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Background: 2‐Hydroxyethyl methacrylate (HEMA) was added to the European baseline series (EBS) in 2019. Few recent data are available on the frequency and relevance of positive reactions to this hapten. Objectives: To investigate the frequency and relevance of positive patch tests to HEMA in the EBS in a university hospital in Amsterdam, The Netherlands. Patients and Methods: Retrospective study in patients with positive patch tests to HEMA investigated between June 2019 and August 2023. Results: Of 2927 consecutive patients, 88 (79 women and 9 men; 3.0%) had a positive reaction to HEMA. The prevalence in women was 3.9%, in men 1.0%. Forty‐three (49%) reactions were judged to be of current clinical relevance and 21 (24%) of past relevance. In this group of 64 patients with relevant reactions, 18 (28%) had occupational contact with (meth)acrylate‐containing products, of who 11 (61%) were nail stylists. In 46 patients with non‐occupational allergic contact dermatitis, 31 (67%) had allergic reactions to nail cosmetics. Glues and glue‐containing products accounted for 22% of the materials causing allergic contact dermatitis and dental products for 8%. Conclusions: Allergic reactions to HEMA are very frequent in women investigated in Amsterdam. Nearly two thirds of cases were caused by nail cosmetics. [ABSTRACT FROM AUTHOR]

Background: Over the last 10 years, allergic contact dermatitis (ACD) from acrylate‐containing nail cosmetics (acrylic nails, gel nails, gel nail polish) has been reported repeatedly. Objectives: To investigate the frequency and clinical features of ACD in nail cosmetics in a university hospital in Amsterdam, The Netherlands. Patients and Methods: A retrospective study in patients diagnosed with ACD from acrylate‐containing nail cosmetics at the Amsterdam University Medical Centers between January 2015 and August 2023. Results: Sixty‐seven patients, all women, were diagnosed with ACD from nail cosmetics, representing 1.6% of all individuals and 2.3% of all women patch tested in this period. Sixty‐five of sixty‐seven (97%) subjects had a positive patch test to 2‐hydroxyethyl methacrylate (HEMA). Forty‐nine patients (73%) were consumers and 18 (27%) were professional nail stylists. The sites most frequently affected with dermatitis were the fingers (79%), hands (40%) and the head and/or neck. Avoidance of contact with acrylate‐containing products resulted in complete clearing of dermatitis in 80% of patients. Conclusions: ACD from acrylate‐containing nail cosmetics is frequent in women patch tested in Amsterdam. Nearly all were identified by a positive patch test to 2‐hydroxyethyl methacrylate in the (meth)acrylate series or the European baseline series. [ABSTRACT FROM AUTHOR]

Background: During the last 15–20 years, allergic contact dermatitis from acrylates‐containing nail cosmetics (acrylic nails, gel nails, gel nail polish) has been increasingly reported. 2‐Hydroxyethyl methacrylate (HEMA) is considered to be the major allergenic culprit; few data on its presence in nail cosmetics are available. Objectives: To investigate (1) the frequency in which HEMA and di‐HEMA trimethylhexyl dicarbamate are present in nail cosmetics; (2) whether nail cosmetics comply with EU regulations; (3) which other (meth)acrylates are present in nail cosmetics and how often. Methods: One‐line market survey. Results: HEMA was present in nearly 60% of 394 cosmetic nail products and di‐HEMA trimethylhexyl dicarbamate in 34%. Mandatory warnings on the packages of products containing HEMA were absent in 35% ('For professional use only') resp. 55% ('Can cause an allergic reaction'). Forty‐five other (meth)acrylates were identified, of which the most frequent were hydroxypropyl methacrylate (25%), isobornyl methacrylate (16%) and trimethylolpropane triacrylate (12%). Some ingredient lists mentioned non‐INCI names or non‐specific names. Conclusions: HEMA was by far the most common ingredient of nail cosmetics, being present in nearly 60% of the products. Violations of EU legislation occurred in >30% (mandatory warnings missing) resp. 10% (mislabelling) of nail cosmetics. [ABSTRACT FROM AUTHOR]