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7. IMPLEMENTATION OF DISCOVERY LEARNING MODEL TO IMPROVE LEARNING RESULT OF NATURAL SCIENCE AT FIFTH GRADE OF SD KATOLIK ST. PAULUS KEMBES

Author

Stief Aristo Walewangko

Subjects
Theory and practice of education, LB5-3640
Abstract

This study was intended to describe the application of Discovery Learning Model on natural science subject and to improve teacher’s skill and learning result of student on fifth grade of Elementary School. This research was classroom action research conducted in two cycles. Each cycle consists of planning, action, observation and reflection. Subjects of this research were students at fifth grade of SD Katolik St. Paulus Kembes. The collecting data technique was using test and observation. Technique of analyzing data was using quantitive descriptive analysis and qualitative descriptive analysis. The results showed that: 1) teacher’s skill in first cycle gained score 25 or 71,42% with ‘good’ criteria, and in second cycle obtained score 29 or 82,85% also with ‘good’ criteria; 2) student’s learning result in first cycle was 62,2% and the second cycle was 81,6%. These results concluded that the application of Discovery Learning Model can improve the quality of natural science subject learning, such as: teacher’s skill and learning result of the fifth grade student in SD Katolik St. Paulus Kembes. It was suggested that Discovery Learning model can be used as teacher’s solution to improve the quality of natural science learning.

Published
2019
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9. Neural foundation of the diathesis-stress model: longitudinal gray matter volume changes in response to stressful life events in major depressive disorder and healthy controls

Author

Thomas-Odenthal, Florian, Ringwald, Kai, Teutenberg, Lea, Stein, Frederike, Alexander, Nina, Bonnekoh, Linda M., Brosch, Katharina, Dohm, Katharina, Flinkenflügel, Kira, Grotegerd, Dominik, Hahn, Tim, Jansen, Andreas, Leehr, Elisabeth J., Meinert, Susanne, Pfarr, Julia-Katharina, Renz, Harald, Schürmeyer, Navid, Stief, Thomas, Straube, Benjamin, Thiel, Katharina, Usemann, Paula, Winter, Alexandra, Krug, Axel, Nenadić, Igor, Dannlowski, Udo, and Kircher, Tilo

Published
2024
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10. Perineale Prostatabiopsie

Author

Pfitzinger, Paulo Leonardo, Askari, Darjusch Andreas, Ivanova, Troya, Hoffmann, Marina, Blajan, Iulia, Atzler, Michael, Stadelmeier, Leo Federico, Apfelbeck, Maria, Chaloupka, Michael, Kazmierczak, Philipp, Stief, Christian, and Enzinger, Benazir

Published
2024
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11. [68Ga]Ga-FAPI-46 PET/CT for penile cancer – a feasibility study

Author

Eismann, Lennert, Ledderose, Stephan T., Enzinger, Benazir, Berg, Elena, Westhofen, Thilo, Rodler, Severin, Schulz, Gerald B., Toms, Johannes, Holzgreve, Adrien, Gildehaus, Franz J., Brendel, Matthias, Cyran, Clemens C., Unterrainer, Marcus, Stief, Christian G., Bartenstein, Peter, Schlenker, Boris, and Unterrainer, Lena M.

Published
2024
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29. [68 Ga]Ga-FAPI-46 PET/CT for locoregional lymph node staging in urothelial carcinoma of the bladder prior to cystectomy: initial experiences from a pilot analysis

Author

Unterrainer, Lena M., Eismann, Lennert, Lindner, Simon, Gildehaus, Franz-Josef, Toms, Johannes, Casuscelli, Jozefina, Holzgreve, Adrien, Kunte, Sophie C., Cyran, Clemens C., Menold, Paula, Karl, Alexander, Unterrainer, Marcus, Ledderose, Stephan T., Stief, Christian G., Bartenstein, Peter, Kretschmer, Alexander, and Schulz, Gerald B.

Published
2024
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35. Is PSMA PET/CT cost-effective for the primary staging in prostate cancer? First results for European countries and the USA based on the proPSMA trial.

