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4. Diagnosis and management in Rubinstein-Taybi syndrome: first international consensus statement

Author

Lacombe, Didier, primary, Bloch-Zupan, Agnès, additional, Bredrup, Cecilie, additional, Cooper, Edward B, additional, Houge, Sofia Douzgou, additional, García-Miñaúr, Sixto, additional, Kayserili, Hülya, additional, Larizza, Lidia, additional, Lopez Gonzalez, Vanesa, additional, Menke, Leonie A, additional, Milani, Donatella, additional, Saettini, Francesco, additional, Stevens, Cathy A, additional, Tooke, Lloyd, additional, Van der Zee, Jill A, additional, Van Genderen, Maria M, additional, Van-Gils, Julien, additional, Waite, Jane, additional, Adrien, Jean-Louis, additional, Bartsch, Oliver, additional, Bitoun, Pierre, additional, Bouts, Antonia H M, additional, Cueto-González, Anna M, additional, Dominguez-Garrido, Elena, additional, Duijkers, Floor A, additional, Fergelot, Patricia, additional, Halstead, Elizabeth, additional, Huisman, Sylvia A, additional, Meossi, Camilla, additional, Mullins, Jo, additional, Nikkel, Sarah M, additional, Oliver, Chris, additional, Prada, Elisabetta, additional, Rei, Alessandra, additional, Riddle, Ilka, additional, Rodriguez-Fonseca, Cristina, additional, Rodríguez Pena, Rebecca, additional, Russell, Janet, additional, Saba, Alicia, additional, Santos-Simarro, Fernando, additional, Simpson, Brittany N, additional, Smith, David F, additional, Stevens, Markus F, additional, Szakszon, Katalin, additional, Taupiac, Emmanuelle, additional, Totaro, Nadia, additional, Valenzuena Palafoll, Irene, additional, Van Der Kaay, Daniëlle C M, additional, Van Wijk, Michiel P, additional, Vyshka, Klea, additional, Wiley, Susan, additional, and Hennekam, Raoul C, additional

Published
2024
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5. Diagnosis and management in Rubinstein-Taybi syndrome: first international consensus statement

Author

Lacombe, Didier, Bloch-Zupan, Agnès, Bredrup, Cecilie, Cooper, Edward B., Houge, Sofia Douzgou, García-Miñaúr, Sixto, Kayserili, Hülya, Larizza, Lidia, Lopez Gonzalez, Vanesa, Menke, Leonie A., Milani, Donatella, Saettini, Francesco, Stevens, Cathy A., Tooke, Lloyd, Van der Zee, Jill A., Van Genderen, Maria M., Van-Gils, Julien, Waite, Jane, Adrien, Jean-Louis, Bartsch, Oliver, Bitoun, Pierre, Bouts, Antonia H. M., Cueto-González, Anna M., Dominguez-Garrido, Elena, Duijkers, Floor A., Fergelot, Patricia, Halstead, Elisabeth, Huisman, Sylvia A., Meossi, Camilla, Mullins, Jo, Nikkel, Sarah M., Oliver, Chris, Prada, Elisabetta, Rei, Alessandra, Riddle, Ilka, Rodriguez-Fonseca, Cristina, Rodríguez Pena, Rebecca, Russell, Janet, Saba, Alicia, Santos-Simarro, Fernando, Simpson, Brittany N., Smith, David F., Stevens, Markus F., Szakszon, Katalin, Taupiac, Emmanuelle, Totaro, Nadia, Valenzuena Palafoll, Irene, Van Der Kaay, Daniëlle C. M., Van Wijk, Michiel P., Vyshka, Klea, Wiley, Susan, Hennekam, Raoul C., Lacombe, Didier, Bloch-Zupan, Agnès, Bredrup, Cecilie, Cooper, Edward B., Houge, Sofia Douzgou, García-Miñaúr, Sixto, Kayserili, Hülya, Larizza, Lidia, Lopez Gonzalez, Vanesa, Menke, Leonie A., Milani, Donatella, Saettini, Francesco, Stevens, Cathy A., Tooke, Lloyd, Van der Zee, Jill A., Van Genderen, Maria M., Van-Gils, Julien, Waite, Jane, Adrien, Jean-Louis, Bartsch, Oliver, Bitoun, Pierre, Bouts, Antonia H. M., Cueto-González, Anna M., Dominguez-Garrido, Elena, Duijkers, Floor A., Fergelot, Patricia, Halstead, Elisabeth, Huisman, Sylvia A., Meossi, Camilla, Mullins, Jo, Nikkel, Sarah M., Oliver, Chris, Prada, Elisabetta, Rei, Alessandra, Riddle, Ilka, Rodriguez-Fonseca, Cristina, Rodríguez Pena, Rebecca, Russell, Janet, Saba, Alicia, Santos-Simarro, Fernando, Simpson, Brittany N., Smith, David F., Stevens, Markus F., Szakszon, Katalin, Taupiac, Emmanuelle, Totaro, Nadia, Valenzuena Palafoll, Irene, Van Der Kaay, Daniëlle C. M., Van Wijk, Michiel P., Vyshka, Klea, Wiley, Susan, and Hennekam, Raoul C.

Abstract

Rubinstein-Taybi syndrome (RTS) is an archetypical genetic syndrome that is characterised by intellectual disability, well-defined facial features, distal limb anomalies and atypical growth, among numerous other signs and symptoms. It is caused by variants in either of two genes (CREBBP, EP300) which encode for the proteins CBP and p300, which both have a function in transcription regulation and histone acetylation. As a group of international experts and national support groups dedicated to the syndrome, we realised that marked heterogeneity currently exists in clinical and molecular diagnostic approaches and care practices in various parts of the world. Here, we outline a series of recommendations that document the consensus of a group of international experts on clinical diagnostic criteria for types of RTS (RTS1: CREBBP; RTS2: EP300), molecular investigations, long-term management of various particular physical and behavioural issues and care planning. The recommendations as presented here will need to be evaluated for improvements to allow for continued optimisation of diagnostics and care.

Published
2024

6. Intercostal Nerve Cryoablation or Epidural Analgesia for Multimodal Pain Management after the Nuss Procedure:A Cohort Study

Author

van Braak, Hendrik, de Beer, Sjoerd A., de Jong, Justin R., Stevens, Markus F., Musters, Gijsbert, Zwaveling, Sander, Oomen, Matthijs W. N., Van der Made, Wendeline, Krug, Egbert, van Heurn, L. W. Ernest, van Braak, Hendrik, de Beer, Sjoerd A., de Jong, Justin R., Stevens, Markus F., Musters, Gijsbert, Zwaveling, Sander, Oomen, Matthijs W. N., Van der Made, Wendeline, Krug, Egbert, and van Heurn, L. W. Ernest

Abstract

Background Nuss procedure for pectus excavatum is a minimally invasive, but painful procedure. Recently, intercostal nerve cryoablation has been introduced as a pain management technique. Materials and methods In this cohort study, we compared the efficacy of multimodal pain management strategies in children undergoing a Nuss procedure. The effectiveness of intercostal nerve cryoablation combined with patient-controlled systemic opioid analgesia (PCA) was compared to continuous epidural analgesia (CEA) combined with PCA. The study was conducted between January 2019 and July 2022. Primary outcome was length of stay (LOS), secondary outcomes were operation room time, postoperative pain, opioid consumption and gabapentin use. Results Sixty-six consecutive patients were included, 33 patients in each group. The cryoablation group exhibited lower Numeric Rating Scale (NRS) pain scores on postoperative day one and two (p=.002, p=.001) and a shorter LOS (three versus six days (p<.001)). Cryoablation resulted in less patients requiring opioids at discharge (30.3% versus 97.0% (p<.001)) and one week after surgery (6.1% versus 45.4% (p<.001)). In the CEA group gabapentin use was more prevalent (78.8% versus 18.2%, p<.001) and the operation room time was shorter (119.4 versus 135.0 minutes (p<.010)). No neuropathic pain was reported. Conclusions Intercostal nerve cryoablation is a superior analgesic method compared to CEA, with reduced LOS, opioid use and NRS pain scores. The prophylactic use of gabapentin is redundant.

Published
2024

8. Intercostal Nerve Cryoablation or Epidural Analgesia for Multimodal Pain Management after the Nuss Procedure: A Cohort Study

Author

van Braak, Hendrik, additional, de Beer, Sjoerd A., additional, de Jong, Justin R., additional, Stevens, Markus F., additional, Musters, Gijsbert, additional, Zwaveling, Sander, additional, Oomen, Matthijs W. N., additional, der Made, Wendeline Van, additional, Krug, Egbert, additional, and van Heurn, L.W. Ernest, additional

Published
2024
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9. Different Analgesia Techniques for Postoperative Pain in Children Undergoing Abdominal Surgery for Intractable Constipation: A Retrospective Cohort Study in a Single Tertiary Children’s Hospital

Author

Admiraal, Manouk, primary, van der Burg, Fleur A. E., additional, Hermanns, Henning, additional, Hermanides, Jeroen, additional, Hollmann, Markus W., additional, Benninga, Marc A., additional, de Jong, Justin, additional, Gorter, Ramon R., additional, and Stevens, Markus F., additional

Published
2024
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12. Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

