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344 results on '"Steven G. Younkin"'

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1. APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

2. Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

3. Alzheimer’s disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions

4. Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight

5. Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease

6. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience

7. Author Correction: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

8. Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience

9. A Presenilin 1 Mutation Associated with Familial Frontotemporal Dementia Inhibits γ-Secretase Cleavage of APP and Notch

10. Alterations in Cerebral Blood Flow and Glucose Utilization in Mice Overexpressing the Amyloid Precursor Protein

11. Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains

12. Additive Effects of PS1 and APP Mutations on Secretion of the 42-Residue Amyloid β-Protein

13. Co-expression of β-amyloid precursor protein (βAPP) and apolipoprotein E in cell culture: analysis of βAPP processing

14. Correction: Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease.

15. Impact of variant-level batch effects on identification of genetic risk factors in large sequencing studies.

16. New insights into the genetic etiology of Alzheimer's disease and related dementias

17. Gene‐based polygenic score analysis identifies novel immune genes with deleterious variants that associate with Alzheimer’s disease

18. Association of Midlife Plasma Amyloid-β Levels With Cognitive Impairment in Late Life

19. Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids

20. Polygenic risk score analysis identifies deleterious protein-coding variants in novel immune pathway genes ATP8B4, FCGR1A, and LILRB1 that associate with Alzheimer’s disease

21. Polygenic risk score analysis identifies deleterious protein-coding variants in novel immune pathway genesATP8B4, FCGR1A, andLILRB1that associate with Alzheimer’s disease

22. Correction to: Apolipoprotein E regulates lipid metabolism and α‑synuclein pathology in human iPSC‑derived cerebral organoids

23. Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease

24. Alzheimer’s disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions

25. APOE3 -Jacksonville (V236E) variant reduces self-aggregation and risk of dementia

26. Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.

27. Conserved Architecture of Brain Transcriptome Changes between Alzheimer’s Disease and Progressive Supranuclear Palsy in Pathologically Affected and Unaffected Regions

28. Identification of novel Alzheimer’s disease genes co-expressed with TREM2

29. APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

31. Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy

32. APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

33. Comprehensive Screening for Disease Risk Variants in Early-Onset Alzheimer’s Disease Genes in African Americans Identifies Novel PSEN Variants

34. Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes

35. Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study

36. Evaluation of Associations of Alzheimer's Disease Risk Variants that Are Highly Expressed in Microglia with Neuropathological Outcome Measures

37. Systematic analysis of dark and camouflaged genes: disease-relevant genes hiding in plain sight

38. Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight

39. Author Correction: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

40. Impact of variant-level batch effects on identification of genetic risk factors in large sequencing studies

41. A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression

42. MAPT haplotype diversity in multiple system atrophy

43. Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci

44. Evaluating pathogenic dementia variants in posterior cortical atrophy

45. O3‐06‐02: POLYGENIC SCORE ANALYSIS OF EXONIC VARIANTS IN AN IMMUNE CO‐REGULATORY NETWORK IDENTIFIES NOVEL PROTEIN‐ALTERING VARIANTS THAT ASSOCIATE WITH ALZHEIMER'S DISEASE

46. Association study between multiple system atrophy and TREM2 p.R47H

47. O2-10-01: STOP-GAIN AND NON-SYNONYMOUS VARIANTS IN NOVEL GENES OF AN IMMUNE CO-REGULATORY NETWORK SHOW STRONG ASSOCIATION WITH ALZHEIMER'S DISEASE

48. Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia

49. Convergent genetic and expression data implicate immunity in Alzheimer's disease

50. Late-onset Alzheimer’s risk variants in memory decline, incident mild cognitive impairment, and Alzheimer’s disease

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