Author

Holzgreve, Adrien, Unterrainer, Marcus, Adams, Thaiza, Oprea-Lager, Daniela, Goffin, Karolien, Lopci, Egesta, Unterrainer, Lena, Kramer, Kristina, Schmidt-Hegemann, Nina-Sophie, Casuscelli, Jozefina, Stief, Christian, Ricke, Jens, Bartenstein, Peter, Kunz, Wolfgang, Mehrens, Dirk, and Calais, Jeremie

Subjects
Cost-effectiveness analysis, PSMA PET/CT, Primary staging, ProPSMA trial, Prostate cancer, Male, Humans, Positron Emission Tomography Computed Tomography, Cost-Benefit Analysis, Gallium Radioisotopes, Australia, Prostatic Neoplasms, Neoplasm Staging
Abstract

PURPOSE: The proPSMA trial at ten Australian centers demonstrated increased sensitivity and specificity for PSMA PET/CT compared to conventional imaging regarding metastatic status in primary high-risk prostate cancer patients. A cost-effectiveness analysis showed benefits of PSMA PET/CT over conventional imaging for the Australian setting. However, comparable data for other countries are lacking. Therefore, we aimed to verify the cost-effectiveness of PSMA PET/CT in several European countries as well as the USA. METHODS: Clinical data on diagnostic accuracy were derived from the proPSMA trial. Costs for PSMA PET/CT and conventional imaging were taken from reimbursements of national health systems and individual billing information of selected centers in Belgium, Germany, Italy, the Netherlands, and the USA. For comparability, scan duration and the decision tree of the analysis were adopted from the Australian cost-effectiveness study. RESULTS: In contrast to the Australian setting, PSMA PET/CT was primarily associated with increased costs in the studied centers in Europe and the USA. Mainly, the scan duration had an impact on the cost-effectiveness. However, costs for an accurate diagnosis using PSMA PET/CT seemed reasonably low compared to the potential consequential costs of an inaccurate diagnosis. CONCLUSION: We assume that the use of PSMA PET/CT is appropriate from a health economic perspective, but this will need to be verified by a prospective evaluation of patients at initial diagnosis.

Published
2023

49. Physician reported toxicities and patient reported quality of life of transperineal ultrasound-guided radiotherapy of prostate cancer

Author

Jing Ma, Paul Rogowski, Christian Trapp, Farkhad Manapov, Bin Xu, Alexander Buchner, Shun Lu, Nina Sophie Schmidt-Hegemann, Xuanbin Wang, Cheng Zhou, Christian Stief, Claus Belka, and Minglun Li

Subjects
Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Purpose: This study aims to address therapy-related toxicities and quality of life in prostate cancer patients undergoing transperineal ultrasound (TPUS) guided radiotherapy (RT). Methods: Acute and late gastrointestinal (GI) and genitourinary (GU) toxicities were assessed by physicians using CTCAE v5.0. Patient-reported quality of life outcomes were evaluated using EORTC QLQ-C30, -PR25 and IPSS. We utilized Volumetric Modulated Arc Therapy (VMAT) or intensity modulated radiation therapy (IMRT) as the RT technique for this study. The assessments were carried out before RT, at RT end, 3 months after RT and subsequently at 1-year intervals. Prostate-specific antigen (PSA) was also evaluated at each follow-up. Results: In this study, a total of 164 patients were enrolled, while among them, 112 patients delivered quality-of-life data in a prospective evaluation. The median pre-treatment PSA was 7.9 ng/mL (range: 1.8–169 ng/ml). At the median follow-up of 19 months (3–82 months), the median PSA decreased to 0.22 ng/ml. Acute grade II GI and GU toxicities occurred in 8.6 % and 21.5 % patients at RT end. Regarding late toxicities, 2.2 % patients experienced grade II GI toxicities at 27 months and only one patient at 51 months, whereas no grade II GU late toxicities were reported at these time points. Quality of life scores also indicated a well-tolerated treatment. Patients mainly experienced acute clinically relevant symptoms of fatigue, pain, as well as deterioration in bowel and urinary symptoms. However, most symptoms normalized at 3 months and remained stable thereafter. Overall functioning showed a similar decline at RT end but improved over time. Conclusion: The outcomes of TPUS-guided RT demonstrated promising results in terms of minimal physician-reported toxicities and satisfactory patient-reported QoL.

Published
2024
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