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236 results on '"Stevens-Ayers, Terry"'

1. High-frequency home self-collection of capillary blood correlates IFI27 expression kinetics with SARS-CoV-2 viral clearance

Author

Lim, Fang Yun, Kim, Soo-Young, Kulkarni, Karisma N., Blazevic, Rachel L., Kimball, Louise E., Lea, Hannah G., Haack, Amanda J., Gower, Maia S., Stevens-Ayers, Terry, Starita, Lea M., Boeckh, Michael, Hyrien, Ollivier, Schiffer, Joshua T., Theberge, Ashleigh B., and Waghmare, Alpana

Subjects
Blood banks -- Health aspects, Health care industry
Abstract

To the Editor: Blood transcriptional profiling is a powerful tool to evaluate immune responses to infection; however, blood collection via traditional phlebotomy remains a barrier to precise characterization of the [...]

Published
2023

2. The effect of gastrointestinal graft-versus-host disease and diarrhea on the pharmacokinetic profile of sotrovimab in hematopoietic stem cell transplant recipients

Author

Boonyaratanakornkit, Jim, primary, Wang, Qianwen, additional, Nader, Ahmed, additional, Kimball, Louise, additional, Stevens-Ayers, Terry, additional, Levkova, Marta, additional, Blazevic, Rachel, additional, Nguyen, Jeanette, additional, Wright, Jennifer, additional, Castor, Jared, additional, Greninger, Alexander L, additional, Ford, Emily, additional, Mielcarek, Marco, additional, Fordred, Shelley, additional, Han, Jennifer, additional, Boeckh, Michael, additional, and Waghmare, Alpana, additional

Published
2024
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5. 2291. SARS-CoV-2 Viral Kinetics Among Immunologically Naïve Adults: Comparison by Variant and Reinfection Status

Author

Doll, Margaret K, primary, Shakoor, Brianna Levenson, additional, Kimball, Louise E, additional, Crukley, Jeffery, additional, Ozbek, Nina, additional, Blazevic, Rachel L, additional, Mose, Larry, additional, Boonyaratanakornkit, Jim, additional, Stevens-Ayers, Terry L, additional, Cornell, Kevin, additional, Sheppard, Benjamin D, additional, Hampson, Emma, additional, Sharmin, Faria, additional, Goodwin, Benjamin, additional, Dan, Jennifer M, additional, Archie, Tom, additional, O’Connor, Terry, additional, Boeckh, Michael J, additional, Crotty, Shane, additional, and Waghmare, Alpana, additional

Published
2023
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6. 2712. Respiratory syncytial virus (RSV) pre-fusion F antibody titers in hematopoietic cell transplant recipients with upper versus lower respiratory tract infections

Author

Kim, Sara R, primary, Krantz, Elizabeth M, additional, Andrews, Claire, additional, Yahya, Khaleel, additional, Stevens-Ayers, Terry L, additional, Ogimi, Chikara, additional, Englund, Janet A, additional, Martin, Emily T, additional, Boeckh, Michael J, additional, and Waghmare, Alpana, additional

Published
2023
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7. Cytomegalovirus (CMV) Reactivation and CMV-Specific Cell-Mediated Immunity After Chimeric Antigen Receptor T-Cell Therapy

Author

Kampouri, Eleftheria, primary, Ibrahimi, Sarah S, additional, Xie, Hu, additional, Wong, Elizabeth R, additional, Hecht, Jessica B, additional, Sekhon, Mandeep K, additional, Vo, Alythia, additional, Stevens-Ayers, Terry L, additional, Green, Damian J, additional, Gauthier, Jordan, additional, Maloney, David G, additional, Perez, Ailyn, additional, Jerome, Keith R, additional, Leisenring, Wendy M, additional, Boeckh, Michael J, additional, and Hill, Joshua A, additional

Published
2023
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11. Cytomegalovirus (CMV) Reactivation and CMV-Specific Cell-Mediated Immunity After Chimeric Antigen Receptor T-Cell Therapy.

