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This research work analyses the influence of the use of by-products from a fluorite mine to replace the fine fraction of natural aggregates, on the properties of Ultra-High-Performance Fibre-Reinforced Concrete (UHPFRC). Replacing natural aggregates for different kinds of wastes is becoming common in concrete manufacturing and there are a number of studies into the use of waste from the construction sector in UHPFRC. However, there is very little work concerning the use of waste from the mining industry. Furthermore, most of the existing studies focus on granite wastes. So, using mining sand waste is an innovative alternative to replace natural aggregates in the manufacture of UHPFRC. The substitutions in this study are of 50%, 70% and 100% by volume of 0-0.5 mm natural silica sand. The results obtained show that the variations in the properties of consistency, compressive strength, modulus of elasticity and tensile strength, among others, are acceptable for substitutions of up to 70%. Therefore, fluorite mining sand waste is proved to be a viable alternative in the manufacturing of UHPFRC.