Author

Klimscha, Walter, Konecny, Regina, Luntzer, Robert, Morawk-Wintersperger, Ulrike, Neiger, Franz, Rustemeyer, Lydia, Breschan, Christian, Frey, Denise, Platzer, Manuela, Germann, Reinhard, Oeding, Joachim, Stoegermüller, Birgit, Ziegler, Bernhard, Brotatsch, Philipp, Gutmann, Anton, Mausser, Gerlinde, Messerer, Brigitte, Toller, Wolfgang, Vittinghoff, Maria, Zangl, Gregor, Seidel-Ahyai, Natascha, Hochhold, Christoph, Kroess, Ruth, Paal, Peter, Cnudde, Steven, Coucke, Patricia, Loveniers, Birgit, Mitchell, John, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Veyckemans, Francis, Coppens, Marc, De Hert, Stefan, Heyse, Björn, Neckebroek, Martine, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Van Den Eynde, Nancy, Vanpeteghem, Caroline, Wyffels, Piet, Lalot, Michaël, Lechat, Jean-Paul, Stevens, France, Casaer, Sari, De Groote, Françoise, De Pooter, Françoise, De Villé, Andrée, Gerin, Marc, Magasich, Natalia, Sanchez Torres, Cristel, Van Deenen, Denise, Berghmans, Johan, Himpe, Dirk, Roofthooft, Eva, Joukes, Ellen, Smitz, Carine, Van Reeth, Veronique, Huygens, Christel, Lauweryns, Julie, De Smet, Karen, Najafi, Nadia, Poelaert, Jan, Van de Velde, Anne, Van Mossevelde, Veerle, Bekavac, Ivan, Butkovic, Diana, Heli Litvic, Dubravka, Kerovec Soric, Ivana, Maretic, Hrvoje, Moscatello, Djurdjica, Popovic, Ljiljana, Micici, Slobodan, Stuck Tus, Ivana, Kalagac Fabris, Lada, Simurina, Tatjana, Sulen, Nina, Kesic-Valpotic, Gordana, Djapic, Dajana, Žurek, Jirí, Jureckova, Lucie, Mackova, Iveta, Skacel, Monika, Weinlichova, Stanislava, Divák, Jan, Frelich, Michal, Urbanec, René, Biskupova, Vera, Mixa, Vladimir, Pavlickova, Jana, Afshari, Arash, Bøttger, Morten, Ellekvist, Marguerite B., Johansen, Mathias, Ingeborg Madsen, Birgitte, Christian Nilsson, Jens, Schousboe, Birgitte MB, Clausen, Nicola G., Hansen, Tom G., Phaff Steen, Nick, Ilmoja, Mari-Liis, Tonise, Virge, Karjagin, Juri, Kikas, Reet, Isohanni, Mika, Lyly, Anniina, Takala, Annika, Happo, Johanna, Kiviluoma, Kai, Martikainen, Kati, Aantaa, Riku, Manner, Tuula, Vilo, Sanna, Amory, Catherine, Ludot, Hugues, Lambotte, Patricia, Busche, René, Jacqmarcq, Olivier, Lejus, Corinne, Corouge, Julien, Erb, Christian, Garrigue, Delphine, Gillet, Patricia, Laffargue, Anne, Lambelin, Veronique, Le Freche, Hélène, Peresbota, Daliana, Richart, Pierre, Berton, Jerome, Chapotte, Catherine, Colbus, Laurent, Lehousse, Thierry, Monrigal, Jean, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Batoz, Hélène, Bordes, Maryline, Didier, Anne, Hamonic, Yann, Lagarde, Sylvaine, Nouette-Gaulain, Karine, Semjen, François, Zaghet, Brigitte, Dekens, Jacky, Delcuze, Axelle, Dupont, Hervé, Legrand, Aurélien, Raffoflandreur, Celine, Audren, Noémie, Camus, Blandine, Cartal, Marielle, Chazelet, Chantal, Davin, Isabelle, Guillier, Marion, Desjeux, Luc, Larcher, Claire, Grein, Elodie, Leclercq, Mickeal, Levitchi, Roxana, Rosu, Lilica, Simon, Dominique, Zang, Aurélien, Migeon, Anne, Gagey, Anne-Charlotte, Bourdaud, Nathalie, Carre, Anne-Charlotte, Duflo, Frédéric, Riche, Jean-Claude, Robert, Philippe, Druot, Emilie, Maupain, Olivier, Orliaguet, Gilles, Sabau, Lucie, Taright, Hanna, Uhrig, Lynn, Verchere-Montmayeur, Juliette, Debrabant, Lise, Pilla, Clotaire, Podvin, Alexandre, Roth, Benjamin, Dahmani, Souhayl, Julien-Marsollier, Florence, Sabourdin, Nada, Alexandri, Bogdan, Brezac, Gilles, de la Brière, Francois, Hayem, Catherine, Lhubat, Elizabeth, Paul Mission, Jean, Rémond, Charlotte, Dadure, Christophe, Maniora, Maud, Marie, Anais, Pirat, Philippe, Saour, Anne-Charlotte, Sola, Chrystelle, Ecoffey, Claude, Wodey, Eric, Adam, Christian, Standl, Thomas, Schindler, Ehrenfried, Yamamoto, Tomohiro, Brackhahn, Michael, Eich, Christoph Bernhard, Guericke, Holger, Kindermann, Petra, Laschat, Michael, Schink, Cornel, Wappler, Frank, Hoehne, Claudia, Skordou, Natalia, Ulrici, Johanna, Jetzek-Zader, Martin, Kienbaum, Peter, Meyer-Treschan, Tanja, Picker, Olaf, Schaefer, Maximilian S., Mielke, Golo, Baethge, Sabine, Ramminger, Axel, Bauer, Martin, Bollinger, Matthias, Hinz, José, Quintel, Michael, Russo, Sebastian G., Bauer, Michael, Geil, Dfominik, Kortgen, Andreas, Preussler, Niels-Peter, Hofmann, Ulrich, Raber, Manfred, Reindl, Doris, Becke, Karin, Oppenrieder, Karin, Schierlinger, Bettina, Roth, Jens, Funk, Wolfgang, Fischer, Thomas, Gernoth, Christian, Wiefelspütz, Christina, Volger, Hauke, Zederer, Nicole, Diers, Anja, Huber, Matthias, Schorer, Clemens, Weyland, Andreas, Schwarzkopf, Konrad, Grau, Catharina, Roth, Winfried, Holy, Rolf, Mader, Thomas, Peter, Laura, Supthut, Hauke, Kuehhirt, Thomas, Milde, Alexander, Fiedler, Fritz, Isselhorst, Carsten, Grundmann, Ulrich, Pattar, Alexander, Reinert, Jennifer, Ehm, Birgit, Fritzsche, Katrin, Gaebler, Ralf, Meybohm, Patrick, Hein, Maximilian, Guzman, Ines, Jokinen, Johanna, Kranke, Peter, Goebel, Ulrich, Harris, Sarah, Eisner, Christoph, Ochsenreiter, Miriam, Schoeler, Michael, Thil, Elke, Ellerkmann, Richard, Hoeft, Andreas, Neumann, Claudia, Weber, Stefan, Keilhauer, Julia, Kloessing, Jan, Schramm, Michael, Trieschmann, Uwe, Knauss, Kristina, Sinner, Barbara, Steinmann, Johannes, Koessler, Herbert, Kalliardou, Evagelia, Malisiova, Anna, Tsiotou, Adelais, Chloropoulou, Pelagia, Chrysi, Mpratzou, Iordanidou, Despoina, Ntavlis, Merkourios, Boda, Krisztina B, Guerin, Christilynn, Irwin, Janice, Magner, Claire, Nakhjavani, Solmaz, O'Hare, Brendan, Galvin, Deborah, Jamil, Yosry, Lesmes, Carlos, Barak, Yuri, Fisher, Haran, Kachko, Ludmyla, Katz, Jacob, Kirilov, Dmitry, Levinzon, Michael, Manevich, Yair, Nekrasov, Konstantin, Peled, Elia, Sanko, Elena, Schmain, Dmitri, Sheinkin, Olga, Simhi, Eliahu, Tarabikin, Alex, Trabkin, Evelina, Yagudaev, Irena, Zeitlin, Yelena, Zunser, Igor, Cerutti, Elisabetta, Maddalena Schellino, Maria, Valzan, Silvia, Lucia Pinciroli, Rosa, Bortone, Luciano, Cerati, Giorgia, Salici, Fabiana, Bussolin, Leonardo, Rizzo, Giuliana, Rossetti, Francesca, Marchesini, Laura, Tesoro, Simonetta, De Lorenzo, Brita, Guarracino, Fabio, Kuppers, Beate, Astuto, Marinella, Pitino, Sofia, Scalisi, Rita, Scordo, Lucia, D'Alessandro, Sandra, Dei Giudici, Luigi, Farinelli, Ivano, Lofino, Giuseppe, Marchetti, Giuliano, Giuseppe Picardo, Sergio, Reali, Simone, Vittori, Alessandro, Antonio Idone, Francesco, Sammartino, Maria, Sbaraglia, Fabio, Barbera, Cinzia, Bevilacqua, Michela, Cento, Valeria, Disma, Nicola, Kotzeva, Svetlana, Mameli, Leila, Montobbio, Giovanni, Passariello, Leandro, Punzo, Cinzia, Sileo, Rosanna, Viacava, Rosanna, Volpe, Claudia, Zanaboni, Clelia, Calderini, Edoardo, Genco, Daniele, Neri, Simona, Ottolina, Davide, Camporesi, Anna, Izzo, Francesca, Salvo, Ida, Wolfler, Andrea, Sanna, Andrea, Sciascia, Angela, Stoia, Paolo, Guddo, Annamaria, Lapi, Maria, Ivani, Giorgio, Longobardo, Annalisa, Mossetti, Valeria, Pedrotti, Dino, Grazzini, Maurizia, Meneghini, Luisa, Metrangolo, Salvatore, Michelon, Stefania, Minardi, Carmelo, Tognon, Costanza, Zadra, Nicola, Busi, Ilaria, Khotcholava, Magda, Guido Locatelli, Bruno, Sonzogni, Valter, Starita, Giusi, Almenrader, Nicole, Aurilio, Caterina, Sansone, Pasquale, Albarello, Raffaella, Bracci, Paolo, Cecini, Mariateresa, Cristina Mondardini, Maria, Pasini, Lorena, Vason, Milo, Zani, Gianluca, Zoppellari, Roberto, Pistidda, Laura, Cortegiani, Andrea, Maurizio Raineri, Santi, Hasani, Antigona, Hashimi, Medita, Ancupans, Agris, Barzdina, Arta, Straume, Zane, Zundane, Anda, Chlopin, Mikhail, Gestautaite, Dalia, Lukosiene, Laura, Paliokaite, Evelina, Razlevice, Ilona, Armoniene, Inesa, Bernotiene, Aurelija, Daugelavicius, Vidunas, Dockiene, Ilona, Gaidelyte, Lina, Saviciene, Nijole, Krikstaponiene, Jolita, Sidlovskaite-Baltake, Dominika, Stasevski, Vladyslav, Vaitoskaite, Agne, Gatt, David, Mifsud, Stephanie, Zammit, Simone, Allison, Celia, Aslami, Hamid, Eberl, Susanne, van Stijn, Mireille F M, Stevens, Markus F, Punt, Kees, van Osch, Rob, Bauwman, Arthur, Scholten, Harm, Svircevic, Vesna, Adriaens, Veronique, Dirckx, Maaike, Dogger, Jaap, Dons-Sinke, Ilse, Machotta, Andreas, Moors, Xavier, Rad, Mandana, Staals, Lonneke, van der Knijff - van Dortmont, Anouk, van der Marel, Caroline, Sieben, Anne, van der Zwan, Tim, Veldhuizen, Marianne, Alders, David, Buhre, Wolfgang, Vermeulen, Petronella M, Engel, Nicole, Vossen, Carine, Mahadewsing, Ravin, Meijer, Patrick, Gerling, Volker, van der Schatte Olivier, Roelof, van Doorn, Thea, Vons Mark Hendriks, Kristy, Lako, Sandra, jan Scheffer, Gert, Tielens, Luc, Voet, Marieke, Absalom, Anthony, Bergsma, Margot, Spanjer, Vera, Spanjersberg, Rob, van de Riet, Yvette, Volkers, Martin, de Graaff, Jurgen C., Hopman, Geranne A.J., Kappen, Teus H., Hannie, J., Megens, A.M., Numan, Sandra C., Schouten, Anton N.J., Turner, Nigel M., Van Der Werff, Désirée B.M., Wensing, Renee T.M., Ephraim, Erik, Nolte, Claire, Reikvam, Tore, Fredrik Lund, Ole, Skaaden, Lene, Marthe Ballovarre, Kari, Bakken