomy to the Department of General Surgery II with the preoperative diagnosis of pheochromocytoma. The diagnosis of pheochromocytoma was based on the finding of elevated 24-hour urine methoxycatecholamines. Based on the results of the histopathological examination patients were divided into two groups. Group 1 included 27 patients (14 women and 13 men) with histopathologically confirmed pheochromocytoma of adrenal gland. Group 2 consisted of 18 patients (11 women and 7 men), in which histopathological examination did not confirm the presence of pheochromocytoma. Mean age of patients in group 1: 46.8 +/- 14.4 years, in group 2: 55.7 +/- 13.7 years. Hypertension was diagnosed in 77.8% of those with group 1 and 94.4% from group 2. Based on the analyzed results of the CT, we found that the average tumor size in group 1 (4.2 +/- 1.9 cm) was statistically higher than in group 2 (2.9 +/- 1.1 cm). The average concentration of normetanephrine (NMN) in 24-hour urine in group 1 was statistically significantly higher than in group 2 (2,686 +/- 870.4 vs. 2375.1 +/- 754 mg/24h), as well as the average concentration of metanephrine (MN) (2533.4 +/- 3269.3 +/- 491.6 vs. 371.5 mg/24 hrs), and the sum of both methoxycatecholamines (NMN + MN) (5219.3 +/- 5190.6 vs. 1241.8 +/- 1202.2). The highest sensitivity in diagnosing pheochromocytoma with the rate of 81.5% was obtained for the sum of normetanephrine and metanephrine in 24-hour urine, while the sensivity for levels of each methoxycatecholamine separately was similar (63%). The highest specificity in the exclusion of PH was shown for 24-hour urine metanephrine (94.4%). The highest positive predictive value was found for the level of metanephrine in 24-hour urine (94.4%). The diagnostic cutoff concentrations of NMN, MN and NMN + MN for the diagnosis of pheochromocytoma were set. For the 24-hour urine NMN- cut-off > 1500 ug/24 h, for MN > 700 ug/24h and for NMN + MN > 1350 ug/24h. Shown above cut-off levels of methoxycatecholamines urine concentration will allow to pose a more accurate preoperative diagnosis of PH.
- Published
- 2010
27. [The impact of polichlorinated biphenyls on neoplastic processes].
- Author
-
Pulka M, Milewicz T, Gosztyła K, Lurzyńska M, Opiła J, Stochmal E, Hubalewska-Dydejczyk A, Galicka-Latała D, and Krzysiek J
- Subjects
- Animals, Environmental Pollutants chemistry, Environmental Pollutants pharmacokinetics, Humans, Neoplastic Processes, Polychlorinated Biphenyls chemistry, Polychlorinated Biphenyls pharmacokinetics, Environmental Pollutants toxicity, Neoplasms chemically induced, Polychlorinated Biphenyls toxicity
- Abstract
The structure and turnover of polichlorinated biphenyls (PCB) in environment was presented. The PCB absorption and metabolism in organisms as well as the PCB influence on neoplastic process.
- Published
- 2010
28. Nontraditional atherosclerotic risk factors and extent of coronary atherosclerosis in patients with combined impaired fasting glucose and impaired glucose tolerance.
