393 results on '"Stewart, Grant S."'
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2. The structural mechanism of dimeric DONSON in replicative helicase activation
3. Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease
4. Bi-allelic TTI1 variants cause an autosomal-recessive neurodevelopmental disorder with microcephaly
5. Genome-scale clustered regularly interspaced short palindromic repeats screen identifies nucleotide metabolism as an actionable therapeutic vulnerability in diffuse large B-cell lymphoma
6. Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy
7. Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans
8. E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease.
9. Induction of apoptosis in Ogg1-null mouse embryonic fibroblasts by GSH depletion is independent of DNA damage
10. Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair
11. Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening
12. Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability
13. RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells
14. RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1
15. MYBL2 and ATM suppress replication stress in pluripotent stem cells
16. Isomerization of BRCA1–BARD1 promotes replication fork protection
17. Human Claspin Works with BRCA1 to Both Positively and Negatively Regulate Cell Proliferation
18. Disruption of the Mammalian Ccr4–Not Complex Contributes to Transcription-Mediated Genome Instability
19. USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status
20. Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion
21. DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain
22. Chromosome instability syndromes
23. Identification of Adenovirus E1B-55K Interaction Partners through a Common Binding Motif.
24. Novel PNKP mutations causing defective DNA strand break repair and PARP1 hyperactivity in MCSZ
25. Actin nucleators safeguard replication forks by limiting nascent strand degradation
26. Data from BRCA2 and RAD51 Promote Double-Strand Break Formation and Cell Death in Response to Gemcitabine
27. Data Supplement from BRCA2 and RAD51 Promote Double-Strand Break Formation and Cell Death in Response to Gemcitabine
28. Data from Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors
29. Supplementary Table from Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors
30. Figure S1 to S7 from MYBL2 Supports DNA Double Strand Break Repair in Hematopoietic Stem Cells
31. Supplementary Data from Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors
32. Table S1 from MYBL2 Supports DNA Double Strand Break Repair in Hematopoietic Stem Cells
33. Data from MYBL2 Supports DNA Double Strand Break Repair in Hematopoietic Stem Cells
34. Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers
35. RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells
36. Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers
37. Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism
38. RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks
39. Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy
40. H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
41. Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors
42. Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation
43. Constitutive Phosphorylation of MDC1 Physically Links the MRE11-RAD50-NBS1 Complex to Damaged Chromatin
44. RIDDLE Immunodeficiency Syndrome Is Linked to Defects in 53BP1-Mediated DNA Damage Signaling
45. The Promotion of Genomic Instability in Human Fibroblasts by Adenovirus 12 Early Region 1B 55K Protein in the Absence of Viral Infection
46. ATRX proximal protein associations boast roles beyond histone deposition
47. Ubiquitin‐dependent recruitment of the Bloom Syndrome helicase upon replication stress is required to suppress homologous recombination
48. A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses
49. Reply: A single strand that links multiple neuropathologies in human disease
50. A Degenerate PCNA-Interacting Peptide (DPIP) box targets RNF168 to replicating DNA to limit 53BP1 signaling
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