Boerke, Wenche, Grindheim, Guro, Lindenskov, Pal H H, Beate Solas, Anne, Sponheim, Sjur, Ullensvang, Kyrre, Viken, Oddbjorn, Marie Drage, Inger, Gymoese Berthelsen, Kasper, Anders Kroken, Bjørn, Bergland, Unni, Pryzmont, Miroslaw, Talalaj, Mariola, Wasiluk, Malgorzata, Zalewska, Dorota, Damps, Maria, Siemek-Mitela, Jadzia, Wieczorek, Pawel, Juzwa, Magdalena, Rosada-Kurasinska, Jowita, Bartkowska-Sniatkowska, Alicja, Cettler, Maciej, Kopycinska, Renata, Rudewicz, Iwona, Sobczyk, Jaek, Wojciechowski, Dariusz, Baranowski, Artur, Basiewicz, Ewa, Mierzewska-Schmidt, Magdalena, Retka, Wlodzimierz, Sawicki, Piotr, Checinska, Magdalena, Zielinska, Marzena, Zurawska, Magdalena, Leal, Teresa, Mascarenhas, Catia, Pedro Pina, António, Joao Susano, Maria, Moniz, Antonio, Teresa Rocha, Maria, Calvao Santos, Carolina, Domingas Patuleia, M, Pereira, Ricardo, Roxo, Helena, Amaral, Rosa, Guedes, Isabel, Gomes, Cristina, Gonçalves, Marta, Salgado, Helena, Santos, Maria, Rodrigues, Sara, Sa, Angela, Machado, Elvira, Pé d'Arca, Sandra, Seabra, Manuel, Mihaela Gheorghe, Ligia, Ivascu, Constantin, Moraru-Draghici, Lucia, Suvejan, Mirela, Babici, Remus, Eniko, Kovacs, Hogea, Cristiana, Mihaela, Dubau, Nicoleta, Daraban, Barbunc, Danut, Maria Nistor, Alina, Stefan, Violeta, Catalina Ionescu, Gabriela, Davidescu, Irina, Teodora Nastase, Alina, Dumitru Rusu, Florin, Badarau, Victoria, Cindea, Iulia, Moscaliuc, Melania, Olteanu, Dana, Petrescu, Luxita, Ceuca, Daniela, Galinescu, Irena, Badeti, Rodica, Capusan, Alin, Cucui-Cozma, Cosmina, Popescu, Barbura, Cimpeanu, Luminita, Birliba, Mihaela-Petronela, Miulescu, Magdalena, Balamat, Stefania, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Pick, Darina, Sirghie, Rodica, Tabacaru, Radu, Trante, Irinel, Horhota, Lucian, Bandrabur, Daniela, Ciobanu, Tudor, Cuciuc, Veaceslav, Munteanu, Valentin, Olaru, Valentin, Paiu, Corneliu, Savu, Anca, Trifan, Oana, Elena Malos, Anca, Glazunov, Anton, Ivanov, Alexander, Poduskov, Evgeny, Popov, Alexander, Guskov, Igor, Lugovoy, Alexander, Nechaev, Vladislav, Ovezov, Alexey, Basov, Mikhail, Kochkin, Vladimir, Lazarev, Vladimir, Chizhov, Dmitri, Ostreikov, Ivan, Tolasov, Konstantin, Budic, Ivana, Marjanovic, Vesna, Draskovic, Biljana, Pandurov, Marina, Simin, Jovana, Dolinaj, Vladimir, Janjevic, Dusanka, Mandras, Ana, Mircetic, Maja, Petrovic, Sladjana, Rebac, Vlatka, Slavkovic, Bojana, Stevanovic, Vesna, Velcev, Ana, Knezevic, Mirjana, Milojevic, Irina, Puric, Selena, Simic, Irena, Stevic, Marija, Stranjanac, Vladimir, Simic, Dusica, Cabanova, Barbora, Hanula, Miloslav, Grynyuk, Andry, Berger, Jelena, Cerne, Uros, Nastran, Andraz, Pirc, Dejan, Popic, Rok, Stupnik, Spela, Rubio, Paloma, del Río, Cristina, Benito, Pilar, Pino, Gema, Gutierrez, Ignacio, Gutierrez Valcarcel, Andrea, León Carsi, Irene, Perez Garcia, Anibal, López Galera, Sílvia, Marco Valls, Joan, Ricol Lainez, Laura, Vallejo Tarrat, Andrea, Artes, David, Banus, Ester, Chirichiello, Luca, De Abreu, Leidy, De Josemaria, Belen, Helena Gaitan, M, Garces, Antonio, Lazaro, Juan J, Manen Berga, Ferran, Molies, Dolors, Monclus, Enric, Navaro, Montserrat, Pamies, Carmen, Perelló, Marina, Prat, Mar, Ribo, Laura, Angeles Sanz, M, Serrano, Silvia, Sola Ruiz, Eva, Anuncia Escontrela Rodríguez, Blanca, Maria Gago Martinez, Andrea, Martínez Ruiz, Alberto, De La Cruz Benito, Fausto, Gabilondo Garcia, Gustavo, Martinez Maldonado, Ever, Noriega, Bryant, Oller Duque, Lara, Olmos Mendez, Alberto, Perez- Ferrer, Antonio, Reinoso Barbero, Francisco, Acevedo Bambaren, Ismael, Domínguez, Fernando, Franco, Teresa, Jiménez, Anabel, Melero, Alicia, Feliu, Montserrat, García, Irene, Montferrer, Núria, Munar, Francisca, Muro, Cristina, Nuño, Rosario, Perera, Remel, Schmucker, Erika, Börjesson, Glenda, Gillberg, Lars, Castellheim, Albert, Sandström, Kerstin, Bauer, Annette, Roos, Torbjörn, Hedlund, Lars, Boegli, Yann, Dolci, Mirko, Marcucci, Carine, Spahr-Schopfer, Isabelle, Habre, Walid, Pellegrini, Michel, Book, Malte, Errass, Loreen, Riggenbach, Christine, Casutt, Mattias, Hölzle, Martin, Hurni, Thomas, Jöhr, Martin, Mauch, Jacqueline, Anselmi, Luciano, Anselmi, Irene, Jacomet, Alfred, Oberhauser, Markus, Wossner, Stephanie, Zettl, Angelika, Erb, Thomas, Mackiewicz, Tomasz, Simitzes, Helena, Ozer, Yetkin, Takil, Arzu, Alanoglu, Zekeriyya, Bermede, Onat, Cakar Turhan, K.Sanem, Alkis, Neslihan, Yildirim Guclu, Cigdem, Ceyda Meco, Basak, Hatipoglu, Zehra, Ozcengiz, Dilek, Begec, Zekine, Ilksen Toprak, Huseyin, Kendigelen, Pinar, Cigdem Tütüncü, Ayse, Karadeniz, Meltem Savran, Seyhan Ozkan, Tulay, Sivrikoz, Nuket, Kemal Arslantas, Mustafa, Hizal, Ayse, Tore Altun, Gülbin, Umuroglu, Tumay, Baris, Sibel, Kazak Bengisun, Zuleyha, Goncharenko, Galyna, Khrapak, Maksym, Klymenko, Tetyana, Pavlenko, Vitaliy, Prysiazhniuk, Dmytro, Rudio, Olga, Varyvoda, Mykhailo, Vodianytskyi, Sergii, Boryshkevych, Ivanna, Kyselova, Iryna, Trikash, Nikolay, Albokrinov, Andrew, Perova-Sharonova, Valentina, Sklyar, Vitaliy, Surkov, Denis, Abdelaal, Amr, Barber, Nicola, Checuti, Sarah, Godsiff, Leisha, Johanne, Lynch, Simpson, Joanna, Underhill, Helen, Diwan, Rishi, Kelgeri, Nivedita, Masip, Nuria, Ravi, Radha, Roberts, Steve, Cillis, Annagrazia, Marcus, Ritchie, Merella, Federica, Love, David, Baraggia, Paolo, Bird, Victoria, Hussey, Joseph, Alderson, Peter, Bartholomew, Karen, Moncreiff, Michael, Davidson, Sarah, Hare, Alison, Kotecha, Ami, Lee, Corina, Liyanage, Ganga, Patel, Shivali, Samani, Amee, Abou-Samra, Mark, Boyd, Matthew, Hullatt, Laurence, Levy, David, Pauling, Mark, Sharman, Sarah-Jane, Smith, Natalie, Rutherford, John, Cavalier, Alison, Locke, Christie, Sage, Frederic, Bapat, Smita, Hammerschlag, Jacinda, Ioannou, Ioannis, King, Stephanie, Pegg, Rachel, Salota, Vishal, Sketcher, Jonathan, Thadsad, Muthu, Zeitlin, Deborah, Jack, Ewan, Lang, Colin, Ahmed, Samira, Ayyash, Reema, Bari, Francoise, Bell, Sarah J, Elizabeth Biercamp, Claire, Briggs, Sandra, Gabriella Elena Clement, Maria, Dalton, Mark, Ali Eissa Eid, Mohamed, Gandhi, Monica, Harmen Herrema, Idse, Khaffaf, Ranj, Jeng Min Law, Savio, McClintock, Joanna, Ireland, Nicholas, Majid Saleem, Mohammed, Smith, Fiona, Cohen, Marc, Lee, Clover-Ann, O'Donahue, Lizanne, Powell, Alex, Rawlinson, Ellen, Snoek, Aarjan, Weiss, Katja, Wellesley, Hugo, Crawford, Michael, Abdel-Hafiz, Mostafa, Day, Alexandra, Rajamani, Balaji, Saha, Rita, Wright, Dave, Chee, Lew-Chin, Bew, Stephanie, Homer, Rachel, Malarkkan, Nalini, Wolfe Barry, Juliet, Angadi, Pradeep, Cagney, Brid, De Melo, Eric, Dekker, Elsa, Helm, Emma, Jones, Gareth, Peiris, Kawshala, Russell, William, Slater, Patricia, Sodhi, Puja, Browning, Mike, Phillips, Trudie, Van Hecke, Rachel, Muir, Vimty, Singh, Piyush, Soskova, Tereza, Cumming, Craig, Farquharson, Pamela, Pearson, Karen, Shaw, Neil, Whiteside, Jonathan, Whyte, Emma, Byers, Gordon, Davies, Kay, Engelhardt, Thomas, Faliszewski, Isabella, Johnston, Graham, Kaufmann, Nils, Kusnirikova, Zuzana, Wilson, Graham, Carachi, Peter, Makin, Andrew, Foster, Brian, Lipczynski, Dariusz, Mawer, Rebecca, Rutherford, William, Rogerson, David, Rushman, Sarah, Taylor, Christopher, Tomlinson, William, Dix, Philippa, Woodward, Tom, Bell, Graham, Boyle, David, Cloherty, Marianne, Cullen, Julia, Cullen, Pauline, Fairgrieve, Ross, Ghent, Robert, Glasgow, Russell, Gordeeva, Elena, Harden, Alison, Hivey, Sarah, Jerome, Kevin, McKee, Lesley, Morton, Neil, Pribul, Vicky, Sinclair, John, Steiner, Maria, Steward, Heather, Sweeney, Lorraine, Thomson, Wendy, Whiteside, Jeanette, Dalton, Andrew, Ross, Mark, Smith, Carolyn, Allen, Claire, Anders, Nicola, Barlow, Victoria, Bassett, Mike, Darwin, Leanne, Davison, Rachel, Diacono, Jacques, Hobbs, Amy, Hutchinson, Adel, Lomas, Bernadette, Lonsdale, Hannah, Nasser, Leila, Oshan, Vimmi, Patel, Pradip, Raistrick, Christopher, Scott-Warren, Victoria, Talbot, Laura, Wai, Carolynn, Childs, Sophie, Dickinson, Matthew, Bloomfield, Tom, Garrioch, Sweyn, Watson, Karen, Gaynor, James, Harrison, Richard, Lee, Juliette, Blythe, Elizabeth, Dorman, Teresa, Eissa, Ayman, Ellwood, James, Gooch, Ingrid, Hearn, Robert, Hodgetts, Vanessa, John, Robert, Kirton, Christine, Ladak, Nadia, Morgan, Judith, Plant, Nina, Shepherd, Elizabeth, Short, Judith, Stack, Charles, Steel, Simon, Taylor, Matthew, Thomas, Deborah, Wilson, Catharine, Wilson-Smith, Elaine, Bradbury, Carol L., Hussain, Nageena, Mayell, Antonia, Mesbah, Ahmed, Qureshi, Arif, Vaidyanath, Chandra, Geary, Tim, Hawksworth, Chris, Parasuraman, Tamaraichelvi, Perry, Nicole, Banerjee, Indrani, Barr, Katharine, Butler, Patrick, Davies, Jack, Flewin, Lisa, Gande, Richard, Montague, James, Plumb, James, Pratt, Thomas, Sutherland, Paul, Vail, Hannah, Wilkins, Andrew, Hunter, Catherine, Russell, Susan, Thomas, Alun, Mifsud, Mark, Strachan, Dominic, Leva, Brigitte, Plichon, Benoit, Harlet, Pierre, Virag, Katalin, Hansen, Tom G, Morton, Neil S, and Boda, Krisztina

