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PurposeEndometrial cancer (EMCA) is the most common gynecologic malignancy, and new diagnoses are increasing in the United States. Black patients are more likely to present with advanced stage, be diagnosed with high-risk uterine serous carcinoma (USC) and die of their cancer.MethodsPatients with endometrial adenocarcinoma who received tumor FoundationOne CDx testing at our institution between January 2017 and August 2022 were identified. Genomic alterations, demographic and clinical characteristics were collected. Descriptive statistics and Fisher’s exact test were used to analyze data.ResultsA total of 289 patients (29.4% Black and 52.6% White) with advanced or recurrent endometrial adenocarcinoma underwent FoundationOne CDx testing. USC comprised 26.3% (76 of 289) of tested tumors. Of USC tumors, 33 of 76 (44%) were of Black race. USC occurred more frequently in Black patients (33 of 85 [38.8%] Black patients compared to 30 of 152 [19.7%] White patients, p

In his celebrated study of colonisation, The Intimate Enemy, Ashis Nandy observes of Indian responses to British colonisation: ‘The pressure to be the obverse of the West distorts the traditional priorities in the Indian’s total view of the…universe…It in fact binds him (sic) even more irrevocably to the West.’ This problem stems, he adds, from a tendency by both coloniser and anti-colonial thinker to ‘absolutise the relative difference between cultures’. This article will argue that Nandy’s observation is an essential element in a South African response to colonisation which does not repeat colonialism’s assumptions in the name of replacing them. In particular, it argues against an essentialism in which a reified ‘Western culture’ is replaced by an equally reified ‘African culture’ which is just as constraining and just as likely to be used as a rationale for domination as the colonial ideology it purports to reject. It will further argue that we avoid the trap of which Nandy warns if we define intellectual colonisation as an ideology which seeks to suppress or eliminate modes of thought which do not conform to a dominant set of values and its antidote, decolonisation, as the removal of this constraint, not as its replacement by new constraints. This decolonisation does not seek to abolish ‘Western culture’ but to integrate it into a world view in which it takes its place alongside African, Asian, and Latin American cultures. It therefore recognises the syncretic nature of all cultures and views of the world and seeks to enhance, rather than obstruct, conversations between them.

Background Prior to the COVID-19 pandemic, about half of patients from populations that sought care in neurology tried complementary and integrative therapies (CITs). With the increased utilization of telehealth services, we sought to determine whether patients also increased their use of virtual CITs. Methods We examined datasets from two separate cross-sectional surveys that included cohorts of patients with neurological disorders. One was a dataset from a study that examined patient and provider experiences with teleneurology visits; the other was a study that assessed patients with a history of COVID-19 infection who presented for neurologic evaluation. We assessed and reported the use of virtual (and non-virtual) CITs using descriptive statistics, and determined whether there were clinical characteristics that predicted the use of CITs using logistic regression analyses. Findings Patients who postponed medical treatment for non-COVID-19-related problems during the pandemic were more likely to seek CITs. Virtual exercise, virtual psychotherapy, and relaxation/meditation smartphone applications were the most frequent types of virtual CITs chosen by patients. In both studies, age was a key demographic factor associated with mobile/virtual CIT usage. Interpretations Our investigation demonstrates that virtual CIT-related technologies were utilized in the treatment of neurologic conditions during the pandemic, particularly by those patients who deferred non-COVID-related care.

Aim: To describe the impact of extracorporeal membrane oxygenation (ECMO) assisted CPR (E-CPR) on cerebral oxygen delivery during in-hospital cardiac arrest (IHCA). Methods: Retrospective case series from a tertiary academic medical center. Regional cerebral oxygen saturation (rSO2) was measured continuously using cerebral oximetry in six patients who experienced IHCA. During CPR, the time of E-CPR initiation was recorded, and rSO2 values were subsequently analyzed for a period beginning 5 min before and ending 2.5 min after the initiation of E-CPR. Results: The average rSO2 value in the 2.5 min period following E-CPR initiation increased by 20.8% as compared to the 5-min period before E-CPR initiation. Conclusions: ECMO can be employed in parallel with cerebral rSO2 monitoring during CPR for adult IHCA patients. E-CPR is associated with rapid and significant increases in brain oxygen delivery.