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In this study, single-grain mineral geochemistry, detrital zircon geochronology, and conventional heavy-mineral analysis are used to elucidate sediment transport pathways that existed in the North Atlantic region during the Triassic. The presence of lateral and axial drainage systems is identified and their source regions are constrained. Axial systems are suggested to have likely delivered sediment sourced in East Greenland (Milne Land–Renland) as far south as the south Viking Graben (>800 km). Furthermore, the data highlight the existence of lateral systems issuing from Western Norway and the Shetland Platform as well as a major east-west–aligned drainage divide positioned adjacent to the Milne Land–Renland region. This divide separated the catchments that flowed north to the Boreal Ocean from those that flowed south into a series of endoreic basins and, ultimately, the Tethys Sea. A further potential drainage divide is identified to the west of Shetland. The data presented and the conclusions reached have major implications for reservoir prediction, as well as correlation, throughout the region. Furthermore, understanding the drainage networks that existed during the Triassic can help constrain paleogeographic reconstructions and provides an important framework for the construction of facies models in the region.

The Jameson Land Basin lies within the Greenland–Norway rift, to the south of Triassic basins on the Halten Bank and East Greenland shelf, and can therefore offer insights into the development of these less-well-documented offshore basins and the wider North Atlantic. This study focuses on the stratigraphic development of the Jameson Land Basin. Broad-scale stratigraphic logging is augmented with heavy mineral analysis that constrains the dominant source catchments during this period. A thickness of over 1.5 km of Middle–Late Triassic strata fill the Jameson Land Basin, predominantly comprising continental deposits laid down during arid to semi-arid climatic conditions. The basal Pingo Dal Group thickens westwards into the Stauning Alper Fault, forming a typical syn-rift succession. Thickness variations have also highlighted the presence of an intrabasinal high and an associated unconformity between the Pingo Dal Group and the overlying Gipsdalen Group, which provides the first direct evidence for Middle–Late Triassic rifting in East Greenland. Thickness variations in the overlying Gipsdalen Group are more subdued, and the Fleming Fjord Group, and its formations, display remarkably tabular geometries, with little evidence for significant lateral facies variance; this is suggestive of reduced topography and a more regional thermal subsidence signature. Provenance data indicate sediment sourcing from both the western and eastern basin margins during the deposition of the Pingo Dal Group, above which the western source area becomes dominant, alongside some axial input from the south.

The Triassic of the Central North Sea is a continental succession that contains prolific hydrocarbon-bearing fluvial sandstone reservoirs stratigraphically partitioned by mudstones. Within the Skagerrak Formation of the UK sector, hydrocarbon accumulations in the Judy, Joanne and Josephine Sandstone members are top sealed by the Julius, Jonathan and Joshua Mudstone members, respectively. However, UK and Norwegian stratigraphic correlations have been problematical for decades, largely due to biostratigraphic challenges but also due to the non-uniqueness of the lithotypes and because the cross-border stratigraphic nomenclature differs and has yet to be rationalized. This study focuses on mudstones rather than sandstones to unify cross-border correlation efforts at a regional scale. The mudstone members have been characterized by integrating sedimentological, petrophysical and geophysical data. The facies are indicative of playa lakes that frequently desiccated and preserved minor anhydrite. These conditions alternated with periods of marshy, palustrine conditions favourable for the formation of dolostones. Regional correlations have detected lateral facies changes in the mudstones which are important for their seismically mappable extents, resulting palaeogeographies and, ultimately, their competency as intraformational top seals. Significant diachroneity is associated with the lithological transitions at sandstone–mudstone member boundaries and although lithostratigraphic surfaces can be used as timelines over short distances (e.g. within a field), they should not be assumed to represent timelines over longer correlation lengths. Palaeoclimatic trends are interpreted and compared to those of adjacent regions to test the extent and impact of climate change as a predictive allogenic forcing factor on sedimentation. Mudstone member deposition occurred as a result of the retreat of large-scale terminal fluvial systems during a return to more arid ‘background’ climatic conditions. The cause of the member-scale climatic cyclicity observed within the Skagerrak Formation may be related to volcanic activity in large igneous provinces which triggered the episodic progradation of fluvial systems.