Published
2017
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13. Perioperative hypoxemia and postoperative respiratory events in infants with hypertrophic pyloric stenosis.

Author

van den Bunder, Fenne A.I.M., Stevens, Markus F., van Woensel, Job B.M., van de Brug, Tim, van Heurn, L.W Ernest, and Derikx, Joep P.M.

Subjects
*HYPERTROPHIC pyloric stenosis, *HYPOXEMIA, *INFANTS, *RESPIRATORY insufficiency, *OXYGEN saturation, *TRACHEA intubation
Abstract

Background: Normalization of metabolic alkalosis is an important pillar in the treatment of infantile hypertrophic pyloric stenosis (IHPS) because uncorrected metabolic alkalosis may lead to perioperative respiratory events. However, the evidence on the incidence of respiratory events is limited. We aimed to study the incidence of peroperative hypoxemia and postoperative respiratory events in infants undergoing pyloromyotomy and the potential role of metabolic alkalosis.Materials and Methods: We retrospectively reviewed all patients undergoing pyloromyotomy between 2007-2017. All infants received intravenous fluids preoperatively to correct metabolic abnormalities close to normal. We assessed the incidence of perioperative hypoxemia (defined as SpO2 <90% for >1min) and postoperative respiratory events. Additionally, the incidence of difficult intubations was evaluated. We performed a multivariate logistic regression analysis to evaluate the association between admission or preoperative serum pH values, bicarbonate or chloride and peri- and postoperative hypoxemia or respiratory events.Results: Of 406 included infants, 208 (51%) developed ≥1 episode of hypoxemia during the perioperative period, of whom 130 (32%) during induction, 43 (11%) intraoperatively and 112 (28%) during emergence. 7.5% of the infants had a difficult intubation and 17 required more than 3 attempts by a paediatric anaesthesiologist. Three patients developed respiratory insufficiency and 95 postoperative respiratory events were noticed. We did not find a clinically meaningful association between laboratory values reflecting metabolic alkalosis and respiratory events.Conclusions: IHPS frequently leads to peri- and postoperative hypoxemia or respiratory events and high incidence of difficult tracheal intubations. Preoperative pH, bicarbonate and chloride were bad predictors of respiratory events. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Accuracy of abdominal organ motion estimation in radiotherapy using the right hemidiaphragm top as a surrogate during prolonged breath‐holds quantified with MRI

Author

Veldman, Johannes K., primary, van Kesteren, Zdenko, additional, Gunwhy, Ebony R., additional, Parkes, Michael J., additional, Stevens, Markus F., additional, van den Aardweg, Joost G., additional, van Tienhoven, Geertjan, additional, Bel, Arjan, additional, and van Dijk, Irma W.E.M., additional

Published
2023
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19. Comparison of Patient-Controlled versus Continuous Epidural Analgesia in Adult Surgical Patients: A Systematic Review.

Author

van Samkar, Ganapathy, Ru Tan, Yan, Hermanns, Henning, Preckel, Benedikt, Jamaludin, Faridi S., Hollmann, Markus W., and Stevens, Markus F.

Subjects
EPIDURAL analgesia, PATIENT-controlled analgesia, PATIENT satisfaction, ADULTS, PAIN management, POSTOPERATIVE pain
Abstract

Background: The advantages of PCEA over CEA have been demonstrated in obstetric patients. Whether a similar benefit applies to surgical patients is unclear. Methods: Embase, PubMed, and Cochrane Library were searched, enabling a systematic review of studies comparing PCEA and CEA in adult surgical patients (PROSPERO: CRD42018106644). The study quality was assessed using the Cochrane risk-of-bias tool (RoB2). The primary outcome was pain scores on postoperative day one (POD1). Secondary outcomes were 24 or 48 h epidural or intravenous total analgesic dose, systemic analgesics, manual top-ups, side effects, and patient satisfaction. Results: Six randomized controlled trials with high heterogeneity of study characteristics were identified with a moderate risk of bias. Two studies showed significantly reduced resting pain scores on POD1 in PCEA compared with CEA patients (36–44%, p < 0.05). Four studies found comparable pain scores between these groups. PCEA use reduced epidural medication (28% to 40% reduction, p < 0.01) in four studies. One study found a 23% reduction (p < 0.001) of top-ups in PCEA; intravenous morphine use by PCEA patients was reduced (0.16 vs. 3.45 mg per patient, p < 0.05) in one study. PCEA patients were more satisfied with analgesia (p < 0.001) in two studies. Nausea and vomiting were reduced in PCEA (p = 0.01). Conclusions: Regarding the reduction in pain scores, the effects of PCEA were not significant or clinically not relevant. However, regarding the amount of epidural drug use, the amount of required rescue systemic analgesics, patient satisfaction, and the number of required top-ups, PCEA had advantages over CEA in surgical patients. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Recommendations for effective documentation in regional anesthesia: an expert panel Delphi consensus project

Author

Ahmed, Hassan M, Atterton, Benjamin P, Crowe, Gillian G, Barratta, Jaime L, Johnson, Mark, Viscusi, Eugene R., Adhikary, Sanjib, Albrecht, Eric, Boretsky, Karen, Boublik, Jan, Breslin, Dara S, Byrne, Kelly, Ch'ng, Alan, Chuan, Alwin, Conroy, Patrick, Daniel, Craig, Daszkiewicz, Andrzej, Delbos, Alain, Dirzu, Dan Sebastian, Dmytriiev, Dmytro, Fennessy, Paul, Fischer, H Barrie J, Frizelle, Henry, Gadsden, Jeff, Gautier, Philippe, Gupta, Rajnish K, Gürkan, Yavuz, Hardman, Harold David, Harrop-Griffiths, William, Hebbard, Peter, Hernandez, Nadia, Hlasny, Jakub, Iohom, Gabriella, Ip, Vivian H Y, Jeng, Christina L, Johnson, Rebecca L, Kalagara, Hari, Kinirons, Brian, Lansdown, Andrew Kenneth, Leng, Jody C, Lim, Yean Chin, Lobo, Clara, Ludwin, Danielle B, Macfarlane, Alan James Robert, Machi, Anthony T, Mahon, Padraig, Mannion, Stephen, McLeod, David H, Merjavy, Peter, Miscuks, Aleksejs, Mitchell, Christopher H, Moka, Eleni, Moran, Peter, Ngui, Ann, Nin, Olga C, O'Donnell, Brian D, Pawa, Amit, Perlas, Anahi, Porter, Steven, Pozek, John-Paul, Rebelo, Humberto C, Roqués, Vicente, Schroeder, Kristopher M, Schwartz, Gary, Schwenk, Eric S., Sermeus, Luc, Shorten, George, Srinivasan, Karthikeyan, Stevens, Markus F, Theodoraki, Kassiani, Turbitt, Lloyd R, Valdés-Vilches, Luis Fernando, Volk, Thomas, Webster, Katrina, Wiesmann, T, Wilson, Sylvia H, Wolmarans, Morné, Woodworth, Glenn, Worek, Andrew K, Moran, E M Louise, Ahmed, Hassan M, Atterton, Benjamin P, Crowe, Gillian G, Barratta, Jaime L, Johnson, Mark, Viscusi, Eugene R., Adhikary, Sanjib, Albrecht, Eric, Boretsky, Karen, Boublik, Jan, Breslin, Dara S, Byrne, Kelly, Ch'ng, Alan, Chuan, Alwin, Conroy, Patrick, Daniel, Craig, Daszkiewicz, Andrzej, Delbos, Alain, Dirzu, Dan Sebastian, Dmytriiev, Dmytro, Fennessy, Paul, Fischer, H Barrie J, Frizelle, Henry, Gadsden, Jeff, Gautier, Philippe, Gupta, Rajnish K, Gürkan, Yavuz, Hardman, Harold David, Harrop-Griffiths, William, Hebbard, Peter, Hernandez, Nadia, Hlasny, Jakub, Iohom, Gabriella, Ip, Vivian H Y, Jeng, Christina L, Johnson, Rebecca L, Kalagara, Hari, Kinirons, Brian, Lansdown, Andrew Kenneth, Leng, Jody C, Lim, Yean Chin, Lobo, Clara, Ludwin, Danielle B, Macfarlane, Alan James Robert, Machi, Anthony T, Mahon, Padraig, Mannion, Stephen, McLeod, David H, Merjavy, Peter, Miscuks, Aleksejs, Mitchell, Christopher H, Moka, Eleni, Moran, Peter, Ngui, Ann, Nin, Olga C, O'Donnell, Brian D, Pawa, Amit, Perlas, Anahi, Porter, Steven, Pozek, John-Paul, Rebelo, Humberto C, Roqués, Vicente, Schroeder, Kristopher M, Schwartz, Gary, Schwenk, Eric S., Sermeus, Luc, Shorten, George, Srinivasan, Karthikeyan, Stevens, Markus F, Theodoraki, Kassiani, Turbitt, Lloyd R, Valdés-Vilches, Luis Fernando, Volk, Thomas, Webster, Katrina, Wiesmann, T, Wilson, Sylvia H, Wolmarans, Morné, Woodworth, Glenn, Worek, Andrew K, and Moran, E M Louise

Abstract

Background and objectives: Documentation is important for quality improvement, education, and research. There is currently a lack of recommendations regarding key aspects of documentation in regional anesthesia. The aim of this study was to establish recommendations for documentation in regional anesthesia. Methods: Following the formation of the executive committee and a directed literature review, a long list of potential documentation components was created. A modified Delphi process was then employed to achieve consensus amongst a group of international experts in regional anesthesia. This consisted of 2 rounds of anonymous electronic voting and a final virtual round table discussion with live polling on items not yet excluded or accepted from previous rounds. Progression or exclusion of potential components through the rounds was based on the achievement of strong consensus. Strong consensus was defined as ≥75% agreement and weak consensus as 50%-74% agreement. Results: Seventy-seven collaborators participated in both rounds 1 and 2, while 50 collaborators took part in round 3. In total, experts voted on 83 items and achieved a strong consensus on 51 items, weak consensus on 3 and rejected 29. Conclusion: By means of a modified Delphi process, we have established expert consensus on documentation in regional anesthesia.