- Author
-
Surdacki A, Stochmal E, Szurkowska M, Bode-Böger SM, Martens-Lobenhoffer J, Stochmal A, Klecha A, Kawecka-Jaszcz K, Dubiel JS, Huszno B, and Szybiński Z
- Subjects
- Adult, Aged, Arginine analogs & derivatives, Arginine blood, C-Reactive Protein metabolism, Cholesterol blood, Discriminant Analysis, Female, Glucose Clamp Technique, Homocysteine blood, Humans, Male, Middle Aged, Risk Factors, Triglycerides blood, Blood Glucose metabolism, Coronary Artery Disease blood, Insulin Resistance physiology
- Abstract
Partially inconsistent data exist on mutual relations between nontraditional atherosclerotic risk factors, including the magnitude of insulin resistance (IR), as well as on their relevance for atherogenesis in the metabolic syndrome. Subjects exhibiting combined impaired fasting glucose and impaired glucose tolerance (IFG/IGT) are exposed to an exceptionally high risk for atherogenesis and development of type 2 diabetes mellitus. Because of islet Beta-cell dysfunction, the usefulness of commonly used indices of IR is limited in IFG/IGT. Our aim was to assess the relationship between extent of angiographic coronary artery disease (CAD) and nontraditional atherosclerotic risk factors (including IR by a clamp-based golden standard method) in IFG/IGT. Fifty-three subjects (32 men, 21 women; mean age, 55 +/- 11 years) with stable angina, preserved left ventricular systolic function, and IFG/IGT were divided into 3 groups: group A (no coronary stenoses >50%, n = 22), group B (1-vessel CAD, n = 15), and group C (2/3-vessel CAD, n = 16). Insulin sensitivity was quantified by a hyperinsulinemic euglycemic clamp technique and expressed as M. M value, plasma homocysteine (Hcy) level, and asymmetric dimethyl-L-arginine (ADMA)/L-arginine ratio were independent determinants of CAD extent as shown by forward stepwise discriminant function analysis. Compared with group A (M = 32.7 +/- 9.3 micromol/kg fat-free mass [FFM] per minute; Hcy, 8.1 +/- 1.4 micromol/L), lower M and higher Hcy levels were found in group B (M = 16.9 +/- 8.2 micromol/kg FFM per minute, P < .001; Hcy, 11.2 +/- 2.9 micromol/L, P = .003) and C (M = 16.4 +/- 7.8 micromol/kg FFM per minute, P < .001; Hcy, 12.8 +/- 3.9 micromol/L, P < .001). The ADMA/L-arginine ratio was increased in group C (0.0078 +/- 0.0011) compared with group A (0.0063 +/- 0.0013, P = .03) and B (0.0058 +/- 0.0012, P = .01). Multivariate correlates (P < .05) of plasma Hcy concentrations were M (beta = -.34 +/- .12, P = .008), creatinine clearance (beta = -.23 +/- .10, P = .03) and fasting insulin (beta = .25 +/- .12, P = .04). This indicates an additive contribution of IR, plasma Hcy, and elevated ADMA/L-arginine ratio to the extent of angiographic CAD in combined IFG/IGT.
- Published
- 2007
- Full Text
- View/download PDF
29. [The influence of physical training on metabolic indices in men with myocardial infarction and impaired glucose tolerance].
- Author
-
Stochmal A, Jasiak-Tyrkalska B, Stochmal E, Huszno B, and Kawecka-Jaszcz K
- Subjects
- Adult, Aged, Body Mass Index, Glucose metabolism, Glucose Intolerance complications, Glucose Tolerance Test, Humans, Hyperinsulinism blood, Lipid Metabolism, Male, Middle Aged, Myocardial Infarction complications, Prospective Studies, Exercise, Glucose Intolerance blood, Insulin blood, Insulin Resistance, Myocardial Infarction blood, Myocardial Infarction rehabilitation
- Abstract
Introduction: Body mass reduction and regular physical training form part of a strategy to treat disorders of carbohydrate metabolism associated with obesity. Evidence shows that even a slight reduction in body mass may improve carbohydrate tolerance, lipid profile and insulin resistance, reduce insulin levels and finally delay or reduce risk of diabetes mellitus. Multiple studies, including prospective studies confirm the independent protective effects of physical training against future development of type 2 diabetes mellitus. Myocardial infarction is a severe complication of atherosclerosis. Patients with glucose intolerance have a 2-fold higher risk of dying. Impaired glucose tolerance is negatively associated with prognosis in patients after myocardial infarction. Glucose intolerance accompanies hyperinsulinemia, a major indicator of insulin resistance., Aim: The aim of the study was to analyze the effect of physical training on hyperinsulinemia/ insulin resistance in patients after myocardial infarction (MI) with impaired glucose tolerance (IGT)., Materials and Methods: 31 men aged 37-69 years (mean 51 +/- 7.4) with IGT 3.5 years after MI, in NYHA class I and II participated in the study. Group A (n=16 men) underwent supervised physical training and group B (n=15) received standard information on physical training. Tissue glucose disposal using normoglycemic glucose clamp technique, fasting insulinemia, glycemia during OGTT, lipid profile, BMI and body mass composition were obtained in all patients., Results: The groups were matched for age. There were no differences in BMI, percent fat content, blood pressure, diet, smoking status and pharmacotherapy. Glycemia during baseline OGTT did not differentiate the groups, either. Analysis of insulinemia and glycemia during OGTT at baseline and at 12 weeks after regular physical training showed lower levels of insulinemia and glycemia compared with baseline levels in group A (fasting glycemia 6.41+/-0.46 vs. 4.8+/-0.32 mmol/l, p<0.001; fasting insulinemia 59.42+/-38.9 vs. 27.42+/-26.5 umol/l, p<0.001). A similar analysis in group B did not reveal any significant differences (fasting glycemia 6.17+/-0.49 vs. 6.18+/-0.46 mmol/ l; fasting insulinemia 61.86+/-48.5 vs. 68.86+/-78.5 umol/l). Mean tissue glucose disposal in the whole study population was 2.96+/-1.03 mg/kg bm/min., Conclusions: The present findings indicate the beneficial effects of regular physical training on the reduction of fasting insulinemia in patients after myocardial infarction with insulin resistance and improve lipid profile. In patients after myocardial infarction standard recommendations concerning physical activity are not well realized. It seems that better compliance, more strict control and motivation of patients can result in better metabolic control.