[The Laplace Bjerg exhumed hydrocarbon trap in East Greenland. Superb exposures of both this fault bounded horst and the tilted fault block of the Mols Bjerge have allowed detailed mapping to be carried out. Both of these exhumed hydrocarbon traps were sealed, at depth, by Cretaceus mudstones, which blanketed much of East Greenland. The identification of pyrobitumen, resulting in a dark staining in the sandstones, has allowed the distribution of the palaeohydocarbon accumulation to be assessed and intra reservoir compartmentalisation by thick, mature calcretes to be recognised. Palynological analysis has determined a Triassic age for the main reservoir units providing evidence for a further potential play in the North Atlantic petroleum system. , Abstract Previous work has demonstrated the presence of a number of exhumed hydrocarbon traps in central East Greenland. Re‐evaluation of the stratigraphy alongside detailed investigation of the occurrence of bitumen within the Mols Bjerge and Laplace Bjerg exhumed hydrocarbon traps provides new perspectives on these structures, as well as the petroleum geology of East Greenland and the wider North Atlantic. Sedimentological and stratigraphic studies, augmented with palynological and provenance investigations, have constrained the dating and correlation of the strata exposed in the Mols Bjerge and Laplace Bjerg. Petrographic analysis, alongside analysis of the bitumen identified, has highlighted a much wider distribution of hydrocarbon than previously recognized. It was previously considered that Jurassic strata formed the main reservoir interval within the Mols Bjerge and Laplace Bjerg exhumed hydrocarbon traps. It is shown here that the reservoir intervals in the Laplace Bjerg trap lie within the Late Triassic Orsted Dal and Vega Sund members, which contain up to 18% pyrobitumen and were previously misidentified as Jurassic. The Jurassic Bristol Elv Formation is the most extensively bitumen stained unit in the Mols Bjerge trap. However, occurrences of pyrobitumen (up to 3%) are recorded throughout the Triassic stratigraphy, including the Early Triassic Wordie Creek Formation. Faults, thick calcrete development and regionally continuous mudstone units play an important role in compartmentalizing the palaeohydrocarbon accumulations.]

Permian to Triassic outcrops in East Greenland diminish significantly northwards. Understanding the northward extent, and nature, of the Permian and Triassic successions has implications for regional palaeogeographic reconstructions and exploration in adjacent offshore basins. Examining the structural relationships between the basement, Permian, Triassic, Jurassic and Cretaceous successions can further our understanding of the tectonic evolution of the region. Here, we describe a hitherto overlooked section through the Permian to Cretaceous from central Wollaston Forland and consider its structural context. The western side of Permpasset forms the upthrown eroded crest of a horst block, which provides exposure of the earliest stratigraphic intervals in the region. The fractured Caledonian basement is overlain by evaporitic marine limestone facies of the Karstryggen Formation, which are succeeded by shallow marine sandstones assigned to the Schuchert Dal Formation, both Upper Permian. The overlying unit records a period of fluvial deposition and is not possible to date. However, an Early to Middle Triassic age (Pingo Dal Group) seems most likely, given regional eustatic considerations. This is, therefore, the most northerly record of Triassic strata in North–East Greenland. West of the horst structure, fine-grained sandstones and bioturbated siltstones of the Jurassic (Oxfordian) Jakobsstigen Formation are recorded. These were downfaulted prior to a prolonged hiatus after which both the Triassic and Jurassic strata were draped by Cretaceous shales of the Fosdalen Formation. The Cretaceous succession is overlain by a thick basalt pile of Eocene age, heralding the opening of the North-East Atlantic. Glendonites overlie Oxfordian siltstones at the base of the middle Albian Fosdalen Formation. These were likely winnowed from slightly older Cretaceous strata and overlie the hiatus surface between the Jurassic and Cretaceous. This is the first record of glendonites from the Cretaceous of East Greenland and they are interpreted to record the Circum–Arctic late Aptian – early Albian cooling event.