Published
2022

22. Recommendations for effective documentation in regional anesthesia: an expert panel Delphi consensus project.

Author

UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'anesthésiologie, Ahmed, Hassan M, Atterton, Benjamin P, Crowe, Gillian G, Barratta, Jaime L, Johnson, Mark, Viscusi, Eugene, Adhikary, Sanjib, Albrecht, Eric, Boretsky, Karen, Boublik, Jan, Breslin, Dara S, Byrne, Kelly, Ch'ng, Alan, Chuan, Alwin, Conroy, Patrick, Daniel, Craig, Daszkiewicz, Andrzej, Delbos, Alain, Dirzu, Dan Sebastian, Dmytriiev, Dmytro, Fennessy, Paul, Fischer, H Barrie J, Frizelle, Henry, Gadsden, Jeff, Gautier, Philippe, Gupta, Rajnish K, Gürkan, Yavuz, Hardman, Harold David, Harrop-Griffiths, William, Hebbard, Peter, Hernandez, Nadia, Hlasny, Jakub, Iohom, Gabriella, Ip, Vivian H Y, Jeng, Christina L, Johnson, Rebecca L, Kalagara, Hari, Kinirons, Brian, Lansdown, Andrew Kenneth, Leng, Jody C, Lim, Yean Chin, Lobo, Clara, Ludwin, Danielle B, Macfarlane, Alan James Robert, Machi, Anthony T, Mahon, Padraig, Mannion, Stephen, McLeod, David H, Merjavy, Peter, Miscuks, Aleksejs, Mitchell, Christopher H, Moka, Eleni, Moran, Peter, Ngui, Ann, Nin, Olga C, O'Donnell, Brian D, Pawa, Amit, Perlas, Anahi, Porter, Steven, Pozek, John-Paul, Rebelo, Humberto C, Roqués, Vicente, Schroeder, Kristopher M, Schwartz, Gary, Schwenk, Eric S, Sermeus, Luc, Shorten, George, Srinivasan, Karthikeyan, Stevens, Markus F, Theodoraki, Kassiani, Turbitt, Lloyd R, Valdés-Vilches, Luis Fernando, Volk, Thomas, Webster, Katrina, Wiesmann, T, Wilson, Sylvia H, Wolmarans, Morné, Woodworth, Glenn, Worek, Andrew K, Moran, E M Louise, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'anesthésiologie, Ahmed, Hassan M, Atterton, Benjamin P, Crowe, Gillian G, Barratta, Jaime L, Johnson, Mark, Viscusi, Eugene, Adhikary, Sanjib, Albrecht, Eric, Boretsky, Karen, Boublik, Jan, Breslin, Dara S, Byrne, Kelly, Ch'ng, Alan, Chuan, Alwin, Conroy, Patrick, Daniel, Craig, Daszkiewicz, Andrzej, Delbos, Alain, Dirzu, Dan Sebastian, Dmytriiev, Dmytro, Fennessy, Paul, Fischer, H Barrie J, Frizelle, Henry, Gadsden, Jeff, Gautier, Philippe, Gupta, Rajnish K, Gürkan, Yavuz, Hardman, Harold David, Harrop-Griffiths, William, Hebbard, Peter, Hernandez, Nadia, Hlasny, Jakub, Iohom, Gabriella, Ip, Vivian H Y, Jeng, Christina L, Johnson, Rebecca L, Kalagara, Hari, Kinirons, Brian, Lansdown, Andrew Kenneth, Leng, Jody C, Lim, Yean Chin, Lobo, Clara, Ludwin, Danielle B, Macfarlane, Alan James Robert, Machi, Anthony T, Mahon, Padraig, Mannion, Stephen, McLeod, David H, Merjavy, Peter, Miscuks, Aleksejs, Mitchell, Christopher H, Moka, Eleni, Moran, Peter, Ngui, Ann, Nin, Olga C, O'Donnell, Brian D, Pawa, Amit, Perlas, Anahi, Porter, Steven, Pozek, John-Paul, Rebelo, Humberto C, Roqués, Vicente, Schroeder, Kristopher M, Schwartz, Gary, Schwenk, Eric S, Sermeus, Luc, Shorten, George, Srinivasan, Karthikeyan, Stevens, Markus F, Theodoraki, Kassiani, Turbitt, Lloyd R, Valdés-Vilches, Luis Fernando, Volk, Thomas, Webster, Katrina, Wiesmann, T, Wilson, Sylvia H, Wolmarans, Morné, Woodworth, Glenn, Worek, Andrew K, and Moran, E M Louise

Abstract

Documentation is important for quality improvement, education, and research. There is currently a lack of recommendations regarding key aspects of documentation in regional anesthesia. The aim of this study was to establish recommendations for documentation in regional anesthesia. Following the formation of the executive committee and a directed literature review, a long list of potential documentation components was created. A modified Delphi process was then employed to achieve consensus amongst a group of international experts in regional anesthesia. This consisted of 2 rounds of anonymous electronic voting and a final virtual round table discussion with live polling on items not yet excluded or accepted from previous rounds. Progression or exclusion of potential components through the rounds was based on the achievement of strong consensus. Strong consensus was defined as ≥75% agreement and weak consensus as 50%-74% agreement. Seventy-seven collaborators participated in both rounds 1 and 2, while 50 collaborators took part in round 3. In total, experts voted on 83 items and achieved a strong consensus on 51 items, weak consensus on 3 and rejected 29. By means of a modified Delphi process, we have established expert consensus on documentation in regional anesthesia.

Published
2022

23. Recommendations for effective documentation in regional anesthesia: an expert panel Delphi consensus project

Author

Gürkan, Yavuz (ORCID 0000-0002-2307-6943 & YÖK ID 154129), Ahmed, Hassan M.; Atterton, Benjamin P.; Crowe, Gillian G.; Barratta, Jaime L.; Johnson, Mark; Viscusi, Eugene; Adhikary, Sanjib; Albrecht, Eric; Boretsky, Karen; Boublik, Jan; Breslin, Dara S.; Byrne, Kelly; Ch'ng, Alan; Chuan, Alwin; Conroy, Patrick; Daniel, Craig; Daszkiewicz, Andrzej; Delbos, Alain; Dirzu, Dan Sebastian; Dmytriiev, Dmytro; Fennessy, Paul; Fischer, H. Barrie J.; Frizelle, Henry; Gadsden, Jeff; Gautier, Philippe; Gupta, Rajnish K.; Hardman, Harold David; Harrop-Griffiths, William; Hebbard, Peter; Hernandez, Nadia; Hlasny, Jakub; Iohom, Gabriella; Ip, Vivian H. Y.; Jeng, Christina L. .; Johnson, Rebecca L.; Kalagara, Hari; Kinirons, Brian; Lansdown, Andrew Kenneth; Leng, Jody C.; Lim, Yean Chin; Lobo, Clara; Ludwin, Danielle B.; Macfarlane, Alan James Robert; Machi, Anthony T.; Mahon, Padraig; Mannion, Stephen; McLeod, David H.; Merjavy, Peter; Miscuks, Aleksejs; Mitchell, Christopher H.; Moka, Eleni; Moran, Peter; Ngui, Ann; Nin, Olga C.; O'Donnell, Brian D.; Pawa, Amit; Perlas, Anahi; Porter, Steven; Pozek, John-Paul; Rebelo, Humberto C.; Roques, Vicente; Schroeder, Kristopher M.; Schwartz, Gary; Schwenk, Eric S.; Sermeus, Luc; Shorten, George; Srinivasan, Karthikeyan; Stevens, Markus F.; Theodoraki, Kassiani; Turbitt, Lloyd R.; Valdes-Vilches, Luis Fernando; Volk, Thomas; Webster, Katrina; Wiesmann, T.; Wilson, Sylvia H.; Wolmarans, Morne; Woodworth, Glenn; Worek, Andrew K.; Moran, E. M. Louise, Koç University Hospital, School of Medicine, Gürkan, Yavuz (ORCID 0000-0002-2307-6943 & YÖK ID 154129), Ahmed, Hassan M.; Atterton, Benjamin P.; Crowe, Gillian G.; Barratta, Jaime L.; Johnson, Mark; Viscusi, Eugene; Adhikary, Sanjib; Albrecht, Eric; Boretsky, Karen; Boublik, Jan; Breslin, Dara S.; Byrne, Kelly; Ch'ng, Alan; Chuan, Alwin; Conroy, Patrick; Daniel, Craig; Daszkiewicz, Andrzej; Delbos, Alain; Dirzu, Dan Sebastian; Dmytriiev, Dmytro; Fennessy, Paul; Fischer, H. Barrie J.; Frizelle, Henry; Gadsden, Jeff; Gautier, Philippe; Gupta, Rajnish K.; Hardman, Harold David; Harrop-Griffiths, William; Hebbard, Peter; Hernandez, Nadia; Hlasny, Jakub; Iohom, Gabriella; Ip, Vivian H. Y.; Jeng, Christina L. .; Johnson, Rebecca L.; Kalagara, Hari; Kinirons, Brian; Lansdown, Andrew Kenneth; Leng, Jody C.; Lim, Yean Chin; Lobo, Clara; Ludwin, Danielle B.; Macfarlane, Alan James Robert; Machi, Anthony T.; Mahon, Padraig; Mannion, Stephen; McLeod, David H.; Merjavy, Peter; Miscuks, Aleksejs; Mitchell, Christopher H.; Moka, Eleni; Moran, Peter; Ngui, Ann; Nin, Olga C.; O'Donnell, Brian D.; Pawa, Amit; Perlas, Anahi; Porter, Steven; Pozek, John-Paul; Rebelo, Humberto C.; Roques, Vicente; Schroeder, Kristopher M.; Schwartz, Gary; Schwenk, Eric S.; Sermeus, Luc; Shorten, George; Srinivasan, Karthikeyan; Stevens, Markus F.; Theodoraki, Kassiani; Turbitt, Lloyd R.; Valdes-Vilches, Luis Fernando; Volk, Thomas; Webster, Katrina; Wiesmann, T.; Wilson, Sylvia H.; Wolmarans, Morne; Woodworth, Glenn; Worek, Andrew K.; Moran, E. M. Louise, Koç University Hospital, and School of Medicine

Abstract

Background and objectives: documentation is important for quality improvement, education, and research. There is currently a lack of recommendations regarding key aspects of documentation in regional anesthesia. The aim of this study was to establish recommendations for documentation in regional anesthesia. Methods: following the formation of the executive committee and a directed literature review, a long list of potential documentation components was created. A modified Delphi process was then employed to achieve consensus amongst a group of international experts in regional anesthesia. This consisted of 2 rounds of anonymous electronic voting and a final virtual round table discussion with live polling on items not yet excluded or accepted from previous rounds. Progression or exclusion of potential components through the rounds was based on the achievement of strong consensus. Strong consensus was defined as >= 75% agreement and weak consensus as 50%-74% agreement. Results: seventy-seven collaborators participated in both rounds 1 and 2, while 50 collaborators took part in round 3. In total, experts voted on 83 items and achieved a strong consensus on 51 items, weak consensus on 3 and rejected 29. Conclusion: by means of a modified Delphi process, we have established expert consensus on documentation in regional anesthesia., European Society of Regional Anaesthesia and Pain Therapy (ESRA); ASRA Pain Medicine