Author

Kampouri, Eleftheria, Ibrahimi, Sarah S, Xie, Hu, Wong, Elizabeth R, Hecht, Jessica B, Sekhon, Mandeep K, Vo, Alythia, Stevens-Ayers, Terry L, Green, Damian J, Gauthier, Jordan, Maloney, David G, Perez, Ailyn, Jerome, Keith R, Leisenring, Wendy M, Boeckh, Michael J, and Hill, Joshua A

Subjects
RISK assessment, ADRENOCORTICAL hormones, CYTOPENIA, VIRAL load, RECEIVER operating characteristic curves, RESEARCH funding, CYTOMEGALOVIRUS diseases, IMMUNOTHERAPY, CELLULAR immunity, TREATMENT effectiveness, DESCRIPTIVE statistics, REINFECTION, ANTIGENS, LONGITUDINAL method, PRE-tests & post-tests, INTERFERONS, CONFIDENCE intervals, REGULATORY T cells, CELL receptors, REGRESSION analysis, DISEASE risk factors
Abstract

Background The epidemiology of cytomegalovirus (CMV) after chimeric antigen receptor–modified T-cell immunotherapy (CARTx) is poorly understood owing to a lack of routine surveillance. Methods We prospectively enrolled 72 adult CMV-seropositive CD19-, CD20-, or BCMA-targeted CARTx recipients and tested plasma samples for CMV before and weekly up to 12 weeks after CARTx. We assessed CMV-specific cell-mediated immunity (CMV-CMI) before and 2 and 4 weeks after CARTx, using an interferon γ release assay to quantify T-cell responses to IE-1 and pp65. We tested pre-CARTx samples to calculate a risk score for cytopenias and infection (CAR-HEMATOTOX). We used Cox regression to evaluate CMV risk factors and evaluated the predictive performance of CMV-CMI for CMV reactivation in receiver operator characteristic curves. Results CMV was detected in 1 patient (1.4%) before and in 18 (25%) after CARTx, for a cumulative incidence of 27% (95% confidence interval, 16.8–38.2). The median CMV viral load (interquartile range) was 127 (interquartile range, 61–276) IU/mL, with no end-organ disease observed; 5 patients received preemptive therapy based on clinical results. CMV-CMI values reached a nadir 2 weeks after infusion and recovered to baseline levels by week 4. In adjusted models, BCMA-CARTx (vs CD19/CD20) and corticosteroid use for >3 days were significantly associated with CMV reactivation, and possible associations were detected for lower week 2 CMV-CMI and more prior antitumor regimens. The cumulative incidence of CMV reactivation almost doubled when stratified by BCMA-CARTx target and use of corticosteroids for >3 days (46% and 49%, respectively). Conclusions CMV testing could be considered between 2 and 6 weeks in high-risk CARTx recipients. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Serial Quantitation of Plasma Microbial Cell-Free DNA Before and After Diagnosis of Pulmonary Invasive Mold Infections After Hematopoietic Cell Transplant.

Author

Heldman, Madeleine R, Ahmed, Asim A, Liu, Winnie, Vo, Alythia, Keane-Candib, Jacob, Stevens-Ayers, Terry, Boeckh, Michael, Blauwkamp, Timothy A, Fisher, Cynthia E, and Hill, Joshua A

Subjects
CELL-free DNA, INVASIVE diagnosis, ASPERGILLOSIS, DNA sequencing, INFECTION, PULMONARY aspergillosis
Abstract

Background Plasma microbial cell-free DNA sequencing (mcfDNA-Seq) is a noninvasive test for microbial diagnosis of invasive mold infection (IMI). The utility of mcfDNA-Seq for predicting IMI onset and the clinical implications of mcfDNA concentrations are unknown. Methods We retrospectively tested plasma from hematopoietic cell transplant (HCT) recipients with pulmonary IMI and ≥1 mold identified by mcfDNA-Seq in plasma collected within 14 days of clinical diagnosis. Samples collected from up to 4 weeks before and 4 weeks after IMI diagnosis were evaluated using mcfDNA-Seq. Results Thirty-five HCT recipients with 39 IMIs (16 Aspergillus and 23 non- Aspergillus infections) were included. Pathogenic molds were detected in 38%, 26%, 11%, and 0% of samples collected during the first, second, third, and fourth week before clinical diagnosis, respectively. In non- Aspergillus infections, median mcfDNA concentrations in samples collected within 3 days of clinical diagnosis were higher in infections with versus without extrapulmonary spread (4.3 vs 3.3 log10 molecules per microliter [mpm], P =.02), and all patients (8/8) with mcfDNA concentrations >4.0 log10 mpm died within 42 days after clinical diagnosis. Conclusions Plasma mcfDNA-Seq can identify pathogenic molds up to 3 weeks before clinical diagnosis of pulmonary IMI. Plasma mcfDNA concentrations may correlate with extrapulmonary spread and mortality in non- Aspergillus IMI. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Serial Quantitation of Plasma Microbial Cell-Free DNA Before and After Diagnosis of Pulmonary Invasive Mold Infections After Hematopoietic Cell Transplant