The paleoenvironmental and paleogeographic development of the Norwegian–Greenland seaway remains poorly understood, despite its importance for the oceanographic and climatic conditions of the Paleocene–Eocene greenhouse world. Here we present analyses of the sedimentological and paleontological characteristics of Paleocene–Eocene deposits (between 63 and 47 million years old) in northeast Greenland, and investigate key unconformities and volcanic facies observed through seismic reflection imaging in offshore basins. We identify Paleocene–Eocene uplift that culminated in widespread regression, volcanism, and subaerial exposure during the Ypresian. We reconstruct the paleogeography of the northeast Atlantic–Arctic region and propose that this uplift led to fragmentation of the Norwegian–Greenland seaway during this period. We suggest that the seaway became severely restricted between about 56 and 53 million years ago, effectively isolating the Arctic from the Atlantic ocean during the Paleocene–Eocene thermal maximum and the early Eocene. Uplift and volcanism drove fragmentation of the Norwegian-Greenland seaway, which may have restricted Arctic-Atlantic exchange during the Paleocene-Eocene Thermal Maximum, according to sedimentological, paleontological and seismic analyses from NE Greenland.

Christansen et al. (2020) have raised concerns over the validity of the data and interpretation in our study of the exhumed hydrocarbon traps of East Greenland. Furthermore, they have put forward a model which they suggest that better suits their data. However, this markedly contradicts the data we presented.The concerns raised by Christansen et al. (2020) centre around a number of key points: Acknowlegement of the history of previous debate around these structures It is suggested that pyrobitumen is only minor in occurrence and much of this material is, in fact, iron oxides The distribution of pyrobitumen that we document is disputed in favour of irregular distribution as would fit their model The requirement for a detailed diagenetic study The maturity of potential source rocks.A model is then presented which is suggested to best suit the available data. Each of these points is discussed, in turn, in this reply.

The Boltysh meteorite impact crater, Ukraine, formed at the Cretaceous-Paleogene boundary at ca 65.2 Ma. A borehole drilled in the central part of the crater cored a >400 m thick high-resolution lacustrine succession that covers the Dan-C2 hyperthermal event associated with a negative carbon isotope excursion. Continuous terrestrial records of past hyperthermals are of limited availability, which makes this record a unique case study of the continental impact of rapid climate warming. This study uses high-resolution sedimentological core log data together with thin section, X-ray diffraction, microprobe and palynological analyses to: (i) reconstruct lake sedimentological and ecological development across the carbon isotope excursion; and (ii) assess the environmental effect of hyperthermals on terrestrial ecosystems. Based on detailed facies analysis, five gradual stages of lake formation are identified, which show a strong relationship to carbon isotope shifts and associated climatic trends. Initially, sediment supply into the Boltysh lake was controlled by crater morphology. During later lake stages, sediment supply was increasingly controlled by changes in inflow-evaporation ratios which affected seasonal stratification patterns and longer-term lake levels. An inferred increase in atmospheric pCO2 related to the carbon isotope excursion, together with increasing mean annual temperatures, was probably responsible for periodic increases in biological activity of photosynthesising organisms and biomass production. These fluctuations in facies and lake settings largely correspond to orbital-paced moisture availability oscillations. The gradual reduction in sediment supply commencing during early lake formation prior to carbon isotope excursion inception suggest that the Dan-C2 event did not initiate sedimentary changes, but intensified sedimentary response to orbital controlled climate change. This article is protected by copyright. All rights reserved.