Published
2022

27. Recommendations for effective documentation in regional anesthesia: an expert panel Delphi consensus project

Author

Ahmed, Hassan M, primary, Atterton, Benjamin P, additional, Crowe, Gillian G, additional, Barratta, Jaime L, additional, Johnson, Mark, additional, Viscusi, Eugene, additional, Adhikary, Sanjib, additional, Albrecht, Eric, additional, Boretsky, Karen, additional, Boublik, Jan, additional, Breslin, Dara S, additional, Byrne, Kelly, additional, Ch'ng, Alan, additional, Chuan, Alwin, additional, Conroy, Patrick, additional, Daniel, Craig, additional, Daszkiewicz, Andrzej, additional, Delbos, Alain, additional, Dirzu, Dan Sebastian, additional, Dmytriiev, Dmytro, additional, Fennessy, Paul, additional, Fischer, H Barrie J, additional, Frizelle, Henry, additional, Gadsden, Jeff, additional, Gautier, Philippe, additional, Gupta, Rajnish K, additional, Gürkan, Yavuz, additional, Hardman, Harold David, additional, Harrop-Griffiths, William, additional, Hebbard, Peter, additional, Hernandez, Nadia, additional, Hlasny, Jakub, additional, Iohom, Gabriella, additional, Ip, Vivian H Y, additional, Jeng, Christina L, additional, Johnson, Rebecca L, additional, Kalagara, Hari, additional, Kinirons, Brian, additional, Lansdown, Andrew Kenneth, additional, Leng, Jody C, additional, Lim, Yean Chin, additional, Lobo, Clara, additional, Ludwin, Danielle B, additional, Macfarlane, Alan James Robert, additional, Machi, Anthony T, additional, Mahon, Padraig, additional, Mannion, Stephen, additional, McLeod, David H, additional, Merjavy, Peter, additional, Miscuks, Aleksejs, additional, Mitchell, Christopher H, additional, Moka, Eleni, additional, Moran, Peter, additional, Ngui, Ann, additional, Nin, Olga C, additional, O'Donnell, Brian D, additional, Pawa, Amit, additional, Perlas, Anahi, additional, Porter, Steven, additional, Pozek, John-Paul, additional, Rebelo, Humberto C, additional, Roqués, Vicente, additional, Schroeder, Kristopher M, additional, Schwartz, Gary, additional, Schwenk, Eric S, additional, Sermeus, Luc, additional, Shorten, George, additional, Srinivasan, Karthikeyan, additional, Stevens, Markus F, additional, Theodoraki, Kassiani, additional, Turbitt, Lloyd R, additional, Valdés-Vilches, Luis Fernando, additional, Volk, Thomas, additional, Webster, Katrina, additional, Wiesmann, T, additional, Wilson, Sylvia H, additional, Wolmarans, Morné, additional, Woodworth, Glenn, additional, Worek, Andrew K, additional, and Moran, E M Louise, additional

Published
2022
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29. Contralateral surgical exploration during inguinal hernia repair in infants (HERNIIA trial): study protocol for a multi-centre, randomised controlled trial

Author

Dreuning, Kelly M.A., Tulder, Maurits W. van, Been, J.V., Rovers, M.M., Graaff, Jurgen C. de, Stevens, Markus F., Heurn, L.W.E. van, Derikx, Joep P.M., Dreuning, Kelly M.A., Tulder, Maurits W. van, Been, J.V., Rovers, M.M., Graaff, Jurgen C. de, Stevens, Markus F., Heurn, L.W.E. van, and Derikx, Joep P.M.

Abstract

Contains fulltext : 238397.pdf (Publisher’s version ) (Open Access)

Published
2021

34. Interventions with Music in PECTus excavatum treatment (IMPECT trial): a study protocol for a randomised controlled trial investigating the clinical effects of perioperative music interventions

Author

Billar, Ryan J, primary, Kühlmann, A Y Rosalie, additional, Schnater, J Marco, additional, Vlot, John, additional, Tomas, Jeremy J P, additional, Zijp, Gerda W, additional, Rad, Mandana, additional, de Beer, Sjoerd A, additional, Stevens, Markus F, additional, Poley, Marten J, additional, van Rosmalen, Joost, additional, Jeekel, Johannes F, additional, and Wijnen, Rene M H, additional

Published
2020
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38. Contralateral surgical exploration during inguinal hernia repair in infants (HERNIIA trial): study protocol for a multi-centre, randomised controlled trial.

Author

Dreuning, Kelly M. A., van Tulder, Maurits W., Been, Jasper V., Rovers, Maroeska M., de Graaff, Jurgen C., Stevens, Markus F., Anema, Johannes R., Twisk, Jos W. R., van Heurn, L. W. Ernest, Derikx, Joep P. M., and HERNIIA study group

Subjects
INGUINAL hernia, RESEARCH protocols, INFANTS, QUALITY of life, LOGISTIC regression analysis, SCHOOL building maintenance & repair
Abstract

Background: The incidence of metachronous contralateral inguinal hernia (MCIH) is high in infants with an inguinal hernia (5-30%), with the highest risk in infants aged 6 months or younger. MCIH is associated with the risk of incarceration and necessitates a second operation. This might be avoided by contralateral exploration during primary surgery. However, contralateral exploration may be unnecessary, leads to additional operating time and costs and may result in additional complications of surgery and anaesthesia. Thus, there is no consensus whether contralateral exploration should be performed routinely.Methods: The Hernia-Exploration-oR-Not-In-Infants-Analysis (HERNIIA) study is a multicentre randomised controlled trial with an economic evaluation alongside to study the (cost-)effectiveness of contralateral exploration during unilateral hernia repair. Infants aged 6 months or younger who need to undergo primary unilateral hernia repair will be randomised to contralateral exploration or no contralateral exploration (n = 378 patients). Primary endpoint is the proportion of infants that need to undergo a second operation related to inguinal hernia within 1 year after primary repair. Secondary endpoints include (a) total duration of operation(s) (including anaesthesia time) and hospital admission(s); (b) complications of anaesthesia and surgery; and (c) participants' health-related quality of life and distress and anxiety of their families, all assessed within 1 year after primary hernia repair. Statistical testing will be performed two-sided with α = .05 and according to the intention-to-treat principle. Logistic regression analysis will be performed adjusted for centre and possible confounders. The economic evaluation will be performed from a societal perspective and all relevant costs will be measured, valued and analysed.Discussion: This study evaluates the effectiveness and cost-effectiveness of contralateral surgical exploration during unilateral inguinal hernia repair in children younger than 6 months with a unilateral inguinal hernia.Trial Registration: ClinicalTrials.gov NCT03623893 . Registered on August 9, 2018 Netherlands Trial Register NL7194. Registered on July 24, 2018 Central Committee on Research Involving Human Subjects (CCMO) NL59817.029.18. Registered on July 3, 2018. [ABSTRACT FROM AUTHOR]

Published
2021
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39. Low-dose dexamethasone during arthroplasty

Author

Wegener, Jessica T., Kraal, Tim, Stevens, Markus F., Hollmann, Markus W., Kerkhoffs, Gino M.M.J., and Haverkamp, Daniël

Subjects
General Orthopaedics, Hip, Ssi, Surgical Site Infections, Post-Operative Nausea and Vomiting, Ponv, Knee, Arthroplasty
Abstract

Dexamethasone is commonly applied during arthroplasty to control post-operative nausea and vomiting (PONV). However, conflicting views of orthopaedic surgeons and anaesthesiologists regarding the use of dexamethasone raise questions about risks of impaired wound healing and surgical site infections (SSI). The aim of this systematic review is to determine the level of evidence for the safety of a peri-operative single low dose of dexamethasone in hip and knee arthroplasty. We systematically reviewed literature in PubMed, EMBASE and Cochrane databases and cited references in articles found in the initial search from 1980 to 2013 based on predefined inclusion criteria. The review was completed with a ‘pro’ and ‘con’ discussion. After identifying 11 studies out of 104, only eight studies met the inclusion criteria. In total, 1335 patients were studied without any incidence of SSI. Causes of SSI are multifactorial. Therefore, 27 205 patients would be required (power = 90%, alpha = 0.05) to provide substantiated conclusions on safety of a single low dose of dexamethasone. Positively, many studies demonstrated showed convincing effects of low-dose dexamethasone on prevention of PONV and dose-dependent effects on post-operative pain and quality of recovery. Dexamethasone induces hyperglycaemia, but none of the studies demonstrated a concomitant SSI. Conversely, animal studies showed that high dose dexamethasone inhibits wound healing. A team approach of anaesthesiologists and orthopaedic surgeons is mandatory in order to balance the risk–benefit ratio of peri-operatively applied steroids for individual arthroplasty patients. We did not find evidence that a single low dose of dexamethasone contributes to SSI or wound healing impairment from the current studies. Cite this article: Wegener JT, Kraal T, Stevens MF, Hollman MW, Kerkhoffs GMMJ, Haverkamp D. Low-dose dexamethasone during arthroplasty: what do we know about the risks? EFORT Open Rev 2016;1:303-309. DOI: 10.1302/2058-5241.1.000039.

Published
2016

40. Perioperative apnea in infants with hypertrophic pyloric stenosis: A systematic review.

Author

Bunder, Fenne A. I. M., Wijk, Lotte, Woensel, Job B. M., Stevens, Markus F., Heurn, L. W. Ernest, Derikx, Joep P. M., and Veyckemans, Francis

Subjects
HYPERTROPHIC pyloric stenosis, APNEA, INFANTS, META-analysis
Abstract

Background: Infantile hypertrophic pyloric stenosis (IHPS) leads to excessive vomiting and metabolic alkalosis, which may subsequently cause apnea. Although it is generally assumed that metabolic derangements should be corrected prior to surgery to prevent apnea, the exact incidence of perioperative apneas in infants with IHPS and the association with metabolic alkalosis are unknown. We performed this systematic review to assess the incidence of apnea in infants with IHPS and to verify the possible association between apnea and metabolic alkalosis. Methods: We searched MEDLINE, Embase, and Cochrane library to identify studies regarding infants with metabolic alkalosis, respiratory problems, and hypertrophic pyloric stenosis. We conducted a descriptive synthesis of the findings of the included studies. Results: Thirteen studies were included for analysis. Six studies described preoperative apnea, three studies described postoperative apnea, and four studies described both. All studies were of low quality or had other research questions. We found an incidence of 27% of preoperative and 0.2%‐16% of postoperative apnea, respectively. None of the studies examined the association between apnea and metabolic alkalosis in infants with IHPS. Conclusions: Infants with IHPS may have a risk to develop perioperative apnea. However, the incidence rates should be interpreted with caution because of the low quality and quantity of the studies. Therefore, further studies are required to determine the incidence of perioperative apnea in infants with IHPS. The precise underlying mechanism of apnea in these infants is still unknown, and the role of metabolic alkalosis should be further evaluated. [ABSTRACT FROM AUTHOR]

Published
2020
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42. In Response

Author

Hulst, Abraham H., primary, Avis, Hans J., additional, Hollmann, Markus W., additional, and Stevens, Markus F., additional

Published
2017
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43. Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