Author

Heldman, Madeleine R, primary, Ahmed, Asim A, additional, Liu, Winnie, additional, Vo, Alythia, additional, Keane-Candib, Jacob, additional, Stevens-Ayers, Terry, additional, Boeckh, Michael, additional, Blauwkamp, Timothy A, additional, Fisher, Cynthia E, additional, and Hill, Joshua A, additional

Published
2023
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21. Acute and Postacute COVID-19 Outcomes Among Immunologically Naive Adults During Delta vs Omicron Waves

Author

Doll, Margaret K., primary, Waghmare, Alpana, additional, Heit, Antje, additional, Levenson Shakoor, Brianna, additional, Kimball, Louise E., additional, Ozbek, Nina, additional, Blazevic, Rachel L., additional, Mose, Larry, additional, Boonyaratanakornkit, Jim, additional, Stevens-Ayers, Terry L., additional, Cornell, Kevin, additional, Sheppard, Benjamin D., additional, Hampson, Emma, additional, Sharmin, Faria, additional, Goodwin, Benjamin, additional, Dan, Jennifer M., additional, Archie, Tom, additional, O’Connor, Terry, additional, Heckerman, David, additional, Schmitz, Frank, additional, Boeckh, Michael, additional, and Crotty, Shane, additional

Published
2023
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23. CMV and HHV-6 after Chimeric Antigen Receptor (CAR)-T-Cell Immunotherapy for B-Cell Malignancies: A Prospective Study

Author

Kampouri, Eleftheria, primary, Ibrahimi, Sarah, additional, Hecht, Jessica, additional, Keane-Candib, Jacob, additional, Xie, Hu, additional, Stevens-Ayers, Terry, additional, Gauthier, Jordan, additional, Maloney, David G., additional, Huang, Meei-Li, additional, Jerome, Keith R., additional, Zerr, Danielle, additional, Leisenring, Wendy M., additional, Boeckh, Michael J., additional, and Hill, Joshua A., additional

Published
2023
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24. CMV viral load kinetics as surrogate endpoints after allogeneic transplantation

Author

Duke, Elizabeth R., Williamson, Brian D., Borate, Bhavesh, Golob, Jonathan L., Wychera, Chiara, Stevens-Ayers, Terry, Huang, Meei-Li, Cossrow, Nicole, Wan, Hong, Mast, T. Christopher, Marks, Morgan A., Flowers, Mary E., Jerome, Keith R., Corey, Lawrence, Gilbert, Peter B., Schiffer, Joshua T., and Boeckh, Michael

Subjects
Outcome and process assessment (Health Care) -- Methods, Viremia -- Measurement, Cytomegalovirus infections -- Drug therapy -- Risk factors -- Patient outcomes, Hematopoietic stem cells -- Transplantation, Health care industry
Abstract

BACKGROUND. Viral load (VL) surrogate endpoints transformed development of HIV and hepatitis C therapeutics. Surrogate endpoints for CMV-related morbidity and mortality could advance development of antiviral treatments. Although observational data support using CMV VL as a trial endpoint, randomized controlled trials (RCTs) demonstrating direct associations between virological markers and clinical endpoints are lacking. METHODS. We performed CMV DNA PCR on frozen serum samples from the only placebo-controlled RCT of ganciclovir for early treatment of CMV after hematopoietic cell transplantation (HCT). We used established criteria to assess VL kinetics as surrogates for CMV disease or death by weeks 8, 24, and 48 after randomization and quantified antiviral effects captured by each marker. We used ensemble-based machine learning to assess the predictive ability of VL kinetics and performed this analysis on a ganciclovir prophylaxis RCT for validation. RESULTS. VL suppression with ganciclovir reduced cumulative incidence of CMV disease and death for 20 years after HCT. Mean VL, peak VL, and change in VL during the first 5 weeks of treatment fulfilled the Prentice definition for surrogacy, capturing more than 95% of ganciclovir's effect, and yielded highly sensitive and specific predictions by week 48. In the prophylaxis trial, the viral shedding rate satisfied the Prentice definition for CMV disease by week 24. CONCLUSIONS. Our results support using CMV VL kinetics as surrogates for CMV disease, provide a framework for developing CMV preventative and therapeutic agents, and support reductions in VL as the mechanism through which antivirals reduce CMV disease. FUNDING. Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Introduction Despite advances in the treatment and prevention of CMV complications after hematopoietic cell transplantation (HCT), CMV remains an important cause of morbidity and mortality. CMV viremia is associated with [...]