During the Early Triassic the Jameson Land Basin (Central East Greenland) was located around 30° N, in the Northern arid belt, but by the Early Jurassic was positioned at a latitude of approximately 50° N. This study examines the record of this transition through a largely continental succession using clay mineralogy, sedimentology, petrography and heavy mineralogy. The Jameson Land Basin is aligned north–south and is 280 km long and 80 km wide. Following an Early Triassic marine phase the basin was filled by predominantly continental sediments. The Early‐to‐Late Triassic succession comprises coarse alluvial clastics (Pingo Dal Formation) overlain by a succession of fine‐grained evaporite‐rich playa/lacustrine sediments (Gipsdalen Formation), indicative of arid climatic conditions. The overlying buff, dolomitic and then red lacustrine mudstones with subordinate sandstones (Fleming Fjord Formation) record reduced aridity. The uppermost Triassic grades into dark organic‐rich, and in places coaly, mudstones and buff coarse‐grained sandstones of lacustrine origin that belong to the Kap Stewart Group, which spans the Triassic–Jurassic boundary, and appear to record more humid climatic conditions. Clay mineralogy analyses highlight significant variations in the kaolinite/illite ratio, from both mudstone and sandstone samples, through the Triassic and into the earliest Jurassic. Complementary heavy mineral analyses demonstrate that the variations recognised in clay mineralogy and sandstone maturity through the Triassic–Early Jurassic succession are not a product of major provenance change or the effect of significant diagenetic alteration. The observed variations are consistent with sedimentological evidence for a long‐term trend towards more humid conditions through the Late Triassic to Early Jurassic, and the suggestion of a significant pluvial episode in the mid‐Carnian.

Detailed sedimentological examination of onshore sections through cyclic lacustrine deposits of the Middle Devonian succession of northern Scotland has been augmented with offshore data to allow the construction of a continuous 2.3 myr record of orbital forcing. These data provide an important record of climatic variance through the Devonian, which, by comparison with other records from this time, can significantly improve our understanding of the Devonian global climatic system. Precessional and eccentricity cycles are shown to be dominant by the direct measurement and extrapolation of depositional rates in well-exposed sections as well as the analysis of ratios between primary and modulating cycles. Spectral analysis has confirmed the presence of regular cycles throughout the offshore data, which provide a far longer record of orbitally forced cyclicity than previously available. The presence of a half precession cycle is also suggested. Similar up-section variations in cycle thicknesses are recorded from both the onshore and offshore succession. These variations and those in cycle symmetry are related to a trend from an underfilled to a balanced-fill basin state. Of further importance in controlling cycle thickness is the period of each cycle during which lacustrine conditions, and therefore lake level controlled accommodation, existed.

ACKNOWLEDGEMENTS M. J. Newman is gratefully acknowledged for his identification of fossil fish specimens from the Easter Ross coast which helped in confirmation of the position of the Achanarras fish bed in this region. The Inverness Field Club and the Carnegie Trust are thanked by SDA for financial support of fieldwork undertaken. Nigel Trewin is acknowledged for inspiring a long-lived interest in the Devonian of Northern Scotland which has led to some fantastic journeys. Gary Nichols and Alberto Saez are thanked for constructive reviews

Fault block basins exposed along NE Greenland provide insights into the tectonic evolution of East Greenland and the Norwegian-Greenland Sea. We present a new geological map and cross sections of the Traill Ø region, NE Greenland, which formed the western margin of the Vøring Basin prior to Cenozoic seafloor spreading. Observations support a polyphase rift evolution with three rift phases during Devonian-Triassic, Jurassic-Cretaceous, and Cenozoic time. The greatest amounts of faulting and block rotation occurred during Cenozoic rifting, which we correlate with development of the continent- ocean transition after ca. 56 Ma and the Jan Mayen microcontinent after ca. 36 Ma. A newly devised macrofaunal-based stratigraphic framework for the Cretaceous sandy mudstone succession provides insights into Jurassic- Cretaceous rifting. We identify a reduction in sedimentation rates during the Late Cretaceous; this corresponds to a transition from structurally confined to unconfined sedimentation that coincides with increased clastic sedimentation to the Vøring and Møre Basins derived from East Greenland. With each rift phase we record an increase in the number of active faults and a decrease in the spacing between them. We attribute this to fault block rotation that leads to an excess build-up of stress that can only be released by the creation of new steep faults. In addition, we observe a stepwise migration of deformation toward the rift axis that we attribute to preexisting lithospheric heterogeneity that was modified during subsequent rift and post-rift phases. Such observations are not readily conformable to classic rift evolution models and highlight the importance of post-rift lithospheric processes that occur during polyphase rift evolution.