Author

Habre, Walid, primary, Disma, Nicola, additional, Virag, Katalin, additional, Becke, Karin, additional, Hansen, Tom G, additional, Jöhr, Martin, additional, Leva, Brigitte, additional, Morton, Neil S, additional, Vermeulen, Petronella M, additional, Zielinska, Marzena, additional, Boda, Krisztina, additional, Veyckemans, Francis, additional, Klimscha, Walter, additional, Konecny, Regina, additional, Luntzer, Robert, additional, Morawk-Wintersperger, Ulrike, additional, Neiger, Franz, additional, Rustemeyer, Lydia, additional, Breschan, Christian, additional, Frey, Denise, additional, Platzer, Manuela, additional, Germann, Reinhard, additional, Oeding, Joachim, additional, Stoegermüller, Birgit, additional, Ziegler, Bernhard, additional, Brotatsch, Philipp, additional, Gutmann, Anton, additional, Mausser, Gerlinde, additional, Messerer, Brigitte, additional, Toller, Wolfgang, additional, Vittinghoff, Maria, additional, Zangl, Gregor, additional, Seidel-Ahyai, Natascha, additional, Hochhold, Christoph, additional, Kroess, Ruth, additional, Paal, Peter, additional, Cnudde, Steven, additional, Coucke, Patricia, additional, Loveniers, Birgit, additional, Mitchell, John, additional, Kahn, David, additional, Pirotte, Thierry, additional, Pregardien, Caroline, additional, Coppens, Marc, additional, De Hert, Stefan, additional, Heyse, Björn, additional, Neckebroek, Martine, additional, Parashchanka, Aliaksandra, additional, Van Limmen, Jurgen, additional, Van Den Eynde, Nancy, additional, Vanpeteghem, Caroline, additional, Wyffels, Piet, additional, Lalot, Michaël, additional, Lechat, Jean-Paul, additional, Stevens, France, additional, Casaer, Sari, additional, De Groote, Françoise, additional, De Pooter, Françoise, additional, De Villé, Andrée, additional, Gerin, Marc, additional, Magasich, Natalia, additional, Sanchez Torres, Cristel, additional, Van Deenen, Denise, additional, Berghmans, Johan, additional, Himpe, Dirk, additional, Roofthooft, Eva, additional, Joukes, Ellen, additional, Smitz, Carine, additional, Van Reeth, Veronique, additional, Huygens, Christel, additional, Lauweryns, Julie, additional, De Smet, Karen, additional, Najafi, Nadia, additional, Poelaert, Jan, additional, Van de Velde, Anne, additional, Van Mossevelde, Veerle, additional, Bekavac, Ivan, additional, Butkovic, Diana, additional, Heli Litvic, Dubravka, additional, Kerovec Soric, Ivana, additional, Maretic, Hrvoje, additional, Moscatello, Djurdjica, additional, Popovic, Ljiljana, additional, Micici, Slobodan, additional, Stuck Tus, Ivana, additional, Kalagac Fabris, Lada, additional, Simurina, Tatjana, additional, Sulen, Nina, additional, Kesic-Valpotic, Gordana, additional, Djapic, Dajana, additional, Žurek, Jirí, additional, Jureckova, Lucie, additional, Mackova, Iveta, additional, Skacel, Monika, additional, Weinlichova, Stanislava, additional, Divák, Jan, additional, Frelich, Michal, additional, Urbanec, René, additional, Biskupova, Vera, additional, Mixa, Vladimir, additional, Pavlickova, Jana, additional, Afshari, Arash, additional, Bøttger, Morten, additional, Ellekvist, Marguerite B., additional, Johansen, Mathias, additional, Ingeborg Madsen, Birgitte, additional, Christian Nilsson, Jens, additional, Schousboe, Birgitte MB, additional, Clausen, Nicola G., additional, Hansen, Tom G., additional, Phaff Steen, Nick, additional, Ilmoja, Mari-Liis, additional, Tonise, Virge, additional, Karjagin, Juri, additional, Kikas, Reet, additional, Isohanni, Mika, additional, Lyly, Anniina, additional, Takala, Annika, additional, Happo, Johanna, additional, Kiviluoma, Kai, additional, Martikainen, Kati, additional, Aantaa, Riku, additional, Manner, Tuula, additional, Vilo, Sanna, additional, Amory, Catherine, additional, Ludot, Hugues, additional, Lambotte, Patricia, additional, Busche, René, additional, Jacqmarcq, Olivier, additional, Lejus, Corinne, additional, Corouge, Julien, additional, Erb, Christian, additional, Garrigue, Delphine, additional, Gillet, Patricia, additional, Laffargue, Anne, additional, Lambelin, Veronique, additional, Le Freche, Hélène, additional, Peresbota, Daliana, additional, Richart, Pierre, additional, Berton, Jerome, additional, Chapotte, Catherine, additional, Colbus, Laurent, additional, Lehousse, Thierry, additional, Monrigal, Jean, additional, Baujard, Catherine, additional, Roulleau, Philippe, additional, Staiti, Giuseppe, additional, Batoz, Hélène, additional, Bordes, Maryline, additional, Didier, Anne, additional, Hamonic, Yann, additional, Lagarde, Sylvaine, additional, Nouette-Gaulain, Karine, additional, Semjen, François, additional, Zaghet, Brigitte, additional, Dekens, Jacky, additional, Delcuze, Axelle, additional, Dupont, Hervé, additional, Legrand, Aurélien, additional, Raffoflandreur, Celine, additional, Audren, Noémie, additional, Camus, Blandine, additional, Cartal, Marielle, additional, Chazelet, Chantal, additional, Davin, Isabelle, additional, Guillier, Marion, additional, Desjeux, Luc, additional, Larcher, Claire, additional, Grein, Elodie, additional, Leclercq, Mickeal, additional, Levitchi, Roxana, additional, Rosu, Lilica, additional, Simon, Dominique, additional, Zang, Aurélien, additional, Migeon, Anne, additional, Gagey, Anne-Charlotte, additional, Bourdaud, Nathalie, additional, Carre, Anne-Charlotte, additional, Duflo, Frédéric, additional, Riche, Jean-Claude, additional, Robert, Philippe, additional, Druot, Emilie, additional, Maupain, Olivier, additional, Orliaguet, Gilles, additional, Sabau, Lucie, additional, Taright, Hanna, additional, Uhrig, Lynn, additional, Verchere-Montmayeur, Juliette, additional, Debrabant, Lise, additional, Pilla, Clotaire, additional, Podvin, Alexandre, additional, Roth, Benjamin, additional, Dahmani, Souhayl, additional, Julien-Marsollier, Florence, additional, Sabourdin, Nada, additional, Alexandri, Bogdan, additional, Brezac, Gilles, additional, de la Brière, Francois, additional, Hayem, Catherine, additional, Lhubat, Elizabeth, additional, Paul Mission, Jean, additional, Rémond, Charlotte, additional, Dadure, Christophe, additional, Maniora, Maud, additional, Marie, Anais, additional, Pirat, Philippe, additional, Saour, Anne-Charlotte, additional, Sola, Chrystelle, additional, Ecoffey, Claude, additional, Wodey, Eric, additional, Adam, Christian, additional, Standl, Thomas, additional, Schindler, Ehrenfried, additional, Yamamoto, Tomohiro, additional, Brackhahn, Michael, additional, Eich, Christoph Bernhard, additional, Guericke, Holger, additional, Kindermann, Petra, additional, Laschat, Michael, additional, Schink, Cornel, additional, Wappler, Frank, additional, Hoehne, Claudia, additional, Skordou, Natalia, additional, Ulrici, Johanna, additional, Jetzek-Zader, Martin, additional, Kienbaum, Peter, additional, Meyer-Treschan, Tanja, additional, Picker, Olaf, additional, Schaefer, Maximilian S., additional, Mielke, Golo, additional, Baethge, Sabine, additional, Ramminger, Axel, additional, Bauer, Martin, additional, Bollinger, Matthias, additional, Hinz, José, additional, Quintel, Michael, additional, Russo, Sebastian G., additional, Bauer, Michael, additional, Geil, Dfominik, additional, Kortgen, Andreas, additional, Preussler, Niels-Peter, additional, Hofmann, Ulrich, additional, Raber, Manfred, additional, Reindl, Doris, additional, Oppenrieder, Karin, additional, Schierlinger, Bettina, additional, Roth, Jens, additional, Funk, Wolfgang, additional, Fischer, Thomas, additional, Gernoth, Christian, additional, Wiefelspütz, Christina, additional, Volger, Hauke, additional, Zederer, Nicole, additional, Diers, Anja, additional, Huber, Matthias, additional, Schorer, Clemens, additional, Weyland, Andreas, additional, Schwarzkopf, Konrad, additional, Grau, Catharina, additional, Roth, Winfried, additional, Holy, Rolf, additional, Mader, Thomas, additional, Peter, Laura, additional, Supthut, Hauke, additional, Kuehhirt, Thomas, additional, Milde, Alexander, additional, Fiedler, Fritz, additional, Isselhorst, Carsten, additional, Grundmann, Ulrich, additional, Pattar, Alexander, additional, Reinert, Jennifer, additional, Ehm, Birgit, additional, Fritzsche, Katrin, additional, Gaebler, Ralf, additional, Meybohm, Patrick, additional, Hein, Maximilian, additional, Guzman, Ines, additional, Jokinen, Johanna, additional, Kranke, Peter, additional, Goebel, Ulrich, additional, Harris, Sarah, additional, Eisner, Christoph, additional, Ochsenreiter, Miriam, additional, Schoeler, Michael, additional, Thil, Elke, additional, Ellerkmann, Richard, additional, Hoeft, Andreas, additional, Neumann, Claudia, additional, Weber, Stefan, additional, Keilhauer, Julia, additional, Kloessing, Jan, additional, Schramm, Michael, additional, Trieschmann, Uwe, additional, Knauss, Kristina, additional, Sinner, Barbara, additional, Steinmann, Johannes, additional, Koessler, Herbert, additional, Kalliardou, Evagelia, additional, Malisiova, Anna, additional, Tsiotou, Adelais, additional, Chloropoulou, Pelagia, additional, Chrysi, Mpratzou, additional, Iordanidou, Despoina, additional, Ntavlis, Merkourios, additional, Boda, Krisztina B, additional, Guerin, Christilynn, additional, Irwin, Janice, additional, Magner, Claire, additional, Nakhjavani, Solmaz, additional, O'Hare, Brendan, additional, Galvin, Deborah, additional, Jamil, Yosry, additional, Lesmes, Carlos, additional, Barak, Yuri, additional, Fisher, Haran, additional, Kachko, Ludmyla, additional, Katz, Jacob, additional, Kirilov, Dmitry, additional, Levinzon, Michael, additional, Manevich, Yair, additional, Nekrasov, Konstantin, additional, Peled, Elia, additional, Sanko, Elena, additional, Schmain, Dmitri, additional, Sheinkin, Olga, additional, Simhi, Eliahu, additional, Tarabikin, Alex, additional, Trabkin, Evelina, additional, Yagudaev, Irena, additional, Zeitlin, Yelena, additional, Zunser, Igor, additional, Cerutti, Elisabetta, additional, Maddalena Schellino, Maria, additional, Valzan, Silvia, additional, Lucia Pinciroli, Rosa, additional, Bortone, Luciano, additional, Cerati, Giorgia, additional, Salici, Fabiana, additional, Bussolin, Leonardo, additional, Rizzo, Giuliana, additional, Rossetti, Francesca, additional, Marchesini, Laura, additional, Tesoro, Simonetta, additional, De Lorenzo, Brita, additional, Guarracino, Fabio, additional, Kuppers, Beate, additional, Astuto, Marinella, additional, Pitino, Sofia, additional, Scalisi, Rita, additional, Scordo, Lucia, additional, D'Alessandro, Sandra, additional, Dei Giudici, Luigi, additional, Farinelli, Ivano, additional, Lofino, Giuseppe, additional, Marchetti, Giuliano, additional, Giuseppe Picardo, Sergio, additional, Reali, Simone, additional, Vittori, Alessandro, additional, Antonio