- Published
- 2007
30. Association of coronary atherosclerosis with insulin resistance in patients with impaired glucose tolerance.
- Author
-
Stochmal E, Szurkowska M, Czarnecka D, Stochmal A, Klecha A, Kawecka-Jaszcz K, and Szybiński Z
- Subjects
- Adult, Comorbidity, Coronary Artery Disease epidemiology, Disease Progression, Female, Glucose Intolerance epidemiology, Glucose Tolerance Test, Humans, Male, Middle Aged, Myocardial Infarction epidemiology, ROC Curve, Regression Analysis, Coronary Artery Disease physiopathology, Glucose Intolerance physiopathology, Insulin Resistance
- Abstract
Objectives: The purpose of the study was to evaluate the role of insulin resistance (IR) in the development of coronary atherosclerosis in patients with impaired glucose tolerance., Methods and Results: The study group consisted of 42 patients with impaired glucose tolerance. Based upon coronary angiography the patients were divided into group A--with prior myocardial infarction and critical coronary stenosis (n=20) and group B--without prior myocardial infarction and without critical coronary stenosis (n=22). In each patient glucose disposal rate (GDR) during metabolic clamp, insulinaemia in the fasting state and during the clamp, glycaemia during oral glucose tolerance test (OGTT), BMI and body mass composition were measured. The groups did not differ in age, BMI, percent fat content and distribution, and blood pressure. Fasting insulinaemia (56.7 microU/ml) was higher in group A than in group B (22.3 microU/ml). GDR in group A (2.96 mg/kg b.m./min) was lower than in group B (5.36 mg/kg b.m./min). There was a negative correlation between the number of critically narrowed coronary vessels and GDR in group A. GDR below 3.97 mg/kg b.m./min was found, based on regression analysis, to be a powerful risk factor for myocardial infarction., Conclusions: The relationship between IR and severity of coronary atherosclerosis implies its unfavourable role in the development of atherosclerosis. The present findings indicate a negative role of IR in the development of myocardial infarction and suggest that it is an independent risk factor, which identifies high-risk patients requiring treatment that would increase tissue insulin sensitivity.
- Published
- 2005
- Full Text
- View/download PDF
31. [The effect of melatonin on directional motility of human sperm under in vitro conditions].
- Author
-
Sliwa L and Stochmal E
- Subjects
- Adult, Chemotaxis physiology, Humans, In Vitro Techniques, Male, Melatonin pharmacology, Sperm Motility drug effects, Melatonin metabolism, Sperm Motility physiology
- Abstract
In model experiments carried out in vitro, human spermatozoa move in well-ordered manner following the concentration gradient. Such behavior is called sperm chemotaxis. The investigations with use of melatonin indicate that this hormone, contained in the follicular liquid, cannot be regarded as chemotactic substance for human spermatozoa. Melatonin in concentrations of 1 mM and 10 mM respectively, do not influence the sperm behavior, however in concentration of 20 mM inhibits their movements in canals of incubation chamber, i.e. shows chemorepelent effect.
- Published
- 2001
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.