Complex environmental controls have influenced deposition of the Graklint Beds, a prospective oil- and gas-prone Late Triassic (Mid-Carnian) source rock in the Jameson Land Basin, East Greenland. The identification of a Late Triassic source rock is significant for hydrocarbon exploration in the North Atlantic region. Detailed sedimentological analysis, biostratigraphy and geochemical analysis provide insights into the controls on source rock development and have wider implications for palaeoclimatic trends and palaeogeographical reconstructions of the North Atlantic at this time. The Graklint Beds were deposited in a predominantly lacustrine setting during a phase of climatic cooling that can be ascribed to the ‘Mid-Carnian Pluvial Event’. This further extends the evidence for the global effect of such climatic perturbations and furthermore highlights the potential for the use of climatic events for global and regional correlation between varying environmental settings. Evidence is also recorded for marine ingression, which resulted in the precipitation of magadiite (NaSi 7 (OH) 3 .3H 2 O) and the brief influx of a marine fauna. This provides the most southerly record of marine influence from the Boreal Ocean at this time and has important implications for palaeoenvironmental reconstructions and correlation in the region.

The form of microbialite accumulations is largely the product of environmental processes and microbial activity. Recent work has largely concentrated on the identification and classification of microbialites with little attention being paid to their environmental significance. This study describes the environmental distribution of the varied stromatolite forms recorded from the Middle Old Red Sandstone sequences of the Orcadian Basin. Comparisons are made with Triassic examples from East Greenland and modern microbialite accumulations. The Middle Old Red Sandstone of Northern Scotland was deposited in a predominantly lacustrine setting. Stromatolites are recorded from both steep basin margin coincident settings and lower gradient settings where the lake margin was distant from the basin margin. In the latter case stromatolite development is largely restricted to transgressive lacustrine sequences, during the deposition of which reduced rates of sedimentation resulted from the migration of sediment input points towards the basin margin. Stromatolite sheets, domal mounds, aligned mounds (and associated runnels), sand-cored stromatolite mounds and reefal stromatolite accumulations have been identified representing the transition from more sheltered to more exposed environments. In basin margin coincident settings stromatolite accumulation is restricted to areas of low sedimentation where microbialites coat boulders and pebbles. A model for the palaeoenvironmental distribution of the stromatolite forms described is proposed and is shown to be applicable to similar examples from the Triassic of East Greenland. It is suggested that this model may be more widely applicable to stromatolitic accumulations in similar lacustrine settings through large portions of the Phanerozoic.

Continental lacustrine laminites deposited in low latitudes have been examined from the Devonian and Torridonian (Mesoproterozoic) strata of northern Scotland to investigate the consistency of sunspot periodicity through geological time. The thicknesses of 2448 annual laminae were measured from the Middle Devonian ( c . 388 Ma) Achanarras Limestone Member, Lower Caithness Flagstone Group, and of 2821 laminae from the Mesoproterozoic (1.2 Ga) Poll a9Mhuilt Member of the Stoer Group. Time-series analysis resolved periodicities of 13.8 and 13.9 years in the complete Devonian and Mesoproterozoic datasets respectively. When sedimentological variance was considered and the data were examined as evolutive spectra those sections consisting of the most robust data consistently yielded periodicities between 8.6 and 13.7 years for the Devonian section and 9.2 and 10.6 years for the Mesoproterozoic section. These correspond well to Schwabe cycles. Evidence for the presence of the longer Hale cycles (20 years) was also recognized in the Devonian time series. The sunspot periodicities identified within the Devonian and Mesoproterozoic show little variance from published examples from the Quaternary and Eocene and therefore provide evidence for the consistency of solar processes and solar–atmospheric interactions for the past 1.2 Ga.

