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Your search keyword '"Stewart, Rachel C."' showing total 18 results
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18 results on '"Stewart, Rachel C."'

10. Effect of contrast agent charge on visualization of articular cartilage using computed tomography: exploiting electrostatic interactions for improved sensitivity

Author

Joshi, Neels S., Bansal, Prashant N., Stewart, Rachel C., Snyder, Brian D., and Grinstaff, Mark W.

Subjects
CT imaging -- Usage, Cartilage -- Composition, Cartilage -- Research, Contrast media -- Chemical properties, Electrostatic interactions -- Analysis, Chemistry
Abstract

The synthesis and analysis of a new class of cationic iodinated contrast agents for the imaging of cartilage using computed tomography (CT) is described. The cationic contrast agents have produced higher equilibrium concentrations in the articular cartilage of ex vivo rabbit femurs and greater imaging sensitivity and the studies have represented the first step in developing sensitive, nondestructive CT-based methods to study the biochemical properties of cartilage.

Published
2009

11. The Expansion of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva Is Activin A-Dependent

Author

Upadhyay, Jaymin, primary, Xie, LiQin, additional, Huang, Lily, additional, Das, Nanditha, additional, Stewart, Rachel C, additional, Lyon, Morgan C, additional, Palmer, Keryn, additional, Rajamani, Saathyaki, additional, Graul, Chris, additional, Lobo, Merryl, additional, Wellman, Tyler J, additional, Soares, Edward J, additional, Silva, Matthew D, additional, Hesterman, Jacob, additional, Wang, Lili, additional, Wen, Xialing, additional, Qian, Xiaobing, additional, Nannuru, Kalyan, additional, Idone, Vincent, additional, Murphy, Andrew J, additional, Economides, Aris N, additional, and Hatsell, Sarah J, additional

Published
2017
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14. Contrast-Enhanced Computed Tomography Enables Quantitative Evaluation of Tissue Properties at Intrajoint Regions in Cadaveric Knee Cartilage

Author

Stewart, Rachel C., primary, Honkanen, Juuso T.J., additional, Kokkonen, Harri T., additional, Tiitu, Virpi, additional, Saarakkala, Simo, additional, Joukainen, Antti, additional, Snyder, Brian D., additional, Jurvelin, Jukka S., additional, Grinstaff, Mark W., additional, and Töyräs, Juha, additional

Published
2016
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18. Contrast-Enhanced Computed Tomography Enables Quantitative Evaluation of Tissue Properties at Intrajoint Regions in Cadaveric Knee Cartilage

Author

Stewart, Rachel C., Honkanen, Juuso T.J., Kokkonen, Harri T., Tiitu, Virpi, Saarakkala, Simo, Joukainen, Antti, Snyder, Brian D., Jurvelin, Jukka S., Grinstaff, Mark W., and Töyräs, Juha

Subjects
cartilage imaging, contrast enhanced computed tomography, osteoarthritis, cone beam computed tomography
Abstract

Objective: The aim of this study was to investigate whether the concentration of the anionic contrast agent ioxaglate, as quantitated by contrast-enhanced computed tomography (CECT) using a clinical cone-beam CT (CBCT) instrument, reflects biochemical, histological, and biomechanical characteristics of articular cartilage imaged in an ex vivo, intact human knee joint. Design: An osteoarthritic human cadaveric knee joint (91 years old) was injected with ioxaglate (36 mg I/mL) and imaged using CBCT over 61 hours of ioxaglate diffusion into cartilage. Following imaging, the joint surfaces were excised, rinsed to remove contrast agent, and compressive stiffness (equilibrium and instantaneous compressive moduli) was measured via indentation testing (n = 17 sites). Each site was sectioned for histology and assessed for glycosaminoglycan content using digital densitometry of Safranin-O stained sections, Fourier transform infrared spectroscopy for collagen content, and morphology using both the Mankin and OARSI semiquantitative scoring systems. Water content was determined using mass change after lyophilization. Results: CECT attenuation at all imaging time points, including those <1 hour of ioxaglate exposure, correlated significantly (P < 0.05) with cartilage water and glycosaminoglycan contents, Mankin score, and both equilibrium and instantaneous compressive moduli. Early time points (<30 minutes) also correlated (P < 0.05) with collagen content and OARSI score. Differences in cartilage quality between intrajoint regions were distinguishable at diffusion equilibrium and after brief ioxaglate exposure. Conclusions: CECT with ioxaglate affords biochemical and biomechanical measurements of cartilage health and performance even after short, clinically relevant exposure times, and may be useful in the clinic as a means for detecting early signs of cartilage pathology.

Published
2016
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