Published
2021
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25. Longitudinal home self-collection of capillary blood usinghomeRNA correlates interferon and innate viral defense pathways with SARS-CoV-2 viral clearance

Author

Lim, Fang Yun, primary, Kim, Soo-Young, additional, Kulkarni, Karisma N., additional, Blazevic, Rachel L., additional, Kimball, Louise E., additional, Lea, Hannah G., additional, Haack, Amanda J., additional, Gower, Maia. S., additional, Stevens-Ayers, Terry, additional, Starita, Lea M., additional, Boeckh, Michael, additional, Schiffer, Joshua T., additional, Hyrien, Ollivier, additional, Theberge, Ashleigh B., additional, and Waghmare, Alpana, additional

Published
2023
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26. 2109. HHV-6 and EBV Reactivation after Allogeneic Hematopoietic Cell Transplantation in the Era of Letermovir for CMV Prophylaxis: A Retrospective Cohort Study

Author

Kampouri, Eleftheria, primary, Krantz, Elizabeth M, additional, Zamora, Danniel, additional, Kimball, Louise E, additional, Kiem, Erika, additional, Lovas, Erika A, additional, Blazevic, Rachel, additional, Stevens-Ayers, Terry L, additional, Huang, Meei-Li, additional, Masumi, Ueda Oshima, additional, Jerome, Keith R, additional, Zerr, Danielle M, additional, Boeckh, Michael J, additional, and Hill, Joshua A, additional

Published
2022
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27. 491. Characterizing the Association of Pre-Existing Cytomegalovirus (CMV)-specific Humoral Immunity with CMV Reactivation Risk after Hematopoietic Cell Transplantation (HCT)

Author

Zamora, Danniel, primary, Krantz, Elizabeth M, additional, Joncas-Schronce, Laurel, additional, Akoto, Brenda, additional, Stevens-Ayers, Terry L, additional, Bender Ignacio, Rachel A, additional, Hill, Joshua A, additional, Degli-Esposti, Mariapia, additional, Hill, Geoffrey, additional, and Boeckh, Michael J, additional

Published
2022
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28. Acute and Post-Acute COVID-19 Outcomes Among Immunologically Naïve Adults During Delta Versus Omicron Waves

Author

Doll, Margaret K., primary, Waghmare, Alpana, additional, Heit, Antje, additional, Levenson Shakoor, Brianna, additional, Kimball, Louise E., additional, Ozbek, Nina, additional, Blazevic, Rachel L., additional, Mose, Larry, additional, Boonyaratanakornkit, Jim, additional, Stevens-Ayers, Terry L., additional, Cornell, Kevin, additional, Sheppard, Benjamin D., additional, Hampson, Emma, additional, Sharmin, Faria, additional, Goodwin, Benjamin, additional, Dan, Jennifer M., additional, Archie, Tom, additional, O’Connor, Terry, additional, Heckerman, David, additional, Schmitz, Frank, additional, Boeckh, Michael, additional, and Crotty, Shane, additional

Published
2022
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29. Chromosome-Specific Human Herpesvirus 6 Integration and Hematologic Malignancies

Author

Heldman, Madeleine R., primary, Wight, Darren J., additional, Aiewsakun, Pakorn, additional, Aswad, Amr, additional, Fang, Min, additional, Roychoudhury, Pavitra, additional, Stevens-Ayers, Terry, additional, Jerome, Keith R., additional, Zerr, Danielle M., additional, Greninger, Alexander L., additional, Kaufer, Benedikt B., additional, Boeckh, Michael, additional, and Hill, Joshua A., additional

Published
2022
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30. Structure, receptor recognition, and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein

Author

Tortorici, M. Alejandra, primary, Walls, Alexandra C., additional, Joshi, Anshu, additional, Park, Young-Jun, additional, Eguia, Rachel T., additional, Miranda, Marcos C., additional, Kepl, Elizabeth, additional, Dosey, Annie, additional, Stevens-Ayers, Terry, additional, Boeckh, Michael J., additional, Telenti, Amalio, additional, Lanzavecchia, Antonio, additional, King, Neil P., additional, Corti, Davide, additional, Bloom, Jesse D., additional, and Veesler, David, additional

Published
2022
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34. Structure, receptor recognition and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein

Author

Tortorici, M. Alejandra, primary, Walls, Alexandra C., additional, Joshi, Anshu, additional, Park, Young-Jun, additional, Eguia, Rachel T., additional, Stevens-Ayers, Terry, additional, Boeckh, Michael J., additional, Telenti, Amalio, additional, Lanzavecchia, Antonio, additional, Corti, Davide, additional, Bloom, Jesse D., additional, and Veesler, David, additional