Smith & Bailey (2017 a ) have raised concerns over the methodologies we applied for time series analysis in our study of the cyclic Devonian lacustrine deposits of northern Scotland (Andrews et al. 2016). Similar concerns have been raised on a number of occasions for similar studies (Bailey et al. 2009 on Kemp & Coe 2007; Smith & Bailey 2017 c on Howe et al. 2016; Smith et al. …

Biological membranes contain a high density of protein molecules, many of which associate into two- dimensional microdomains with important physiological functions. We have used Monte Carlo simulations to examine the self-association of idealized protein species in two dimensions. The proteins have defined bond strengths and bond angles, allowing us to estimate the size and composition of the aggregates they produce at equilibrium. With a single species of protein, the extent of cluster formation and the sizes of individual clusters both increase in non-linear fashion, showing a ''phase change'' with protein concentration and bond strength. With multiple co-aggregating proteins, we find that the extent of cluster formation also depends on the relative proportions of participating species. For some lattice geometries, a stoichiometric excess of particular species depresses cluster formation and moreover distorts the composition of clusters that do form. Our results suggest that the self-assembly of microdomains might require a critical level of subunits and that for optimal co-aggre- gation, proteins should be present in the membrane in the correct stoichiometric ratios.

The Trk family of genes, which includes trkA/NTRK1, trkB/NTRK2 and trkC/NTRK3, encode the tyrosine kinase receptors for the neurotrophin family of nerve growth factors. Deregulated kinase activity of trk family members is associated with human cancer. Oncogenic translocations involving trkC kinase domain have been identified in AML, salivary gland carcinoma, adult secretory breast cancer, congenital fibrosarcoma, and pediatric nephroma. Oncogenic trkA translocations have been reported in papillary thyroid and colorectal cancers. We have identified orally bioavailable, potent and selective ATP-competitive inhibitors of the trk family of receptor tyrosine kinases and are developing these for the treatment of Trk-driven cancers. AR523 is a pan-Trk inhibitor which demonstrates similar activity against TrkA, TrkB and TrkC receptors in a cell based assay (IC50 ∼10 nM). In a screen at 1 µM against a panel of 230 kinases, AR523 inhibited only three additional kinases more than 50% (TNK2, Bmx and Txk). In cell culture AR523 was found to exhibit selective anti-proliferative activity toward the cell line KM12, which harbors the oncogenic TPM-TrkA translocation, while exhibiting no activity toward HT29, a cell line with no trk gene rearrangements. Studies in mice engrafted with KM12 tumors revealed significant anti-tumor and pharmacodynamic activity of AR523. Administration of a single oral dose of AR523 reduced tyrosine phosphorylation of TrkA by nearly 80% at twelve hours after dosing. Parallel analysis of Akt and Erk revealed reduced phosphorylation of these downstream effectors. Administration of 100 mg AR523 daily for two weeks to mice with KM12 xenografts produced mean tumor growth inhibition of 86% and a mean of 42% tumor regression. AR523 exhibits dose dependent inhibition of tumor growth at 10 and 30 mg/kg in KM12 xenografts with 54 and 72% TGI respectively. AR523 was well-tolerated, causing no weight loss or deaths compared with vehicle control. Increasingly Trk mutations have been shown to be activating and the use of Trk inhibitors may provide a new therapeutic strategy for targeted treatment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1798. doi:1538-7445.AM2012-1798