Idone, Francesco, additional, Sammartino, Maria, additional, Sbaraglia, Fabio, additional, Barbera, Cinzia, additional, Bevilacqua, Michela, additional, Cento, Valeria, additional, Kotzeva, Svetlana, additional, Mameli, Leila, additional, Montobbio, Giovanni, additional, Passariello, Leandro, additional, Punzo, Cinzia, additional, Sileo, Rosanna, additional, Viacava, Rosanna, additional, Volpe, Claudia, additional, Zanaboni, Clelia, additional, Calderini, Edoardo, additional, Genco, Daniele, additional, Neri, Simona, additional, Ottolina, Davide, additional, Camporesi, Anna, additional, Izzo, Francesca, additional, Salvo, Ida, additional, Wolfler, Andrea, additional, Sanna, Andrea, additional, Sciascia, Angela, additional, Stoia, Paolo, additional, Guddo, Annamaria, additional, Lapi, Maria, additional, Ivani, Giorgio, additional, Longobardo, Annalisa, additional, Mossetti, Valeria, additional, Pedrotti, Dino, additional, Grazzini, Maurizia, additional, Meneghini, Luisa, additional, Metrangolo, Salvatore, additional, Michelon, Stefania, additional, Minardi, Carmelo, additional, Tognon, Costanza, additional, Zadra, Nicola, additional, Busi, Ilaria, additional, Khotcholava, Magda, additional, Guido Locatelli, Bruno, additional, Sonzogni, Valter, additional, Starita, Giusi, additional, Almenrader, Nicole, additional, Aurilio, Caterina, additional, Sansone, Pasquale, additional, Albarello, Raffaella, additional, Bracci, Paolo, additional, Cecini, Mariateresa, additional, Cristina Mondardini, Maria, additional, Pasini, Lorena, additional, Vason, Milo, additional, Zani, Gianluca, additional, Zoppellari, Roberto, additional, Pistidda, Laura, additional, Cortegiani, Andrea, additional, Maurizio Raineri, Santi, additional, Hasani, Antigona, additional, Hashimi, Medita, additional, Ancupans, Agris, additional, Barzdina, Arta, additional, Straume, Zane, additional, Zundane, Anda, additional, Chlopin, Mikhail, additional, Gestautaite, Dalia, additional, Lukosiene, Laura, additional, Paliokaite, Evelina, additional, Razlevice, Ilona, additional, Armoniene, Inesa, additional, Bernotiene, Aurelija, additional, Daugelavicius, Vidunas, additional, Dockiene, Ilona, additional, Gaidelyte, Lina, additional, Saviciene, Nijole, additional, Krikstaponiene, Jolita, additional, Sidlovskaite-Baltake, Dominika, additional, Stasevski, Vladyslav, additional, Vaitoskaite, Agne, additional, Gatt, David, additional, Mifsud, Stephanie, additional, Zammit, Simone, additional, Allison, Celia, additional, Aslami, Hamid, additional, Eberl, Susanne, additional, van Stijn, Mireille F M, additional, Stevens, Markus F, additional, Punt, Kees, additional, van Osch, Rob, additional, Bauwman, Arthur, additional, Scholten, Harm, additional, Svircevic, Vesna, additional, Adriaens, Veronique, additional, Dirckx, Maaike, additional, Dogger, Jaap, additional, Dons-Sinke, Ilse, additional, Machotta, Andreas, additional, Moors, Xavier, additional, Rad, Mandana, additional, Staals, Lonneke, additional, van der Knijff - van Dortmont, Anouk, additional, van der Marel, Caroline, additional, Sieben, Anne, additional, van der Zwan, Tim, additional, Veldhuizen, Marianne, additional, Alders, David, additional, Buhre, Wolfgang, additional, Engel, Nicole, additional, Vossen, Carine, additional, Mahadewsing, Ravin, additional, Meijer, Patrick, additional, Gerling, Volker, additional, van der Schatte Olivier, Roelof, additional, van Doorn, Thea, additional, Vons Mark Hendriks, Kristy, additional, Lako, Sandra, additional, jan Scheffer, Gert, additional, Tielens, Luc, additional, Voet, Marieke, additional, Absalom, Anthony, additional, Bergsma, Margot, additional, Spanjer, Vera, additional, Spanjersberg, Rob, additional, van de Riet, Yvette, additional, Volkers, Martin, additional, de Graaff, Jurgen C., additional, Hopman, Geranne A.J., additional, Kappen, Teus H., additional, Hannie, J., additional, Megens, A.M., additional, Numan, Sandra C., additional, Schouten, Anton N.J., additional, Turner, Nigel M., additional, Van Der Werff, Désirée B.M., additional, Wensing, Renee T.M., additional, Ephraim, Erik, additional, Nolte, Claire, additional, Reikvam, Tore, additional, Fredrik Lund, Ole, additional, Skaaden, Lene, additional, Marthe Ballovarre, Kari, additional, Bakken Boerke, Wenche, additional, Grindheim, Guro, additional, Lindenskov, Pal H H, additional, Beate Solas, Anne, additional, Sponheim, Sjur, additional, Ullensvang, Kyrre, additional, Viken, Oddbjorn, additional, Marie Drage, Inger, additional, Gymoese Berthelsen, Kasper, additional, Anders Kroken, Bjørn, additional, Bergland, Unni, additional, Pryzmont, Miroslaw, additional, Talalaj, Mariola, additional, Wasiluk, Malgorzata, additional, Zalewska, Dorota, additional, Damps, Maria, additional, Siemek-Mitela, Jadzia, additional, Wieczorek, Pawel, additional, Juzwa, Magdalena, additional, Rosada-Kurasinska, Jowita, additional, Bartkowska-Sniatkowska, Alicja, additional, Cettler, Maciej, additional, Kopycinska, Renata, additional, Rudewicz, Iwona, additional, Sobczyk, Jaek, additional, Wojciechowski, Dariusz, additional, Baranowski, Artur, additional, Basiewicz, Ewa, additional, Mierzewska-Schmidt, Magdalena, additional, Retka, Wlodzimierz, additional, Sawicki, Piotr, additional, Checinska, Magdalena, additional, Zurawska, Magdalena, additional, Leal, Teresa, additional, Mascarenhas, Catia, additional, Pedro Pina, António, additional, Joao Susano, Maria, additional, Moniz, Antonio, additional, Teresa Rocha, Maria, additional, Calvao Santos, Carolina, additional, Domingas Patuleia, M, additional, Pereira, Ricardo, additional, Roxo, Helena, additional, Amaral, Rosa, additional, Guedes, Isabel, additional, Gomes, Cristina, additional, Gonçalves, Marta, additional, Salgado, Helena, additional, Santos, Maria, additional, Rodrigues, Sara, additional, Sa, Angela, additional, Machado, Elvira, additional, Pé d'Arca, Sandra, additional, Seabra, Manuel, additional, Mihaela Gheorghe, Ligia, additional, Ivascu, Constantin, additional, Moraru-Draghici, Lucia, additional, Suvejan, Mirela, additional, Babici, Remus, additional, Eniko, Kovacs, additional, Hogea, Cristiana, additional, Mihaela, Dubau, additional, Nicoleta, Daraban, additional, Barbunc, Danut, additional, Maria Nistor, Alina, additional, Stefan, Violeta, additional, Catalina Ionescu, Gabriela, additional, Davidescu, Irina, additional, Teodora Nastase, Alina, additional, Dumitru Rusu, Florin, additional, Badarau, Victoria, additional, Cindea, Iulia, additional, Moscaliuc, Melania, additional, Olteanu, Dana, additional, Petrescu, Luxita, additional, Ceuca, Daniela, additional, Galinescu, Irena, additional, Badeti, Rodica, additional, Capusan, Alin, additional, Cucui-Cozma, Cosmina, additional, Popescu, Barbura, additional, Cimpeanu, Luminita, additional, Birliba, Mihaela-Petronela, additional, Miulescu, Magdalena, additional, Balamat, Stefania, additional, Gurita, Adriana, additional, Ilie, Luminita, additional, Mocioiu, Gabriel, additional, Pick, Darina, additional, Sirghie, Rodica, additional, Tabacaru, Radu, additional, Trante, Irinel, additional, Horhota, Lucian, additional, Bandrabur, Daniela, additional, Ciobanu, Tudor, additional, Cuciuc, Veaceslav, additional, Munteanu, Valentin, additional, Olaru, Valentin, additional, Paiu, Corneliu, additional, Savu, Anca, additional, Trifan, Oana, additional, Elena Malos, Anca, additional, Glazunov, Anton, additional, Ivanov, Alexander, additional, Poduskov, Evgeny, additional, Popov, Alexander, additional, Guskov, Igor, additional, Lugovoy, Alexander, additional, Nechaev, Vladislav, additional, Ovezov, Alexey, additional, Basov, Mikhail, additional, Kochkin, Vladimir, additional, Lazarev, Vladimir, additional, Chizhov, Dmitri, additional, Ostreikov, Ivan, additional, Tolasov, Konstantin, additional, Budic, Ivana, additional, Marjanovic, Vesna, additional, Draskovic, Biljana, additional, Pandurov, Marina, additional, Simin, Jovana, additional, Dolinaj, Vladimir, additional, Janjevic, Dusanka, additional, Mandras, Ana, additional, Mircetic, Maja, additional, Petrovic, Sladjana, additional, Rebac, Vlatka, additional, Slavkovic, Bojana, additional, Stevanovic, Vesna, additional, Velcev, Ana, additional, Knezevic, Mirjana, additional, Milojevic, Irina, additional, Puric, Selena, additional, Simic, Irena, additional, Stevic, Marija, additional, Stranjanac, Vladimir, additional, Simic, Dusica, additional, Cabanova, Barbora, additional, Hanula, Miloslav, additional, Grynyuk, Andry, additional, Berger, Jelena, additional, Cerne, Uros, additional, Nastran, Andraz, additional, Pirc, Dejan, additional, Popic, Rok, additional, Stupnik, Spela, additional, Rubio, Paloma, additional, del Río, Cristina, additional, Benito, Pilar, additional, Pino, Gema, additional, Gutierrez, Ignacio, additional, Gutierrez Valcarcel, Andrea, additional, León Carsi, Irene, additional, Perez Garcia, Anibal, additional, López Galera, Sílvia, additional, Marco Valls, Joan, additional, Ricol Lainez, Laura, additional, Vallejo Tarrat, Andrea, additional, Artes, David, additional, Banus, Ester, additional, Chirichiello, Luca, additional, De Abreu, Leidy, additional, De Josemaria, 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Published
2017
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50. Metamizol bij postoperatieve pijnbestrijding

Author

Koster, Harriëtte T., Avis, Hans J., Stevens, Markus F., Hollmann, Markus W., Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam institute for Infection and Immunity, and Other Research

Abstract

Postoperative pain management is an essential part of surgical management. In the Netherlands paracetamol, NSAIDs and, if necessary, opioids are the most commonly used drugs for perioperative analgesia. Metamizole is a non-opioid analgesic that is rarely used in the Netherlands, although it is one of the most frequently used analgesics around the world. Metamizole is registered in the Netherlands for intravenous therapy for acute pain. However, the drug has been rarely used since the 1970s because of what was thought to be an unacceptable risk of agranulocytosis. Recent scientific data do not justify this reasoning. Its mechanism of action is still under discussion, but the main action is likely to be an inhibition of prostaglandin synthesis in both peripheral tissues and the central nervous system. Based on the current literature, metamizole deserves a role in the management of post-operative pain in the Netherlands. It seems to be a safe and effective drug for acute pain management especially when compared with NSAIDs

Published
2012

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