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10 results on '"Steven, Craig F."'

1. Contributors

Author

Andersen, Ulrik Lund, primary, Brinkmann, Maximilian, additional, Brunton, Valerie G., additional, Cerullo, Giulio, additional, Chen, Tao, additional, Chen, Xueli, additional, Cheng, Ji-Xin, additional, Cheng, Qian, additional, Chiarparin, Elisabetta, additional, Dastagirzada, Yosef, additional, de Aguiar, Hilton B., additional, de Andrade, Rayssa Bruzaca, additional, Deng, Dinghuan, additional, Dong, Pu-Ting, additional, Du, Jiajun, additional, Fallnich, Carsten, additional, Figueroa, Benjamin, additional, Fu, Dan, additional, Fujita, Katsumasa, additional, Gehring, Tobias, additional, Gong, Li, additional, Hellwig, Tim, additional, Hong, Weili, additional, Huang, Zhiliang, additional, Huang, Zhiwei, additional, Hulme, Alison N., additional, Ji, Minbiao, additional, Jin, Qingqing, additional, Karuna, Arnica, additional, Kieu, Khanh, additional, Lee, Dongkwan, additional, Lee, Hyeon Jeong, additional, Li, Yajuan, additional, Liang, Rongguang, additional, Liao, Chien-Sheng, additional, Lin, Haonan, additional, Lin, Peng, additional, Manifold, Bryce, additional, Meyer, Tobias, additional, Miao, Yupeng, additional, Min, Wei, additional, Moskalik, Anzhela, additional, Ni, Hongli, additional, Oron, Dan, additional, Orringer, Daniel, additional, Ozeki, Yasuyuki, additional, Polli, Dario, additional, Popp, Jürgen, additional, Potma, Eric O., additional, Prince, Richard C., additional, Qian, Naixin, additional, Raanan, Dekel, additional, Rigneault, Hervé, additional, Schmitt, Michael, additional, Shi, Lingyan, additional, Slipchenko, Mikhail N., additional, Soffer, Yahel, additional, Steven, Craig F., additional, Tang, Xinjing, additional, Wang, Haomin, additional, Wang, Jing, additional, Wang, Ke, additional, Wang, Lin, additional, Wang, Meng C., additional, Wang, Nan, additional, Wang, Ping, additional, Wei, Lu, additional, Xiong, Hanqing, additional, Xu, Chris, additional, Yamakoshi, Hiroyuki, additional, Yang, Chen, additional, Yang, Wenlong, additional, Yang, Yuan, additional, Yue, Shuhua, additional, Zhang, Chi, additional, Zhang, Delong, additional, Zhang, Meng, additional, Zhang, Ruiwen, additional, Zheng, Wei, additional, Zhu, Hanlin, additional, and Zong, Cheng, additional

Published
2022
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8. Design, Synthesis, and Analytical Evaluation of Fsp3‐Inspired Raman Probes for Cellular Imaging.

Author

Steven, Craig F., Lee, Martin, Nichol, Gary S., Davey, Paul R. J., Chiarparin, Elisabetta, Brunton, Valerie G., and Hulme, Alison N.

Subjects
*CELL imaging, *STIMULATED Raman scattering, *STATISTICAL correlation, *MASS spectrometry, *PHARMACEUTICAL chemistry
Abstract

The fraction of sp3‐hybdrised carbons (Fsp3) in drug candidates and other biologically relevant compounds has been proposed to be an important physicochemical consideration within medicinal chemistry. Currently available small‐molecule probes for Raman imaging are not optimised for biological applications. We sought to improve upon the highly Raman‐active, yet rigid, lipophilic, and aggregative, bisarylbutadiyne (BADY) motif by introducing Fsp3 character. BADY analogues were designed, efficiently synthesised, and analysed by mass spectrometry – revealing a statistical correlation between compound aggregation and cLogP, but no correlation with Fsp3. However, X‐ray crystallography demonstrated that the modifications to the BADY structure had a marked effect on crystal packing, suggesting Fsp3 may still be important in reducing intermolecular stacking, and thus aggregation, of BADY. Cellular imaging by stimulated Raman scattering (SRS) microscopy allowed comparison of the intracellular distribution of the tags, guiding the design of future Raman probes. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Stretching the Bisalkyne Raman Spectral Palette Reveals a New Electrophilic Covalent Motif.

Author

Ravindra MP, Lee M, Dimova S, Steven CF, Bluntzer MTJ, Brunton VG, and Hulme AN

Abstract

Small heteroaryl-diyne (Het-DY) tags with distinct vibrational frequencies, and physiologically relevant cLog P were designed for multiplexed bioorthogonal Raman imaging. Pd-Cu catalyzed coupling, combined with the use of Lei ligand, was shown to improve overall yields of the desired heterocoupled Het-DY tags, minimizing the production of homocoupled side-products. Spectral data were in agreement with the trends predicted by DFT calculations and systematic introduction of electron- rich/poor rings stretched the frequency limit of aryl-capped diynes (2209-2243 cm -1 ). The improved Log P of these Het-DY tags was evident from their diffuse distribution in cellular uptake studies and functionalizing tags with organelle markers allowed the acquisition of location-specific biological images. LC-MS- and NMR-based assays showed that some heteroaryl-capped internal alkynes are potential nucleophile traps with structure-dependent reactivity. These biocompatible Het-DY tags, equipped with covalent reactivity, open up new avenues for Raman bioorthogonal imaging., (© 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)

Published
2023
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