Published
2021
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38. Antibodies to vaccine-preventable infections after CAR-T-cell therapy for B-cell malignancies

Author

Walti, Carla S., primary, Krantz, Elizabeth M., additional, Maalouf, Joyce, additional, Boonyaratanakornkit, Jim, additional, Keane-Candib, Jacob, additional, Joncas-Schronce, Laurel, additional, Stevens-Ayers, Terry, additional, Dasgupta, Sayan, additional, Taylor, Justin J., additional, Hirayama, Alexandre V., additional, Bar, Merav, additional, Gardner, Rebecca A., additional, Cowan, Andrew J., additional, Green, Damian J., additional, Boeckh, Michael J., additional, Maloney, David G., additional, Turtle, Cameron J., additional, and Hill, Joshua A., additional

Published
2021
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41. Quantitative real-time polymerase chain reaction for detection of adenovirus after T cell-replete hematopoietic cell transplantation: viral load as a marker for invasive disease

Author

Erard, Veronique, Huang, Meei-Li, Ferrenberg, James, Nguy, Long, Stevens-Ayers, Terry L., Hackman, Robert C., Corey, Lawrence, and Boeckh, Michael

Subjects
Polymerase chain reaction -- Usage, Adenoviruses, Human -- Health aspects, Hematopoietic stem cells -- Transplantation, Hematopoietic stem cells -- Complications and side effects, Viremia -- Measurement, Health, Health care industry
Published
2007

45. Liquid Biopsy for Invasive Mold Infections in Hematopoietic Cell Transplant Recipients With Pneumonia Through Next-Generation Sequencing of Microbial Cell-Free DNA in Plasma

Author

Hill, Joshua A, primary, Dalai, Sudeb C, additional, Hong, David K, additional, Ahmed, Asim A, additional, Ho, Carine, additional, Hollemon, Desiree, additional, Blair, Lily, additional, Maalouf, Joyce, additional, Keane-Candib, Jacob, additional, Stevens-Ayers, Terry, additional, Boeckh, Michael, additional, Blauwkamp, Timothy A, additional, and Fisher, Cynthia E, additional

Published
2020
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46. 194. Combinatorial Polyfunctionality Analysis of Antigen-specific T-cell Subsets (COMPASS) as a Predictor for Clinically Significant CMV Infection in the Letermovir Era

Author

Zamora, Danniel, primary, Duke, Elizabeth, additional, Xie, Hu, additional, Edmison, Bradley, additional, Akoto, Brenda, additional, Kiener, Richard, additional, Stevens-Ayers, Terry, additional, Wagner, Ralf, additional, Mielcarek, Marco, additional, Schiffer, Joshua, additional, De Rosa, Stephen, additional, and Boeckh, Michael, additional

Published
2020
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48. Effect of Preemptive Therapy vs Antiviral Prophylaxis on Cytomegalovirus Disease in Seronegative Liver Transplant Recipients With Seropositive Donors

Author

Singh, Nina, primary, Winston, Drew J., additional, Razonable, Raymund R., additional, Lyon, G. Marshall, additional, Silveira, Fernanda P., additional, Wagener, Marilyn M., additional, Stevens-Ayers, Terry, additional, Edmison, Bradley, additional, Boeckh, Michael, additional, and Limaye, Ajit P., additional

Published
2020
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49. Impact of Inherited Chromosomally Integrated HHV-6 on Central Nervous System Dysfunction and Management after Hematopoietic Cell Transplantation

Author

Job, Cassandra, primary, Maalouf, Joyce, additional, Morris, Jessica, additional, Xie, Hu, additional, Davis, Chris, additional, Stevens-Ayers, Terry, additional, Huang, Meei-Li, additional, Jerome, Keith, additional, Fann, Jesse, additional, Zerr, Danielle, additional, Boeckh, Michael, additional, and Hill, Joshua, additional

Published
2020
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50. Cytomegalovirus (CMV)-Specific Polyfunctional T-Cell Responses after Letermovir (LET) Prophylaxis in Hematopoietic Cell Transplantation (HCT)

Author

Zamora, Danniel, primary, Akoto, Brenda, additional, Xie, Hu, additional, Kiener, Richard, additional, Edmison, Bradley C., additional, Stevens-Ayers, Terry, additional, Wagner, Ralf, additional, Mielcarek, Marco, additional, Leisenring, Wendy M, additional, De Rosa, Stephen, additional, and Boeckh, Michael, additional

Published
2020
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